Jun Chen

Summary

Affiliation: Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders, The Fourth Military Medical University Tangdu Hospital
Location: Xian, China
Summary:
Dr. Jun Chen has been working on neurobiology, pharmacology and behaviors of pathological pain by means of various advanced techiques and methodology. The bee venom-induced pain and pain hypersensitivity is similar to the inflammatory pain processing in human beings by which the underlying mechanisms of pathological pain can be unraveled at molecular, cellular, neural network and behavioral levels. Through development and long-term use of the bee venom test, many pharmacological action sites of drugs in both peripheral and central CNS of pain pathways that are potential to become novel targets for pain relief have been examined.
Grants:
1) Establishment of a novel animal model of pathological pain ?? the bee venom test: behavioral and electrophysiological models (Supported by grants from National Ministry of Education and the Fourth Military Medical University, No. HG97009, 40,000.00 RMBYuan)
(2) Spinal intracellular signal transduction mechanisms of clinical persistent pain and exploration of a novel strategy for analgesia (Supported by National Natural Science Foundation of China, No.39870791, 130,000.00 RMBYuan, 1999.01-2001.12)
(3) Encoding and processing of neuronal circuitry and information (National Basic Research ??973?? Program on ??Basic Research on Brain Function and Important Brain Diseases?? sponsored by National Ministry of Science and Technology, No. G1999054004, 4,216,000.00 RMBYuan, 1999.09-2004.08)
(4) Peripheral mechanisms of subcutaneous bee venom-induced mechanical allodynia (supported by National Natural Science Foundation of China, No.30000051, 140,000.00 RMBYuan, 2001.01-2003.12)
(5) Temporal encoding features of spinal dorsal horn wide dynamic range neurons (supported by National Natural Science Foundation of China, No.30100052, 190,000.00 RMBYuan, 2002.01-2004.12)
(6) Roles of spinal ERK/PKC/PKA in development of pathological pain (supported by National Natural Science Foundation of China, No.30200077, 220,000.00 RMBYuan, 2003.01-2005.12)
(7) Plastic changes of somatosensory system induced by subcutaneous honeybee toxin (??Outstanding Youth Foundation?? of Natural Science Foundation of China, No.30325023, 1,000,000.00 RMB Yuan, 2004.01-2007.12)
(8) A study on synaptic plasticity of spinally-organized nociceptive flexion reflex circuitry by using slice patch-clamp whole cell recording technique (supported by National Natural Science Foundation of China, No.30300105, 190,000.00 RMBYuan, 2004.01-2006.12)
(9) Innovation Fund of Science and Technology for Biomedical Sciences of Pain (Sponsored by Beijing Educational Committee, 2.1587 millions RMB Yuan, 2005.01-2005.12)
(10) Structural and functional changes of somatosensory system induced by subcutaneous honeybee toxin (A collaborative grant of Beijing Natural Science Foundation, No.KZ200510025016, 250,000.00 RMB Yuan, 2004.01-2007.12)
(11) Innovation Research Team Program for Biomedical Sciences of Pain (Sponsored by Beijing Educational Committee, 1.5 millions RMB Yuan, 2006.01-2008.12)
(12) National Basic Research ??973?? Program: ??Dynamic homeostasis of the Brain?? (Sponsored by the National Ministry of Science and Technology, Jun Chen is the Scientist-in-Chief of this program, No. 2006CB500800, 25 millions RMB Yuan, 2006.01-2010.12)
(13) Innovation Research Team Program: ??Loss of brain homeostasis and mechanisms underlying pathological pain??(sponsored by The Ministry of Education, Jun Chen is the Scientist-in-Chief of this program, No. IRT0560, 3 millions RMB Yuan, 2006.01-2008.12)
(14) The 11th 5-year Science & Technology Program of Military Medicine and Health (Sponsored by General Department of Logistics, PLA, No. 06G095, 350,000.00 RMB Yuan, 2006.01-2010.12)
(15) Network synaptic transmission and modulation of somatosensory information (Sponsored by National Natural Science Foundation of China [NSFC], No. 30670692, 280, 000.00 RMB Yuan, 2007.1-2009.12)
(16) Dynamic properties of nociceptor action potentials and ionic mechanisms (Sponsored by National Natural Science Foundation of China [NSFC], No. 30770668, 300, 000.00 RMB Yuan, 2008.1-2010.12)
(17) Neural circuits and plasticity of pathological pain information coding and processing in the cerebral cortex of mammals (Sponsored by National Natural Science Foundation of China [NSFC], No. 81070899, 350,000.00 RMB Yuan, 2011.01-2013.12)
Publications:
Selected Publications (in chronological order, * corresponding author):
1. Chen J*, Rao ZR, Zhao ZQ, Wang LG, Dong YX and Li JS, The structure of the subnuclei of the human neonatal interpeduncular nucleus and distribution patterns of substance P-, enkephalin-and serotonin-like immunoreactive elements in it, Acta Anatomica Sinica, Suppl 2 (1991) 46-48.
2. Chen J*, Rao ZR and Shi JW, The sites of origin of alpha-melanocyte stimulating hormone-containing axonal components in the lateral area of the midbrain periaqueductal gray of the rat, Brain Research 575 (1992) 333-336.
3. Chen J*, Zeng SL, Rao ZR and Shi JW, Serotonergic projections from the midbrain periaqueductal gray and nucleus raphe dorsalis to the nucleus parafascicularis of the thalamus, Brain Research 584 (1992) 294-298.
4. Chen J*, Xiong KH, Rao ZR, Shi JW, Subnuclear division of the nucleus parafascicularis in the rat, Chin J Neuroanat 10 (1994) 57-60.
5. Koyama N, Nishikawa Y, Chen J, Balderrama RP and Yokota T, Differential inhibitory mechanisms in VPL versus intralaminar nociceptive neurons of the cat: II. Effects of systemic morphine and CCK, Jpn J Physiol., 45 (1995) 1029-1041.
6. Osada A, Fujino Y and Chen J, Inhibitory effects of ketamine on C-fiber responses of dorsal horn neurons in the cat, Pharmacoanesthesiology 8 (1995) 25-26.
7. Chen J*, Koyama N and Yokota T, Effects of subcutaneous formalin on responses of dorsal hornwide dynamic range neurons and primary afferent neurons in the cat, Pain Research 11 (1996) 71-83.
8. Koyama N, Hanai F, Chen J and Yokota T, Activation of descending antinociceptive system produced by intravenous picrotoxin, Pain Research 11 (1996) 85-95.
9. Chen J* and Koyama N, Effects of subcutaneous formalin on responses of identified primary afferent units in the cat: An electrophysiological study, Chin J Neuroanat, 12 (1996) 381-393.
10. Osada A, Fujino Y, Chen J and Koyama N, Differential effects of ketamine and MK-801 on A- and C-fiber responses of spinal wide dynamic range neurons in the cat, J Anesth, 11 (1997) 184-192.
11. Chen J, Koyama N, Kaneko T and Mizuno N, The locus coeruleus of the Japanese monkey (Macaca fuscata) does not express mu-opioid receptor-like immunoreactivity, Brain Research 755 (1997) 326-330.
12. Chen J*, Koyama N, Mechanisms underlying persistent increase in hyperexcitability of spinal dorsal horn nociceptive neurons induced by peripheral tissue injury, Chin J Anesthesiol, 18 (1998) 490-493.
13. Chen J* and Koyama N, Differential activation of spinal dorsal horn units by subcutaneous formalin injection in the cat: An electrophysiological study, Experimental Brain Research 118 (1998) 14-18.
14. Chen J*, Koyama N, Kaneko T and Mizuno N, Distribution of -opioid receptor-like immunoreactivity in the brain of the Japanese monkey (Macaca fuscata): I. Diencephalon and brain stem, Chin J Neuroanat, 14 (1998) 101-110.
15. Chen J*, Koyama N, Kaneko T and Mizuno N, Distribution of -opioid receptor-like immunoreactivity in the brain of the Japanese monkey (Macaca fuscata): II. Rostrocaudal neuraxis of spinal cord and dorsal root ganglia, Chin J Neuroanat, 14 (1998) 321-327.
16. Luo C, Chen J*, Li HL and Li JS, Spacial and temporal expression of c-Fos protein in the spinal cord of rat induced by subcutaneous bee venom injection, Brain Res, 806 (1998) 175-185.
17. Chen J*, Luo C and Li HL, The contribution of spinal neuronal changes to development of prolonged, tonic nociceptive responses of the cat induced by subcutaneous bee venom injection, Eur J Pain, 2 (1998) 359-376.
18. Chen J*, Luo C, Li HL and Chen HS, Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: A comparative study with the formalin test, Pain, 83 (1999) 67-76.
19. Chen J*, Li HL, Luo C, Li Z and Zheng JH, Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat, Brain Res, 844 (1999) 98-105.
20. You HJ, and Chen J*, Differential effects of subcutaneous injection of formalin and bee venom on responses of wide-dynamic-range neurons in spinal dorsal horn of the rat, Eur J Pain, 3 (1999) 177-180.
21. Li HL and Chen J*, Quantitative analysis of dorsal root ganglion cells expressing mu-opioid receptors in the Japanese monkey, Chin J Neurosci, 15 (1999) 173-180.
22. Sun YY, Chen J*, Xiong LZ, Li HL, Zeng XL, Suppressive effects of intrathecal etomidate on persistent pain induced by intraplantar bee venom injection in the conscious rat, J Fourth Mil Med Univ, 20 (1999) 300-303.
23. Luo C and Chen J*, Involvement of peripheral NMDA receptors in persistent nociception induced by subcutaneous bee venom injection: A behavioral study, Chin J Neuroanat, 16 (2000) 15-20.
24. Li HL, Chen J* and Luo C, Peripherally suppressive effects of ketamine on subcutaneous bee venom-induced prolonged, persistent firing of spinal wide-dyanamic-range neurons in the cat, Chin J Neuroanat, 16 (2000) 222-230.
25. Zheng JH and Chen J*, Modulatory roles of the ATP P2x-purinoceptor in generation of the persistent nociception induced by subcutaneous bee venom injection in the conscious rat, Neurosci Lett, 278 (2000) 41-44.
26. Chen HS, Chen J* and Sun YY, Contralateral heat hyperalgesia induced by unilaterally intraplantar bee venom injection is produced by central changes: a behavioral study in the conscious rat, Neurosci Lett, 284 (2000) 45-48.
27. Li KC, Zheng JH and Chen J*, Involvement of spinal protein kinase C in induction and maintenance of both persistent spontaneous flinching reflex and contralateral heat hyperalgesia induced by subcutaneous bee venom in the conscious rat, Neurosci Lett, 285 (2000) 103-106.
28. Chen HS and Chen J*, Secondary heat, but not mechanical, hyperalgesia induced by subcutaneous injection of bee venom in the conscious rat: effect of systemic MK-801, a non-competitive NMDA receptor antagonist, Eur J Pain, 4 (2000) 389-401.
29. Li Z, Sun YY, Chen J*, Roles of spinal cyclooxygenases in subcutaneous bee venom-induced persistent pain-related response, Med J Chin PLA, 25 (2000) 182-184.
30. Chen HS, Chen J*, Chen J, Guo WG and Zheng MH, Establishment of bee venom-induced contralateral heat hyperalgesia in the rat is dependent upon central temporal summation of afferent input from the site of injury, Neurosci Lett, 298 (2001) 57-60.
31. Zheng JH and Chen J*, Differential roles of spinal neurokinin 1/2 receptors in development of persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat, Neuropeptides, 35 (2001) 32-44.
32. Chen J* and Chen HS, Pivotal role of capsaicin-sensitive primary afferents in development of both heat and mechanical hyperalgesia induced by intraplantar bee venom injection, Pain, 91 (2001) 367-376.
33. Chen J*, Diversity of pathological pain: New evidence from the bee venom model, Chin J Neuroanat, 17 Suppl. (2001) 28-34.
34. Sun YY, Xiong LZ, Chen J*, Two methods of quantitating the bee venom-induced spontaneous pain-related responses and the analgesic effect of morphine, J.FMMU, 22 (2001) 391-394.
35. Li Z and Chen J*, Roles of spinal cyclooxygenases in the development of bee venom-induced persistent spontaneous pain, primary hyperalgesia and spinal c-fos protein expression in the rat, Chin J Neuroanat, 17 (2001) 151-156.
36. Sun YY, Chen J*, Xiong LZ, Li HL, Zeng XL, Effects of intravenous and/or intrathecal etomidate on thermal and mechanical hyperalgesia induced by intraplantar injection of bee venom in rats, Chin J Anesthesiol, 21 (2001) 302-305.
37. Luo C., Kumamoto E., Furue H., Chen J. and Yoshimura M, Nociceptin inhibits excitatory but not inhibitory transmission to substantia gelatinosa neurones of adult rat spinal cord. Neuroscience, 109 (2002) 349-358.
38. Luo C., Kumamoto E., Furue H., Chen J. and Yoshimura M, Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin. Neurosci. Lett., 321 (2002) 17-20.
39. Ge W, Chen J*, Li Y, Chen HS, Pain-related behavioral response of elderly rats to peripheral different chemical tissue injury, J Fourth Mil Med Univ, 23 (2002) 433-436.
40. Li MM, Chen J*, Chen HS, Zhang YM, Effects of neonatal peripheral tissue injury on pain-related pain behaviors in male and female mature rats, J Fourth Mil Med Univ, 23 (2002) 118-121.
41. Zheng JH, Jian Z, Chen J*, Detection of deterministic behavior within the tissue injury-induced persistent firing of nociceptive neurons in the dorsal horn of the rat spinal cord, Journal of Computational Neuroscience, 13 (2002) 23-34.
42. You HJ, Chen J, Morch CD & Arendt-Nielson L, Differential effect of peripheral glutamate (NMDA, non-NMDA) receptor antagonists on bee venom induced spontaneous nociception and sensitization, Brain Research Bulletin, 58 (2002) 561-567.
43. You HJ, Morch CD, Chen J*, Arendt-Nielsen L*. Simultaneous recordings of wind-up of paired spinal dorsal horn nociceptive neuron and nociceptive flexion reflex in the rat, Brain Res, 960 (2003 )228-238.
44. Chen HS, Li MM, Shi J, Chen J*, Supraspinal contribution to development of both tonic nociception and referred mirror hyperalgesia: A comparative study between formalin test and bee venom test in the rat, Anesthesiology, 98 (2003) 1231-1236.
45. You HJ, Morch CD, Chen J, Arendt-Nielsen L, Role of central NMDA versus non-NMDA receptor in spinal withdrawal reflex in spinal anesthetized rats under normal and hyperexcitable conditions, Brain Res, 981 (2003) 12-22.
46. You HJ, Morch CD, Chen J, Arendt-Nielsen L, Differential antinociceptive effects induced by highly selective COX-2 inhibitor SC-236 on simultaneous dorsal horn neuron responses and spinal cord reflex in anesthetized spinal rats, Neuroscience, 121 (2003) 459-472.
47. Peng XL, Chen J*, Huang X, Chen HS, Gao XL, Effects of intravenous Injections Paederiae and Stauntonia on spontaneous pain, hyperalgesia and inflammation induced by cutaneous chemical injury in the conscious rat, Acta Physiological Sinica, 55 (2003) 516-524.
48. Song JL, Li T, Zhou H, Ye XY, Rao ZR, Chen J, A novel quantitative behavioral animal model of experimental tooth movement?Cinduced pain in conscious rats: effects of a systemic NSAID, Chin J Aesthetic Medicine, 12 (2003) 239-242.
49. Chen YN, Jiao K, Gao XL, Liu XY, Ji QH, Chen J*. Effects of experimental changes in blood pressure on basic pain threshold, Chin Heart J, 15 (2003) 400-403.
50. Wang LY, Wang GL, Sun YY, Zhang YM, Chen J*, Inhibition of bee venom-induced persistent pain by intrathecal propofol in rats, Chin J Anesthesiol, 23(2003)118-119.
51. Hou SX, Tang JG, Chen HS, Chen J. Chronic inflammation and compression of the dorsal root contribute to sciatica induced by the intervertebral disc herniation in rats, Pain, 105 (2003) 255-264.
52. Li KC, Chen J*, Differential roles of spinal protein knases C and A in development of primary heat and mechanical hypersensitivity induced by subcutaneous bee venom chemical injury in the rat, Neurosignals, 12 (2003) 292-301.
53. Peng XL, Gao XL, Chen J*, Huang X, Chen HS, Evaluation of anti-nociceptive effects of Radix Angelicae Dahuricae on persistent nociception: comparative study between bee venom test and formalin test, Chin J Neuroanat, 20 (2004) 48-54.
54. Li HL, Li CL, Chen J*. Evidence for involvement of spinal vanilloid receptor 1 (VR1) in thermal sensitivity: A combined behavioral and immunohistochemical study in aged rats. Chinese Journal of Neuroanatomy, 20 (2004) 125-131.
55. Li CL, Li HL, Chen J*. Effect of age on the expression of transient receptor potential vanilloid 1 (TRPV1) in the spinal cord of normal rats and rats with peripheral inflammation. Chinese Journal of Neuroanatomy, 20 (2004) 137-142.
56. Zheng JH, Chen J, Arendt-Nielson L, Complexity of tissue injury-induced nociceptive discharge of dorsal horn wide dynamic range neurons in the rat, correlation with the effect of systemic morphine, Brain Res, 1001 (2004) 143-149.
57. Zheng JH, Feng W, Jian Z, Chen J*, Age-related change in deterministic behaviors of nociceptive firing of rat dorsal horn neurons, Acta Physiologica Sinica, 56 (2004) 178-182.
58. Sun YY, Luo C, Li Z, Chen J*, Differential actions of intrathecal nociceptin on persistent spontaneous nociception, hyperalgesia and inflammation produced by subcutaneous bee venom injection in conscious rats, Acta Physiologica Sinica, 56 (2004) 269-274.
59. Li Z, Luo C, Sun YY, Chen J*, Effects of etomidate on local synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord, Acta Physiologica Sinica, 56 (2004) 413-418.
60. Sun YY, Li KC, Chen J*. Inhibitory effects of spinal propofol on the responses of spinal dorsal horn neurons om normal rats, Acta Physiologica Sinica, 56 (2004) 444-450.
61. Li KC, Chen J*, Altered pain-related behaviors and spinal neuronal responses produced by s.c. injection of melittin in rats, Neuroscience, 126 (2004) 753-762.
62. Lariviere WR, Chesler EJ, Li Z, Shang GW, Chen YN, Yu YQ, Lu ZM, Chang Y, Luo C, Li KC, Chen J*. Correlations between edema and the immediate and prolonged painful consequences of inflammation: therapeutic implications? Acta Physiologica Sinica, 57 (2005) 278-288.
63. Yu YQ, Chen J*. Activation of spinal extracellular signaling-regulated kinases by intraplantar melittin injection, Neurosci Lett, 381 (2005) 194-198.
64. Sun YY, Li KC, Chen J*. Evidence for peripherally antinociceptive action of propofol in rats: Behavioral and spinal neuronal responses to subcutaneous bee venom, Brain Res, 1043 (2005) 231-235.
65. Chen YN, Li KC, Li Z, Zhang ZW, Ji YH, Gao GD, Chen J*. Effects of bee venom peptidergic components on rat behaviors related to pain and inflammation, Neuroscience, 138 (2006) 631-640.
66. Shang GW, Liu DN, Yan LH, Cui XY, Zhang KP, Qi C, Chen J*. Nociceptive stimulus modality related difference in pharmacokinetic-pharmacodynamic modeling of morphine in the rat, Pharmacology, Biochemistry and Behaviors, 85 (2006) 464-473.
67. Guo SW, Liu MG, Long YL, Ren LY, Lu ZM, Yu HY, Hou JF, Li H, Gao CY, Cui XY, An YY, Li JF, Zhao LF and Chen J*. Region- or state-related differences in expression and activation of extracellular signal-regulated kinases (ERKs) in naïve and pain-experiencing rats, BMC Neuroscience, 8 (2007) 53.
68. Yu HY, Liu MG, Liu DN, Shang GW, Wang Y, Qi C, Zhang KP, Song ZJ, Chen J*. Antinociceptive effects of systemic paeoniflorin on bee venom-induced various ??phenotypes?? of nociception and hypersensitivity, Pharmacology, Biochemistry and Behaviors, 88 (2007) 131-140.
69. Duan B, Wu LJ, Yu YQ, Ding Y, Jing L, Xu L, Chen J*, Xu TL*. Upregulation of Acid-Sensing Ion Channel ASIC1a in Spinal Dorsal Horn Neurons Contributes to Inflammatory Pain Hypersensitivity, Journal of Neuroscience, 27 (2007) 11139-11148.
70. Liu MG, Zhang FK, Guo SW, Zhao LF, An YY, Cui XY, Chen J*. Phosphorylation of c-Jun N-terminal kinase isoforms and their different roles in spinal cord dorsal horn and primary somatosensory cortex, Neurosci Lett, 427 (2007) 39-43.
71. Cao FL, Liu MG, Hao J, Li Z, Lu ZM, Chen J*. Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors, Neurosci Lett, 427 (2007) 50-54.
72. Ren LY, Lu ZM, Liu MG, Yu YQ, Li Z, Shang GW, Chen J*. Distinct roles of the anterior cingulate cortex in spinal and supraspinal bee venom-induced pain behaviors, Neuroscience, 153 (2008) 268-278.
73. Hao J, Liu MG, Yu YQ, Cao FL, Li Z, Lu ZM, Chen J*. Roles of peripheral mitogen-activated protein kinases in melittin-indced nociception and hyperalgesia, Neuroscience, 152 (2008) 1067-1075.
74. Cui XY, Dai Y, Wang SL, Yamanaka H, Kobayashi K, Obata K, Chen J*, Noguchi K*. Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia. Molecular Pain, 4 (2008) 17 (pp1-11).
75. Lu ZM, Xie F, Fu H, Liu MG, Cao FL, Hao J, Chen J*. Roles of peripheral P2X and P2Y receptors in the development of melittin-induced nociception and hypersensitivity, Neurochem Res, 33 (2008) 2085-2091.
76. Li MM, Yu YQ, Fu H, Xie F, Xu LX, Chen J*. Activation of extracellular signaling-regulated kinases in primary injury site of melittin is required to maintain spinal neuronal hypersensitivity to chemical and thermal, but not mechanical, stimulus modalities, Brain Res Bull, 77 (2008) 227-232.
77. Chang Y, Gong KR, Liu MG, Zhang FK, Xie F, Fu H, Xiao Y, Chen J*. Spatiotemporal characteristics of pain-associated neuronal activities in primary somatosensory cortex induced by peripheral persistent nociception, Neurosci Lett, 448 (2008) 134-138.
78. Chen J*. Spinal processing of bee venom-induced pain and hyperalgesia, Acta Physiologica Sinica, 60 (2008) 645-652. (Special Issue on Pain: Physiology and Pathophysiology edited by Jun Chen, Zhi-Qi Zhao, and Robert H. LaMotte)
79. Yan LH, Hou JF, Liu MG, Li MM, Cui XY, Lu ZM, Zhang FK, An YY, Shi L, Chen J*. Imbalance between excitatory and inhibitory amino acids at spinal level is associated with maintenance of persistent pain-related behaviors, Pharmacological Research, 59 (2009) 290-299.
80. Yu YQ, Zhao F, Chen J*. Activation of ERK1/2 in the primary injury site is required to maintain melittin-enhanced wind-up of rat spinal wide-dynamic-range neurons. Neurosci Lett, 459 (2009) 137-141.
81. Tian LJ, Du YR, Xiao Y, Lv ZM, Yu YQ, Cui XY, Chen J*. Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde. Acta Physiologica Sinica, 61 (2009) 404-416.
82. Chen J*. Toward the brain matrix of pain. Neuroscience Bulletin, 25 (2009) 234-236.
83. Zhang W, Miao JT, Hao J, Li Z, Xu J, Liu R, Cao FL, Wang RR, Chen J*, Li ZY*. Protective effect of S14G-humanin against beta-amyloid induced LTP inhibition in mouse hippocampal slices. Peptides, 30 (2009) 1197-1202.
84. Zhao XY, Liu MG, Yuan DL, Wang Y, He Y, Wang DD, Chen XF, Zhang FK, Li H, He XS, Chen J*. Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording. Mol Pain, 2009, 5:55.
85. Liu MG and Chen J*. Roles of the hippocampal formation in pain information processing. Neuroscience Bulletin, 25 (2009) 237-266.
86. He Y, Liu MG, Gong KR, Chen J*. Differential effects of long and short train theta burst stimulation on LTP induction in rat anterior cingulate cortex slices: Multi-electrode array recordings. Neuroscience Bulletin, 25 (2009) 309-318.
87. Wang DD, Li Z, Chang Y, Wang RR, Chen XF, Zhao ZY, Cao FL, Jin JH, Liu MG, Chen J*. Neural circuits and temporal plasticity in hindlimb representation of rat primary somatosensory cortex: revisited by multi-electrode array on brain slices. Neuroscience Bulletin, 26 (2010) 175-187.
88. Chen J*, Lariviere WR. The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword. Progress in Neurobiology, 92 (2010) 151-183.
89. Gong KR, Cao FL, He Y, Gao CY, Wang DD, Li H, Zhang FK, An YY, Lin Q, Chen J*. Enhanced excitatory and reduced inhibitory synaptic transmission contribute to persistent pain-induced neuronal hyper-responsiveness in anterior cingulated cortex. Neuroscience, 171 (2010) 1314-1325.
90. Liu MG, Wang RR, Chen XF, Zhang FK, Cui XY, Chen J*. Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: Multi-electrode array recordings. Brain Res., 1382 (2011) 57-69.
91. Du YR, Xiao Y, Lu ZM, Ding J, Xie F, Fu H, Wang Y, Strong JA, Zhang JM, Chen J*. Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways. Biochem Biophys Res Commun, 408 (2011) 32-37.
92. Wang CM, Yang L, Lu D, Lu YF, Chen XF, Yu YQ, Li Z, Zhang FK, Chen J*. Simultaneous multisite recordings of neural ensemble responses in the motor cortex of behaving rats to peripheral noxious heat and chemical stimuli. Behavioural Brain Res, 2011 (in press).
93. Yu YQ, Zhao F, Guan SM, Chen J*. Antisense-mediated knockdown of NaV1.8, but not NaV1.9, generates inhibitory effects on complete Freund??s adjuvant-induced inflammatory pain in rat. PLoS One, 2011 (in press).

Publications

  1. Cao F, Liu M, Hao J, Li Z, Lu Z, Chen J. Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors. Neurosci Lett. 2007;427:50-4 pubmed
  2. Yu Y, Chen J. Activation of spinal extracellular signaling-regulated kinases by intraplantar melittin injection. Neurosci Lett. 2005;381:194-8 pubmed
  3. Liu M, Chen J. Roles of the hippocampal formation in pain information processing. Neurosci Bull. 2009;25:237-66 pubmed publisher
    ..At last, we further expound on the relationship between pain and memory and present some unresolved issues. ..
  4. He Y, Liu M, Gong K, Chen J. Differential effects of long and short train theta burst stimulation on LTP induction in rat anterior cingulate cortex slices: multi-electrode array recordings. Neurosci Bull. 2009;25:309-18 pubmed publisher
  5. Sun Y, Luo C, Li Z, Chen J. Differential actions of intrathecal nociceptin on persistent spontaneous nociception, hyperalgesia and inflammation produced by subcutaneous bee venom injection in conscious rats. Sheng Li Xue Bao. 2004;56:321-7 pubmed
  6. Zhang W, Miao J, Hao J, Li Z, Xu J, Liu R, et al. Protective effect of S14G-humanin against beta-amyloid induced LTP inhibition in mouse hippocampal slices. Peptides. 2009;30:1197-202 pubmed publisher
  7. Yu Y, Zhao F, Chen J. Activation of ERK1/2 in the primary injury site is required to maintain melittin-enhanced wind-up of rat spinal wide-dynamic-range neurons. Neurosci Lett. 2009;459:137-41 pubmed publisher
    ..We conclude that peripheral ERKs pathway in the primary injury site is required to maintain melittin-enhanced wind-up of rat spinal cord wide-dynamic-range neurons. ..
  8. Liu M, Zhang F, Guo S, Zhao L, An Y, Cui X, et al. Phosphorylation of c-Jun N-terminal kinase isoforms and their different roles in spinal cord dorsal horn and primary somatosensory cortex. Neurosci Lett. 2007;427:39-43 pubmed
    ..Also, the two JNK isoforms are supposed to function differently according to their locations within the rat central nervous system. ..
  9. Chen J, Lariviere W. The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword. Prog Neurobiol. 2010;92:151-83 pubmed publisher
    ..This report highlights key patterns of results, critical shortcomings, and essential areas requiring further study. ..

Detail Information

Publications47

  1. You H, Chen J, Morch C, Arendt Nielsen L. Differential effect of peripheral glutamate (NMDA, non-NMDA) receptor antagonists on bee venom-induced spontaneous nociception and sensitization. Brain Res Bull. 2002;58:561-7 pubmed
    ..The data suggest that the peripheral NMDA receptor, but not non-NMDA receptor, plays a pivotal role in the bee venom-induced persistent nociception and hyperexcitability. ..
  2. Zheng J, Jian Z, Chen J. Detection of deterministic behavior within the tissue injury-induced persistent firing of nociceptive neurons in the dorsal horn of the rat spinal cord. J Comput Neurosci. 2002;13:23-34 pubmed
    ..By using this method we suggest that BV-induced nociceptive discharge of spinal WDR neuron be a kind of deterministic activity and various UPOs may play some role in temporal coding of sensory information. ..
  3. Chen J, Luo C, Li H, Chen H. Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: a comparative study with the formalin test. Pain. 1999;83:67-76 pubmed
  4. Luo C, Kumamoto E, Furue H, Chen J, Yoshimura M. Nociceptin inhibits excitatory but not inhibitory transmission to substantia gelatinosa neurones of adult rat spinal cord. Neuroscience. 2002;109:349-58 pubmed
    ..Nociceptin could inhibit more potently slow-conducting than fast-conducting pain transmission. ..
  5. Liu M, Wang R, Chen X, Zhang F, Cui X, Chen J. Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: multi-electrode array recordings. Brain Res. 2011;1382:57-69 pubmed publisher
    ..In addition, a possible mechanistic separation between spatial and temporal magnification of pain is also indicated in this study. ..
  6. Chen J, Li H, Luo C, Li Z, Zheng J. Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat. Brain Res. 1999;844:98-105 pubmed
    ..c. bee venom injection. ..
  7. Cui X, Dai Y, Wang S, Yamanaka H, Kobayashi K, Obata K, et al. Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia. Mol Pain. 2008;4:17 pubmed publisher
    ..The results indicate that differential activation of p38 and ERK1/2 in the dorsal horn may contribute to the generation and development of BV-induced pain hypersensitivity by different mechanisms. ..
  8. Yan L, Hou J, Liu M, Li M, Cui X, Lu Z, et al. Imbalance between excitatory and inhibitory amino acids at spinal level is associated with maintenance of persistent pain-related behaviors. Pharmacol Res. 2009;59:290-9 pubmed publisher
    ..This result provides a new line of evidence emphasizing an importance of restoration of EAAs-IAAs balance at the spinal level to prevent persistence or chronicity of pain. ..
  9. Chang Y, Yan L, Zhang F, Gong K, Liu M, Xiao Y, et al. Spatiotemporal characteristics of pain-associated neuronal activities in primary somatosensory cortex induced by peripheral persistent nociception. Neurosci Lett. 2008;448:134-8 pubmed publisher
    ..The present results demonstrated that BV-induced peripheral persistent nociception could evoke increased neuronal activities in the S1 area with predominant localization in layers II-III. ..
  10. Wang D, Li Z, Chang Y, Wang R, Chen X, Zhao Z, et al. Neural circuits and temporal plasticity in hindlimb representation of rat primary somatosensory cortex: revisited by multi-electrode array on brain slices. Neurosci Bull. 2010;26:175-87 pubmed publisher
    ..The present data provide a useful experimental model for further studying microcircuit properties in S1 cortex at the network level in vitro. ..
  11. Hou S, Tang J, Chen H, Chen J. Chronic inflammation and compression of the dorsal root contribute to sciatica induced by the intervertebral disc herniation in rats. Pain. 2003;105:255-64 pubmed
    ..Moreover, AF and NP may contribute similarly to the development of sciatica and back pain. ..
  12. Luo C, Kumamoto E, Furue H, Chen J, Yoshimura M. Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin. Neurosci Lett. 2002;321:17-20 pubmed
    ..It is concluded that unlike capsaicin, anandamide inhibits more effectively Adelta-fibre than C-fibre-mediated excitatory transmission in the SG, possibly through the activation of the cannabinoid receptor. ..
  13. Zheng J, Chen J. Differential roles of spinal neurokinin 1/2 receptors in development of persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat. Neuropeptides. 2001;35:32-44 pubmed
    ..c. bee venom injection. The spinal NK3 receptor seems not likely to be involved in the bee venom-induced behavioral response characterized by spontaneous pain and thermal and mechanical hyperalgesia. ..
  14. Chen H, Chen J, Guo W, Zheng M. Establishment of bee venom-induced contralateral heat hyperalgesia in the rat is dependent upon central temporal summation of afferent input from the site of injury. Neurosci Lett. 2001;298:57-60 pubmed
    ..The results suggest that the amount of primary afferent input determines the time window required to establish central changes that are independent of further afferent input. ..
  15. Zhao X, Liu M, Yuan D, Wang Y, He Y, Wang D, et al. Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording. Mol Pain. 2009;5:55 pubmed publisher
    ..In addition, the multi-synaptic model established in the present investigation may open a new avenue for future studies of pain-related brain dysfunctions at the higher level of the neuromatrix. ..
  16. Chen H, Li M, Shi J, Chen J. Supraspinal contribution to development of both tonic nociception and referred mirror hyperalgesia: a comparative study between formalin test and bee venom test in the rat. Anesthesiology. 2003;98:1231-6 pubmed
  17. Tian L, DU Y, Xiao Y, Lv Z, Yu Y, Cui X, et al. Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde. Sheng Li Xue Bao. 2009;61:404-16 pubmed
    ..The activation of primary nociceptor cells by FA is likely to be mediated, at least in part, through TRPV1 and/or TRPA1 receptors. ..
  18. Duan B, Wu L, Yu Y, Ding Y, Jing L, Xu L, et al. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci. 2007;27:11139-48 pubmed
    ..Specific blockade of Ca2+-permeable ASIC1a channels thus may have antinociceptive effect by reducing or preventing the development of central sensitization induced by inflammation. ..
  19. Lu Z, Xie F, Fu H, Liu M, Cao F, Hao J, et al. Roles of peripheral P2X and P2Y receptors in the development of melittin-induced nociception and hypersensitivity. Neurochem Res. 2008;33:2085-91 pubmed publisher
    ..Taken together, these data indicate that activation of P2X and P2Y receptors might be essential to the maintenance of melittin-induced primary thermal and mechanical hyperalgesia as well as on-going pain. ..
  20. Ren L, Lu Z, Liu M, Yu Y, Li Z, Shang G, et al. Distinct roles of the anterior cingulate cortex in spinal and supraspinal bee venom-induced pain behaviors. Neuroscience. 2008;153:268-78 pubmed publisher
    ..The present study also provides additional evidence for the ACC-mediated descending facilitation of primary hyperalgesia (pain hypersensitivity) identified in the injured area under inflammatory pain state. ..
  21. Yu H, Liu M, Liu D, Shang G, Wang Y, Qi C, et al. Antinociceptive effects of systemic paeoniflorin on bee venom-induced various 'phenotypes' of nociception and hypersensitivity. Pharmacol Biochem Behav. 2007;88:131-40 pubmed
  22. Shang G, Liu D, Yan L, Cui X, Zhang K, Qi C, et al. Nociceptive stimulus modality-related difference in pharmacokinetic-pharmacodynamic modeling of morphine in the rat. Pharmacol Biochem Behav. 2006;85:464-73 pubmed
  23. Lariviere W, Chesler E, Li Z, Shang G, Chen Y, Yu Y, et al. Correlations between edema and the immediate and prolonged painful consequences of inflammation: therapeutic implications?. Sheng Li Xue Bao. 2005;57:278-88 pubmed
    ..This analysis represents a method for determining which inflammatory processes are the most promising therapeutic targets against the multiple painful consequences of inflammation. ..
  24. Sun Y, Li K, Chen J. Evidence for peripherally antinociceptive action of propofol in rats: behavioral and spinal neuronal responses to subcutaneous bee venom. Brain Res. 2005;1043:231-5 pubmed
    ..This result indicates that besides central actions, propofol has peripherally antinociceptive action as well. ..
  25. Li Z, Luo C, Sun Y, Chen J. [Effects of etomidate on local synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord]. Sheng Li Xue Bao. 2004;56:413-8 pubmed
    ..e. by prolonging the mean open time of GABA(A) receptors, however, ET has no direct effect on local excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord. ..
  26. Li K, Chen J. Altered pain-related behaviors and spinal neuronal responses produced by s.c. injection of melittin in rats. Neuroscience. 2004;126:753-62 pubmed
  27. Zheng J, Chen J, Arendt Nielsen L. Complexity of tissue injury-induced nociceptive discharge of dorsal horn wide dynamic range neurons in the rat, correlation with the effect of systemic morphine. Brain Res. 2004;1001:143-9 pubmed
    ..Moreover, the response of the nociceptive discharge to analgesics may be related to the nonlinear dynamics feature of nociceptive neurons, which can be quantitatively characterized by the degree of complexity. ..
  28. You H, Mørch C, Chen J, Arendt Nielsen L. Role of central NMDA versus non-NMDA receptor in spinal withdrawal reflex in spinal anesthetized rats under normal and hyperexcitable conditions. Brain Res. 2003;981:12-22 pubmed
    ..In BV-induced inflammation, however, central non-NMDA receptors, but not NMDA receptors, play a pivotal role in the generation of persistent hyperexcitability to mechanical and electrical stimuli at different frequencies (3 Hz, 20 Hz). ..
  29. Chen J, Chen H. Pivotal role of capsaicin-sensitive primary afferents in development of both heat and mechanical hyperalgesia induced by intraplantar bee venom injection. Pain. 2001;91:367-76 pubmed
  30. Sun W, Yang F, Wang Y, Fu H, Yang Y, Li C, et al. Contribution of large-sized primary sensory neuronal sensitization to mechanical allodynia by upregulation of hyperpolarization-activated cyclic nucleotide gated channels via cyclooxygenase 1 cascade. Neuropharmacology. 2017;113:217-230 pubmed publisher
    ..These results suggest that BV can excite the large-sized DRG neurons at least in part by increasing Ih through activation of COX-1. ..
  31. Geng K, He T, Wang R, Li C, Luo W, Wu F, et al. Ethanol Increases Mechanical Pain Sensitivity in Rats via Activation of GABAA Receptors in Medial Prefrontal Cortex. Neurosci Bull. 2016;32:433-44 pubmed publisher
    ..In conclusion, ethanol increases mechanical pain sensitivity through activation of GABAA receptors in the mPFC of rats. ..
  32. Yang Y, Yang F, Yang F, Li C, Wang Y, Li Z, et al. Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity. Neurosci Bull. 2016;32:41-50 pubmed publisher
  33. Chen J. Empathy for Distress in Humans and Rodents. Neurosci Bull. 2018;34:216-236 pubmed publisher
    ..Finally, the author highlights the perspectives and challenges for the further use of rodent models in the study of empathy for pain or distress. ..
  34. Yang F, Sun W, Luo W, Yang Y, Yang F, Wang X, et al. SDF1-CXCR4 Signaling Contributes to the Transition from Acute to Chronic Pain State. Mol Neurobiol. 2017;54:2763-2775 pubmed publisher
  35. Yang F, Sun W, Yang Y, Wang Y, Li C, Fu H, et al. SDF1-CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation. J Neuroinflammation. 2015;12:219 pubmed publisher
    ..8 up-regulation, leading to hyperexcitability of tonic type of the primary nociceptor cells and development and maintenance of persistent spontaneous pain and hypersensitivity. ..
  36. Yang F, Fu H, Lu Y, Wang X, Yang Y, Yang F, et al. Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin. Neurosci Bull. 2014;30:887-902 pubmed publisher
    ..In addition, GBP did not change the basal pain sensitivity and the motor impairment caused by the ITC lesion, suggesting selective action of GBP on the somatosensory system...
  37. Chen J. Spinal processing of bee venom-induced pain and hyperalgesia. Sheng Li Xue Bao. 2008;60:645-52 pubmed
    ..Unraveling the phenotype-based mechanisms of pain might be useful in development of novel therapeutic drugs against complex clinic pathological pain. ..