Research Topics
Genomes and Genes | Huawei LiSummaryAffiliation: Fudan University Country: China Publications
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Detail Information
Publications
Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cellsHuawei Li
Department of Otolarygology, EENT Hospital of Shanghai Medical College of Fudan University, Institute of Biomedical Sciences, Fudan University Shanghai, 200031, PR China
BMC Neurosci 10:122. 2009..Obtaining reproducible percentages of neural cells is difficult and the methods are time consuming...- A six-generation Chinese family in haplogroup B4C1C exhibits high penetrance of 1555A > G-induced hearing LossYan Bai
Department of Otolaryngology, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai 200031, China
BMC Med Genet 11:129. 2010..Environmental factors, nuclear genes, mitochondrial haplotypes/variants and a possible threshold effect have been reported to may be involved in its manifestation... - BMP4 signaling is involved in the generation of inner ear sensory epitheliaHuawei Li
Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
BMC Dev Biol 5:16. 2005..Homozygous BMP4-/- animals die before the inner ear's sensory organs develop, which precludes determining the role of BMP4 in these organs with simple gene knockout experiments... 
Islet-1 expression in the developing chicken inner earHuawei Li
Department of Otolaryngology and Program in Neuroscience, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Comp Neurol 477:1-10. 2004..Our data is consistent with a role for islet-1 in differentiating inner ear neurons and sensory epithelia cells, perhaps in the specification of cellular subtypes in conjunction with other LIM/homeodomain proteins...- Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of CortiC Eduardo Corrales
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
J Neurobiol 66:1489-500. 2006..The regeneration of these neurons shows that neurons differentiated from stem cells have the capacity to grow to a specific target in an animal model of neuronal degeneration... - Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear developmentMingqian Huang
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary and Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
Dev Dyn 237:3305-12. 2008..With the exception of Lmx1a and Lhx3, all LIM-HDs are expressed in ganglion neurons. Expression of multiple LIM-HDs within a cell type suggests their redundant function... - Generation of hair cells by stepwise differentiation of embryonic stem cellsHuawei Li
Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 100:13495-500. 2003.... - Correlation of Pax-2 expression with cell proliferation in the developing chicken inner earHuawei Li
Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA
J Neurobiol 60:61-70. 2004..Furthermore, the likelihood that Pax-2-expressing cells in the otocyst die by apoptosis is much lower when compared with cells residing in Pax-2-negative regions... 
Early postnatal virus inoculation into the scala media achieved extensive expression of exogenous green fluorescent protein in the inner ear and preserved auditory brainstem response thresholdsYunfeng Wang
Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA, USA
J Gene Med 15:123-33. 2013..The present study aimed to define a suitable strategy for preserving hearing after viral inoculation directly into the scala media performed at various postnatal developmental stages...- Generation of inner ear cell types from embryonic stem cellsMarcelo N Rivolta
Department of Otolaryngology and Program in Neuroscience, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA
Methods Mol Biol 330:71-92. 2006..Inner ear progenitor cells, generated from ES cells, may be used for the development of cell replacement therapy for the diseased inner ear, for high-throughput drug screening, and for the study of inner ear development... - Correlation of expression of the actin filament-bundling protein espin with stereociliary bundle formation in the developing inner earHuawei Li
Department of Otolaryngology and Program in Neuroscience, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Comp Neurol 468:125-34. 2004.... - Stem cells as therapy for hearing lossHuawei Li
Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Trends Mol Med 10:309-15. 2004.... - Pluripotent stem cells from the adult mouse inner earHuawei Li
Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Nat Med 9:1293-9. 2003..Our observation that these stem cells are capable of differentiating into hair cell-like cells implies a possible use of such cells for the replacement of lost inner-ear sensory cells... - A low-cost exon capture method suitable for large-scale screening of genetic deafness by the massively-parallel sequencing approachWenxue Tang
Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Genet Test Mol Biomarkers 16:536-42. 2012..The high coverage depth and cost benefits of the cDNA-probe-based exon capture approach may also facilitate widespread applications in clinical practices beyond screening mutations in deafness genes... - Sonic hedgehog initiates cochlear hair cell regeneration through downregulation of retinoblastoma proteinNa Lu
Otology Skull Base Surgery Department, Hearing Research Institute, Eye and ENT Hospital of Shanghai Medical School, Fudan University, Shanghai 200031, China Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Biochem Biophys Res Commun 430:700-5. 2013..This study provides an additional route to modulate pRb function with important implications in mammalian hair cell regeneration... - Disrupting Rb-Raf-1 interaction inhibits hair cell regeneration in zebrafish lateral line neuromastsQin Lin
Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China
Neuroreport 24:190-5. 2013..Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous HC regeneration in zebrafish... - Survival-enhancing of spiral ganglion cells under influence of olfactory ensheathing cells by direct cellular contactQuan Liu
Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Shanghai Medical College of Fudan University, 83 Fen Yang Road, Shanghai 200031, PR China
Neurosci Lett 478:37-41. 2010..In conclusion, our results suggest that enhancement in co-cultures is in part due to direct cellular contact. Transplantation of OECs may be a cell-based therapy for the application of neurotrophic factors to the inner ear... - Targeted connexin26 ablation arrests postnatal development of the organ of CortiYunfeng Wang
Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
Biochem Biophys Res Commun 385:33-7. 2009..These results demonstrated that Cx26 plays essential roles in postnatal maturation and homoeostasis of the organ of Corti before the onset of hearing... - [Clinical experience in facial nerve tumors: a review of 27 cases]Fan Zhang
Department of Otolaryngology, Eye Ear Nose Throat Hospital of Fudan University, Shanghai, 200031, China
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 24:4-7. 2010..To analyze the clinical manifestations and the diagnosis of the facial nerve tumor according to the clinical information, and evaluate the different surgical approaches depending on tumor location...