Ai Jun Hou
Affiliation: Fudan University
Hu Z, Zong J, Yili A, Yu M, Aisa H, Hou A. Isosteroidal alkaloids from the bulbs of Fritillaria tortifolia. Fitoterapia. 2018;131:112-118 pubmed publisher
..Compound 1 showed significant relaxant effect on Ach-induced tracheal contraction with pA2 and EC50 values equivalent to those of aminophylline. ..
Xue J, Lei C, Wang P, Kim K, Li J, Li J, et al
. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki. Fitoterapia. 2018;130:37-42 pubmed publisher
..The structures of these compounds were elucidated by extensive spectroscopic methods, including NMR, MS, and ECD analyses. Compounds 1, 2, 5, 8, 9, 11, and 12 showed in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B). ..
Wang M, Gao L, Wang J, Li J, Yu M, Li J, et al
. Diels-Alder adducts with PTP1B inhibition from Morus notabilis. Phytochemistry. 2015;109:140-6 pubmed publisher
..Their structures were elucidated by extensive spectroscopic analysis, including 1D, 2D NMR, MS, and ECD data. Compounds 1, 5, and 7-9 showed inhibition against PTP1B phosphatase activity in vitro. ..
Ji J, Zhu J, Hu X, Wang T, Zhang X, Hou A, et al
. (2S)-7,4'-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells. Biochem Biophys Res Commun. 2015;460:578-82 pubmed publisher
Wang M, Yu B, Yu M, Gao L, Li J, Wang H, et al
. New Isoprenylated Phenolic Compounds from Morus laevigata. Chem Biodivers. 2015;12:937-45 pubmed publisher
..Laevigasin A (1) showed significant inhibitory effect on Î±-glucosidase in vitro. Notabilisin E (5), taxifolin (10), and hultenin (11) inhibited PTP1B phosphatase activity in vitro. ..
Zhang L, Lei C, Gao L, Li J, Li J, Hou A. Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulata. Nat Prod Bioprospect. 2016;6:25-30 pubmed publisher
..Some compounds showed inhibitory activities against PTP1B in vitro. ..
Zhu J, Huang J, Wang T, Ji J, Hou A, Wang H. Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression. Endocrine. 2017;56:73-81 pubmed publisher
..These results showed the potential of SGF as a candidate for the therapy of type 2 diabetes. ..
Huang Q, Lei C, Wang P, Li J, Li J, Hou A. Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba. Fitoterapia. 2017;122:138-143 pubmed publisher
..All the new compounds and most of the known ones showed significant inhibitory effects on PTP1B in vitro with IC50 values ranging from 0.57 to 7.49?M. ..