Affiliation: Fudan University
Chen J, Liu L, You C, Gu J, Ruan W, Zhang L, et al
. Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun. 2018;9:3585 pubmed publisher
..These extensive structural and biochemical studies may shed light on a common 3' end trimming mechanism for 3'→5' exonucleases in the metabolism of small non-coding RNAs. ..
Gu J, Wang M, Yang Y, Qiu D, Zhang Y, Ma J, et al
. GoldCLIP: Gel-omitted Ligation-dependent CLIP. Genomics Proteomics Bioinformatics. 2018;16:136-143 pubmed publisher
..GoldCLIP is readily applicable to diverse proteins to uncover their endogenous RNA targets. ..
Sun G, Yu X, Bao C, Wang L, Li M, Gan J, et al
. Identification and characterization of a novel prokaryotic peptide: N-glycosidase from Elizabethkingia meningoseptica. J Biol Chem. 2015;290:7452-62 pubmed publisher
..These structural and functional analyses indicated that the candidate protein is a novel prokaryotic N-glycosidase. The protein has been named PNGase F-II. ..
Wu B, Zhang M, Su S, Liu H, Gan J, Ma J. Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana. Biochem Biophys Res Commun. 2018;501:415-422 pubmed publisher
..Our structural analysis reveals the specific DNA recognition by B3 domain, combined with our in vitro experiments, we provide the structural insight into the important implication of AtVAL1-B3 domain in flowering process. ..
Zhang J, Liu H, Yao Q, Yu X, Chen Y, Cui R, et al
. Structural basis for single-stranded RNA recognition and cleavage by C3PO. Nucleic Acids Res. 2016;44:9494-9504 pubmed
..The work presented here further advances our understanding on the RNAi pathway. ..
Wu B, Su S, Patil D, Liu H, Gan J, Jaffrey S, et al
. Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun. 2018;9:420 pubmed publisher
Wu B, Li L, Huang Y, Ma J, Min J. Readers, writers and erasers of N6-methylated adenosine modification. Curr Opin Struct Biol. 2017;47:67-76 pubmed publisher
..Overall, we aim to mechanistically explain the reversible and dynamic nature of this unique RNA internal modification that contributes to the complexity of RNA-mediated gene regulation, and inspire new studies in epitranscriptomics. ..
Wu B, Xu J, Su S, Liu H, Gan J, Ma J. Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1. Biochem Biophys Res Commun. 2017;491:310-316 pubmed publisher
..Moreover, different from other YTH domain family proteins, Mmi1-YTH domain has a distinctive RNA-binding properties although it has a similar fold as other ones. ..
Liu H, Yu X, Chen Y, Zhang J, Wu B, Zheng L, et al
. Crystal structure of an RNA-cleaving DNAzyme. Nat Commun. 2017;8:2006 pubmed publisher
..Our studies reveal that DNA is capable of forming a compacted structure and that the functionality-limited bio-polymer can have a novel solution for a functional need in catalysis. ..