Research Topics
Genomes and Genes
| Libo YaoSummaryAffiliation: Fourth Military Medical University Country: China Publications
| Collaborators
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Detail Information
Publications
Knock-down of NDRG2 sensitizes cervical cancer Hela cells to cisplatin through suppressing Bcl-2 expressionJunye Liu
Department of Radiation Medicine, Fourth Military Medical University, Xi an, China
BMC Cancer 12:370. 2012..This interesting phenomenon drove us to evaluate the role of NDRG2 in chemosensitivity of Hela cells...- NDRG2 suppresses the proliferation of clear cell renal cell carcinoma cell A-498Jian Jun Ma
Department of Urology, Tangdu Hospital, The Fourth Military Medical University, Xi an, China
J Exp Clin Cancer Res 29:103. 2010..Recently, the anti-tumor activity of N-myc downstream-regulated gene 2 (NDRG2) was shown decreased expression in clear cell renal cell carcinoma (CCRCC), but the role of the down-expression of NDRG2 has not been described... 
NDRG2: a Myc-repressed gene involved in cancer and cell stressLibo Yao
The Institute of Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, China
Acta Biochim Biophys Sin (Shanghai) 40:625-35. 2008..This review summarizes the recent studies on the structure, tissue distribution and functions of NDRG2 that try to show its significance in studying cancer and its therapeutic potential...- NDRG2 expression regulates CD24 and metastatic potential of breast cancer cellsJin Zheng
Department of Oncology, Xijing Hospital, China
Asian Pac J Cancer Prev 11:1817-21. 2010..In conclusion, the data from the current study indicated that NDRG2, the product of a tumor suppressor gene, can regulate CD24 expression to decrease the metastatic potential of breast cancer cells... 
Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritisJin Su
Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, 17 Changle Western Road, Xi an, Shaanxi, 710032, People s Republic of China
Mol Cell Biochem 330:141-52. 2009..The data in this study suggest that DDR2-mediated MMP-13 induction by collagen matrix in synovial fibroblasts of RA contributed to articular cartilage destruction...- Suppression of N-myc downstream-regulated gene 2 is associated with induction of Myc in colorectal cancer and correlates closely with differentiationHai Shi
Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
Biol Pharm Bull 32:968-75. 2009..Taken together, NDRG2 may play a role during the differentiation of colorectal cancer cells, and the function of NDRG2 in the development of colorectal cancer should be further investigated... - NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-β1/Smad pathway and altering the MMP2/TIMP2 ratio in ratsJiandong Yang
Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, China
PLoS ONE 6:e27710. 2011..In conclusion, the present findings indicate that the modulation of NDRG2 is a promising strategy for the treatment of liver fibrosis... - E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulationGuodong Yang
The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi an, China
Cell Cycle 10:2703-13. 2011..Taken together, our results reveal that E2F1 directly transcribes QKI, which, in turn, negatively regulates the cell cycle by targeting multiple cell cycle regulators, forming an E2F1-QKI-pRb/E2F1 negative feedback loop... - Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1Fang Yu
Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an 710032, PR China
Biochem Biophys Res Commun 358:1041-6. 2007.... - Identification of Juxtanodin promoter and its transcriptional regulation during the ATRA-induced differentiation of C6 cellsTao Wang
Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, People s Republic of China
Mol Cell Biochem 350:177-83. 2011..In summary, our study here suggests that Nkx2.2 is one of the essential transcription factors delivering the specificity of JN promoter in oligodendrocytes... - Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathwayHai Shi
State Key Laboratory of Cancer Biology and Department of Gastrointestinal Surgery, Xijing Hospital, Xi an, China
Cancer Sci 100:1585-90. 2009..These results indicated that MSP58 might play an important role in the carcinogenesis of CRC via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway... - Fusion expression of DDR2 extracellular domain in insect cells and its purification and function characterizationWei Zhang
Department of Microbiology, The Fourth Military Medical University, Xi an, Shaanxi 710032, P R China
J Cell Biochem 102:41-51. 2007..These findings suggested that the expressed DR inhibited the activity of natural DDR2 and relevant MMP-1 and MMP-2 expression in RA synoviocytes and NIH3T3 cells provoked by collagen II... - HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cellsJunye Liu
Department of Radiation Medicine, Fourth Military Medical University, Xi an, China
Exp Cell Res 316:1985-93. 2010..It would be meaningful to further explore the clinical application potential of HIF-1 and NDRG2 blockade as radiosensitizer for tumor therapy... - The physical and functional interaction of NDRG2 with MSP58 in cellsJing Zhang
The Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China 710032, China
Biochem Biophys Res Commun 352:6-11. 2007..Furthermore, the modulation of Ndrg2 level influences the cell cycle process together with MSP58. In conclusion, the findings offered a novel insight into the physiological roles of Ndrg2... - Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter regionJian Zhang
The Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, 710032, People s Republic of China
Gene 417:5-12. 2008..Taken together, our results demonstrate that, in common with NDRG2, human NDRG1 can be indirectly transcriptionally down-regulated by Myc via interaction with the NDRG1 core promoter... - The RNA-binding protein QKI5 is a direct target of C/EBPα and delays macrophage differentiationHaiyan Fu
State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Mgilitary Medical University, 710032 Xi an, China
Mol Biol Cell 23:1628-35. 2012.... - NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicityLan Shen
Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
Cell Mol Life Sci 67:1371-81. 2010..Collectively, these data indicate that NDRG2 acts as a key molecule in pancreatic beta cells and is involved in the Akt-mediated protection of beta cells against lipotoxicity... - N-myc downstream-regulated gene 2, a novel estrogen-targeted gene, is involved in the regulation of Na+/K+-ATPaseYan Li
Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, China
J Biol Chem 286:32289-99. 2011..Our results demonstrate that estrogen/NDRG2/Na(+)/K(+)-ATPase β1 pathway is important in promoting Na(+)/K(+)-ATPase activity and suggest this novel pathway might have substantial roles in ion transport, fluid balance, and homeostasis... - Expression of NDRG2 in esophageal squamous cell carcinomaHai Shi
State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, China
Cancer Sci 101:1292-9. 2010..In summary, our results demonstrated that NDRG2 played an important role in the proliferation of ESCC cells and the expression of NDRG2 in ESCC was closely related with the prognosis... - N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosisNa Liu
Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Biotechnology Center, Department of Immunology, The Fourth Military Medical University, Xi an, 710032, China
Nucleic Acids Res 36:5335-49. 2008..Our results indicate that NDRG2 is a novel p53-inducible target that is involved in the p53-mediated apoptosis pathway... - NDRG2 is a new HIF-1 target gene necessary for hypoxia-induced apoptosis in A549 cellsLiFeng Wang
Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, PR China
Cell Physiol Biochem 21:239-50. 2008..Taken together, this study suggests that NDRG2 is a Hif-1 target gene and closely related with hypoxia-induced apoptosis in A549 cells... - Degradation of HER2 by Cbl-based chimeric ubiquitin ligasesXia Li
State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
Cancer Res 67:8716-24. 2007..Collectively, our findings suggest that the Cbl-based chimeric ubiquitin ligases designed in the present study may represent a novel approach for the targeted therapy of HER2-overexpressing cancers... - Ras homolog gene family, member A promotes p53 degradation and vascular endothelial growth factor-dependent angiogenesis through an interaction with murine double minute 2 under hypoxic conditionsJi Ma
Department of Oncology, Xijing Hospital, State Key Discipline of Cell Biology, Fourth Military Medical University, Xi an, China
Cancer 118:4105-16. 2012.... - RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancerGuodong Yang
The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
Gastroenterology 138:231-40.e1-5. 2010..Here we studied the role of RNA-binding protein quaking (QKI) in colon cancer... - Regulation of histone acetylation by NDRG2 in glioma cellsLi Li
Department of Neurology, Xijing Hospital, The Fourth Military Medical University, 15 Changle xi Road, Xi an, 710032, China
J Neurooncol 106:485-92. 2012..Furthermore, NDRG2 siRNA significantly reduced the level of histone acetylation induced by trichostatin A. Taken together, these data demonstrate that NDRG2 can regulate the level of histone acetylation to control glioma cell growth... - CD167 acts as a novel costimulatory receptor in T-cell activationNana Dang
Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an, Shaanxi 710032, China
J Immunother 32:773-84. 2009..Together these findings, we demonstrate for the first time that CD167 could serve as a novel costimulatory receptor for T-cell activation... - Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cellsYan Li
The Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an 710032, China
Eur J Pharmacol 591:252-8. 2008..These results suggest that Calebin-A might be an effective compound for the treatment of human gastric and other MDR cancers... - Preparation and application of monoclonal antibody against hNDRG2Xinping Liu
Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
Appl Biochem Biotechnol 152:306-15. 2009..Some tissue distribution features of Ndrg2 proteins, such as thyroid, kidney, testis, prostate, and pancreas islets, were present by immunohistochemistry... - Variation of NDRG2 and c-Myc expression in rat heart during the acute stage of ischemia/reperfusion injuryZhongchan Sun
Department of Cardiovascular Medicine, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
Histochem Cell Biol 135:27-35. 2011..This stress response might be involved in the novel mechanism of myocardial apoptosis induced by I/R injury in rat... - Inhibition of endothelial cell proliferation and tumor angiogenesis by up-regulating NDRG2 expression in breast cancer cellsJi Ma
Department of Oncology, Xijing Hospital, The State Key Discipline of Cell Biology, The Fourth Military Medical University, Xi an, Shaanxi Province, China
PLoS ONE 7:e32368. 2012..Thus, specific overexpression of NDRG2 by adenovirus represents a promising approach for the treatment of tumor angiogenesis... - NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expressionJin Zheng
State Key Discipline of Cell Biology, Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, China
BMC Cancer 11:251:1-9. 2011..Understanding the molecular mechanisms underlying HCC metastasis is extremely urgent. The role of CD24 and NDRG2 (N-myc downstream-regulated gene 2), a candidate tumor suppressor gene, has not yet been explored in HCC... - Reduced expression of N-Myc downstream-regulated gene 2 in human thyroid cancerHuadong Zhao
Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi an, 710038, PR China
BMC Cancer 8:303. 2008..NDRG2 also exerts important functions in cell differentiation and tumor suppression. However, it remains unclear whether NDRG2 participates in carcinogenesis of the thyroid... - An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activationYan Zhang
Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, People s Republic of China
J Bone Miner Res 26:604-17. 2011..Thus this study reveals for the first time that DDR2 plays an essential role in osteoblast and chondrocyte differentiation. The mechanism disclosure may provide therapeutic targets for human genetic disorders caused by DDR2 deficiency... - Inhibition of N-myc downstream-regulated gene 2 in prostatic carcinomaChuigong Yu
Department of Biochemistry and Molecular Biology State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi an, China
Cancer Biol Ther 12:304-13. 2011..Moreover, adenovirus-mediated NDRG2 can suppress the proliferation of PC3 cells significantly both in vitro and in vivo. These results indicate that NDRG2 may become a new target gene for PCA diagnosis and therapy... - Human Ermin (hErmin), a new oligodendrocyte-specific cytoskeletal protein related to epileptic seizureTao Wang
Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi an 710032, China
Brain Res 1367:77-84. 2011..These findings suggest a role for hErmin as a novel cytoskeleton-related oligodendroglial protein in human brain myelination and human epileptogenesis, and provide new evidence for the relationship between oligodendrocytes and epilepsy... - Spatial-temporal expression of NDRG2 in rat brain after focal cerebral ischemia and reperfusionYan Li
Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
Brain Res 1382:252-8. 2011..In conclusion, NDRG2 expression is up-regulated in ischemic penumbra following transient focal cerebral ischemia. NDRG2 expression in astrocytes may play important pathological roles in cell apoptosis after stroke... - Altered expression of NDRG2 in the testes of experimental rat model of cryptorchidismWugang Hou
Department of Histology and Embryology, The Fourth Military Medical University, Xi an, People s Republic of China
Urology 75:985-91. 2010..To examine the expression of N-Myc downstream regulated gene 2 (NDRG2) in the cryptorchid testes and its potential association with germ cell apoptosis in a rat model of cryptorchidism... - Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patientsTingting Ren
State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, ChangLe Western Road, Xi an, Shaanxi 710032, People s Republic of China
Med Oncol 30:397. 2013..The present research provided the first evidence that increased DDR2 mRNA expression in primary human breast cancer might be a powerful, independent predictor of recurrence and outcome... - Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9Yan Li
Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an 710032, China
Appl Biochem Biotechnol 135:181-92. 2006..These results indicate that resveratrol seems to exert its growth-inhibitory/apoptotic effect on the breast cancer cell line MCF7 via the Akt-caspase-9 pathway... - NDRG2 in rat liver regeneration: role in proliferation and apoptosisJiandong Yang
Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi an, China
Wound Repair Regen 18:524-31. 2010..In conclusion, our findings point to physiological roles for NDRG2 in liver regeneration... - Expression of NDRG2 in clear cell renal cell carcinomaJianjun Ma
Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
Biol Pharm Bull 31:1316-20. 2008..These results indicated that NDRG2 might play an important role in the carcinogenesis and development of CCRCC and may function as a tumor suppressor in CCRCC... - Autophagy is a therapeutic target in anticancer drug resistanceSuning Chen
Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province 710032, People s Republic of China
Biochim Biophys Acta 1806:220-9. 2010.... - The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoterJian Zhang
Institute of Molecular Biology and the State Key Laboratory of Cancer Biology, Fourth Military Medical University, 710032 Xi an, China
J Biol Chem 281:39159-68. 2006..The regulatory function of Myc on NDRG2 gene expression implicated the role of the Ndrg2 in regulating cell differentiation... - N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferationYanchun Deng
Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
Int J Cancer 106:342-7. 2003..Our findings provide the first evidence to suggest that hNDRG2 may play a role in glioblastoma carcinogenesis... - Production and characterization of a recombinant single-chain antibody against Hantaan virus envelop glycoproteinJie Yang
Department of Nephrology, Tangdu Hospital, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
Appl Microbiol Biotechnol 86:1067-75. 2010..Our results showed that the E. coli-produced scFv had potential applications in targeted and intracellular delivery of therapeutics against HTNV infections... - Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaBGuodong Yang
Department of Biochemistry and Molecular Biology, State Key Lab of Cancer Biology, Fourth Military Medical University, Xi an 710032, P R China
Mol Cell Biochem 302:187-94. 2007..Our data suggested that APR3 might be functionally important in certain processes under which NFAT and/or NFkappaB are/is activated... - A naturally-occurring mutation in Cacna1f in a rat model of congenital stationary night blindnessYonghao Gu
Department of Clinical Aerospace Medicine, Fourth Military Medical University, Xi an, China
Mol Vis 14:20-8. 2008..To identify the gene mutation responsible for a previously described rat model of X-linked congenital stationary night blindness (CSNB)... - Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cellsWei Zhang
Department of Microbiology, The Fourth Military Medical University, Xi an, Shaanxi 710032, P R China
Mol Cell Biochem 290:43-53. 2006..All these findings suggested that the fused expressed His-DR inhibited the activity of natural DDR2, and relevant MMP-1 and MMP-2 expression in synoviocytes and NIH3T3 cells provoked by collagen II... - Transcriptional up-regulation of restin by all-trans retinoic acid through STAT1 in cancer cell differentiation processHaiyan Fu
Department of Biochemistry and Molecular Biology, State Key Lab of Cancer Biology, Fourth Military Medical University, Xi an 710032, PR China
Biochem Biophys Res Commun 343:1009-16. 2006.... - Expression of NDRG2 in human lung cancer and its correlation with prognosisShu Jun Li
State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi an 710032, Shanxi, People s Republic of China
Med Oncol 30:421. 2013..These data showed that NDRG2 may play an important role in human lung cancer tumourigenesis, and NDRG2 might serve as a novel prognostic marker in human lung cancer... - Promoter methylation, mutation, and genomic deletion are involved in the decreased NDRG2 expression levels in several cancer cell linesNa Liu
Department of Biochemistry and Molecular Biology, The Center of Molecular Medicine, The Fourth Military Medical University, The State Key Laboratory of Cancer Biology, 17 Changle Western Road, 710032 Xi an, People s Republic of China
Biochem Biophys Res Commun 358:164-9. 2007..Unexpectedly, changes in the NDRG2 gene were not observed. Here, we describe for the first time, the mechanisms involved in NDRG2 gene down-regulation...