Research Topics

Song Kedong


Affiliation: Dalian University of Technology
Country: China


  1. Li L, Song K, Chen Y, Wang Y, Shi F, Nie Y, et al. Design and Biophysical Characterization of Poly (l-Lactic) Acid Microcarriers with and without Modification of Chitosan and Nanohydroxyapatite. Polymers (Basel). 2018;10: pubmed publisher
    ..Overall, the modified microcarriers may be considered as a promising tool for bone tissue engineering. ..
  2. Xu J, Hu X, Jiang S, Wang Y, Parungao R, Zheng S, et al. The Application of Multi-Walled Carbon Nanotubes in Bone Tissue Repair Hybrid Scaffolds and the Effect on Cell Growth In Vitro. Polymers (Basel). 2019;11: pubmed publisher
    ..6%MWCNTs scaffolds for the adhesion, proliferation, and osteogenesis differentiation of MC3T3-E1 cells in vitro highlights the potential applications of this scaffold in bone tissue regeneration. ..
  3. Li W, Song K, Wang S, Zhang C, Zhuang M, Wang Y, et al. Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation. Mater Sci Eng C Mater Biol Appl. 2019;98:685-695 pubmed publisher
    ..The anti-breast cancer effect of APS and the in vivo mechanism will be further elucidated with a review to provide a therapeutic strategy for breast cancer. ..
  4. Li W, Hu X, Wang S, Xing Y, Wang H, Nie Y, et al. Multiple comparisons of three different sources of biomaterials in the application of tumor tissue engineering in vitro and in vivo. Int J Biol Macromol. 2019;130:166-176 pubmed publisher
    ..The results demonstrate that 3D engineered tumor model can better mimic in vivo tumor and can serve as a more appropriate platform for the study and screening of novel cancer therapeutics. ..
  5. Li L, Chen Y, Wang Y, Shi F, Nie Y, Liu T, et al. Effects of concentration variation on the physical properties of alginate-based substrates and cell behavior in culture. Int J Biol Macromol. 2019;128:184-195 pubmed publisher
    ..Overall, the ability to tailor this system to support in vitro growth of MC3T3-E1 cells might have significance for the future use of other cell types in regenerative medicine. ..
  6. Song K, Wang H, Zhang B, Lim M, Liu Y, Liu T. Numerical simulation of fluid field and in vitro three-dimensional fabrication of tissue-engineered bones in a rotating bioreactor and in vivo implantation for repairing segmental bone defects. Cell Stress Chaperones. 2013;18:193-201 pubmed publisher
    ..This study demonstrates that stress stimulation in an RWVB can be beneficial for cell/bio-derived bone constructs fabricated in an RWVB, with an application for repairing segmental bone defects. ..
  7. Song K, Liu Y, Macedo H, Jiang L, Li C, Mei G, et al. Fabrication and evaluation of a sustained-release chitosan-based scaffold embedded with PLGA microspheres. Mater Sci Eng C Mater Biol Appl. 2013;33:1506-13 pubmed publisher
    ..44±1.81)×10(-2) mg/mL. This novel chitosan-based scaffold embedded with PLGA microspheres has proven to be a promising technique for the development of new and improved tissue engineering scaffolds. ..
  8. Zhuang M, Liu T, Song K, Ge D, Li X. Thermo-responsive poly(N-isopropylacrylamide)-grafted hollow fiber membranes for osteoblasts culture and non-invasive harvest. Mater Sci Eng C Mater Biol Appl. 2015;55:410-9 pubmed publisher
  9. Song K, Li L, Li W, Zhu Y, Jiao Z, Lim M, et al. Three-dimensional dynamic fabrication of engineered cartilage based on chitosan/gelatin hybrid hydrogel scaffold in a spinner flask with a special designed steel frame. Mater Sci Eng C Mater Biol Appl. 2015;55:384-92 pubmed publisher

More Information


  1. Song K, Yan X, Zhang Y, Song F, Lim M, Fang M, et al. Numberical simulation of fluid flow and three-dimensional expansion of tissue engineering seed cells in large scale inside a novel rotating wall hollow fiber membrane bioreactor. Bioprocess Biosyst Eng. 2015;38:1527-40 pubmed publisher
    ..Besides, hollow fiber membrane carrier with a diameter of 0.2 mm has an excellent biocompatibility and their radial locations presented a tiny influence on flow field inside the culture chamber. ..
  2. Song K, Ge D, Guan S, Sun C, Ma X, Liu T. Mass transfer analysis of growth and substance metabolism of NSCs cultured in collagen-based scaffold in vitro. Appl Biochem Biotechnol. 2014;174:2114-30 pubmed publisher
    ..This study also confirmed that 2-mm thickness of collagen scaffold was capable of in vitro cultivation and growth of NSCs with an inoculating density of 1 × 10(6) cells/mL. ..
  3. Song K, Li L, Wang Y, Liu T. Hematopoietic stem cells: multiparameter regulation. Hum Cell. 2016;29:53-7 pubmed publisher
  4. Song K, Yang Y, Xu L, Tian J, Fan J, Jiao Z, et al. Fabrication and detection of tissue engineered bone aggregates based on encapsulated human ADSCs within hybrid calcium alginate/bone powder gel-beads in a spinner flask. Mater Sci Eng C Mater Biol Appl. 2016;62:787-94 pubmed publisher
    ..In summary, hybrid gel-beads encapsulating ADSCs are proved to be feasible as a new method to fabricate tissue engineered bone aggregation with potential to treat skeletal injury in the near future. ..
  5. Zhang Y, Li P, Wang H, Wang Y, Song K, Li T. Research progress on reconstruction of meniscus in tissue engineering. J Sports Med Phys Fitness. 2017;57:595-603 pubmed publisher
    ..This review discusses aspects of meniscus tissue engineering, which is relative to the clinical treatment of meniscus injuries for further support and establishment of fundamental and clinical studies. ..
  6. Song K, Li L, Yan X, Zhang Y, Li R, Wang Y, et al. Fabrication and development of artificial osteochondral constructs based on cancellous bone/hydrogel hybrid scaffold. J Mater Sci Mater Med. 2016;27:114 pubmed publisher
    ..Therefore, a bi-layered composite scaffold is an appropriate candidate for fabrication of osteochondral tissue. ..
  7. Zhu Y, Song K, Jiang S, Chen J, Tang L, Li S, et al. Numerical Simulation of Mass Transfer and Three-Dimensional Fabrication of Tissue-Engineered Cartilages Based on Chitosan/Gelatin Hybrid Hydrogel Scaffold in a Rotating Bioreactor. Appl Biochem Biotechnol. 2017;181:250-266 pubmed publisher
    ..The improved mass transfer also accelerated a dynamic fabrication of cell-hydrogel constructs, providing an alternative method in tissue engineering cartilage. ..
  8. Song K, Li L, Yan X, Zhang W, Zhang Y, Wang Y, et al. Characterization of human adipose tissue-derived stem cells in vitro culture and in vivo differentiation in a temperature-sensitive chitosan/?- glycerophosphate/collagen hybrid hydrogel. Mater Sci Eng C Mater Biol Appl. 2017;70:231-240 pubmed publisher
    ..Histology analysis indicated that induced ADSCs-C/GP/Co hydrogel has a greater number of adipocytes and vascularized adipose tissues compared with non-induced ADSCs-C/GP/Co hydrogel. ..
  9. Song K, Yang Y, Wu S, Zhang Y, Feng S, Wang H, et al. In vitro culture and harvest of BMMSCs on the surface of a novel thermosensitive glass microcarrier. Mater Sci Eng C Mater Biol Appl. 2016;58:324-30 pubmed publisher
    ..More importantly, BMMSCs could be fully removed from the thermosensitive glass microcarriers with remained cell viability. ..
  10. Song K, Ji L, Zhang J, Wang H, Jiao Z, Mayasari L, et al. Fabrication and Cell Responsive Behavior of Macroporous PLLA/Gelatin Composite Scaffold with Hierarchical Micro-Nano Pore Structure. Nanomaterials (Basel). 2015;5:415-424 pubmed publisher
    ..In comparison with PLLA scaffold, the PLLA/gel scaffold had better biological performance and the mechanical properties because the gelatin fibers homogeneously distributed in each pore of PLLA scaffold and formed 3D network structure. ..