Hong Yan

Summary

Affiliation: Fourth Military Medical University
Country: China

Publications

  1. pmc Hydrogen saline prevents selenite-induced cataract in rats
    Chun Xiao Yang
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 19:1684-93. 2013
  2. pmc Hyperoxia-induced lens damage in rabbit: protective effects of N-acetylcysteine
    Ping Wang
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 15:2945-52. 2009
  3. pmc Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats
    Qiong Shi
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 15:2129-38. 2009
  4. pmc Inhibition of glucocorticoid-induced alteration of vimentin by a glucocorticoid receptor antagonist RU486 in the organ-cultured rat lens
    Guo Li Xie
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Mol Vis 17:32-40. 2011
  5. pmc Seminal vesicle metastasis after partial hepatectomy for hepatocellular carcinoma
    Li Gong
    The Helmholtz Sino German Laboratory for Cancer Research, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, 710038 Xi an, Shaanxi Province, PR China
    BMC Cancer 11:111. 2011
  6. pmc Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 14:2282-91. 2008
  7. ncbi request reprint Revival of glutathione reductase in human cataractous and clear lens extracts by thioredoxin and thioredoxin reductase, in conjunction with alpha-crystallin or thioltransferase
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Curr Eye Res 32:455-63. 2007
  8. ncbi request reprint [Preventive effect of carnosine on cataract development]
    Yong Guo
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Yan Ke Xue Bao 22:85-8. 2006
  9. ncbi request reprint [The molecular chaperone function of alpha-crystallin in age-related cataract]
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, The Fourth Military Medical University, Xi an 710038, China
    Yan Ke Xue Bao 21:156-60. 2005
  10. ncbi request reprint Thioredoxin, thioredoxin reductase, and alpha-crystallin revive inactivated glyceraldehyde 3-phosphate dehydrogenase in human aged and cataract lens extracts
    Hong Yan
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford, UK
    Mol Vis 12:1153-9. 2006

Collaborators

Detail Information

Publications40

  1. pmc Hydrogen saline prevents selenite-induced cataract in rats
    Chun Xiao Yang
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 19:1684-93. 2013
    ..The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats...
  2. pmc Hyperoxia-induced lens damage in rabbit: protective effects of N-acetylcysteine
    Ping Wang
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 15:2945-52. 2009
    ..To investigate the efficacies of different concentrations of N-acetylcysteine (NAC) in preventing hyperoxia-induced lens opacification and changes to biochemical parameters in organ-cultured rabbit lenses...
  3. pmc Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats
    Qiong Shi
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 15:2129-38. 2009
    ..To investigate the effect of a combination of carnosine and aspirin eye drops on the progression of diabetic cataract formation induced by streptozotocin (STZ)...
  4. pmc Inhibition of glucocorticoid-induced alteration of vimentin by a glucocorticoid receptor antagonist RU486 in the organ-cultured rat lens
    Guo Li Xie
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Mol Vis 17:32-40. 2011
    ..Based on a model of steroid-induced cataract from our previous study, the present study focuses on whether changes in vimentin can be induced in vitro through specific GR activation in glucocorticoid-induced cataracts of the rat lens...
  5. pmc Seminal vesicle metastasis after partial hepatectomy for hepatocellular carcinoma
    Li Gong
    The Helmholtz Sino German Laboratory for Cancer Research, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, 710038 Xi an, Shaanxi Province, PR China
    BMC Cancer 11:111. 2011
    ..The purpose of the present paper was to report a case of metastasis to the seminal vesicle after HCC resection, along with its histological features and immunohistochemical characteristics...
  6. pmc Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 14:2282-91. 2008
    ..To investigate the effect of carnosine (CA), aminoguanidine (AG), and aspirin (ASA) drops, all inhibitors of glycation, on the development of diabetic cataract in rat...
  7. ncbi request reprint Revival of glutathione reductase in human cataractous and clear lens extracts by thioredoxin and thioredoxin reductase, in conjunction with alpha-crystallin or thioltransferase
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Curr Eye Res 32:455-63. 2007
    ..These results indicate that both disulfide bond formation and protein unfolding are responsible for GR inactivation...
  8. ncbi request reprint [Preventive effect of carnosine on cataract development]
    Yong Guo
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Yan Ke Xue Bao 22:85-8. 2006
    ..Further study of carnosine on its biological features and the mechanisms of delaying the progression of cataractogenesis may provide a new therapy for preventing cataract...
  9. ncbi request reprint [The molecular chaperone function of alpha-crystallin in age-related cataract]
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, The Fourth Military Medical University, Xi an 710038, China
    Yan Ke Xue Bao 21:156-60. 2005
    ..To evaluate the molecular chaperone function of alpha-crystallin in age-related cataract...
  10. ncbi request reprint Thioredoxin, thioredoxin reductase, and alpha-crystallin revive inactivated glyceraldehyde 3-phosphate dehydrogenase in human aged and cataract lens extracts
    Hong Yan
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford, UK
    Mol Vis 12:1153-9. 2006
    ....
  11. ncbi request reprint Carnosine inhibits modifications and decreased molecular chaperone activity of lens alpha-crystallin induced by ribose and fructose 6-phosphate
    Hong Yan
    Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, UK
    Mol Vis 12:205-14. 2006
    ..Additionally, we investigated whether carnosine could directly react with a sugar and a sugar phosphate...
  12. pmc Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats
    Shu Zhang
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Mol Vis 14:862-70. 2008
    ..To evaluate the effect of N-acetylcysteine (NAC) and glutathione ethyl ester (GSH-EE) eye drops on the progression of diabetic cataract formation induced by streptozotocin (STZ)...
  13. ncbi request reprint Carnosine protects against the inactivation of esterase induced by glycation and a steroid
    Hong Yan
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton St, Oxford OX2 6AW, UK
    Biochim Biophys Acta 1741:120-6. 2005
    ..Carnosine decreased the extent of the cross-linking. These results provide further evidence for carnosine's role as an anti-glycation compound. It is also proposed that carnosine may be an anti-steroid agent...
  14. ncbi request reprint The molecular chaperone, alpha-crystallin, protects against loss of antigenicity and activity of esterase caused by sugars, sugar phosphate and a steroid
    Hong Yan
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton St, Oxford OX2 6AW, UK
    Biol Chem 384:1185-94. 2003
    ..The protective effect of alpha-crystallin against loss of antigenicity indicates a novel aspect of its chaperoning function...
  15. doi request reprint [Relationship between female menopause and hypertension/isolated systolic hypertension in rural districts of Hanzhong in Shaanxi province]
    Shi hua Fang
    Department of Epidemiology and Health Statistics, Xi an Jiaotong University College of Medicine, Xi an, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 35:422-6. 2013
    ..To analyze the associations between menopause and hypertension/isolated systolic hypertension(ISH)among rural females in Hanzhong,Shaanxi Province,China...
  16. ncbi request reprint Protective effect of aspirin against dexamethasone-induced cataract in cultured rat lens
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Ophthalmic Res 38:303-8. 2006
    ..To investigate the effect of aspirin on dexamethasone-induced cataract formation in cultured rat lenses...
  17. pmc Ultraviolet radiation-induced cataract in mice: the effect of age and the potential biochemical mechanism
    Jie Zhang
    Department of Ophthalmology, Tangdu Hospital, The Fourth Military Medical University, Xi an, China
    Invest Ophthalmol Vis Sci 53:7276-85. 2012
    ..To study the effect of age on the morphologic and biochemical alterations induced by in vivo exposure of ultraviolet radiation (UV)...
  18. pmc Oxidative responses induced by pharmacologic vitreolysis and/or long-term hyperoxia treatment in rat lenses
    Qi Li
    Department of Ophthalmology, Tangdu Hospital, Xi an, China
    Curr Eye Res 38:639-48. 2013
    ..The aim of the study was to investigate the protective effects of intact vitreous gel on the lens after pharmacologic vitreolysis and hyperoxia exposure in rats in vivo...
  19. doi request reprint Identification of the primary targets of carbamylation in bovine lens proteins by mass spectrometry
    Jie Zhang
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Curr Eye Res 33:963-76. 2008
    ..The aim of this study was to isolate the primary targets of carbamylation in the lens and identify them by mass spectrometry...
  20. ncbi request reprint [Change of alpha-crystallin acting as molecular chaperone activity with ageing]
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Yan Ke Xue Bao 19:239-43. 2003
    ..To evaluate the molecular chaperone function of alpha-crystallin with ageing...
  21. ncbi request reprint [Decreased chaperone activity of alpha-crystallin by carbamylation in vitro]
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Yan Ke Xue Bao 20:264-7. 2004
    ..To investigate the effort of carbamylation, an important post-translational modification of lens proteins, on chaperone activity of alpha-crystallin...
  22. pmc Gamma III-crystallin is the primary target of glycation in the bovine lens incubated under physiological conditions
    Hong Yan
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton Street, Oxford OX2 6AW, UK
    Biochem J 374:677-85. 2003
    ..The early glycation of gammaIII-crystallin by glucose and fructose could result in structural alterations, leading to aggregation of crystallin and eventually cataract formation...
  23. doi request reprint [Survey on the prevalences of overweight and obesity in 9 rural areas in Hanzhong, Shaanxi province]
    Lin Ren
    Department of Epidemiology and Health Statistics, Xi an Jiaotong University College of Medicine, Xi an, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 35:47-51. 2013
    ..To investigate the prevalences of overweight and obesity in the rural communities in Hanzhong, Shaanxi Province...
  24. doi request reprint Preventive measures against sexually transmitted infections among female sex workers in Lanzhou, China
    Wenlong Gao
    Department of Epidemiology and Biostatistics, College of Medicine, Xi an Jiaotong University, Xi an, Shaanxi, China
    Scand J Infect Dis 44:374-80. 2012
    ..We assessed the effects of preventive practices on sexually transmitted infections (STIs) and reproductive tract infections (RTIs) among female sex workers (FSWs) in Lanzhou, China...
  25. doi request reprint Measuring and decomposing the inequality of maternal health services utilization in western rural China
    Xiaoning Liu
    Department of Epidemiology and Biostatistics, School of Public Health, Xi an Jiaotong University College of Medicine, P, O Box 46, NO, 76 West Yanta Road, Xi an, Shaanxi 710061, China
    BMC Health Serv Res 14:102. 2014
    ..To measure socioeconomic inequalities in maternal health services in rural western China and to analyze the determinants' contributions of inequalities.Study design: a cross-sectional study...
  26. pmc Identification of the preferentially targeted proteins by carbamylation during whole lens incubation by using radio-labelled potassium cyanate and mass spectrometry
    Hong Yan
    Department of Ophthalmology, Tangdu Hospital, The Fourth Military Medical University, Xi an 710038, Shaanxi Province, China
    Int J Ophthalmol 3:104-11. 2010
    ..To attempt to identify the primary targets of carbamylation in bovine lenses incubated under physiological condition...
  27. ncbi request reprint [Preventive effect of estrogen on cataract development]
    Jianwei Wang
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, China
    Yan Ke Xue Bao 22:20-4. 2006
    ..The research of these effects and its interactions may lead to a better understanding of the protective mechanism of estrogen and also provide a new thought for treatment and prevention of cataract...
  28. doi request reprint A survey of undernutrition in children under three years of age in rural Western China
    Leilei Pei
    Department of Epidemiology and Health Statistics, School of Public Health, Xi an Jiaotong University Health Science Center, Xi an, Shaanxi 710061, P, R, China
    BMC Public Health 14:121. 2014
    ..The purpose of this study was to investigate the prevalence of childhood undernutrition and explore its association with socio-economic characteristics in Western China...
  29. ncbi request reprint [Investigation on the unintentional injuries among rural children in Shaanxi province]
    Chao Zhang
    Department of Health Statistics, College of Medicine, Xi an Jiaotong University, Xi an, China
    Zhonghua Liu Xing Bing Xue Za Zhi 32:1221-3. 2011
    ..To investigate the current status of unintentional injuries among rural children aged 0 - 12 years in Shaanxi...
  30. doi request reprint Significance of human papillomavirus 16/18 infection in association with p53 mutation in lung carcinomas
    Yan Yu
    Department of Public Health, Xi an Jiaotong University School of Medicine, Xi an, Shanxi, China
    Clin Respir J 7:27-33. 2013
    ..The role of high-risk human papillomavius (HPV) 16/18 in the development of lung cancer has recently been explored, and p53 mutation is a finding in lung cancer; however, its association with HPV infection is not well studied...
  31. ncbi request reprint Interaction between dietary factors and Helicobacter pylori infection in noncardia gastric cancer: a population-based case-control study in China
    Xiao Qin Wang
    Department of Statistics and Epidemiology, School of Medicine, Xi an Jiaotong University, Xi an, Shaanxi Province, China
    J Am Coll Nutr 31:375-84. 2012
    ..The aim of this study was to investigate the relationships among Helicobacter pylori, dietary factors, and the risk of noncardia gastric cancer in a hospital-based case-control study in China...
  32. doi request reprint Equity in use of maternal health services in Western Rural China: a survey from Shaanxi province
    Yuan Shen
    Department of Epidemiology and Health Statistics, School of Public Health, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, P, R, China
    BMC Health Serv Res 14:155. 2014
    ..This study was designed to assess the use of maternal health services by pregnant women in China, with a focus on the inequity related to family income level...
  33. doi request reprint Integrin-linked kinase inhibition attenuates permeability of the streptozotocin-induced diabetic rat retina
    Yangjun Li
    Department of Ophthalmology, Tangdu Hospital, the Fourth Military Medical University of PLA, Xian, People s Republic of China
    Cell Biochem Biophys 67:1467-72. 2013
    ..Furthermore, QLT0267 inhibited Akt (Ser473) activation and reduced expression of HIF1α and VEGF which were evaluated by western blot, real time PCR, and immunohistochemistry. We conclude that ILK may be a new target for DR...
  34. pmc Assessment of maternal anemia in rural Western China between 2001 and 2005: a two-level logistic regression approach
    Leilei Pei
    Department of Epidemiology and Health Statistics, School of Public Health, Xi an Jiaotong University College of Medicine, No 76 West Yanta Road, P O Box 46, Xi an, Shaanxi 710061, P R China
    BMC Public Health 13:366. 2013
    ..However, few researches are conducted on women anemia in rural Western China. This study mainly aims to investigate the levels and associated factors of maternal anemia between 2001 and 2005 in this region...
  35. pmc Changes of the thiol levels in the corneas of the diabetic rats: effect of carnosine, aspirin and a combination eye drops
    Qiong Shi
    Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, Shaanxi Province, China
    Int J Ophthalmol 3:211-5. 2010
    ..To investigate the effect of carnosine (Car), aspirin (Asp) and a combination of Car and Asp eye drops on the change of the thiol contents from glutathione (GSH) and protein in the corneas of the diabetic rats...
  36. doi request reprint Use of maternal healthcare services in 10 provinces of rural western China
    Xiaoning Liu
    Department of Epidemiology and Biostatistics, School of Public Health, Xi an Jiaotong University College of Medicine, Xi an, China
    Int J Gynaecol Obstet 114:260-4. 2011
    ..To explore maternal healthcare utilization in rural western China, and to analyze the socioeconomic and demographic determinants associated with use of maternal health services...
  37. ncbi request reprint [Pathogenesis and prevention strategies of indirect injured cataract formation after vitrectomy]
    Xiaocui Liu
    Department of Ophthalmology, Tangdu Hospital, The 4th Military Medical University, Xi an 710038, China
    Yan Ke Xue Bao 23:252-6. 2007
    ..Therefore, the measure of decreasing oxygen concentration and the treatment of Zinc-desferrioxamine may reduce the incidence of cataract, which provides a new way for the prevention and treatment of cataract after vitrectomy...
  38. pmc Validity of self-reported weight, height and resultant body mass index in Chinese adolescents and factors associated with errors in self-reports
    Xiaoyan Zhou
    From the Department of Epidemiology and Health Statistics, School of Public Health, Xi an Jiaotong University College of Medicine, NO, 76 West Yanta Road, Xi an, China
    BMC Public Health 10:190. 2010
    ..This study aims to examine the accuracy of self-reported weight, height, and resultant BMI values in Chinese adolescents, and of the adolescents' subsequent classification into overweight categories...
  39. ncbi request reprint Effects of melatonin in age-related macular degeneration
    Changxian Yi
    Department of Fundus Diseases, Zhongshan Ophthalmic Center, Sun Yat Sen University, 510060 Guangzhou, China
    Ann N Y Acad Sci 1057:384-92. 2005
    ..The majority had reduced pathologic macular changes. We conclude that the daily use of 3 mg melatonin seems to protect the retina and to delay macular degeneration. No significant side effects were observed...
  40. ncbi request reprint CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes
    Lie Gang Liu
    Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 11:4530-5. 2005
    ....