Huawei Li

Summary

Affiliation: Fudan University
Country: China

Publications

  1. Chang Q, Wang J, Li Q, Kim Y, Zhou B, Wang Y, et al. Virally mediated Kcnq1 gene replacement therapy in the immature scala media restores hearing in a mouse model of human Jervell and Lange-Nielsen deafness syndrome. EMBO Mol Med. 2015;7:1077-86 pubmed publisher
    ..Our results demonstrate the first successful gene therapy treatment for gene defects specifically affecting the function of the stria vascularis, which is a major site affected by genetic mutations in inherited hearing loss. ..
  2. Ni W, Lin C, Guo L, Wu J, Chen Y, Chai R, et al. Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea. J Neurosci. 2016;36:8734-45 pubmed publisher
    ..This provides a better understanding of the mechanisms behind mitotic HC generation and might provide new approaches to stimulating mitotic HC regeneration. ..
  3. Li W, Wu J, Yang J, Sun S, Chai R, Chen Z, et al. Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci U S A. 2015;112:166-71 pubmed publisher
  4. Sang Q, Li W, Xu Y, Qu R, Xu Z, Feng R, et al. ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42. Biol Open. 2015;4:411-8 pubmed publisher
    ..A few of these proteins are closely related to hearing development. Taken together, our data suggest that ILDR1 is important for the survival of OHCs and provide novel insights into the pathogenesis of human deafness DFNB42 deafness. ..
  5. Chen Y, Zhang S, Chai R, Li H. Hair Cell Regeneration. Adv Exp Med Biol. 2019;1130:1-16 pubmed publisher
  6. Chen F, Ni W, Li W, Li H. Cochlear Implantation and Rehabilitation. Adv Exp Med Biol. 2019;1130:129-144 pubmed publisher
    ..Here we reviewed the surgical approaches for cochlear implants as well as the complications. ..
  7. Xie B, Dai C, Li H. Attenuated infrared neuron stimulation response in cochlea of deaf animals may associate with the degeneration of spiral ganglion neurons. Biomed Opt Express. 2015;6:1990-2005 pubmed publisher
    ..Deafened guinea pigs have elevated thresholds and smaller amplitude responses, likely a result of degenerated SGNs. Short pulse durations are more suitable to evoke responses in both normal hearing and deafened animals. ..
  8. Li H, Corrales C, Wang Z, Zhao Y, Wang Y, Liu H, et al. BMP4 signaling is involved in the generation of inner ear sensory epithelia. BMC Dev Biol. 2005;5:16 pubmed
  9. Lu X, Sun S, Qi J, Li W, Liu L, Zhang Y, et al. Bmi1 Regulates the Proliferation of Cochlear Supporting Cells Via the Canonical Wnt Signaling Pathway. Mol Neurobiol. 2017;54:1326-1339 pubmed publisher

More Information

Publications13

  1. Li W, You D, Chen Y, Chai R, Li H. Regeneration of hair cells in the mammalian vestibular system. Front Med. 2016;10:143-51 pubmed publisher
    ..Furthermore, this review highlights the current limitations of hair cell regeneration and provides the possible solutions to regenerate functional hair cells and to partially restore vestibular function. ..
  2. Chen Y, Li W, Li W, Chai R, Li H. Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium. Front Med. 2016;10:330-5 pubmed publisher
    ..Ezh2 continued to be expressed in the cochlear epithelium of adult mice. Our results provide the basic Ezh2 expression pattern and might be useful for further investigating the detailed role of Ezh2 during cochlear development. ..
  3. He Y, Tang D, Cai C, Chai R, Li H. LSD1 is Required for Hair Cell Regeneration in Zebrafish. Mol Neurobiol. 2016;53:2421-34 pubmed publisher
    ..Thus, LSD1 plays a critical role in hair cell regeneration and might represent a novel biomarker and potential therapeutic approach for the treatment of hearing loss. ..
  4. He Y, Wang Z, Sun S, Tang D, Li W, Chai R, et al. HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish. Mol Neurobiol. 2016;53:5103-17 pubmed publisher
    ..Our results indicate that HDAC3 plays a crucial role in regulating posterior lateral line (PLL) formation and provide evidence for epigenetic regulation in auditory organ development. ..