Affiliation: Fourth Military Medical University
Yan Z, Qu K, Zhang J, Huang Q, Qu P, Xu X, et al
. CD147 promotes liver fibrosis progression via VEGF-A/VEGFR2 signalling-mediated cross-talk between hepatocytes and sinusoidal endothelial cells. Clin Sci (Lond). 2015;129:699-710 pubmed publisher
..New strategies based on the intervention of CD147 can be expected for prevention of liver fibrosis. ..
Bao D, Zhao J, Zhou X, Yang Q, Chen Y, Zhu J, et al
. Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression. Oncogene. 2019;: pubmed publisher
..In conclusion, our findings reveal a novel mechanism of TAM infiltration in HCC by mitochondrial fission-induced mtDNA stress. ..
Jin M, Wang J, Ji X, Cao H, Zhu J, Chen Y, et al
. MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38:136 pubmed publisher
..Our study provides evidence supporting a metastasis-promoting role for MCUR1-dependent mitochondrial Ca2+ uptake in HCC. Our findings suggest that MCUR1 may be a potential therapeutic target for HCC treatment. ..
Jin X, Zhang K, Guo X, Myers R, Ye Z, Zhang Z, et al
. Fatty acid synthesis pathway genetic variants and clinical outcome of non-small cell lung cancer patients after surgery. Asian Pac J Cancer Prev. 2014;15:7097-103 pubmed
..Our data suggest that the SNPs in DNL genes may serve as independent prognostic markers for NSCLC patients after surgery. ..
Li J, Huang Q, Long X, Zhang J, Huang X, Aa J, et al
. CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARÎ± pathways. J Hepatol. 2015;63:1378-89 pubmed publisher
..Our findings demonstrate that CD147 is a critical regulator of fatty acid metabolism, which provides a strong line of evidence for this molecule to be used as a drug target in cancer treatment. ..
Bao D, Ba Y, Zhou F, Zhao J, Yang Q, Ge N, et al
. Alterations of telomere length and mtDNA copy number are associated with overall survival in hepatocellular carcinoma patients treated with transarterial chemoembolization. Cancer Chemother Pharmacol. 2016;78:791-9 pubmed publisher
..10, 95 % CI 1.34-3.27, P = 0.001). Our data suggest that combination of leukocyte RTL-mtDNAcn may be a potential efficient prognostic marker for HCC patients receiving the TACE treatment. ..
Zhu J, Jin M, Wang J, Zhang H, Wu Y, Li D, et al
. TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells. J Exp Clin Cancer Res. 2018;37:43 pubmed publisher