Yan Jin


Affiliation: Fourth Military Medical University
Country: China


  1. Xuan K, Li B, Guo H, Sun W, Kou X, He X, et al. Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth. Sci Transl Med. 2018;10: pubmed publisher
    ..Our study suggests that hDPSCs are able to regenerate whole dental pulp and may be useful for treating tooth injuries due to trauma. ..
  2. Shao B, Liao L, Yu Y, Shuai Y, Su X, Jing H, et al. Estrogen preserves Fas ligand levels by inhibiting microRNA-181a in bone marrow-derived mesenchymal stem cells to maintain bone remodeling balance. FASEB J. 2015;29:3935-44 pubmed publisher
    ..Taken together, our results showed that estrogen preserves FasL protein accumulation by inhibiting miR-181a expression in BMMSCs to maintain bone remodeling balance, suggesting a novel mechanism by which estrogen preserves bone mass. ..
  3. Sui B, Hu C, Zhang X, Zhao P, He T, Zhou C, et al. Allogeneic Mesenchymal Stem Cell Therapy Promotes Osteoblastogenesis and Prevents Glucocorticoid-Induced Osteoporosis. Stem Cells Transl Med. 2016;5:1238-46 pubmed publisher
    ..The current study also indicates that minimizing the time of cell culture confers an advantage for increasing transplanted mesenchymal stem cells to the targeted organ to promote therapeutic effects. ..
  4. Sui B, Chen J, Zhang X, He T, Zhao P, Zheng C, et al. Gender-independent efficacy of mesenchymal stem cell therapy in sex hormone-deficient bone loss via immunosuppression and resident stem cell recovery. Exp Mol Med. 2018;50:166 pubmed publisher
    ..Collectively, these data revealed recipient sexually monomorphic responses to MSC therapy in gonadal steroid deficiency-induced osteoporosis via immunosuppression/anti-inflammation and resident stem cell recovery. ..
  5. Lu Y, Shao A, Shan Y, Zhao H, Leiguo M, Zhang Y, et al. A standardized quantitative method for detecting remnant alpha-Gal antigen in animal tissues or animal tissue-derived biomaterials and its application. Sci Rep. 2018;8:15424 pubmed publisher
    ..yy/t 1561-2017). ..
  6. Wang M, Bao L, Qiu X, Yang X, Liu S, Su Y, et al. Immobilization of heparin on decellularized kidney scaffold to construct microenvironment for antithrombosis and inducing reendothelialization. Sci China Life Sci. 2018;61:1168-1177 pubmed publisher
    ..Taken together, our results reveal that the whole kidney can be modified by CBP-heparin composite to reduce the thrombosis and provide the better conditions for neovascularization. ..
  7. Sui B, Zhu B, Hu C, Zhao P, Jin Y. Reconstruction of Regenerative Stem Cell Niche by Cell Aggregate Engineering. Methods Mol Biol. 2018;: pubmed publisher
    ..Here, we describe the basic methodology of stem cell aggregate-based niche engineering and quality check indexes prior to application. ..
  8. request reprint
    Yang R, Ming L, Deng Z, Jin Y. [Myogenic differentiation of laryngeal mucosal mesenchymal stem cells]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014;49:473-8 pubmed
    ..The LM-MSCs have the properties of mesenchymal stem cells and could be differentiated into myoblasts, providing with the possibility to repair the damaged vocal cords with LM-MSCs through tissue engineering techniques. ..
  9. Shuai Y, Ma Y, Guo T, Zhang L, Yang R, Qi M, et al. Dental Stem Cells and Tooth Regeneration. Adv Exp Med Biol. 2018;1107:41-52 pubmed publisher

More Information


  1. Zhai Q, Dong Z, Wang W, Li B, Jin Y. Dental stem cell and dental tissue regeneration. Front Med. 2018;: pubmed publisher
    ..All these cells can regenerate the tissue of tooth. This review outlines the cell types and strategies of stem cell therapy applied in tooth regeneration, in order to provide theoretical basis for clinical treatments. ..
  2. Wang Y, Zhao P, Sui B, Liu N, Hu C, Chen J, et al. Resveratrol enhances the functionality and improves the regeneration of mesenchymal stem cell aggregates. Exp Mol Med. 2018;50:74 pubmed publisher
  3. Li L, Liu W, Wang H, Yang Q, Zhang L, Jin F, et al. Mutual inhibition between HDAC9 and miR-17 regulates osteogenesis of human periodontal ligament stem cells in inflammatory conditions. Cell Death Dis. 2018;9:480 pubmed publisher
    ..We conclude that HDAC inhibitors improved osteogenesis of PDLSCs in vitro and periodontitis in vivo. ..
  4. Qiu X, Liu S, Zhang H, Zhu B, Su Y, Zheng C, et al. Mesenchymal stem cells and extracellular matrix scaffold promote muscle regeneration by synergistically regulating macrophage polarization toward the M2 phenotype. Stem Cell Res Ther. 2018;9:88 pubmed publisher
    ..Our findings uncover a previously unknown mechanism that MSCs and decellularized ECM scaffold promote tissue regeneration via collaboratively regulating macrophage polarization. ..
  5. Zheng C, Sui B, Liu N, Hu C, He T, Zhang X, et al. Adipose mesenchymal stem cells from osteoporotic donors preserve functionality and modulate systemic inflammatory microenvironment in osteoporotic cytotherapy. Sci Rep. 2018;8:5215 pubmed publisher
    ..Collectively, our findings optimize osteoporotic cytotherapy by using ADMSCs in resistance to and in modulation of diseased microenvironments. ..
  6. Jing H, Su X, Gao B, Shuai Y, Chen J, Deng Z, et al. Epigenetic inhibition of Wnt pathway suppresses osteogenic differentiation of BMSCs during osteoporosis. Cell Death Dis. 2018;9:176 pubmed publisher
    ..Taken together, our study demonstrated that disrupted histone acetylation modification in BMSCs lead to bone formation defect during osteoporosis. The findings also introduced a novel therapeutic target for osteoporosis. ..
  7. Liu S, Liu D, Chen C, Hamamura K, Moshaverinia A, Yang R, et al. MSC Transplantation Improves Osteopenia via Epigenetic Regulation of Notch Signaling in Lupus. Cell Metab. 2015;22:606-18 pubmed publisher
    ..Collectively our findings unravel the means by which MSCT rescues MRL/lpr BMMSC function through reuse of donor exosome-provided Fas to regulate the miR-29b/Dnmt1/Notch epigenetic cascade. ..
  8. Lei M, Li K, Li B, Gao L, Chen F, Jin Y. Mesenchymal stem cell characteristics of dental pulp and periodontal ligament stem cells after in vivo transplantation. Biomaterials. 2014;35:6332-43 pubmed publisher
    ..These findings provide additional cellular and molecular evidence that supports expanding the use of dental tissue-derived stem cells in cell therapy and tissue engineering. ..
  9. Zhang H, Liu S, Zhu B, Xu Q, Ding Y, Jin Y. Composite cell sheet for periodontal regeneration: crosstalk between different types of MSCs in cell sheet facilitates complex periodontal-like tissue regeneration. Stem Cell Res Ther. 2016;7:168 pubmed
  10. Jing H, Liao L, An Y, Su X, Liu S, Shuai Y, et al. Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis. Mol Ther. 2016;24:217-229 pubmed publisher
    ..We also provided EZH2 as a novel therapeutic target for improving bone formation during osteoporosis. ..
  11. Ou D, Wang Q, Huang Y, Zeng D, Wei T, Ding L, et al. Co-culture with neonatal cardiomyocytes enhances the proliferation of iPSC-derived cardiomyocytes via FAK/JNK signaling. BMC Dev Biol. 2016;16:11 pubmed publisher
    ..These findings indicated that co-culture of EBs with NCMs induces genes expressed in a mature pattern and stimulates the proliferation of iPSC-derived CMs (iPS-CMs) by activating FAK/JNK signaling. ..
  12. Chen F, Gao L, Tian B, Zhang X, Zhang Y, Dong G, et al. Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial. Stem Cell Res Ther. 2016;7:33 pubmed publisher
    ..The efficacy of cell-based periodontal therapy requires further validation by multicenter, randomized controlled studies with an increased sample size. NCT01357785 Date registered: 18 May 2011. ..
  13. Jing H, Liao L, Su X, Shuai Y, Zhang X, Deng Z, et al. Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis. FASEB J. 2017;31:4422-4433 pubmed publisher
    ..Jing, H., Liao, L., Su, X., Shuai, Y. Zhang, X., Deng, Z., Jin, Y. Declining histone acetyltransferase GCN5 represses BMSC-mediated angiogenesis during osteoporosis. ..
  14. Li Y, Fan L, Hu J, Zhang L, Liao L, Liu S, et al. MiR-26a Rescues Bone Regeneration Deficiency of Mesenchymal Stem Cells Derived From Osteoporotic Mice. Mol Ther. 2015;23:1349-1357 pubmed publisher
    ..Our findings indicate that miR-26a may be a promising therapeutic candidate to enhance bone formation in treatment of osteoporosis and to promote bone regeneration in osteoporotic fracture healing. ..
  15. Sui B, Hu C, Liu A, Zheng C, Xuan K, Jin Y. Stem cell-based bone regeneration in diseased microenvironments: Challenges and solutions. Biomaterials. 2017;: pubmed publisher
  16. Liao L, Yu Y, Shao B, Su X, Wang H, Kuang H, et al. Redundant let-7a suppresses the immunomodulatory properties of BMSCs by inhibiting the Fas/FasL system in osteoporosis. FASEB J. 2018;32:1982-1992 pubmed publisher
    ..Liao, L., Yu, Y., Shao, B., Su, X., Wang, H., Kuang, H., Jing, H., Shuai, Y., Yang, D., Jin, Y. Redundant let-7a suppresses the immunomodulatory properties of BMSCs by inhibiting the Fas/FasL system in osteoporosis. ..
  17. Sun J, Dong Z, Zhang Y, He X, Fei D, Jin F, et al. Osthole improves function of periodontitis periodontal ligament stem cells via epigenetic modification in cell sheets engineering. Sci Rep. 2017;7:5254 pubmed publisher
    ..Our study suggests that Osthole is a promising drug to cure periodontitis via regulating epigenetic modification in cell sheets engineering. ..
  18. Yu Y, Liao L, Shao B, Su X, Shuai Y, Wang H, et al. Knockdown of MicroRNA Let-7a Improves the Functionality of Bone Marrow-Derived Mesenchymal Stem Cells in Immunotherapy. Mol Ther. 2017;25:480-493 pubmed publisher
    ..With high safety and convenience, knockdown of let-7a is a potential strategy to improve MSC therapy for inflammatory diseases in clinic. ..
  19. Zhang L, Liu W, Zhao J, Ma X, Shen L, Zhang Y, et al. Mechanical stress regulates osteogenic differentiation and RANKL/OPG ratio in periodontal ligament stem cells by the Wnt/?-catenin pathway. Biochim Biophys Acta. 2016;1860:2211-9 pubmed publisher
    ..We describe a novel potential mechanism related to tooth movement. ..
  20. Sui B, Hu C, Jin Y. Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells. Biogerontology. 2016;17:267-79 pubmed publisher