qun wang

Summary

Affiliation: East China Normal University
Location: shanghai, China

Publications

  1. Yang L, Li X, Wu Y, Zhang J, Li W, Wang Q. Iron regulatory protein is involved in the immune defense of the Chinese mitten crab Eriocheir sinensis. Fish Shellfish Immunol. 2019;89:632-640 pubmed publisher
    ..sinensis against S. aureus and V. parahaemolyticus was impaired. In conclusion, our results suggest that the IRP-IRE signaling pathway plays an important role in the innate immune system response in E. sinensis. ..
  2. Wan Z, Li D, Li X, Zhu Y, Gao T, Li W, et al. B52 promotes alternative splicing of Dscam in Chinese mitten crab, Eriocheir sinensis. Fish Shellfish Immunol. 2019;87:460-469 pubmed publisher
    ..Furthermore, EsB52 RNAi decreased the number of Ig7 inclusion in mRNA rather than Ig2 or Ig3. Taken together, these findings suggest that EsB52 acts as an alternative splicing activator of EsDscam. ..
  3. Yang L, Ruan Z, Li X, Li L, Wang Q, Li W. NEDD8-conjugated Cullin4 positive regulates antimicrobial peptides expression in Eriocheir sinensis. Fish Shellfish Immunol. 2019;84:1041-1049 pubmed publisher
    ..Thus, the results show that EsNEDD8-modified EsCullin4 could control antimicrobial activities via regulation of AMPs expression in the Chinese mitten crab. ..
  4. Ruan Z, Wan Z, Yang L, Li W, Wang Q. JAK/STAT signalling regulates antimicrobial activities in Eriocheir sinensis. Fish Shellfish Immunol. 2019;84:491-501 pubmed publisher
    ..In addition, the JAK/STAT signalling pathway positively regulates antimicrobial peptide expression during the antibacterial immune response. Thus, the JAK/STAT pathway plays a critical role in bacterial immune responses in E. sinensis. ..
  5. Tan S, Zhang X, Jin X, Li W, Li J, Wang Q. Fatty acid binding protein FABP3 from Chinese mitten crab Eriocheir sinensis participates in antimicrobial responses. Fish Shellfish Immunol. 2015;43:264-74 pubmed publisher
    ..These collective results demonstrated the role of Es-FABP3 in the immunoreactions of E. sinensis to PAMPs. ..
  6. Zhang J, Li X, Yang L, Li W, Wang Q. Expression pattern and functional analysis of the two RING box protein RBX in spermatogenesis of Chinese mitten crab Eriocheir sinensis. Gene. 2018;668:237-245 pubmed publisher
    ..Co-immunoprecipitation showed that Es-RBX1 could bind Cullin4. These results suggested that Es-RBX1 plays a key role in spermatogenesis of E. sinensis though forming a complex with Cullin4. ..
  7. Zhu M, Sun W, Wang Y, Li Q, Yang H, Duan Z, et al. P38 participates in spermatogenesis and acrosome reaction prior to fertilization in Chinese mitten crab Eriocheir sinensis. Gene. 2015;559:103-11 pubmed publisher
    ..The results suggest the involvement of p38 MAPK in spermatogenesis and the AR in E. sinensis. ..
  8. Li Q, Xie J, He L, Wang Y, Duan Z, Yang H, et al. Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis. Gene. 2015;562:117-27 pubmed publisher
    ..This study first showed that Es-ADAM10 and Es-ADAM17 were also involved in the spermatogenesis and mainly participated in the later germ cell apoptosis in E. sinensis. ..
  9. Li Q, Wang Y, Xie J, Sun W, Zhu M, He L, et al. Characterization and expression of DDX6 during gametogenesis in the Chinese mitten crab Eriocheir sinensis. Genet Mol Res. 2015;14:4420-37 pubmed publisher
    ..Since oocytes and spermatocytes are active in meiosis and oocytes undergo rapid growth in October, these results provide preliminary evidence that Es-DDX6 plays a role in E. sinensis gametogenesis and oocyte growth processes. ..

More Information

Publications23

  1. Zhu Y, Li D, Zhang X, Li X, Li W, Wang Q. Role of transglutaminase in immune defense against bacterial pathogens via regulation of antimicrobial peptides. Dev Comp Immunol. 2016;55:39-50 pubmed publisher
    ..Thus, EsTGase is an important component of the crab immune response and is involved in the regulation of certain immune-related genes, particularly those encoding anti-microbial peptides. ..
  2. Li Q, Liu L, Wang Y, Xie J, He L, Wang Q. Characterization and expression analysis of serpins in the Chinese mitten crab Eriocheir sinensis. Gene. 2016;575:632-40 pubmed publisher
    ..Together, our results indicate that Esserpin-3 is an intrinsic sperm protein involved in regulation of sperm maturation and the acrosome reaction in E. sinensis. ..
  3. Zhu Y, Zhang X, Wang S, Li W, Wang Q. Antimicrobial functions of EsLecH, a C-type lectin, via JNK pathway in the Chinese mitten crab, Eriocheir sinensis. Dev Comp Immunol. 2016;61:225-35 pubmed publisher
    ..These results indicate that EsLecH could regulate AMPs via JNK signaling. ..
  4. Zhang X, Zhu Y, Li X, Wang S, Li D, Li W, et al. Lipopolysaccharide and beta-1, 3-glucan binding protein (LGBP) stimulates prophenoloxidase activating system in Chinese mitten crab (Eriocheir sinensis). Dev Comp Immunol. 2016;61:70-9 pubmed publisher
    ..Taken together, these results provide experimental evidence for role of LGBP in innate immunity, especially in the activation of prophenoloxidase activating system. ..
  5. Wang Y, Li D, Yang H, He L, Sun W, Duan Z, et al. The E3 Ubiquitin Ligase CRL4 Regulates Proliferation and Progression Through Meiosis in Chinese Mitten Crab Eriocheir sinensis. Biol Reprod. 2016;94:65 pubmed publisher
    ..sinensis Given its widespread evolutionary conservation, Cullin4 may regulate germ line development similarly in other organisms. ..
  6. Yu A, Shi Y, Wang Q. Characterisation of a novel Type I crustin involved in antibacterial and antifungal responses in the red claw crayfish, Cherax quadricarinatus. Fish Shellfish Immunol. 2016;48:30-8 pubmed publisher
    ..These findings suggest that CqCrs is involved in a specific innate immune recognition and defense mechanisms against bacterial and fungal in C. quadricarinatus. ..
  7. Li D, Yu A, Li X, Zhu Y, Jin X, Li W, et al. Antimicrobial activity of a novel hypervariable immunoglobulin domain-containing receptor Dscam in Cherax quadricarinatus. Fish Shellfish Immunol. 2015;47:766-76 pubmed publisher
    ..These results suggested that CqDscam, as one of pattern-recognition receptors (PRRs), involved in innate immune recognition and defense mechanisms in C. quadricarinatus, possibly through alternative splicing. ..
  8. Li Q, Yang H, He L, Wang Q. Characterization of the Es-DDX52 involved in the spermatogonial mitosis and spermatid differentiation in Chinese mitten crab (Eriocheir sinensis). Gene. 2018;646:106-119 pubmed publisher
    ..These results indicated that Es-DDX52 may participate in regulation of P-bodies and microtubules by Es-XRN1, and involved in the mitosis of spermatonia and spermatid differentiation. ..
  9. Li Q, Xie J, He L, Wang Y, Yang H, Duan Z, et al. FOXL2 down-regulates vitellogenin expression at mature stage in Eriocheir sinensis. Biosci Rep. 2015;35: pubmed publisher
    ..This report is the first to describe the molecular mechanism of VTG synthesis in E. sinensis and may shed new light on the regulation of cytochrome P450 enzyme by FOXL2 and FTZ-F1 in vitellogenesis. ..
  10. He L, Wang Y, Li Q, Yang H, Duan Z, Wang Q. Profiling microRNAs in the testis during sexual maturation stages in Eriocheir sinensis. Anim Reprod Sci. 2015;162:52-61 pubmed publisher
  11. Fang A, Li X, Wang Y, Pan D, Wang Q. A core component of the CUL4 ubiquitin ligase complexes, DDB1, regulates spermatogenesis in the Chinese mitten crab, Eriocheir sinensis. Gene. 2017;601:11-20 pubmed publisher
    ..Immunofluorescence assays showed that Es-DDB1 was mainly distributed in the cytoplasm in the early and middle developmental stages. These results indicated that Es-DDB1 might play a key role in spermatogenesis of E. sinensis. ..
  12. Li L, Li X, Wu Y, Yang L, Li W, Wang Q. Vitellogenin regulates antimicrobial responses in Chinese mitten crab, Eriocheir sinensis. Fish Shellfish Immunol. 2017;69:6-14 pubmed publisher
    ..Collectively, these results demonstrate that Es-Vtg1 plays critical roles in antimicrobial function. ..
  13. Fang Z, Li D, Li X, Zhang X, Zhu Y, Li W, et al. A single CRD C-type lectin from Eriocheir sinensis (EsLecB) with microbial-binding, antibacterial prophenoloxidase activation and hem-encapsulation activities. Fish Shellfish Immunol. 2016;50:175-90 pubmed publisher
    ..sinensis. ..
  14. Wu Y, Yang L, Li X, Li L, Wang Q, Li W. A class B scavenger receptor from Eriocheir sinensis (EsSR-B1) restricts bacteria proliferation by promoting phagocytosis. Fish Shellfish Immunol. 2017;70:426-436 pubmed publisher
    ..aureus or V. parahaemolyticus. Thus, EsSR-B1 has a critical role in the binding of bacteria and subsequent promotion of hemocyte phagocytosis. ..