Affiliation: Fudan University
Zhang P, Li S, Gao Y, Lu W, Huang K, Ye D, et al
. Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3Î² (GSK-3Î²) with cellular activity of promoting glucose uptake. Bioorg Med Chem Lett. 2014;24:5639-5643 pubmed publisher
..All of these results suggested BTO-5s and BTO-5h maybe have potentially therapeutic value for anti-diabetes. The results also offer a new scaffold for designing and developing selective inhibitors with novel mechanisms of action. ..
Li S, Zhu C, Wang Y, Xie X, Xiao L, Zhang Z, et al
. Downregulation of Î²1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation. Cell Death Dis. 2018;9:196 pubmed publisher
..These results demonstrated B4GalT5 downregulation improved insulin resistance by promoting adipogenic commitment and decreasing M1 macrophage infiltration. ..
Zhang Z, Liu Y, Li S, Guo L, Zhao Y, Qian S, et al
. Suv39h1 mediates AP-2?-dependent inhibition of C/EBP? expression during adipogenesis. Mol Cell Biol. 2014;34:2330-8 pubmed publisher
..These findings indicate that Suv39h1 enhances AP-2?-mediated transcriptional repression of C/EBP? in an epigenetic manner and further inhibits adipocyte differentiation. ..
Zhang Z, Liu Y, Xiao L, Li S, Jiang J, Zhao Y, et al
. Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice. J Hepatol. 2015;63:1466-75 pubmed publisher
..Our findings identify a novel mechanism by which estrogen protects against hepatic steatosis in female mice via upregulating miR-125b expression. ..