Lan MaSummaryAffiliation: Fudan University Country: China Publications
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Publications
Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoformsXiaoqing Zhang
Pharmacology Research Center and National Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China
J Neurochem 106:781-92. 2008..Thus, the post-endocytic fate of internalized DOR can be regulated by GRK2-catalyzed receptor phosphorylation as well as distinct beta-arrestin isoforms...
Beta-arrestin signaling and regulation of transcriptionLan Ma
Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
J Cell Sci 120:213-8. 2007..This beta-arrestin-mediated regulation of transcription appears to play important roles in cell growth, apoptosis and modulation of immune functions...- Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal grayBaohong Jiang
Pharmacology Research Center and Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Neurosci Lett 400:150-3. 2006..These findings support the notion that PAG is an important site where beta-arrestin 2 plays its regulatory effects on morphine analgesia... - The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in ratsWei Wang
Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
Neuropharmacology 52:355-61. 2007..These results demonstrate that SPD can inhibit acquisition, maintenance, and re-acquisition of morphine conditioned place preference and suggest its potential for treatment of opioid addiction... - Single and repeated morphine administrations differently regulate expression of N-ethylmaleimide-sensitive factor gene in the rat brainHaohong Li
Pharmacology Research Center, Department of Pharmacology, Shanghai Medical College Fudan University, Shanghai, China
Neuroreport 17:71-4. 2006..These findings suggest that the N-ethylmaleimide-sensitive factor may be involved in the maladaptive changes in the nervous system after opiate treatment... 
Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioningYuting Li
The State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai 200032, China
Proc Natl Acad Sci U S A 106:21918-23. 2009..Taken together, our data demonstrate that the feedback regulation of amygdalar PKA activation by beta-arrestin-2 and PDE-4 complex is critical for the formation of conditioned fear memory...- Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivoJiali Li
National Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai 200032, China
J Biol Chem 278:30219-26. 2003.... - EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activationYuejun Chen
Pharmacology Research Center and State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai 200032, China
Mol Biol Cell 19:2973-83. 2008..These data indicate that EGF transregulates opioid receptors through EGFR-mediated tyrosyl phosphorylation and activation of GRK2 and propose GRK2 as a mediator of cross-talk from RTK to GPCR signaling pathway... - Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin, and cocaine administrationsYan Jiang
National Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Neurosci Lett 352:216-20. 2003.... - Different roles of dopamine receptor subtypes in footshock stress-induced enhancement of morphine conditioned place preferenceZhengze Dai
Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai 200032, PR China
Neurosci Lett 409:52-6. 2006..These results indicate that dopamine D(1), D(2), and D(3) receptor subtypes play different roles in footshock stress-induced enhancement of morphine conditioned place preference... - Metabolic enzymes link morphine withdrawal with metabolic disorderXi Jiang
National Laboratory of Medical Neurobiology and Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China
Cell Res 17:741-3. 2007 - Beta-arrestin1 and beta-arrestin2 are differentially required for phosphorylation-dependent and -independent internalization of delta-opioid receptorsXiaoqing Zhang
Pharmacology Research Center, Shanghai Medical College, Shanghai, China
J Neurochem 95:169-78. 2005..These results thus provide the first evidence of different requirement for beta-arrestin isoforms in the agonist induced phosphorylation-dependent and -independent GPCR internalization... - Chronic, but not acute morphine treatment, up-regulates alpha-Ca2+/calmodulin dependent protein kinase II gene expression in rat brainYuejun Chen
Pharmacology Research Center and State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai 200032, China
Neurochem Res 33:2092-8. 2008..Taken together, our data demonstrate that chronic morphine treatment region-specific up-regulates the levels of the alpha-CaMK II gene expression in hippocampus and frontal cortex... - Role of withdrawal in reinstatement of morphine-conditioned place preferenceLin Lu
National Laboratory of Medical Neurobiology and Pharmacology Research Center, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
Psychopharmacology (Berl) 181:90-100. 2005..The present study suggests that CRF receptor antagonists might be of value in the treatment and prevention of relapse to drug seeking after long-term abstinence... - [Regulation of G protein-coupled receptor kinase 5 mRNA and protein level in rat brain by addictive drugs]Min Zhu
Pharmacological Research Center, Shanghai Medical College, Fudan University, State Key Lab of Medical Neurobiology, China
Sheng Li Xue Bao 56:559-65. 2004..01), Taken together, our results indicate that addictive drugs can regulate GRK5 in the rat brain on protein level as well as on mRNA level and suggest that GRK5 may play a role in addiction of psychoactive substances... - Regulation of EGF-induced ERK/MAPK activation and EGFR internalization by G protein-coupled receptor kinase 2Jingxia Gao
Pharmacology Research Center, Shanghai Medical College, Fudan University, Shanghai 200032, China
Acta Biochim Biophys Sin (Shanghai) 37:525-31. 2005.... - A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcriptionJiuhong Kang
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, The Graduate School, Chinese Academy of Sciences, Shanghai 200031, China
Cell 123:833-47. 2005.... - Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2Ping Wang
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People s Republic of China
J Biol Chem 278:6363-70. 2003..Our study thus suggests that beta-arrestin 2 may serve as a cross-talk linker between GPCR and p53 signaling pathways... - Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activationYue Sun
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People s Republic of China
J Biol Chem 277:49212-9. 2002.... - Morphine and heroin differentially modulate in vivo hippocampal LTP in opiate-dependent ratGuobin Bao
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
Neuropsychopharmacology 32:1738-49. 2007.... - Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7Blanca Camoretti-Mercado
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 281:20383-92. 2006..Our findings thus reveal that SRF-Smad7 interactions in part mediate TGFbeta regulation of gene transcription in airway smooth muscle. This offers potential targets for interventions in treating lung inflammation and asthma... - Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor functionMichael T Roberts
Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, Institutes for Neuroscience and Cell and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712
J Biol Chem 281:3305-11. 2006.... - Analysis of opioid-induced kinase activationLan Ma
National Laboratory of Medical Neurobiology, Fudan University Medical Center, Shanghai, China
Methods Mol Med 84:39-46. 2003 - Subcellular localization of beta-arrestins is determined by their intact N domain and the nuclear export signal at the C terminusPing Wang
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
J Biol Chem 278:11648-53. 2003.... - Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiatesLu Pu
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People's Republic of China
J Neurosci 22:1914-21. 2002..These findings demonstrated that chronic opiate treatment can significantly modulate synaptic plasticity in the hippocampus, leading to an opiate dependence of the plasticity... - Reactivation of morphine conditioned place preference by drug priming: role of environmental cues and sensitizationLin Lu
National Laboratory of Medical Neurobiology, Fudan University Medical Center, Shanghai, China
Psychopharmacology (Berl) 159:125-32. 2002..CONCLUSIONS: Environment-related cues and behavioral sensitization play critical roles in the incentive motivation underlying drug-seeking behaviors...