Yan Jin

Summary

Affiliation: Fourth Military Medical University
Country: China

Publications

  1. ncbi request reprint [Comparison studies on epidermis cell culture efficiency between big graft method and small strip method]
    Tao Lu
    The Dermatology Center of the Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi an Shaanxi, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:505-7. 2004
  2. ncbi request reprint Novel glycidyl methacrylated dextran (Dex-GMA)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: formulation and characteristics
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an 710032, Shaanxi, China
    J Control Release 118:65-77. 2007
  3. pmc Nicotine deteriorates the osteogenic differentiation of periodontal ligament stem cells through α7 nicotinic acetylcholine receptor regulating Wnt pathway
    Zhifei Zhou
    Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi, China
    PLoS ONE 8:e83102. 2013
  4. pmc Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments
    X Chen
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Cell Death Dis 4:e510. 2013
  5. pmc Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrow
    L Liao
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, China
    Cell Death Dis 4:e600. 2013
  6. pmc TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments
    W Liu
    Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Cell Death Dis 4:e539. 2013
  7. pmc Oral and craniofacial manifestations and two novel missense mutations of the NTRK1 gene identified in the patient with congenital insensitivity to pain with anhidrosis
    Li Gao
    Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi Province, People s Republic of China
    PLoS ONE 8:e66863. 2013
  8. pmc Differentiation potential of STRO-1+ dental pulp stem cells changes during cell passaging
    Jinhua Yu
    Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu 210029, China
    BMC Cell Biol 11:32. 2010
  9. ncbi request reprint Reconstruction of a tissue-engineered skin containing melanocytes
    Yuan Liu
    Center for Tissue Engineering, Department of Oral Histology and Pathology, School of Stomatology, The Fourth Military Medical University, Xi an 710032, China
    Cell Biol Int 31:985-90. 2007
  10. ncbi request reprint Periodontal regeneration using novel glycidyl methacrylated dextran (Dex-GMA)/gelatin scaffolds containing microspheres loaded with bone morphogenetic proteins
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an 710032, Shaanxi, China
    J Control Release 121:81-90. 2007

Collaborators

Detail Information

Publications139 found, 100 shown here

  1. ncbi request reprint [Comparison studies on epidermis cell culture efficiency between big graft method and small strip method]
    Tao Lu
    The Dermatology Center of the Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi an Shaanxi, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:505-7. 2004
    ..To compare the efficiency of epidermis cell culture between big graft method and small strip method...
  2. ncbi request reprint Novel glycidyl methacrylated dextran (Dex-GMA)/gelatin hydrogel scaffolds containing microspheres loaded with bone morphogenetic proteins: formulation and characteristics
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an 710032, Shaanxi, China
    J Control Release 118:65-77. 2007
    ....
  3. pmc Nicotine deteriorates the osteogenic differentiation of periodontal ligament stem cells through α7 nicotinic acetylcholine receptor regulating Wnt pathway
    Zhifei Zhou
    Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi, China
    PLoS ONE 8:e83102. 2013
    ..Here we studied whether nicotine impaired the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) through activating α7 nicotinic acetylcholine receptor (α7 nAChR)...
  4. pmc Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments
    X Chen
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Cell Death Dis 4:e510. 2013
    ..Given the molecular mechanisms of NF-κB in osteogenic differentiation governed by inflammation, it can be said that NF-κB helps in improving stem cell-mediated inflammatory bone disease therapy...
  5. pmc Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrow
    L Liao
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, China
    Cell Death Dis 4:e600. 2013
    ..Moreover, the rescue of MSCs lineage commitment disorder by regulating miRNAs expression suggested a novel potential therapeutic target for osteoporosis as well as stem cell-mediated regenerative medicine...
  6. pmc TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments
    W Liu
    Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Cell Death Dis 4:e539. 2013
    ..This understanding of microRNAs regulating signaling pathways in different microenvironments may pave the way for fine-tuning the process of osteogenesis in bone-related disorders...
  7. pmc Oral and craniofacial manifestations and two novel missense mutations of the NTRK1 gene identified in the patient with congenital insensitivity to pain with anhidrosis
    Li Gao
    Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi Province, People s Republic of China
    PLoS ONE 8:e66863. 2013
    ..1561T>C and c.2057G>A in the NTRK1 gene. This report extends the spectrum of NTRK1 mutations observed in patients diagnosed with CIPA and provides additional insight for clinical and molecular diagnosis...
  8. pmc Differentiation potential of STRO-1+ dental pulp stem cells changes during cell passaging
    Jinhua Yu
    Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu 210029, China
    BMC Cell Biol 11:32. 2010
    ..However, the differentiation potential of naive DPSCs after serial passaging in the routine culture system has not been fully elucidated...
  9. ncbi request reprint Reconstruction of a tissue-engineered skin containing melanocytes
    Yuan Liu
    Center for Tissue Engineering, Department of Oral Histology and Pathology, School of Stomatology, The Fourth Military Medical University, Xi an 710032, China
    Cell Biol Int 31:985-90. 2007
    ..Melanocytes located in the basal layer of the athymic mice skin could also be detected by using the S-100 immunohistochemical staining. Our established method is useful to repair the full-thickness skin defects...
  10. ncbi request reprint Periodontal regeneration using novel glycidyl methacrylated dextran (Dex-GMA)/gelatin scaffolds containing microspheres loaded with bone morphogenetic proteins
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an 710032, Shaanxi, China
    J Control Release 121:81-90. 2007
    ....
  11. doi request reprint Synergistic angiogenesis promoting effects of extracellular matrix scaffolds and adipose-derived stem cells during wound repair
    Shiyu Liu
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi, China
    Tissue Eng Part A 17:725-39. 2011
    ....
  12. doi request reprint Differentiation of dermal multipotent cells into odontogenic lineage induced by embryonic and neonatal tooth germ cell-conditioned medium
    Na Huo
    Department of Orthodontics, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Stem Cells Dev 19:93-104. 2010
    ..Our work highlights the potential utility of DMCs as an alternative candidate cell source in hopes of developing more practical strategy of tooth regeneration research and offering promising opportunities for therapeutic approach...
  13. ncbi request reprint Differentiation of dental pulp stem cells into regular-shaped dentin-pulp complex induced by tooth germ cell conditioned medium
    Jinhua Yu
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi, China
    Tissue Eng 12:3097-105. 2006
    ....
  14. doi request reprint Effect of age and extrinsic microenvironment on the proliferation and osteogenic differentiation of rat dental pulp stem cells in vitro
    Dandan Ma
    Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Shaanxi, China
    J Endod 35:1546-53. 2009
    ..In this study, age-related changes in proliferation and osteogenic differentiation ability of rat DPSCs were assessed...
  15. doi request reprint Functional neovascularization in tissue engineering with porcine acellular dermal matrix and human umbilical vein endothelial cells
    Xiaojun Zhang
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, China
    Tissue Eng Part C Methods 17:423-33. 2011
    ..These findings indicate that PADM seeded with HUVECs may be a potential system for successful engineering of large, thick, and complex tissues...
  16. doi request reprint Expansion and delivery of adipose-derived mesenchymal stem cells on three microcarriers for soft tissue regeneration
    Yalei Zhou
    Department of Oral Histology and Pathology, School of Stomatology, The Fourth Military Medical University, Xi an, PR China
    Tissue Eng Part A 17:2981-97. 2011
    ..Our study demonstrates the potential utility of these microcarriers not only as a cell-culture substrate but also as a cell-transplantation vehicle for skin regeneration and soft-tissue reconstruction...
  17. doi request reprint Inhibition of dermal fibrosis in self-assembled skin equivalents by undifferentiated keratinocytes
    Xinwen Wang
    Research and Development Center for Tissue Engineering, School of Stomatology, FMMU, China Department of Periodontology and Oral Medicine, School of Stomatology, FMMU, China
    J Dermatol Sci 53:103-11. 2009
    ..Further investigations showed that keratinocytes derived from normal skin and hypertrophic scar have different effects on dermal fibroblasts...
  18. doi request reprint Periapical follicle stem cell: a promising candidate for cementum/periodontal ligament regeneration and bio-root engineering
    Chun Han
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Stem Cells Dev 19:1405-15. 2010
    ..Our findings suggest that developing tissue-derived PAFSCs are a distinctive cell population from PDLSCs and might be a promising candidate for bio-root engineering...
  19. doi request reprint Mixture of fibroblasts and adipose tissue-derived stem cells can improve epidermal morphogenesis of tissue-engineered skin
    Wei Lu
    Department of Oral Histology and Pathology, School of Stomatology, The Fourth Military Medical University, Xi an, China
    Cells Tissues Organs 195:197-206. 2012
    ..Together, these findings revealed for the first time that a mixture of fibroblasts and ADSCs in bilayered tissue-engineered skin can improve epidermal morphogenesis...
  20. ncbi request reprint Enrichment of epidermal stem cells by rapid adherence and analysis of the reciprocal interaction of epidermal stem cells with neighboring cells using an organotypic system
    Rui Dong
    Department of Oral Histology and Pathology, College of Stomatology, Fourth Military Medical University, Xi an, Shaanxi 710032, P R China
    Cell Biol Int 31:733-40. 2007
    ....
  21. doi request reprint Tissue engineering of cementum/periodontal-ligament complex using a novel three-dimensional pellet cultivation system for human periodontal ligament stem cells
    Zhenhua Yang
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, People s Republic of China
    Tissue Eng Part C Methods 15:571-81. 2009
    ....
  22. doi request reprint The use of laryngeal mucosa mesenchymal stem cells for the repair the vocal fold injury
    Han Peng
    Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, China Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Biomaterials 34:9026-35. 2013
    ....
  23. doi request reprint Porcine tooth germ cell conditioned medium can induce odontogenic differentiation of human dental pulp stem cells
    Yin Xiong Wang
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi 710032, People s Republic of China
    J Tissue Eng Regen Med 5:354-62. 2011
    ..The observations suggest that the application of xenogenic TGC-CM may facilitate generating bioengineered teeth from tooth-derived stem cells in future...
  24. doi request reprint Tissue-engineered skin containing mesenchymal stem cells improves burn wounds
    Peng Liu
    Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Artif Organs 32:925-31. 2008
    ..Grafts proliferated well and contributed to the neo-tissues. These data suggest that TE skin containing MSCs in a burn defect can accelerate wound healing and receive satisfactory effects...
  25. pmc Changes of the unique odontogenic properties of rat apical bud cells under the developing apical complex microenvironment
    Jun Fang
    Department of Pedodontics, School of Stomatology, Fourth Military Medical University, Xi an, China
    Int J Oral Sci 1:26-33. 2009
    ..To characterize the odontogenic capability of apical bud and phenotypical change of apical bud cells (ABCs) in different microenvironment...
  26. doi request reprint Micronized acellular dermal matrix as an efficient expansion substrate and delivery vehicle of adipose-derived stem cells for vocal fold regeneration
    Qiang Liang
    Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, China
    Laryngoscope 122:1815-25. 2012
    ....
  27. doi request reprint Role of bone marrow-derived progenitor cells in the maintenance and regeneration of dental mesenchymal tissues
    Jing Zhou
    Department of Pedodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    J Cell Physiol 226:2081-90. 2011
    ..In conclusion, these data suggest that bone marrow progenitor cells communicate with dental tissues and become tissue-specific mesenchymal progenitor cells to maintain tissue homeostasis...
  28. doi request reprint Dental follicle cells and treated dentin matrix scaffold for tissue engineering the tooth root
    Weihua Guo
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, People s Republic of China
    Biomaterials 33:1291-302. 2012
    ..This strategy could be a promising approach for the treatment of clinical tooth loss and provides a perspective with potential applications to regeneration of other tissues and organs...
  29. doi request reprint Characterization of stem cells from alveolar periodontal ligament
    Lei Wang
    Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Tissue Eng Part A 17:1015-26. 2011
    ..Our data suggest that PDLSCs may have quite different characteristics depending on locations. a-PDLSCs may take a synergistic effect with r-PDLSCs in periodontal regeneration...
  30. doi request reprint Cross-linked collagen-chondroitin sulfate-hyaluronic acid imitating extracellular matrix as scaffold for dermal tissue engineering
    Weihong Wang
    Research and Development Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi an, China
    Tissue Eng Part C Methods 16:269-79. 2010
    ..These results demonstrated that the novel CoCS-HA/CL 9:1:1 tri-copolymer has the potential to be used as a scaffold for dermal tissue engineering...
  31. doi request reprint The effect of aging on the pluripotential capacity and regenerative potential of human periodontal ligament stem cells
    Jing Zhang
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an, China
    Biomaterials 33:6974-86. 2012
    ....
  32. doi request reprint Essential role of ADAM28 in regulating the proliferation and differentiation of human dental papilla mesenchymal cells (hDPMCs)
    Zheng Zhao
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, and Department of Otolaryngology, Xijing Hospital, 145 West Changle Road, 710032, Xi an, China
    Histochem Cell Biol 130:1015-25. 2008
    ....
  33. ncbi request reprint Cloning of full-length cDNA sequence of a novel candidate gene related to mouse cleft palate
    Xin Li
    Department of Oral Pathology, Stomatology College, The Fourth Military Medical University, Xi an, Shaanxi, 710032 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:481-4. 2005
    ..Cloning and screening a novel candidate gene related to developing mouse cleft palate...
  34. doi request reprint Cementum and periodontal ligament-like tissue formation induced using bioengineered dentin
    Yucheng Li
    Department of Endodontics, College of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Tissue Eng Part A 14:1731-42. 2008
    ..The results indicated that tissue-engineered dentin could be induced using an inductive substrate and could be used as a further substrate for cementum and PDL tissue engineering...
  35. ncbi request reprint Preparation and biological characteristics of recombinant human bone morphogenetic protein-2-loaded dextran-co-gelatin hydrogel microspheres, in vitro and in vivo studies
    Faming Chen
    Center Laboratory for Tissue Engineering, College of Stomatology, Fourth Military Medical University, Xi an, China
    Pharmacology 75:133-44. 2005
    ..Therefore, those studies demonstrate the potential of DG-MPs in the sustained delivery of low dosages of rhBMP2 to periodontal defects...
  36. pmc Heterogeneous dental follicle cells and the regeneration of complex periodontal tissues
    Weihua Guo
    Research and Development Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi an, People s Republic of China
    Tissue Eng Part A 18:459-70. 2012
    ..Moreover, our results demonstrate the potential for this treatment approach to address periodontal defects that result from periodontitis, or for the regeneration of teeth...
  37. ncbi request reprint Release of bioactive BMP from dextran-derived microspheres: a novel delivery concept
    Fa Ming Chen
    Department of Periodontology and Mucosal Diseases, College of Stomatology, The Fourth Military Medical University, 145th Chang le Road, Xi an 710032, Shaanxi, China
    Int J Pharm 307:23-32. 2006
    ..These properties make those microspheres interesting osteo-conductive BMP carriers, allowing to decrease the amount of implanted factor required for tissue regeneration...
  38. doi request reprint Comparison of mesenchymal stem cells derived from gingival tissue and periodontal ligament in different incubation conditions
    Hao Yang
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    Biomaterials 34:7033-47. 2013
    ..Whether GMSCs act as an adjunctive or alternative cell source for cytotherapy of inflammatory periodontal disease warrants further investigation. ..
  39. doi request reprint The protection of MSCs from apoptosis in nerve regeneration by TGFβ1 through reducing inflammation and promoting VEGF-dependent angiogenesis
    Hailang Luo
    Engineering Technology Center for Tissue Engineering of Xi an, Shaanxi 710032, China
    Biomaterials 33:4277-87. 2012
    ..This effect was achieved in part through decreasing inflammation and promoting VEGF-dependent angiogenesis...
  40. pmc Supernatant of bone marrow mesenchymal stromal cells induces peripheral blood mononuclear cells possessing mesenchymal features
    Gang Hu
    Department of Dermatology, Second Hospital of Xi an Jiaotong University, Xi an, 710004, China
    Int J Biol Sci 7:364-75. 2011
    ..Our results are clinically relevant because it provide a new method for the acquisition of MSCs which can be used as a candidate for the wound repair...
  41. ncbi request reprint Dentin non-collagenous proteins (dNCPs) can stimulate dental follicle cells to differentiate into cementoblast lineages
    Junjie Wu
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi 710032, People s Republic of China
    Biol Cell 100:291-302. 2008
    ..In the present study, we hypothesized that dNCPs (dentin non-collagenous proteins) extracted from dentin could stimulate DFCs to differentiate into cementoblast lineages...
  42. ncbi request reprint Wound dressings containing bFGF-impregnated microspheres
    Sha Huang
    Department of Oral Histology and Pathology, College of Stomatology, Xi an, PR China
    J Microencapsul 23:277-90. 2006
    ..The application of these novel bilayer wound dressings provided an optimum healing milieu for the proliferating cells and regenerating tissues in pig's skin defect models...
  43. ncbi request reprint Survival and integration of tissue-engineered corneal stroma in a model of corneal ulcer
    Chao Zhang
    Department of Oral Histology and Pathology, Research and Development Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, 710032, People s Republic of China
    Cell Tissue Res 329:249-57. 2007
    ..Our results demonstrate that the tissue-engineered corneal stroma with allogenetic cells is a promising therapeutic method for corneal injury...
  44. doi request reprint The biological effect of dentin noncollagenous proteins (DNCPs) on the human periodontal ligament stem cells (HPDLSCs) in vitro and in vivo
    Zhaofeng Ma
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Tissue Eng Part A 14:2059-68. 2008
    ..To our knowledge, this is the first study to apply active proteins derived from dentin with periodontal stem cells to construct periodontal structure, which may shed light on human periodontal tissue regeneration...
  45. pmc In vitro construction of scaffold-free bilayered tissue-engineered skin containing capillary networks
    Yuan Liu
    Department of Oral Histology and Pathology, School of Stomatology, The Fourth Military Medical University, Xi an 710032, China
    Biomed Res Int 2013:561410. 2013
    ....
  46. doi request reprint Functional bilayered skin substitute constructed by tissue-engineered extracellular matrix and microsphere-incorporated gelatin hydrogel for wound repair
    Sha Huang
    Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    Tissue Eng Part A 15:2617-24. 2009
    ..These results suggest that GG-EGF/TEECM can provide an optimal microenvironment and proper template for skin tissue engineering...
  47. doi request reprint A novel possible strategy based on self-assembly approach to achieve complete periodontal regeneration
    Zhen hua Yang
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Artif Organs 34:603-9. 2010
    ..We hypothesize that this novel strategy might open new options to reconstruct extended periodontal defects and then achieve the ultimate goal of predictable and complete regeneration of the periodontium...
  48. doi request reprint Characterization of mesenchymal stem cells from human normal and hyperplastic gingiva
    Liang Tang
    Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi an, China
    J Cell Physiol 226:832-42. 2011
    ..In addition, gingival MSC over-activation may contribute to gingival hyperplastic phenotype...
  49. ncbi request reprint [Construction of a tissue engineering skin containing capillary-like network]
    Yuan Liu
    Department of Oral Histology and Pathology, Stomatological College, Fourth Military Medical University, Xi an Shaanxi, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 18:502-4. 2004
    ..To construct a tissue engineering skin containing capillary-like network by employing tissue engineering method...
  50. doi request reprint Differentiation of mouse embryonic stem cells into dental epithelial-like cells induced by ameloblasts serum-free conditioned medium
    Fang Ning
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, 710032 Shaanxi, People s Republic of China
    Biochem Biophys Res Commun 394:342-7. 2010
    ..Thus, for the first time, we report that ASF-CM provides a suitable microenvironment for inducing mESC differentiation along the odontogenic epithelial cell lineage. This result has important implications for tooth tissue engineering...
  51. doi request reprint Odontogenic potential of mesenchymal cells from hair follicle dermal papilla
    Gang Wu
    Department of Endodontics, Fourth Military Medical University, Xi an, People s Republic of China
    Stem Cells Dev 18:583-9. 2009
    ..Together, our data indicate for the first time that whisker FDPMCs from adult mice can differentiate to odontoblast-like cells...
  52. doi request reprint Natural mineralized scaffolds promote the dentinogenic potential of dental pulp stem cells via the mitogen-activated protein kinase signaling pathway
    Hongmei Zhang
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, China
    Tissue Eng Part A 18:677-91. 2012
    ..The results indicated that natural mineralized scaffolds (DDM and CBB) have potential as attractive scaffolds for dentin tissue-engineering-promoted odontogenic differentiation of DPSCs through the MAPK signaling pathway...
  53. doi request reprint Inflammatory environment induces gingival tissue-specific mesenchymal stem cells to differentiate towards a pro-fibrotic phenotype
    Nan Li
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Biol Cell 105:261-75. 2013
    ..However, whether these cells exhibit characteristics of pro-fibrotic phenotype under inflammatory condition remains unknown...
  54. doi request reprint Integration of a calcined bovine bone and BMSC-sheet 3D scaffold and the promotion of bone regeneration in large defects
    Yihan Liu
    Institute of Stomatology, Chinese PLA General Hospital, Beijing 100853, China Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an 710032, Shanxi, China
    Biomaterials 34:9998-10006. 2013
    ..Results of our study demonstrated that CBB-BMSC-sheet combination was a promising strategy in healing of large area bone defect in osteoporosis...
  55. doi request reprint The effect of the coumarin-like derivative osthole on the osteogenic properties of human periodontal ligament and jaw bone marrow mesenchymal stem cell sheets
    Li Na Gao
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an, PR China Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, PR China Translational Research Team, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    Biomaterials 34:9937-51. 2013
    ..001). Our data suggest that a suitable concentration and mode of osthole stimulation may enhance ECM production and positively affect cell behavior in cell sheet engineering...
  56. doi request reprint Tumor necrosis factor α suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis
    Nan Yang
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    J Bone Miner Res 28:559-73. 2013
    ..This study may indicate a molecular basis for novel therapeutic strategies against osteoporosis and other inflammatory bone diseases...
  57. doi request reprint The use of dentin matrix scaffold and dental follicle cells for dentin regeneration
    Weihua Guo
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an 710032, China
    Biomaterials 30:6708-23. 2009
    ..The combination of TDM and DFCs may constitute a promising approach for future clinical dentin regeneration...
  58. doi request reprint Expansion and delivery of human fibroblasts on micronized acellular dermal matrix for skin regeneration
    Xiaojun Zhang
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an 710032, China
    Biomaterials 30:2666-74. 2009
    ..In addition, EPDS may be used for cosmetic or reconstructive soft tissue augmentation in a minimally invasive fashion...
  59. doi request reprint Epithelial-mesenchymal cell ratios can determine the crown morphogenesis of dental pulp stem cells
    Jinghua Yu
    Department of Endodontics, School of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China
    Stem Cells Dev 17:475-82. 2008
    ..Together, these findings revealed that the proportions of dental epithelial and mesenchymal cell populations can determine the odontogenic differentiation of DPSCs/ABCs in vitro as well as the bioengineered tooth morphogenesis in vivo...
  60. doi request reprint Loss of proliferation and differentiation capacity of aged human periodontal ligament stem cells and rejuvenation by exposure to the young extrinsic environment
    Wei Zheng
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Tissue Eng Part A 15:2363-71. 2009
    ....
  61. ncbi request reprint Enhancement of periodontal tissue regeneration by locally controlled delivery of insulin-like growth factor-I from dextran-co-gelatin microspheres
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, College of Stomatology, Fourth Military Medical University, 145th Chang le Road, Xi an 710032, Shaanxi, China
    J Control Release 114:209-22. 2006
    ....
  62. doi request reprint The effect of the cleidocranial dysplasia-related novel 1116_1119insC mutation in the RUNX2 gene on the biological function of mesenchymal cells
    Bofu Ding
    Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, Xi an, China
    Eur J Med Genet 56:180-7. 2013
    ..Finally, we demonstrated that manipulation of the Wnt/β-catenin signaling pathway could not overcome this absence...
  63. doi request reprint Multifunctional implantable particles for skin tissue regeneration: preparation, characterization, in vitro and in vivo studies
    Sha Huang
    Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi an, China
    Acta Biomater 4:1057-66. 2008
    ....
  64. ncbi request reprint [Experimental study on adipose-derived stem cells combined with acellular dermal matrix particles for vocal fold injection]
    Qiang Liang
    Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 46:283-7. 2011
    ..To explore the feasibility of adipose-derived stem cells (ASC) combined with micronized acellular dermal matrix (MADM) for vocal cord injection...
  65. pmc Identification and characterization of microRNAs by high through-put sequencing in mesenchymal stem cells and bone tissue from mice of age-related osteoporosis
    Xiaoning He
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi, China Engineering Technology Center for Tissue Engineering of Xi an, Shaanxi, China Department of Oral Histopathology, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    PLoS ONE 8:e71895. 2013
    ....
  66. doi request reprint Clinical, pathological and genetic evaluations of Chinese patients with autosomal-dominant hypophosphatasia
    Ke wen Wei
    Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, 145 West Changle Road, Xi an 710032, China
    Arch Oral Biol 55:1017-23. 2010
    ..The objective of the present work was to explore the correlations between genotype and phenotype in a Chinese family affected by autosomal-dominant HPP...
  67. doi request reprint GSK3β is a checkpoint for TNF-α-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments
    Xiangwei Kong
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, China Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, China Department of Stomatology, Nanjing Bayi Hospital, Nanjing, China
    Biochim Biophys Acta 1830:5119-29. 2013
    ..In chronic inflammatory bone disease, bone regeneration is inhibited. The present study therefore sought to identify the underlying molecule mechanisms...
  68. ncbi request reprint [The reconstruction of bioengineer active corneal stroma and its biocompatibility study]
    Xin Nie
    Department of Oral Pathology and Histology, Stomatological College, Forth Military Medical University, Xi an 710032, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 23:878-81. 2006
    ..All the nuclei of the corneal stromal cells showed positive labeling with BrdU in the BACS. After 4 weeks, BACS became transparent; after 8 weeks, the bioengineer active cornea stroma was fully reconstructed...
  69. doi request reprint A nerve graft constructed with xenogeneic acellular nerve matrix and autologous adipose-derived mesenchymal stem cells
    Yongjie Zhang
    Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Biomaterials 31:5312-24. 2010
    ..Therefore, we conclude that constructed nerve graft, offering nerve regeneration characteristics, hold great promise to replace autologous in repair peripheral nerve defect...
  70. doi request reprint Development of rat antigen-presenting cells from pluripotent ecto-mesenchymal stem cells in vitro and in vivo
    Shijie Hu
    Institute of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Shaanxi, China
    Mol Immunol 45:3818-26. 2008
    ..Our findings related to the development and differentiation of microglial progenitors support the view that microglia are derived prenatally from mesodermal progenitors that are distinct from monocytes...
  71. pmc Periodontal ligament stem cells modulate root resorption of human primary teeth via Runx2 regulating RANKL/OPG system
    Bei Li
    1 State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi an, China
    Stem Cells Dev 23:2524-34. 2014
    ..These data suggest that PDLSCs promote osteoclast differentiation via Runx2 upregulating RANKL and downregulating OPG, leading to enhanced root resorption that results in physiological exfoliation of primary teeth. ..
  72. doi request reprint Canonical Wnt signaling differently modulates osteogenic differentiation of mesenchymal stem cells derived from bone marrow and from periodontal ligament under inflammatory conditions
    Wenjia Liu
    Research and Development Center for Tissue Engineering, The Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China Department of Oral Histology and Pathology, School of Stomatology, The Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Biochim Biophys Acta 1840:1125-34. 2014
    ....
  73. doi request reprint Can bone marrow cells give rise to cornea epithelial cells?
    Yuan Liu
    Center for Tissue Engineering, Department of Oral Histology and Pathology, Stomatological College, The Fourth Military Medical University, Xi an, China
    Med Hypotheses 71:411-3. 2008
    ..Cultured cell sheets composed of autologous c-kit+ enriched bone marrow stem cells may be used to reconstruct corneal surfaces and can restore vision in patients with bilateral severe disorders of the ocular surface...
  74. ncbi request reprint [Tissue engineering peripheral nerve with TGF-beta repair sciatic nerve defect]
    Yongjie Zhang
    Tissue Engineering Center, Department of Oral Histology and Pathology, College of Stomatology, The Fourth Military Medical University, Xi an, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 24:394-8. 2007
    ..TGF-beta can promote not only the proliferation, but also the NGF synthesis of SC obviously. The use of exogenous TGF-beta in the repair of peripheral nerve defect may produce better curative effect...
  75. pmc Licochalcone A up-regulates of FasL in mesenchymal stem cells to strengthen bone formation and increase bone mass
    Leiguo Ming
    1 State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi an, Shaanxi 710032, China 2 State Key Laboratory of Military Stomatology, Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi 710032, China 3 Institute forTissue Engineering and Regenerative Medicine Research of Xi an, Xi an, China
    Sci Rep 4:7209. 2014
    ....
  76. doi request reprint Lamellar keratoplasty with a graft of lyophilized acellular porcine corneal stroma in the rabbit
    Xu Chu Lin
    Department of Oral Histology and Pathology, College of Stomatology, Shanxi, China
    Vet Ophthalmol 11:61-6. 2008
    ..To evaluate the efficacy of lamellar keratoplasty in the rabbit using a graft of lyophilized acellular porcine corneal stroma (APCS)...
  77. doi request reprint MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis
    Yali Liu
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Stem Cells 29:1804-16. 2011
    ....
  78. ncbi request reprint Cosmetic improvement in various acute skin defects treated with tissue-engineered skin
    Xin Nie
    Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Artif Organs 31:703-10. 2007
    ..Furthermore, the TE-skin appears to produce more satisfactory cosmetic results when compared with the conventional therapy...
  79. ncbi request reprint [Expression feature and bioinformatic analysis of molar root patterning gene 1]
    Xiang hui Xing
    Department of Oral Histopathology, College of Stomatology, The Fourth Military Medical University, Xi an 710032, China
    Zhonghua Kou Qiang Yi Xue Za Zhi 43:528-30. 2008
    ..To examine the expression of molar root patterning gene 1 (Mrp1) and predict the Mrp1 structure by bioinformatics analysis...
  80. doi request reprint Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis
    Shiyu Liu
    1 Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi, China 2 Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    J Invest Dermatol 134:2648-57. 2014
    ..In addition, we found that apoptosis has an important role in the activation of the inflammatory regulatory abilities of hMSCs. ..
  81. doi request reprint The effect of licochalcone A on cell-aggregates ECM secretion and osteogenic differentiation during bone formation in metaphyseal defects in ovariectomized rats
    Fenqing Shang
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, Shaanxi 710032, China Department of Oral Histology and Pathology, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi 710032, China Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an 710032, China
    Biomaterials 35:2789-97. 2014
    ..Results of our study demonstrated that LA could positively affect cell behavior in cell-aggregate engineering and could be a promising strategy in treating osteoporotic weight-bearing bones fractures with defects...
  82. pmc The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells
    Wenjia Liu
    State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi an, Shaanxi 710032, People s Republic of China
    Aging (Albany NY) 7:205-18. 2015
    ..Our findings reveal that p53 inhibits osteogenesis via affecting the function of MSCs through miRNA signaling pathways and provide a new potential target for treatment in future. ..
  83. doi request reprint A retrospective study of pediatric traumatic dental injuries in Xi'an, China
    Yu Zhang
    Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xi an, China
    Dent Traumatol 30:211-5. 2014
    ..This study aimed to determine the distributive features of pediatric traumatic dental injury in a university dental hospital in Xi'an, China...
  84. ncbi request reprint Novel composite nanoparticles based on glycidyl methacrylate-derivatized dextrans and gelatin as new bone morphogenetic protein carrier
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, 145th Chang le Road, Xi an 710032, Shaanxi, People s Republic of China
    J Biomed Mater Res A 84:568. 2008
  85. doi request reprint Prospects for translational regenerative medicine
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an 710032, Shaanxi, PR China
    Biotechnol Adv 30:658-72. 2012
    ....
  86. ncbi request reprint [Screening of differentially expressed microRNAs in bone marrow-derived mesenchymal stem cells during osteoporosis and their function in stem cell differentiation]
    Li Liao
    Department of Oral Histology and Pathology, School of Stomatology, Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an 710032, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 41:75-80. 2012
    ..To screen differentially expressed microRNAs in bone marrow-derived mesenchymal stem cells (BMMSCs) during osteoporosis and their function in stem cell differentiation...
  87. ncbi request reprint The induction of growth arrest in fibroblasts by SV40 T antigen
    Xinwen Wang
    Department of Oral Histology and Pathology, Center for Tissue Engineering, Stomatological College, The Fourth Military Medical University, Xi an 710032, China
    Mol Biol Rep 33:181-6. 2006
    ..Moreover, high rate of cell division in early stage after transfection may be associated with the expression of telomerase activity...
  88. ncbi request reprint Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics
    Fa Ming Chen
    Center for Tissue Engineering, College of Stomatology, The Fourth Military Medical University, Xi an 710032, China
    Acta Pharmacol Sin 26:1093-103. 2005
    ..To prepare new pharmaceutical forms with sustained delivery properties of recombinant human bone morphogenetic protein-2 (rhBMP2) for tissue engineering and guided tissue regeneration (GTR) use...
  89. ncbi request reprint [Reconstruction of three different kinds of tympanic membrane in vitro by tissue engineering technique]
    Zhihong Deng
    Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University Xi an Shaanxi, 710032, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:88-91. 2008
    ..To reconstruct three different kinds of tympanic membrane in vitro by tissue engineering technique, and to examine their histological structures and mechanical properties...
  90. ncbi request reprint [Promotion of wound healing through incorporation of bFGF-impregnated microspheres into collagen membrane]
    Sha Huang
    Tissue Engineering Center, Stomatological College, Fourth Military Medical University, Xi an, Shaanxi 710032, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 20:161-4. 2006
    ..To investigate the promotion effects of the collagen membrane incorporating bFGF-impregnated microspheres on the wound healing of the pig skin losing its full-thickness layers...
  91. doi request reprint Deciduous dental pulp stem cells are involved in osteoclastogenesis during physiologic root resorption
    Yuan Zhu
    Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi an, China
    J Cell Physiol 228:207-15. 2013
    ..Collectively, our data indicate that DDPSCs influence osteoclastogenesis during the physiologic root resorption process, and that the canonical Wnt pathway can change the RANKL/OPG expression ratio in DDPSCs...
  92. ncbi request reprint [Spermidine enhances osteogenic differentiation and inhibits adipogenic differentiation of bone marrow-derived mesenchymal stem cells from ovariectomized mice]
    Meng Qi
    State Key Laboratory of Military Stomatology, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi an 710032, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 31:787-91. 2015
    ..To investigate the effects of spermidine (SPD) on the differentiation ability of bone marrow-derived mesenchymal stem cells (BMMSCs) from estrogen-deficient mouse models...
  93. ncbi request reprint Odontogenic capability: bone marrow stromal stem cells versus dental pulp stem cells
    Jinhua Yu
    Department of Endodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Biol Cell 99:465-74. 2007
    ..Although adult bone-marrow-derived cell populations have been used to make teeth when recombined with embryonic oral epithelium, the differences between dental and non-dental stem-cell-mediated odontogenesis remain an open question...
  94. ncbi request reprint [Recombinant human bone morphogenetic protein-2 transform NIH3T3 fibroblast to osteo-like cells]
    Jun lin Wang
    Dept of Oral Histology and Pathology, The Fourth Military Medical University, Xi an 710032, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 22:420-2. 2004
    ..To examine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on NIH3T3 cells...
  95. ncbi request reprint Identification and characterization of a novel gene, Mcpr1, and its possible function in the proliferation of embryonic palatal mesenchymal cells
    Dong Ying Xuan
    Department of Oral Histology and Pathology, College of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    J Biol Chem 281:33997-4008. 2006
    ....
  96. ncbi request reprint [Treatment of rabbit corneal with skin epidermal stem cells]
    Yan Jin
    Research Center for Tissue Engineering, The Fourth Military Medical University, Xi an 710032, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:674-7. 2005
    ..To construct artificial rabbit corneas with autologous skin epidermal stem cells and allogenic stromal cells in vitro and promote healing of corneal wounds...
  97. doi request reprint Localized delivery of growth factors for periodontal tissue regeneration: role, strategies, and perspectives
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, The Fourth Military Medical University, Shaanxi, People s Republic of China
    Med Res Rev 29:472-513. 2009
    ....
  98. doi request reprint Identification of a novel missense mutation of MSX1 gene in Chinese family with autosomal-dominant oligodontia
    Kun Xuan
    Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, 145 West Changle Road, Xi an 710032, PR China
    Arch Oral Biol 53:773-9. 2008
    ..The objective of the present work was to study the phenotype and genotype of three generations of a Han Chinese family affected by non-syndromic autosomal-dominant oligodontia...
  99. ncbi request reprint Determination of genes involved in the early process of molar root development initiation in rat by modified subtractive hybridization
    Xianghui Xing
    Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical University, Xian 710032, China
    Biochem Biophys Res Commun 363:994-1000. 2007
    ..It is anticipated that further study of genes identified will provide insights into their specific roles in the tooth root patterning...
  100. doi request reprint New role of Notch-mediated signaling pathway in myocardial ischemic preconditioning
    Yang Yang
    Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127 ChangLe West Road, Xi an 710032, China
    Med Hypotheses 76:427-8. 2011
    ....
  101. ncbi request reprint [Effects of ADAM28 AS-ODN on proliferation and AKPase of HDFCs]
    Zheng Zhao
    Department of Pediatric Dentistry, College of Stomatology, Fourth Military Medical University, Xi an 710032, Shanxi Province, China
    Shanghai Kou Qiang Yi Xue 15:161-6. 2006
    ..To study the effects of ADAM28 antisense oligodeoxynucleotide (AS-ODN) on proliferation of human dental follicle cells (HDFCs) and activity of alkaline phosphatase (AKPase)...