Ji Yao Chen

Summary

Affiliation: Fudan University
Country: China

Publications

  1. ncbi request reprint The cytotoxic and genotoxic potential of 5-aminolevulinic acid on lymphocytes: a comet assay study
    E S M Chu
    Biomedical Science Section, School of Nursing, Hong Kong Polytechnic University, China
    Cancer Chemother Pharmacol 58:408-14. 2006
  2. doi request reprint The conjugates of gold nanorods and chlorin e6 for enhancing the fluorescence detection and photodynamic therapy of cancers
    Xiao Huang
    State Key Laboratory of Surface Physics and Department of Physics and Key Laboratory of Micro and Nano Photonic Structures Ministry of Education, Fudan University, 220, Handan Road, Shanghai 200433, China
    Phys Chem Chem Phys 15:15727-33. 2013
  3. pmc Quantum dot-aluminum phthalocyanine conjugates perform photodynamic reactions to kill cancer cells via fluorescence resonance energy transfer
    Lei Li
    State Key Laboratory of Surface Physics, Department of Physics, and Key Laboratory of Micro and Nano Photonic Structures Ministry of Education, Fudan University, Shanghai, 200433, People s Republic of China
    Nanoscale Res Lett 7:386. 2012
  4. ncbi request reprint Endogenous production of protoporphyrin IX induced by 5-aminolevulinic acid in leukemia cells
    J Y Chen
    Department of Physics, Fudan University, Shanghai 200433, China
    Acta Pharmacol Sin 22:163-8. 2001
  5. doi request reprint Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging
    Rong Chen
    Surface Physics Laboratory National key laboratory and Department of Physics, Fudan University, Shanghai, China
    Ultrastruct Pathol 32:193-8. 2008
  6. ncbi request reprint Infrared spectral comparison of 5-aminolevulinic acid and its hexyl ester
    J Y Chen
    Department of Physics, Fudan University, Shanghai, China
    Spectrochim Acta A Mol Biomol Spectrosc 59:2571-6. 2003
  7. ncbi request reprint Comparison of 5-aminolevulinic acid and its hexylester mediated photodynamic action on human hepatoma cells
    Qing Guang Ren
    Department of Physics, Fudan University, Shanghai 200433, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34:650-4. 2002
  8. ncbi request reprint Time-dependent photoluminescence blue shift of the quantum dots in living cells: effect of oxidation by singlet oxygen
    Yu Zhang
    State Key Lab for Advanced Photonic Materials and Devices, Department of Optical Science and Engineering, Key Laboratory of Molecular Engineering of Polymers, and Institute of Genetics, Fudan University, Shanghai, China
    J Am Chem Soc 128:13396-401. 2006
  9. doi request reprint Plasmonic gold nanorods can carry sulfonated aluminum phthalocyanine to improve photodynamic detection and therapy of cancers
    Lei Li
    State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China
    J Phys Chem B 114:17194-200. 2010
  10. doi request reprint Photoluminescence decay dynamics of thiol-capped CdTe quantum dots in living cells under microexcitation
    Yu Zhang
    State Key Laboratory for Advanced Photonic Materials and Devices, Department of Optical Science and Engineering, Fudan University, Shanghai 200433, P R China
    Small 4:777-80. 2008

Collaborators

Detail Information

Publications40

  1. ncbi request reprint The cytotoxic and genotoxic potential of 5-aminolevulinic acid on lymphocytes: a comet assay study
    E S M Chu
    Biomedical Science Section, School of Nursing, Hong Kong Polytechnic University, China
    Cancer Chemother Pharmacol 58:408-14. 2006
    ..The side effect, especially the long-term side effect of these drugs is a problem of concern in this field, which has not been clearly understood yet...
  2. doi request reprint The conjugates of gold nanorods and chlorin e6 for enhancing the fluorescence detection and photodynamic therapy of cancers
    Xiao Huang
    State Key Laboratory of Surface Physics and Department of Physics and Key Laboratory of Micro and Nano Photonic Structures Ministry of Education, Fudan University, 220, Handan Road, Shanghai 200433, China
    Phys Chem Chem Phys 15:15727-33. 2013
    ..The increased cellular amount of Ce6 leads to a 3-fold more efficient photodynamic killing of these two cell lines. This demonstrates the potential of this approach to improve photodynamic detection and therapy of cancers. ..
  3. pmc Quantum dot-aluminum phthalocyanine conjugates perform photodynamic reactions to kill cancer cells via fluorescence resonance energy transfer
    Lei Li
    State Key Laboratory of Surface Physics, Department of Physics, and Key Laboratory of Micro and Nano Photonic Structures Ministry of Education, Fudan University, Shanghai, 200433, People s Republic of China
    Nanoscale Res Lett 7:386. 2012
    ....
  4. ncbi request reprint Endogenous production of protoporphyrin IX induced by 5-aminolevulinic acid in leukemia cells
    J Y Chen
    Department of Physics, Fudan University, Shanghai 200433, China
    Acta Pharmacol Sin 22:163-8. 2001
    ..To explore the photosensitization of 5-aminolevulinic acid (ALA) in myeloid leukemia cell line...
  5. doi request reprint Metabolic patterns (NAD(P)H) in rat basophilic leukemia (RBL-2H3) cells and human hepatocellular carcinoma (Hep G2) cells with autofluorescence imaging
    Rong Chen
    Surface Physics Laboratory National key laboratory and Department of Physics, Fudan University, Shanghai, China
    Ultrastruct Pathol 32:193-8. 2008
    ..These results confirm the metabolic pattern of NAD(P)H in living cells and suggest that the expression of the metabolic pattern probably differs in different cell lines...
  6. ncbi request reprint Infrared spectral comparison of 5-aminolevulinic acid and its hexyl ester
    J Y Chen
    Department of Physics, Fudan University, Shanghai, China
    Spectrochim Acta A Mol Biomol Spectrosc 59:2571-6. 2003
    ..Below the temperature of 80 degrees C, the ALA and ALA-H are thermally stable in structure. When temperature reached 120 degrees C, the serious structure breaking (thermal decomposition) happened for both ALA and ALA-H...
  7. ncbi request reprint Comparison of 5-aminolevulinic acid and its hexylester mediated photodynamic action on human hepatoma cells
    Qing Guang Ren
    Department of Physics, Fudan University, Shanghai 200433, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34:650-4. 2002
    ..2 mmol/L He-ALA or 2 mmol/L ALA and a similar level of cell survival was reached following light exposure. These results suggest that He-ALA is much more efficient at producing PpIX and photocytotoxicity than ALA itself in the cells...
  8. ncbi request reprint Time-dependent photoluminescence blue shift of the quantum dots in living cells: effect of oxidation by singlet oxygen
    Yu Zhang
    State Key Lab for Advanced Photonic Materials and Devices, Department of Optical Science and Engineering, Key Laboratory of Molecular Engineering of Polymers, and Institute of Genetics, Fudan University, Shanghai, China
    J Am Chem Soc 128:13396-401. 2006
    ..It was revealed that the PL blue shift resulted from the photooxidation of the QD core by singlet oxygen molecules formed on the QD core surface...
  9. doi request reprint Plasmonic gold nanorods can carry sulfonated aluminum phthalocyanine to improve photodynamic detection and therapy of cancers
    Lei Li
    State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China
    J Phys Chem B 114:17194-200. 2010
    ..In addition, the loaded AlPcS can be photothermally released from AuNRs in the cells by the irradiation with an 800 nm femtosecond laser, demonstrating the potential for controlled drug release...
  10. doi request reprint Photoluminescence decay dynamics of thiol-capped CdTe quantum dots in living cells under microexcitation
    Yu Zhang
    State Key Laboratory for Advanced Photonic Materials and Devices, Department of Optical Science and Engineering, Fudan University, Shanghai 200433, P R China
    Small 4:777-80. 2008
  11. ncbi request reprint Photochemical instability of thiol-capped CdTe quantum dots in aqueous solution and living cells: process and mechanism
    Jiong Ma
    Surface Physics Laboratory National Key Laboratory, Physics Department, State Key Laboratory for Advanced Photonic Materials and Devices, Fudan University, Shanghai, PR China
    J Phys Chem B 111:12012-6. 2007
    ..By comparing the photostability of QDs in C2C12 cells with and without NaN3 treatment, the photooxidation effect of 1O2 on photobleaching of cellular QDs was confirmed...
  12. doi request reprint Enhancement of intracellular delivery of anti-cancer drugs by the Tat peptide
    Jin Feng Zhao
    State Key Laboratory of Surface Physics and Department of Physics, and the Key Laboratory of Micro Nano Photonics Structure Ministry of Education, Fudan University, Shanghai, China
    Ultrastruct Pathol 35:119-23. 2011
    ..This finding may suggest that the Tat peptide-mediated intracellular delivery of anticancer drugs may have the potential for improving efficacy of cancer therapy...
  13. doi request reprint Liposome encapsulation of thiol-capped CdTe quantum dots for enhancing the intracellular delivery
    Jun yong Wang
    State Key Laboratory of Surface Physics and Department of Physics, Fudan University, 220 Handan Road, Shanghai 200433, People s Republic of China
    J Fluoresc 21:1635-42. 2011
    ..These results suggest that the cationic liposome encapsulation is an effective modality to enhance the intracellular delivery of thiol-capped QDs...
  14. ncbi request reprint Surface stress on the erythrocyte under laser irradiation with finite-difference time-domain calculation
    Ji Tong Yu
    Fudan University, Department of Physics, Shanghai 200433, China
    J Biomed Opt 10:064013. 2005
    ..Thus, the FDTD method is more suitable than the RO method for the stress study of erythrocytes...
  15. ncbi request reprint Tracking of mercury ions in living cells with a fluorescent chemodosimeter under single- or two-photon excitation
    Zhou Jun Lu
    State Key Lab for Advanced Photonic Materials and Devices, Department of Optical Science and Engineering, Fudan University, Shanghai 200433, China
    Anal Chim Acta 597:306-12. 2007
    ....
  16. ncbi request reprint Photodynamic effects of 5-aminolevulinic acid and its hexylester on several cell lines
    Shu Min Wu
    Department of Physics, Fudan University, Shanghai 200433, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35:655-60. 2003
    ....
  17. ncbi request reprint Gallium phthalocyanine photosensitizers: carboxylation enhances the cellular uptake and improves the photodynamic therapy of cancers
    Jin F Zhao
    State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, PR China
    Anticancer Agents Med Chem 12:604-10. 2012
    ..Carboxylation is a promising way to prepare water-soluble metal phthalocyanines (MPcCs) and facilitates the cellular uptake of MPcCs for PDT improvement...
  18. doi request reprint Conjugates of folic acids with BSA-coated quantum dots for cancer cell targeting and imaging by single-photon and two-photon excitation
    He Meng
    State Key Laboratory of Surface Physics, Department of Physics, Fudan University, No 220 Handan Road, Shanghai, People s Republic of China
    J Biol Inorg Chem 16:117-23. 2011
    ..These characteristics suggest that FA-BSA-QDs are potential candidates for cancer diagnosis...
  19. doi request reprint Quantum dot-mediated photoproduction of reactive oxygen species for cancer cell annihilation
    Ji Yao Chen
    Surface Physics Laboratory National Key Laboratory, Physics Department, Fudan University, Shanghai, China
    Photochem Photobiol 86:431-7. 2010
    ..Using 0.6 mum quantum dots for incubation and 4.8 J cm(-2) for irradiation, about 80% of the cells were annihilated. These quantum dots promised to be potent sensitizers for photoannihilation of cancer cells...
  20. ncbi request reprint Conjugation of sulfonated aluminum phthalocyanine to doxorubicin can improve the efficacy of photodynamic cancer therapy
    Yan Li Qin
    State Key Laboratory of Surface Physics, Key Laboratory of Micro and Nano Photonic Structures Ministry of Education, Department of Physics, Fudan University, Shanghai, China
    Anticancer Drugs 23:1047-53. 2012
    ..These results indicate that the conjugation of a photosensitizer with a chemotherapy drug may improve photodynamic cancer therapy...
  21. doi request reprint Study on the intracellular fate of Tat peptide-conjugated quantum dots by spectroscopic investigation
    Rongling Xiong
    Department of Optical Science and Engineering, Fudan University, Shanghai 200433, China
    J Fluoresc 20:551-6. 2010
    ..The reasons for the spectral changes have been discussed in detail...
  22. doi request reprint Generation of singlet oxygen via the composites of water-soluble thiol-capped CdTe quantum dots-sulfonated aluminum phthalocyanines
    Jiong Ma
    Surface Physics Laboratory, Physics Department, Fudan University, Shanghai 200433, China
    J Phys Chem B 112:4465-9. 2008
    ..Therefore QD-Pc composites can fully utilize visible region light excitation to effectively produce 1O2, which may facilitate the applications of QD-Pc composites in broad areas...
  23. doi request reprint The use of femto-second lasers to trigger powerful explosions of gold nanorods to destroy cancer cells
    Xi Wu
    State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China
    Biomaterials 34:6157-62. 2013
    ..5 J/mm(2) killed more than 90% of AuNRs-loaded cells, indicating that the fs laser-triggered explosions of intracellular AuNRs are powerful enough to instantaneously kill tumour cells...
  24. doi request reprint Fluorescence detection of protoporphyrin IX in living cells: a comparative study on single- and two-photon excitation
    Sijia Lu
    Fudan University, Department of Physics, 200433, Shanghai, China
    J Biomed Opt 13:024014. 2008
    ....
  25. doi request reprint Mitochondrial signaling for histamine releases in laser-irradiated RBL-2H3 mast cells
    Zu Hui Wu
    Surface Physics Laboratory National Key Laboratory, Department of Physics, Fudan University, Shanghai 200433, China
    Lasers Surg Med 42:503-9. 2010
    ..This study aims to explore the mechanism of histamine release in RBL-2H3 mast cells under laser irradiations...
  26. doi request reprint Thiol-capped CdTe quantum dots with two-photon excitation for imaging high autofluorescence background living cells
    Tao Wang
    Surface Physics Laboratory National key laboratory and Department of Physics, Fudan University, Shanghai, People s Republic of China
    J Fluoresc 19:615-21. 2009
    ..By means of the TPE, the reliable cellular imaging with QDs, even for the cells having the high AF background, can be achieved...
  27. doi request reprint The environmental influence on the photoluminescence behavior of thiol-capped CdTe quantum dots in living cells
    Yu Zhang
    Department of Optical Science and Engineering, Fudan University, Shanghai 200433, People s Republic of China
    Biomed Mater 4:012001. 2009
    ..In this review, the environmental influence on the PL behavior of intracellular thiol-capped CdTe QDs, such as the time-dependent spectral blueshift, photobleaching and lifetime shortening, is introduced and its mechanisms are discussed...
  28. ncbi request reprint Effects of low power laser irradiation on intracellular calcium and histamine release in RBL-2H3 mast cells
    Wen Zhong Yang
    Surface Physics Laboratory National Key Laboratory, Department of Physics, Fudan University, Shanghai, China
    Photochem Photobiol 83:979-84. 2007
    ..These induced responses of mast cells may provide an explanation for the biological effects of laser irradiation on promoting wound healing, as histamine is known to have multi-functions on accelerating wound healing...
  29. doi request reprint Poly (N-isopropylacrylamide)-coated multifunctional nanoparticles for cell tracking
    Pu Wang
    Surface Physics Laboratory National key laboratory and Department of Physics, Fudan University, Shanghai, China
    Photomed Laser Surg 28:201-5. 2010
    ..The tracking of transfused cells in vivo is an important step to study the therapeutic course and mechanism of cell therapeutics...
  30. ncbi request reprint A comparison of the photodynamic effects of temoporfin (mTHPC) and MC540 on leukemia cells: efficacy and apoptosis
    J Y Chen
    Department of Physics, Fudan University, Shanghai, People s Republic of China
    Photochem Photobiol 68:545-54. 1998
    ..Relative to MC540, the ability of mTHPC to trigger large-scale and thorough apoptosis in leukemia cells may help explain its potency and selectivity...
  31. ncbi request reprint Enhancement of intracellular delivery of CdTe quantum dots (QDs) to living cells by Tat conjugation
    F L Xue
    Institute of Genetics, Fudan University, Shanghai, China
    J Fluoresc 17:149-54. 2007
    ..1 (+/-0.3) times in QGY cells and 1.5 (+/-0.2) times in MCF7 cells, demonstrating the enhancing effect of Tat conjugation on the intracellular delivery of QDs...
  32. pmc Comparison of the killing effects between nitrogen-doped and pure TiO2 on HeLa cells with visible light irradiation
    Zheng Li
    Key Laboratory of Micro and Nano Photonic Structures Ministry of Education, Department of Optical Science and Engineering, Shanghai Ultra Precision Optical Manufacturing Engineering Center, Fudan University, 220 Handan Road, 200433, Shanghai, China
    Nanoscale Res Lett 8:96. 2013
    ..The cell morphology changes with time were also examined by a confocal microscope. The cells incubated with N-TiO2 exhibited serious distortion and membrane breakage at 60 min after the PDT...
  33. pmc Study on the visible-light-induced photokilling effect of nitrogen-doped TiO2 nanoparticles on cancer cells
    Zheng Li
    Key Laboratory of Micro and Nano Photonic Structures Ministry of Education, Department of Optical Science and Engineering, Fudan University, Shanghai 200433, China
    Nanoscale Res Lett 6:356. 2011
    ..The co-localization of N-TiO2 nanoparticles with nuclei or Golgi complexes was observed. The aberrant nuclear morphologies such as micronuclei were detected after the N-TiO2-treated cells were irradiated by the visible light...
  34. ncbi request reprint Photodynamic effects on nasopharyngeal carcinoma (NPC) cells with 5-aminolevulinic acid or its hexyl ester
    R W K Wu
    Department of Physics, State Key Laboratory for Advanced Photonic Materials and Devices, Fudan University, Shanghai, China
    Cancer Lett 242:112-9. 2006
    ..The ALA-H shows promising PDT results on NPC in vitro; therefore it is worth investigating further in vivo for NPC treatment...
  35. ncbi request reprint Protoporphyrin IX production and its photodynamic effects on glioma cells, neuroblastoma cells and normal cerebellar granule cells in vitro with 5-aminolevulinic acid and its hexylester
    S M Wu
    Department of Physics, Fudan University, Shanghai 200433, China
    Cancer Lett 200:123-31. 2003
    ..It appears that ALA-H could achieve similar or slightly better results than ALA with respect to PpIX production and photoinactivation of cells, although a 10 times lower concentration of ALA-H was used...
  36. ncbi request reprint In vitro effects of helium-neon laser irradiation on human blood: blood viscosity and deformability of erythrocytes
    Xian Qiang Mi
    Department of Physics, State Key Laboratory of Applied Surface Physics, Fudan University, Shanghai, China
    Photomed Laser Surg 22:477-82. 2004
    ..The purpose of this study was to investigate the in vitro effects of He-Ne laser irradiation on some rheological factors of human blood, such as blood viscosity, erythrocyte deformability, and sedimentation rate...
  37. ncbi request reprint Light distribution in the erythrocyte under laser irradiation: a finite-difference time-domain calculation
    Xiao Qian Wang
    Surface Physics Laboratory, Department of Physics, Fudan University, Shanghai 200433, China
    Appl Opt 47:4037-44. 2008
    ..Because the highest light intensity in the erythrocyte can be about one order of magnitude higher than that of the incident light, this factor should be taken into account for laser safety in medical applications...
  38. doi request reprint Fast differential interference contrast imaging combined with autocorrelation treatments to measure the heart rate of embryonic fish
    Jin Tao Zhu
    Fudan University, Surface Physics Laboratory National key laboratory and Department of Physics, Shanghai 200433, China
    J Biomed Opt 13:020503. 2008
    ..With this high-resolution system, we find that 1-mgL cadmium not only induces the slowing of the heart rate, but also caused signs of arrhythmia in treated fish...
  39. doi request reprint A comparison study of detecting gold nanorods in living cells with confocal reflectance microscopy and two-photon fluorescence microscopy
    Y Zhou
    Surface Physics Laboratory National Key Laboratory, Department of Physics, Fudan University, Shanghai, China
    J Microsc 237:200-7. 2010
    ..Therefore, confocal reflectance microscopy may also be a suitable means to image intracellular gold nanorods with the advantage of reduced photothermal effect...
  40. ncbi request reprint Studies on the photochemical and photocytotoxic properties of the new PDT photosensitizer aluminum sulfonated phthalocyanine
    J Y Chen
    Department of Physics, Fudan University, Shanghai, P R China
    Cancer Biochem Biophys 12:103-16. 1991
    ..Experiments using the latter method also showed DNA damage caused by ALSPC photosensitization...