Affiliation: East China University of Science and Technology
Wei L, Wu Y, Yang G, Xu R, Liu X, Liu Q, et al
. Genome-wide Identification of Fitness Factors in Seawater for Edwardsiella piscicida. Appl Environ Microbiol. 2019;: pubmed publisher
..piscicida and potential improved treatments or vaccines against marine pathogens. ..
Wang Q, Millet Y, Chao M, Sasabe J, Davis B, Waldor M. A Genome-Wide Screen Reveals that the Vibrio cholerae Phosphoenolpyruvate Phosphotransferase System Modulates Virulence Gene Expression. Infect Immun. 2015;83:3381-95 pubmed publisher
..Our findings reveal that the V. cholerae PTS is an additional modulator of the ToxT regulon and demonstrate the potency of loss-of-function TIS sequencing screens for defining regulatory networks. ..
Ma R, Yang G, Xu R, Liu X, Zhang Y, Ma Y, et al
. Pattern analysis of conditional essentiality (PACE)-based heuristic identification of an in vivo colonization determinant as a novel target for the construction of a live attenuated vaccine against Edwardsiella piscicida. Fish Shellfish Immunol. 2019;90:65-72 pubmed publisher
..Taken together, we demonstrated a PACE-based method for heuristic identification of targets for LAV construction and presented ΔETAE_0023 as a new LAV candidate against edwardsiellosis. ..
Guanhua Y, Wang C, Wang X, Ma R, Zheng H, Liu Q, et al
. Complete genome sequence of the marine fish pathogen Vibrio anguillarum and genome-wide transposon mutagenesis analysis of genes essential for in vivo infection. Microbiol Res. 2018;216:97-107 pubmed publisher
..This study provides a wealth of information about V. anguillarum genes related to infection in fish and will facilitate the understanding of its pathogenesis as well as the development of diagnostics and vaccines against the pathogen. ..
Shao S, Lai Q, Liu Q, Wu H, Xiao J, Shao Z, et al
. Phylogenomics characterization of a highly virulent Edwardsiella strain ET080813(T) encoding two distinct T3SS and three T6SS gene clusters: Propose a novel species as Edwardsiella anguillarum sp. nov. Syst Appl Microbiol. 2015;38:36-47 pubmed publisher
..These findings will contribute to development of species-specific control measures against Edwardsiella bacterium in aquatic animals, while also shedding light on the pathogenesis evolution in Edwardsiella bacterium. ..
Chu T, Ni C, Zhang L, Wang Q, Xiao J, Zhang Y, et al
. A quorum sensing-based in vivo expression system and its application in multivalent bacterial vaccine. Microb Cell Fact. 2015;14:37 pubmed publisher
..Considering its high compatibility, ironQS system could function as a universal expression platform for a variety of bacterial hosts. ..
Yang Z, Wang X, Xu W, Zhou M, Zhang Y, Ma Y, et al
. Phosphorylation of PppA at threonine 253 controls T6SS2 expression and bacterial killing capacity in the marine pathogen Vibrio alginolyticus. Microbiol Res. 2018;209:70-78 pubmed publisher
..Collectively, our data demonstrated that phosphorylation of PppA at T253 controls the activity of T6SS2, thereby enhancing the competitive fitness of V. alginolyticus. ..
Gao X, Wang X, Mao Q, Xu R, Zhou X, Ma Y, et al
. VqsA, a Novel LysR-Type Transcriptional Regulator, Coordinates Quorum Sensing (QS) and Is Controlled by QS To Regulate Virulence in the Pathogen Vibrio alginolyticus. Appl Environ Microbiol. 2018;84: pubmed publisher
..This study will facilitate the development of strategies to interfere with QS and effectively control this pathogen that plagues the aquaculture industry. ..
Gu D, Liu H, Yang Z, Zhang Y, Wang Q. Chromatin Immunoprecipitation Sequencing Technology Reveals Global Regulatory Roles of Low-Cell-Density Quorum-Sensing Regulator AphA in the Pathogen Vibrio alginolyticus. J Bacteriol. 2016;198:2985-2999 pubmed
..Taken together, the findings of this study improve our understanding of the complex regulation network of AphA and QS. ..