Qun Ying Lei

Summary

Affiliation: Fudan University
Country: China

Publications

  1. ncbi request reprint Acetylation control of cancer cell metabolism
    Ruiting Lin
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Curr Pharm Des 20:2627-33. 2014
  2. pmc TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
    Qun Ying Lei
    Department of Biological Chemistry, School of Medicine, Molecular and Cellular Biology Laboratory, Institutes of Biomedical Sciences, Department of Biology, School of Life Science, Fudan University, Shanghai 200032, China
    Mol Cell Biol 28:2426-36. 2008
  3. pmc The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition
    Wei Huang
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    J Biol Chem 287:26245-53. 2012
  4. pmc PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ
    Chen Ying Liu
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology School of Medicine, Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
    J Biol Chem 286:5558-66. 2011
  5. pmc The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase
    Chen Ying Liu
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology School of Medicine
    J Biol Chem 285:37159-69. 2010
  6. pmc TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
    Heng Zhang
    Molecular and Cell Biology Laboratory, Institutes of Biomedical Sciences, School of Life Science, Fudan University, Shanghai, China 200032
    J Biol Chem 284:13355-62. 2009
  7. doi request reprint Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization
    Lei Lv
    Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, People s Republic of China Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, People s Republic of China School of Life Sciences, Fudan University 200032, People s Republic of China
    Mol Cell 52:340-52. 2013
  8. pmc Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal
    Tingting Li
    From the Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China
    J Biol Chem 289:3775-85. 2014
  9. pmc Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer
    Di Zhao
    Ministry of Education Key Laboratory of Molecular Medicine, Shanghai Medical College and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200032, China
    Cancer Cell 23:464-76. 2013
  10. doi request reprint Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth
    Ruiting Lin
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Mol Cell 51:506-18. 2013

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Acetylation control of cancer cell metabolism
    Ruiting Lin
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Curr Pharm Des 20:2627-33. 2014
    ..This review focuses on recent advances in the acetylation regulation of metabolic enzymes involved in the Warburg effect, the dysfunction of acetylation regulation in tumorigenesis and their potential role in cancer metabolism therapy. ..
  2. pmc TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
    Qun Ying Lei
    Department of Biological Chemistry, School of Medicine, Molecular and Cellular Biology Laboratory, Institutes of Biomedical Sciences, Department of Biology, School of Life Science, Fudan University, Shanghai 200032, China
    Mol Cell Biol 28:2426-36. 2008
    ..Our results elucidate a molecular mechanism for TAZ regulation and indicate a potential function of TAZ as an important target of the Hippo pathway in regulating cell proliferation tumorigenesis...
  3. pmc The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition
    Wei Huang
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    J Biol Chem 287:26245-53. 2012
    ..This study provides a novel mechanism of TAZ regulation and suggests a role of TAZ in modulating tissue growth and tumor development in response to PI3K signaling...
  4. pmc PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ
    Chen Ying Liu
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology School of Medicine, Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
    J Biol Chem 286:5558-66. 2011
    ..As a result, PP1 and ASPP2 increase TAZ-dependent gene expression. This study demonstrates that PP1A and ASPP2 play a critical role in promoting TAZ function by antagonizing the LATS kinase through TAZ dephosphorylation...
  5. pmc The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase
    Chen Ying Liu
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology School of Medicine
    J Biol Chem 285:37159-69. 2010
    ..The phosphodegron-mediated TAZ degradation plays an important role in negatively regulating TAZ biological functions...
  6. pmc TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
    Heng Zhang
    Molecular and Cell Biology Laboratory, Institutes of Biomedical Sciences, School of Life Science, Fudan University, Shanghai, China 200032
    J Biol Chem 284:13355-62. 2009
    ..Our study establishes a functional partnership between TAZ and TEAD under negative regulation by the Hippo signaling pathway...
  7. doi request reprint Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization
    Lei Lv
    Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, People s Republic of China Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, People s Republic of China School of Life Sciences, Fudan University 200032, People s Republic of China
    Mol Cell 52:340-52. 2013
    ..Hence, K433 acetylation links cell proliferation and transformation to the switch of PKM2 from a cytoplasmic metabolite kinase to a nuclear protein kinase. ..
  8. pmc Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal
    Tingting Li
    From the Key Laboratory of Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, China
    J Biol Chem 289:3775-85. 2014
    ..Our study reveals a mechanism of GAPDH enzyme activity regulation by acetylation and its critical role in cellular regulation. ..
  9. pmc Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer
    Di Zhao
    Ministry of Education Key Laboratory of Molecular Medicine, Shanghai Medical College and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200032, China
    Cancer Cell 23:464-76. 2013
    ..Importantly, K5 acetylation of LDH-A is reduced in human pancreatic cancers. Our study reveals a mechanism of LDH-A upregulation in pancreatic cancers...
  10. doi request reprint Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth
    Ruiting Lin
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Mol Cell 51:506-18. 2013
    ..Our study reveals a crosstalk between acetylation and ubiquitylation by competing for the same lysine residues in the regulation of fatty acid synthesis and cell growth in response to glucose. ..
  11. ncbi request reprint Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase
    Yanping Xu
    Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, School of Life Sciences, Fudan University, Shanghai, PR China
    Cancer Res 74:3630-42. 2014
    ..These results reveal a mechanism of PGAM2 regulation and NADPH homeostasis in response to oxidative stress that impacts cell proliferation and tumor growth. Cancer Res; 74(13); 3630-42. ©2014 AACR. ..
  12. doi request reprint Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage
    Xin Zhou
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Shanghai 200032, China
    Biochem J 441:227-36. 2012
    ..Thus the present study reveals a novel regulation of RASSF1C and the potentially important role of RASSF1C in DNA damage responses...
  13. pmc p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation
    Yue Zhao
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai, People s Republic of China
    Mol Cell Biol 34:315-24. 2014
    ..In summary, we have identified ATF5 as a new cofactor of C/EBPβ and examined how C/EBPβ and ATF5 (acetylated by a p300-dependent mechanism) regulate the transcription of C/EBPα. ..
  14. doi request reprint Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
    Lei Lv
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University, Shanghai 200032, China
    Mol Cell 42:719-30. 2011
    ..These results reveal an acetylation regulation of pyruvate kinase and the link between lysine acetylation and CMA...
  15. doi request reprint Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment
    Hai yan Huang
    Key Laboratory of Molecular Medicine, Ministry of Education Department of Biochemistry and Molecular Biology, Fudan University Shanghai Medical College, Shanghai 200032, PR China
    Stem Cell Res 10:278-87. 2013
    ..In this study, we also found that only Twist was down-regulated after Lox silencing in C3H10T1/2 cells treated with BMP4. This study provides new insights into adipocyte lineage commitment...
  16. ncbi request reprint Acetylation control of metabolic enzymes in cancer: an updated version
    Wei Huang
    Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Acta Biochim Biophys Sin (Shanghai) 46:204-13. 2014
    ..In addition, their potential roles in cancer metabolism therapy will also be briefly discussed. ..
  17. ncbi request reprint The relationship between PTEN expression and anoikis in human lung carcinoma cell lines
    Qun Ying Lei
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Biochemistry Department, Fudan University Medical College, Shanghai 200032, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34:463-8. 2002
    ..PTEN decreased the phosphorylation level of PKB and down-regulated FAK expression in HLCC. These results suggest that PTEN expression is different in 8 HLCC lines, and PTEN was involved in anoikis...