J Dou

Summary

Country: China

Publications

  1. ncbi Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, and Department of Obstetrics and Gynecology, Affiliated Zhongda Hospital, Nanjing 210009, China
    Cell Mol Immunol 3:227-33. 2006
  2. ncbi [Effect of the immune strategy based on BCG priming and Ag85A/GM-CSF DNA vaccine boosting in mice]
    Quan Tang
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing 210009, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23:591-4. 2007
  3. doi Using ABCG2-molecule-expressing side population cells to identify cancer stem-like cells in a human ovarian cell line
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University Medical School, Nanjing, Peoples Republic of China
    Cell Biol Int 35:227-34. 2011
  4. pmc Paclitaxel-Fe3O4 nanoparticles inhibit growth of CD138(-) CD34(-) tumor stem-like cells in multiple myeloma-bearing mice
    Cuiping Yang
    Department of Pathogenic Biology and Immunology, Medical School, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 8:1439-49. 2013
  5. pmc Evaluation of characteristics of CD44+CD117+ ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional monocultures
    Junsong Chen
    Department of Pathogenic Biology and Immunology, Medical School, Southeast University, DingJiaqiao 87, Nanjing, 210009, China
    BMC Cell Biol 14:7. 2013
  6. doi Protection against Mycobacterium tuberculosis challenge in mice by DNA vaccine Ag85A-ESAT-6-IL-21 priming and BCG boosting
    J Dou
    Department of Pathogenic Biology and Immunology, Medical School, Southeast University, Nanjing, 210009 China
    Int J Immunogenet 39:183-90. 2012
  7. doi Immunization with DNA vaccine expressing herpes simplex virus type 1 gD and IL-21 protects against mouse herpes keratitis
    Kai Hu
    Department of Pathogenic Biology and Immunology, Medical College, Southeast University, Nanjing, 210009, China
    Immunol Invest 40:265-78. 2011
  8. doi Antitumor efficacy induced by human ovarian cancer cells secreting IL-21 alone or combination with GM-CSF cytokines in nude mice model
    Jun Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing 210009, China
    Immunobiology 214:483-92. 2009
  9. doi Investigation of immunogenic effect of the BCG priming and Ag85A- GM-CSF boosting in Balb/c mice model
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, Nanjing, China
    Immunobiology 215:133-42. 2010
  10. doi Identifying tumor stem-like cells in mouse melanoma cell lines by analyzing the characteristics of side population cells
    Jun Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, 87 Dingjiaqiao Rd, Nanjing 210009, Jiangsu, China
    Cell Biol Int 33:807-15. 2009

Collaborators

Detail Information

Publications30

  1. ncbi Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, and Department of Obstetrics and Gynecology, Affiliated Zhongda Hospital, Nanjing 210009, China
    Cell Mol Immunol 3:227-33. 2006
    ....
  2. ncbi [Effect of the immune strategy based on BCG priming and Ag85A/GM-CSF DNA vaccine boosting in mice]
    Quan Tang
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing 210009, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23:591-4. 2007
    ..To investigate immune effect in mice on the basis of BCG priming and DNA vaccine boosting, and to provide a new strategy for development of new type of anti-tuberculosis DNA vaccine further...
  3. doi Using ABCG2-molecule-expressing side population cells to identify cancer stem-like cells in a human ovarian cell line
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University Medical School, Nanjing, Peoples Republic of China
    Cell Biol Int 35:227-34. 2011
    ..The cells have the characteristics of cancer stem-like cells, and identification and cloning of such human SP cells can help in improving therapeutic approaches to ovarian cancer in patients...
  4. pmc Paclitaxel-Fe3O4 nanoparticles inhibit growth of CD138(-) CD34(-) tumor stem-like cells in multiple myeloma-bearing mice
    Cuiping Yang
    Department of Pathogenic Biology and Immunology, Medical School, Southeast University, Nanjing, People s Republic of China
    Int J Nanomedicine 8:1439-49. 2013
    ..The purpose of this study was to investigate the inhibitory effect of paclitaxel-loaded Fe3O4 nanoparticles (PTX-NPs) on CD138(-) CD34(-) tumor stem cells in multiple myeloma-bearing mice...
  5. pmc Evaluation of characteristics of CD44+CD117+ ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional monocultures
    Junsong Chen
    Department of Pathogenic Biology and Immunology, Medical School, Southeast University, DingJiaqiao 87, Nanjing, 210009, China
    BMC Cell Biol 14:7. 2013
    ....
  6. doi Protection against Mycobacterium tuberculosis challenge in mice by DNA vaccine Ag85A-ESAT-6-IL-21 priming and BCG boosting
    J Dou
    Department of Pathogenic Biology and Immunology, Medical School, Southeast University, Nanjing, 210009 China
    Int J Immunogenet 39:183-90. 2012
    ..These findings provide further approaches for mucosal-targeted prime-boost vaccination to fight against TB...
  7. doi Immunization with DNA vaccine expressing herpes simplex virus type 1 gD and IL-21 protects against mouse herpes keratitis
    Kai Hu
    Department of Pathogenic Biology and Immunology, Medical College, Southeast University, Nanjing, 210009, China
    Immunol Invest 40:265-78. 2011
    ..The findings suggest that the DNA vaccine pRSC-gD-IL-21 may induce an immune response that can limit HSV-1 infection and development of herpes keratitis in the immunized mice...
  8. doi Antitumor efficacy induced by human ovarian cancer cells secreting IL-21 alone or combination with GM-CSF cytokines in nude mice model
    Jun Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing 210009, China
    Immunobiology 214:483-92. 2009
    ....
  9. doi Investigation of immunogenic effect of the BCG priming and Ag85A- GM-CSF boosting in Balb/c mice model
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, Nanjing, China
    Immunobiology 215:133-42. 2010
    ..tuberculosis challenge. Our data demonstrate that BCG-prime and DNA vaccine expressing Ag85A and GM-CSF boost provides a rational strategy for further development of DNA vaccine against M. tuberculosis infection...
  10. doi Identifying tumor stem-like cells in mouse melanoma cell lines by analyzing the characteristics of side population cells
    Jun Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, 87 Dingjiaqiao Rd, Nanjing 210009, Jiangsu, China
    Cell Biol Int 33:807-15. 2009
    ..We conclude that there were a few of SP cells that had the characteristics of tumor stem-like cells which may provide a useful tool and a readily accessible source for further study when specific TSCs markers are unknown...
  11. ncbi Identification of tumor stem-like cells in a mouse myeloma cell line
    J Dou
    Southeast University Department of Pathogenic Biology and Immunology School of Basic Medical Science, Nanjing, China
    Cell Mol Biol (Noisy-le-grand) 55:OL1151-60. 2009
    ..The biology of tumor stem-like cells contributes to the identification of molecular targets important for future tumor therapy...
  12. doi Emerging strategies for the identification and targeting of cancer stem cells
    Jun Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing 210009, China
    Tumour Biol 31:243-53. 2010
    ..We discuss here some of the approaching strategies that include establishing special methods of identifying CSCs and targeting therapies of CSCs...
  13. doi Eliciting protective immune responses against murine myeloma challenge in lymphopenia mice through adoptive transfer of tumor antigen-specific lymphocytes and immunization of tumor vaccine secreting mIL-21
    J Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing, China
    Cancer Gene Ther 17:675-83. 2010
    ..We conclude that the adoptive transfer of tumor antigen-specific lymphocytes into mice immunized with mIL-21-Sp2/0 induced protective immune responses against myeloma challenge...
  14. doi Comparison of immune responses induced in mice by vaccination with DNA vaccine constructs expressing mycobacterial antigen 85A and interleukin-21 and Bacillus Galmette-Guérin
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, Nanjing, China
    Immunol Invest 37:113-27. 2008
    ....
  15. ncbi Investigation of GM-CSF immune accessory effects in tumor-bearing mice by direct gene immunization
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, Nanjing, China
    Immunol Invest 35:227-37. 2006
    ..1/mGM-CSF compared with a control mice (P < 0.01). In conclusion, direct gene immunization of recombinant pcDNA3.1/mGM-CSF is a feasible strategy for tumor therapy...
  16. ncbi Study of immunotherapy of murine myeloma by an IL-21-based tumor vaccine in BALB/C mice
    Jun Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing, China
    Cancer Biol Ther 6:1871-9. 2007
    ..We conclude that the autologous IL-21-producing tumor vaccine can induce strong cell-mediated immune response and it is a promising immune adjunctive modality to prevent or inhibit growth of SP2/0 cells in mice model...
  17. ncbi Inhibition effect of Chinese herbal medicine on transcription of hepatitis C virus structural gene in vitro
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, Nanjing 210009, Jiangsu Province, China
    World J Gastroenterol 11:3619-22. 2005
    ..To investigate the inhibitory effect of Chinese herbal medicine on the transcription of hepatitis C virus (HCV) structural gene in Hela D cells...
  18. ncbi Effect of hepatitis C virus core shadow protein expressed in human hepatoma cell line on human gene expression profiles
    Jun Dou
    Department of Pathogenic Biology and Immunology, Affiliated Zhongda Hospital, South East University School of Basic Medical Science, Nanjing, China
    J Gastroenterol Hepatol 21:1794-800. 2006
    ..The aim of this study was to identify the effect of HCV core shadow protein expressed in a human hepatoma (Huh-7) cell line on human gene expression profiles...
  19. ncbi Novel constructs of tuberculosis gene vaccine and its immune effect on mice
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, Nanjing, China
    Cell Mol Immunol 2:57-62. 2005
    ..This study might provide possibility for developing novel anti-TB gene vaccine...
  20. ncbi Preliminary study on mouse interleukin-21 application in tumor gene therapy
    Jun Dou
    Department of Microbiology and Immunology, Basic Medical School, Southeast University, Nanjing 210009, China
    Cell Mol Immunol 1:461-6. 2004
    ..1/mIL-21 treated mice. However, the LAK activity did not alter significantly. Taken together, this study suggests that the injection with recombinant plasmid containing mIL-21 is a potential approach for tumor gene therapy...
  21. ncbi [Anti-tumor mechanisms of Sp2/0 tumor vaccine transfected with mIL-21 gene in mice]
    Li Li Chu
    Department of Pathogenic Biology and Immunology, Southeast University, Nanjing 210009, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23:507-10. 2007
    ..To explore the anti-tumor mechanism of Sp2/0-mIL-21 tumor vaccine in mice...
  22. doi Investigation on the anti-tumor efficacy by expression of GPI-anchored mIL-21 on the surface of B16F10 cells in C57BL/6 mice
    Fengshu Zhao
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing, China
    Immunobiology 215:89-100. 2010
    ....
  23. doi Immunotherapy of melanoma by GPI-anchored IL-21 tumour vaccine involves down-regulating regulatory T cells in mouse model
    J Wang
    Department of Gynecology and Obstetrics, Zhongda Hospital, Southeast University, Nanjing, China
    Int J Immunogenet 38:21-9. 2011
    ..Overall, our data demonstrate that the GPI-anchored IL-21 tumour vaccine regulates immune responses at least in part by down-regulating Tregs and reveals enhanced efficacy of tumour vaccine therapy of melanoma...
  24. ncbi Isolation and identification of cancer stem-like cells from murine melanoma cell lines
    Jun Dou
    Department of Pathogenic Biology and Immunology, School of Basic Medical Science, Southeast University, Nanjing 210009, China
    Cell Mol Immunol 4:467-72. 2007
    ..These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy...
  25. doi ESAT-6-gpi DNA vaccine augmented the specific antitumour efficacy induced by the tumour vaccine B16F10-ESAT-6-gpi/IL-21 in a mouse model
    X He
    Department of Pathogenic Biology and Immunology, Medical School, Southeast University, Nanjing, China
    Scand J Immunol 78:69-78. 2013
    ..These findings highlighted the DNA vaccine ESAT-6-gpi as an immune enhancer to augment the immune efficacy of the tumour vaccine B16F10-ESAT -6-gpi/IL-21 against melanoma in a mouse model. ..
  26. ncbi Effect of downregulated β-catenin on cell proliferative activity, the sensitivity to chemotherapy drug and tumorigenicity of ovarian cancer cells
    J Wang
    Department of Gynecology and Obstetrics, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, PR China
    Cell Mol Biol (Noisy-le-grand) 57:OL1606-13. 2011
    ..These results demonstrate that β-catenin might be an effective therapeutic target for human ovarian cancer treatment...
  27. doi Enhancing therapy of B16F10 melanoma efficacy through tumor vaccine expressing GPI-anchored IL-21 and secreting GM-CSF in mouse model
    Fengshu Zhao
    Department of Pathogenic Biology and Immunology, Medical College, Southeast University, 87 Dingjiaqiao Rd, Jiangsu Province, Nanjing 210009, China
    Vaccine 28:2846-52. 2010
    ..The data that we presented here provided a rationale and practical platform for clinical testing of enhancing cell therapy of B16F10 melanoma efficacy by modified tumor vaccine expressing GPI-anchored IL-21 and secreting GM-CSF...
  28. ncbi Cellular response to gene expression profiles of different hepatitis C virus core proteins in the Huh-7 cell line with microarray analysis
    Jun Dou
    Department of Pathogenic Biology and Immunology, Southeast University School of Basic Medical Science, Nanjing 210009, P R China
    J Nanosci Nanotechnol 5:1230-5. 2005
    ....
  29. ncbi [Cloning and eukaryotic expression of mouse interleukin 21]
    Guo Bing Chen
    Department of Microbiology and Immunology, Medical College, Southeast University, Nanjing 210009, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:49-52. 2004
    ..To clone mouse interleukin 21(mIL-21) gene and construct its eukaryotic expression vector...
  30. ncbi A preliminary investigation of the relationship between circulating tumor cells and cancer stem cells in patients with breast cancer
    J Wang
    Department of Gynecology and Obstetrics, Zhongda Hospital, Southeast University, Medical School, Nanjing, China
    Cell Mol Biol (Noisy-le-grand) 58:OL1641-5. 2012
    ..The difference between the two groups was statistically significant (p<0.001). We concluded that there is a significant relationship between CTC and CTC-CSC, but not among TNM stages, in breast cancer metastasis...