Libo Yao

Summary

Affiliation: Fourth Military Medical University
Country: China

Publications

  1. pmc N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis
    Na Liu
    Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Biotechnology Center, Department of Immunology, The Fourth Military Medical University, Xi an, 710032, China
    Nucleic Acids Res 36:5335-49. 2008
  2. pmc NDRG2 suppresses the proliferation of clear cell renal cell carcinoma cell A-498
    Jian Jun Ma
    Department of Urology, Tangdu Hospital, The Fourth Military Medical University, Xi an, China
    J Exp Clin Cancer Res 29:103. 2010
  3. ncbi request reprint NDRG2: a Myc-repressed gene involved in cancer and cell stress
    Libo Yao
    The Institute of Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, China
    Acta Biochim Biophys Sin (Shanghai) 40:625-35. 2008
  4. doi request reprint Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis
    Jin Su
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, 17 Changle Western Road, Xi an, Shaanxi, 710032, People s Republic of China
    Mol Cell Biochem 330:141-52. 2009
  5. doi request reprint RNAi-mediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line
    Wei Lin
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University and The State Key Laboratory of Cancer Biology, Xi an, The People s Republic of China
    J Cell Mol Med 13:4608-22. 2009
  6. ncbi request reprint NDRG2 expression regulates CD24 and metastatic potential of breast cancer cells
    Jin Zheng
    Department of Oncology, Xijing Hospital, China
    Asian Pac J Cancer Prev 11:1817-21. 2010
  7. doi request reprint Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway
    Hai Shi
    State Key Laboratory of Cancer Biology and Department of Gastrointestinal Surgery, Xijing Hospital, Xi an, China
    Cancer Sci 100:1585-90. 2009
  8. pmc NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats
    Jiandong Yang
    Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    PLoS ONE 6:e27710. 2011
  9. ncbi request reprint Suppression of N-myc downstream-regulated gene 2 is associated with induction of Myc in colorectal cancer and correlates closely with differentiation
    Hai Shi
    Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Biol Pharm Bull 32:968-75. 2009
  10. ncbi request reprint The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter
    Jian Zhang
    Institute of Molecular Biology and the State Key Laboratory of Cancer Biology, Fourth Military Medical University, 710032 Xi an, China
    J Biol Chem 281:39159-68. 2006

Collaborators

  • Jian Zhang
  • Lan Shen
  • Yan Li
  • Guodong Yang
  • Wei Zhang
  • Xia Li
  • Jin Zheng
  • Hua Han
  • Haiyan Fu
  • Hai Shi
  • Lei Gao
  • Xinping Liu
  • Jin Su
  • Shaoping Ji
  • Jiangtian Yu
  • Angang Yang
  • Ji Ma
  • Tingting Ren
  • Yanchun Deng
  • LiFeng Wang
  • Na Liu
  • Junye Liu
  • Wenchao Liu
  • Zhongchan Sun
  • Lin Wu
  • Tao Wang
  • Jiandong Yang
  • Wei Lin
  • Yan Guo
  • Yingmei Wang
  • Yan Xue
  • Yan Zhang
  • Xin Bu
  • Chuigong Yu
  • Fuyang Li
  • Tenglong Han
  • Li Li
  • Lintao Jia
  • Wugang Hou
  • Nana Dang
  • Suning Chen
  • Yuanqiang Zhang
  • Huadong Zhao
  • Jianjun Ma
  • Yingqi Zhang
  • Shuya Zhang
  • Bin Zhou
  • Hu Zhao
  • Jianying Li
  • Shu Jun Li
  • Yurong Tao
  • Ruixiao Li
  • Qianrong Wang
  • Haichang Wang
  • Yuanxiong Cheng
  • Xuewu Liu
  • Guang Tong
  • Sen Li
  • Guojun Wu
  • Qingli Zhao
  • Noor Beckwith
  • Lu Miao
  • Feng Cao
  • Ming Shi
  • Zhuo Tang
  • Bin Zhang
  • Kangchu Li
  • Guozhen Guo
  • Yongbin Chen
  • Kefeng Dou
  • Jian Jun Ma
  • Jie Yang
  • Jianlin Yuan
  • Xue Jiang
  • YunXin Cao
  • Wei Han
  • Yonghao Gu
  • Fan Lu
  • Qi Yang
  • Yousheng Wu
  • Fang Yu
  • Jicun Wang
  • Nan Liu
  • Tong Zhu
  • Chuchao Zhu
  • Shuangxing Hou
  • Di Li
  • Yun Cai Liu
  • Shuang Li
  • Yuan Zhang

Detail Information

Publications66

  1. pmc N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis
    Na Liu
    Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Biotechnology Center, Department of Immunology, The Fourth Military Medical University, Xi an, 710032, China
    Nucleic Acids Res 36:5335-49. 2008
    ..Our results indicate that NDRG2 is a novel p53-inducible target that is involved in the p53-mediated apoptosis pathway...
  2. pmc NDRG2 suppresses the proliferation of clear cell renal cell carcinoma cell A-498
    Jian Jun Ma
    Department of Urology, Tangdu Hospital, The Fourth Military Medical University, Xi an, China
    J Exp Clin Cancer Res 29:103. 2010
    ..Recently, the anti-tumor activity of N-myc downstream-regulated gene 2 (NDRG2) was shown decreased expression in clear cell renal cell carcinoma (CCRCC), but the role of the down-expression of NDRG2 has not been described...
  3. ncbi request reprint NDRG2: a Myc-repressed gene involved in cancer and cell stress
    Libo Yao
    The Institute of Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, China
    Acta Biochim Biophys Sin (Shanghai) 40:625-35. 2008
    ..This review summarizes the recent studies on the structure, tissue distribution and functions of NDRG2 that try to show its significance in studying cancer and its therapeutic potential...
  4. doi request reprint Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis
    Jin Su
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, 17 Changle Western Road, Xi an, Shaanxi, 710032, People s Republic of China
    Mol Cell Biochem 330:141-52. 2009
    ..The data in this study suggest that DDR2-mediated MMP-13 induction by collagen matrix in synovial fibroblasts of RA contributed to articular cartilage destruction...
  5. doi request reprint RNAi-mediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line
    Wei Lin
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University and The State Key Laboratory of Cancer Biology, Xi an, The People s Republic of China
    J Cell Mol Med 13:4608-22. 2009
    ..In summary, our data highlight the importance of MSP58 in glioma progression and provided a biological basis for MSP58 as a novel candidate target for treatment of glioma...
  6. ncbi request reprint NDRG2 expression regulates CD24 and metastatic potential of breast cancer cells
    Jin Zheng
    Department of Oncology, Xijing Hospital, China
    Asian Pac J Cancer Prev 11:1817-21. 2010
    ..In conclusion, the data from the current study indicated that NDRG2, the product of a tumor suppressor gene, can regulate CD24 expression to decrease the metastatic potential of breast cancer cells...
  7. doi request reprint Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway
    Hai Shi
    State Key Laboratory of Cancer Biology and Department of Gastrointestinal Surgery, Xijing Hospital, Xi an, China
    Cancer Sci 100:1585-90. 2009
    ..These results indicated that MSP58 might play an important role in the carcinogenesis of CRC via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway...
  8. pmc NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in rats
    Jiandong Yang
    Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    PLoS ONE 6:e27710. 2011
    ..In conclusion, the present findings indicate that the modulation of NDRG2 is a promising strategy for the treatment of liver fibrosis...
  9. ncbi request reprint Suppression of N-myc downstream-regulated gene 2 is associated with induction of Myc in colorectal cancer and correlates closely with differentiation
    Hai Shi
    Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Biol Pharm Bull 32:968-75. 2009
    ..Taken together, NDRG2 may play a role during the differentiation of colorectal cancer cells, and the function of NDRG2 in the development of colorectal cancer should be further investigated...
  10. ncbi request reprint The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter
    Jian Zhang
    Institute of Molecular Biology and the State Key Laboratory of Cancer Biology, Fourth Military Medical University, 710032 Xi an, China
    J Biol Chem 281:39159-68. 2006
    ..The regulatory function of Myc on NDRG2 gene expression implicated the role of the Ndrg2 in regulating cell differentiation...
  11. ncbi request reprint The physical and functional interaction of NDRG2 with MSP58 in cells
    Jing Zhang
    The Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China 710032, China
    Biochem Biophys Res Commun 352:6-11. 2007
    ..Furthermore, the modulation of Ndrg2 level influences the cell cycle process together with MSP58. In conclusion, the findings offered a novel insight into the physiological roles of Ndrg2...
  12. doi request reprint NDRG2 is a new HIF-1 target gene necessary for hypoxia-induced apoptosis in A549 cells
    LiFeng Wang
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, PR China
    Cell Physiol Biochem 21:239-50. 2008
    ..Taken together, this study suggests that NDRG2 is a Hif-1 target gene and closely related with hypoxia-induced apoptosis in A549 cells...
  13. ncbi request reprint E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation
    Guodong Yang
    The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi an, China
    Cell Cycle 10:2703-13. 2011
    ..Taken together, our results reveal that E2F1 directly transcribes QKI, which, in turn, negatively regulates the cell cycle by targeting multiple cell cycle regulators, forming an E2F1-QKI-pRb/E2F1 negative feedback loop...
  14. pmc Knock-down of NDRG2 sensitizes cervical cancer Hela cells to cisplatin through suppressing Bcl-2 expression
    Junye Liu
    Department of Radiation Medicine, Fourth Military Medical University, Xi an, China
    BMC Cancer 12:370. 2012
    ..This interesting phenomenon drove us to evaluate the role of NDRG2 in chemosensitivity of Hela cells...
  15. ncbi request reprint Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1
    Fang Yu
    Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an 710032, PR China
    Biochem Biophys Res Commun 358:1041-6. 2007
    ....
  16. doi request reprint Identification of Juxtanodin promoter and its transcriptional regulation during the ATRA-induced differentiation of C6 cells
    Tao Wang
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, People s Republic of China
    Mol Cell Biochem 350:177-83. 2011
    ..In summary, our study here suggests that Nkx2.2 is one of the essential transcription factors delivering the specificity of JN promoter in oligodendrocytes...
  17. doi request reprint CD167 acts as a novel costimulatory receptor in T-cell activation
    Nana Dang
    Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    J Immunother 32:773-84. 2009
    ..Together these findings, we demonstrate for the first time that CD167 could serve as a novel costimulatory receptor for T-cell activation...
  18. ncbi request reprint Promoter methylation, mutation, and genomic deletion are involved in the decreased NDRG2 expression levels in several cancer cell lines
    Na Liu
    Department of Biochemistry and Molecular Biology, The Center of Molecular Medicine, The Fourth Military Medical University, The State Key Laboratory of Cancer Biology, 17 Changle Western Road, 710032 Xi an, People s Republic of China
    Biochem Biophys Res Commun 358:164-9. 2007
    ..Unexpectedly, changes in the NDRG2 gene were not observed. Here, we describe for the first time, the mechanisms involved in NDRG2 gene down-regulation...
  19. ncbi request reprint Degradation of HER2 by Cbl-based chimeric ubiquitin ligases
    Xia Li
    State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
    Cancer Res 67:8716-24. 2007
    ..Collectively, our findings suggest that the Cbl-based chimeric ubiquitin ligases designed in the present study may represent a novel approach for the targeted therapy of HER2-overexpressing cancers...
  20. pmc Hyperthermia-induced NDRG2 upregulation inhibits the invasion of human hepatocellular carcinoma via suppressing ERK1/2 signaling pathway
    Yan Guo
    Department of Oncology, State Key Discipline of Cell Biology, Xijing Hospital, The Fourth Military Medical University, Shaanxi, China
    PLoS ONE 8:e61079. 2013
    ..The combined application of constitutive NDRG2 expression with HT may yield an optimized therapeutic benefit...
  21. ncbi request reprint A host deficiency of discoidin domain receptor 2 (DDR2) inhibits both tumour angiogenesis and metastasis
    Shuya Zhang
    State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi an, People s Republic of China Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Department of Biochemistry and Molecular Biology, Ningxia Medical University, Yinchuan, People s Republic of China
    J Pathol 232:436-48. 2014
    ..Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  22. doi request reprint NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity
    Lan Shen
    Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Cell Mol Life Sci 67:1371-81. 2010
    ..Collectively, these data indicate that NDRG2 acts as a key molecule in pancreatic beta cells and is involved in the Akt-mediated protection of beta cells against lipotoxicity...
  23. ncbi request reprint Fusion expression of DDR2 extracellular domain in insect cells and its purification and function characterization
    Wei Zhang
    Department of Microbiology, The Fourth Military Medical University, Xi an, Shaanxi 710032, P R China
    J Cell Biochem 102:41-51. 2007
    ..These findings suggested that the expressed DR inhibited the activity of natural DDR2 and relevant MMP-1 and MMP-2 expression in RA synoviocytes and NIH3T3 cells provoked by collagen II...
  24. ncbi request reprint Expression of NDRG2 in esophageal squamous cell carcinoma
    Hai Shi
    State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Cancer Sci 101:1292-9. 2010
    ..In summary, our results demonstrated that NDRG2 played an important role in the proliferation of ESCC cells and the expression of NDRG2 in ESCC was closely related with the prognosis...
  25. doi request reprint NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury
    Zhongchan Sun
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 15 Changle Western Road, Xi an, 710032, China
    Basic Res Cardiol 108:341. 2013
    ..Taken together, these results suggest a novel role of PI3K/Akt/NDRG2 signaling in the cardioprotective effect of insulin...
  26. doi request reprint Microarray profiling of HepG2 cells ectopically expressing NDRG2
    Xuewu Liu
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, People s Republic of China
    Gene 503:48-55. 2012
    ..Our research provides the molecular basis for understanding the role of NDRG2 in tumor cells and raises interesting questions about its mechanisms and potential use in cancer therapy...
  27. doi request reprint Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region
    Jian Zhang
    The Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, 710032, People s Republic of China
    Gene 417:5-12. 2008
    ..Taken together, our results demonstrate that, in common with NDRG2, human NDRG1 can be indirectly transcriptionally down-regulated by Myc via interaction with the NDRG1 core promoter...
  28. pmc N-myc downstream-regulated gene 2, a novel estrogen-targeted gene, is involved in the regulation of Na+/K+-ATPase
    Yan Li
    Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, China
    J Biol Chem 286:32289-99. 2011
    ..Our results demonstrate that estrogen/NDRG2/Na(+)/K(+)-ATPase β1 pathway is important in promoting Na(+)/K(+)-ATPase activity and suggest this novel pathway might have substantial roles in ion transport, fluid balance, and homeostasis...
  29. pmc RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer
    Guodong Yang
    The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
    Gastroenterology 138:231-40.e1-5. 2010
    ..Here we studied the role of RNA-binding protein quaking (QKI) in colon cancer...
  30. pmc AKT inhibitor suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells
    Yurong Tao
    Department of Oncology, State Key Discipline of Cell Biology, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi, China
    Braz J Med Biol Res 46:394-404. 2013
    ..Furthermore, AKT inhibitor VIII suppressed Ndrg2 phosphorylation and rendered gastric cancer cells susceptible to apoptosis induced by hyperthermia...
  31. ncbi request reprint HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells
    Junye Liu
    Department of Radiation Medicine, Fourth Military Medical University, Xi an, China
    Exp Cell Res 316:1985-93. 2010
    ..It would be meaningful to further explore the clinical application potential of HIF-1 and NDRG2 blockade as radiosensitizer for tumor therapy...
  32. ncbi request reprint Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells
    Wei Zhang
    Department of Microbiology, The Fourth Military Medical University, Xi an, Shaanxi 710032, P R China
    Mol Cell Biochem 290:43-53. 2006
    ..All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II...
  33. pmc The RNA-binding protein QKI5 is a direct target of C/EBPα and delays macrophage differentiation
    Haiyan Fu
    State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Mgilitary Medical University, 710032 Xi an, China
    Mol Biol Cell 23:1628-35. 2012
    ....
  34. doi request reprint Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells
    Yan Li
    The Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an 710032, China
    Eur J Pharmacol 591:252-8. 2008
    ..These results suggest that Calebin-A might be an effective compound for the treatment of human gastric and other MDR cancers...
  35. doi request reprint Regulation of histone acetylation by NDRG2 in glioma cells
    Li Li
    Department of Neurology, Xijing Hospital, The Fourth Military Medical University, 15 Changle xi Road, Xi an, 710032, China
    J Neurooncol 106:485-92. 2012
    ..Furthermore, NDRG2 siRNA significantly reduced the level of histone acetylation induced by trichostatin A. Taken together, these data demonstrate that NDRG2 can regulate the level of histone acetylation to control glioma cell growth...
  36. doi request reprint Ras homolog gene family, member A promotes p53 degradation and vascular endothelial growth factor-dependent angiogenesis through an interaction with murine double minute 2 under hypoxic conditions
    Ji Ma
    Department of Oncology, Xijing Hospital, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi an, China
    Cancer 118:4105-16. 2012
    ....
  37. doi request reprint Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients
    Tingting Ren
    State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, ChangLe Western Road, Xi an, Shaanxi 710032, People s Republic of China
    Med Oncol 30:397. 2013
    ..The present research provided the first evidence that increased DDR2 mRNA expression in primary human breast cancer might be a powerful, independent predictor of recurrence and outcome...
  38. ncbi request reprint Expression of NDRG2 in clear cell renal cell carcinoma
    Jianjun Ma
    Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Biol Pharm Bull 31:1316-20. 2008
    ..These results indicated that NDRG2 might play an important role in the carcinogenesis and development of CCRCC and may function as a tumor suppressor in CCRCC...
  39. ncbi request reprint Ubiquitin ligase Cbl-b acts as a negative regulator in discoidin domain receptor 2 signaling via modulation of its stability
    Jiangtian Yu
    Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an 710032, China
    FEBS Lett 588:1509-14. 2014
    ..Thus, Cbl-b, by promoting the ubiquitination and degradation of DDR2, functions as a negative regulator in the DDR2 signaling pathway. ..
  40. pmc NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expression
    Jin Zheng
    State Key Discipline of Cell Biology, Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, China
    BMC Cancer 11:251:1-9. 2011
    ..Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The role of CD24 and NDRG2 (N-myc downstream-regulated gene 2), a candidate tumor suppressor gene, has not yet been explored in HCC...
  41. doi request reprint Preparation and application of monoclonal antibody against hNDRG2
    Xinping Liu
    Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Appl Biochem Biotechnol 152:306-15. 2009
    ..Some tissue distribution features of Ndrg2 proteins, such as thyroid, kidney, testis, prostate, and pancreas islets, were present by immunohistochemistry...
  42. pmc Inhibition of endothelial cell proliferation and tumor angiogenesis by up-regulating NDRG2 expression in breast cancer cells
    Ji Ma
    Department of Oncology, Xijing Hospital, The State Key Discipline of Cell Biology, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    PLoS ONE 7:e32368. 2012
    ..Thus, specific overexpression of NDRG2 by adenovirus represents a promising approach for the treatment of tumor angiogenesis...
  43. ncbi request reprint N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation
    Yanchun Deng
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
    Int J Cancer 106:342-7. 2003
    ..Our findings provide the first evidence to suggest that hNDRG2 may play a role in glioblastoma carcinogenesis...
  44. doi request reprint An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation
    Yan Zhang
    Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, People s Republic of China
    J Bone Miner Res 26:604-17. 2011
    ..Thus this study reveals for the first time that DDR2 plays an essential role in osteoblast and chondrocyte differentiation. The mechanism disclosure may provide therapeutic targets for human genetic disorders caused by DDR2 deficiency...
  45. doi request reprint Human Ermin (hErmin), a new oligodendrocyte-specific cytoskeletal protein related to epileptic seizure
    Tao Wang
    Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi an 710032, China
    Brain Res 1367:77-84. 2011
    ..These findings suggest a role for hErmin as a novel cytoskeleton-related oligodendroglial protein in human brain myelination and human epileptogenesis, and provide new evidence for the relationship between oligodendrocytes and epilepsy...
  46. doi request reprint Variation of NDRG2 and c-Myc expression in rat heart during the acute stage of ischemia/reperfusion injury
    Zhongchan Sun
    Department of Cardiovascular Medicine, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    Histochem Cell Biol 135:27-35. 2011
    ..This stress response might be involved in the novel mechanism of myocardial apoptosis induced by I/R injury in rat...
  47. pmc Overexpression of N-Myc downstream-regulated gene 2 (NDRG2) regulates the proliferation and invasion of bladder cancer cells in vitro and in vivo
    Ruixiao Li
    Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    PLoS ONE 8:e76689. 2013
    ..001). The expression of NDRG2 was low in the three BC cell lines. T24 cells infected with LEN-NDRG2 showed inhibition of proliferation both in vitro and in vivo, and NDRG2 overexpression can inhibit tumor growth and invasion in vitro. ..
  48. doi request reprint NDRG2 in rat liver regeneration: role in proliferation and apoptosis
    Jiandong Yang
    Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Wound Repair Regen 18:524-31. 2010
    ..In conclusion, our findings point to physiological roles for NDRG2 in liver regeneration...
  49. ncbi request reprint Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB
    Guodong Yang
    Department of Biochemistry and Molecular Biology, State Key Lab of Cancer Biology, Fourth Military Medical University, Xi an 710032, P R China
    Mol Cell Biochem 302:187-94. 2007
    ..Our data suggested that APR3 might be functionally important in certain processes under which NFAT and/or NFkappaB are/is activated...
  50. pmc Expression of NDRG2 in human lung cancer and its correlation with prognosis
    Shu Jun Li
    State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi an 710032, Shanxi, People s Republic of China
    Med Oncol 30:421. 2013
    ..These data showed that NDRG2 may play an important role in human lung cancer tumourigenesis, and NDRG2 might serve as a novel prognostic marker in human lung cancer...
  51. doi request reprint Spatial-temporal expression of NDRG2 in rat brain after focal cerebral ischemia and reperfusion
    Yan Li
    Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Brain Res 1382:252-8. 2011
    ..In conclusion, NDRG2 expression is up-regulated in ischemic penumbra following transient focal cerebral ischemia. NDRG2 expression in astrocytes may play important pathological roles in cell apoptosis after stroke...
  52. pmc Reduced expression of N-Myc downstream-regulated gene 2 in human thyroid cancer
    Huadong Zhao
    Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi an, 710038, PR China
    BMC Cancer 8:303. 2008
    ..NDRG2 also exerts important functions in cell differentiation and tumor suppression. However, it remains unclear whether NDRG2 participates in carcinogenesis of the thyroid...
  53. ncbi request reprint PH domain of G protein-coupled receptor kinase-2 binds to protein kinase C (PKC) and negatively regulates activity of PKC kinase
    Shaoping Ji
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, Shaaxi, 710032 PR China
    Front Biosci 8:a34-9. 2003
    ..Thus, GRK2 may play a negative feedback regulatory role on PKCbeta1 activity in interaction between GRK2 and PKCbeta 1...
  54. ncbi request reprint Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9
    Yan Li
    Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an 710032, China
    Appl Biochem Biotechnol 135:181-92. 2006
    ..These results indicate that resveratrol seems to exert its growth-inhibitory/apoptotic effect on the breast cancer cell line MCF7 via the Akt-caspase-9 pathway...
  55. pmc Retrograde Ductal Administration of the Adenovirus-mediated NDRG2 Gene Leads to Improved Sialaden Hypofunction in Estrogen-deficient Rats
    Yan Li
    1 Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China 2 Department of Oral Biology, Stomatology School, The Fourth Military Medical University, Xi an, China 3 Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Mol Ther 22:908-18. 2014
    ..This study elucidates the mechanism of estrogen deficiency-mediated xerostomia or sialaden hypofunction and provides a promising strategy for therapeutic intervention. ..
  56. ncbi request reprint Inhibition of N-myc downstream-regulated gene 2 in prostatic carcinoma
    Chuigong Yu
    Department of Biochemistry and Molecular Biology State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Cancer Biol Ther 12:304-13. 2011
    ..Moreover, adenovirus-mediated NDRG2 can suppress the proliferation of PC3 cells significantly both in vitro and in vivo. These results indicate that NDRG2 may become a new target gene for PCA diagnosis and therapy...
  57. pmc Production and characterization of a recombinant single-chain antibody against Hantaan virus envelop glycoprotein
    Jie Yang
    Department of Nephrology, Tangdu Hospital, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Appl Microbiol Biotechnol 86:1067-75. 2010
    ..Our results showed that the E. coli-produced scFv had potential applications in targeted and intracellular delivery of therapeutics against HTNV infections...
  58. doi request reprint Altered expression of NDRG2 in the testes of experimental rat model of cryptorchidism
    Wugang Hou
    Department of Histology and Embryology, The Fourth Military Medical University, Xi an, People s Republic of China
    Urology 75:985-91. 2010
    ..To examine the expression of N-Myc downstream regulated gene 2 (NDRG2) in the cryptorchid testes and its potential association with germ cell apoptosis in a rat model of cryptorchidism...
  59. doi request reprint The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy
    Lan Shen
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, The People s Republic of China
    Clin Cancer Res 18:1561-7. 2012
    ....
  60. ncbi request reprint Transcriptional up-regulation of restin by all-trans retinoic acid through STAT1 in cancer cell differentiation process
    Haiyan Fu
    Department of Biochemistry and Molecular Biology, State Key Lab of Cancer Biology, Fourth Military Medical University, Xi an 710032, PR China
    Biochem Biophys Res Commun 343:1009-16. 2006
    ....
  61. doi request reprint A rational design of completely random shRNA library
    Guodong Yang
    The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an 710032, PR China
    Biochem Biophys Res Commun 430:987-92. 2013
    ..Here we provide a practical workflow for construction of such a random shRNA library. In the novel shRNA library, there are about tens of different shRNAs targeting one gene, and thus significantly avoids the off-target effects...
  62. ncbi request reprint Tumor suppressor candidate gene, NDRG2 is frequently inactivated in human glioblastoma multiforme
    Bin Zhou
    Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, P R China
    Mol Med Rep 10:891-6. 2014
    ..Furthermore, these findings indicate that NDRG2 downregulation may be due to aberrant methylation of the NDRG2 promoter region and subsequent transcriptional inactivation. ..
  63. doi request reprint Autophagy is a therapeutic target in anticancer drug resistance
    Suning Chen
    Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, People s Republic of China
    Biochim Biophys Acta 1806:220-9. 2010
    ....
  64. pmc A naturally-occurring mutation in Cacna1f in a rat model of congenital stationary night blindness
    Yonghao Gu
    Department of Clinical Aerospace Medicine, Fourth Military Medical University, Xi an, China
    Mol Vis 14:20-8. 2008
    ..To identify the gene mutation responsible for a previously described rat model of X-linked congenital stationary night blindness (CSNB)...
  65. pmc Up-Regulation of pVHL along with Down-Regulation of HIF-1α by NDRG2 Expression Attenuates Proliferation and Invasion in Renal Cancer Cells
    Lei Gao
    Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China Department of Urology, Tangdu Hospital, The Fourth Military Medical University, Xi an, China Department of Urology, Wuhan General Hospital, Guangzhou Command PLA, Wuhan, China
    PLoS ONE 8:e84127. 2013
    ..In conclusion, these data indicate that NDRG2 may be involved in proliferation and invasion by impacting the expression of VHL and HIF-1α. NDRG2 may be an attractive therapeutic target for renal cell carcinoma. ..