Research Topics
Genomes and Genes
| Yung H WongSummaryAffiliation: Clear Water Bay Country: China Publications
| Collaborators
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Detail Information
Publications
Characterization of Substituted Phenylpropylamides as Highly Selective Agonists at the Melatonin MT(2) ReceptorKing H Chan
Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Curr Med Chem 20:289-300. 2013..These ligands represent invaluable tools for delineating the functional roles of distinct melatonin receptor subtypes and are viable candidates for drug development...- Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanismE C H Yip
Department of Biochemistry, Molecular Neuroscience Center, Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Biol Toxicol 22:293-302. 2006..Collectively, our results suggest that PCA is a naturally occurring compound capable of inducing JNK-dependent hepatocellular carcinoma cell death... 
Mutations on the Switch III region and the alpha3 helix of Galpha16 differentially affect receptor coupling and regulation of downstream effectorsMay Ym Yu
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China
J Mol Signal 3:17. 2008..Cognate residues in Galpha16 might also be essential for interacting with PLCbeta, and possibly contribute to TPR1 interaction and other signaling events...- Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activityAnthony S L Chan
Department of Biochemistry, The Biotechnology Research Institute, and the Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Br J Pharmacol 142:635-46. 2004..6. Our results support a mechanistic model where EGF signaling may differentially regulate the JNK activities triggered by GPCRs of different coupling specificities... - Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanismRico K H Lo
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Biol Chem 278:52154-65. 2003..Demonstration of the involvement of different kinases in Galpha16QL-induced STAT3 activation supports the involvement of multiple signaling pathways in the regulation of transcription by G proteins... 
Prostacyclin receptor-induced STAT3 phosphorylation in human erythroleukemia cells is mediated via Galpha(s) and Galpha(16) hybrid signalingRico K H Lo
Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 20:2095-106. 2008..Taken together, our observations illustrate that co-stimulation of G(s) and G(q) can result in the fine-tuning of STAT3 activation status, and this may provide the basis for cell type-specific responses following activation of hIP...- Activation of nuclear factor {kappa}B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G{alpha}14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-SrcAndrew M F Liu
Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Biol Chem 280:34617-25. 2005..Similar results were also obtained using AR42J cells. These data suggest that activation of the IKK/NFkappaB signaling cascade by SSTR2 requires a complicated network consisting of Galpha(14) and multiple intermediates... - G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signalingAndrew M F Liu
Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Biol Chem 279:53196-204. 2004..Similar results were obtained using Reh cells. These data suggest that the G(16)-mediated activation of IKK/NFkappaB by CHA required a complex signaling network composed of multiple intermediates... - Phosphatidylinositol-3 kinase is distinctively required for mu-, but not kappa-opioid receptor-induced activation of c-Jun N-terminal kinaseAngel Y F Kam
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
J Neurochem 89:391-402. 2004..Like the delta-opioid receptor, activation of JNK by the kappa-opioid receptor occurred in a PI3K-independent manner. These studies revealed that the mu-opioid receptor utilize a distinct mechanism to regulate JNK... - Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cellsAnthony S L Chan
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
J Neurochem 94:1457-70. 2005..This report provides evidence that G protein signals can be integrated at the level of MAPK, resulting in differential effects on ERK, JNK and p38 MAPK in SK-N-MC cells... - Transcriptional activation of c-Fos by constitutively active Galpha(16)QL through a STAT1-dependent pathwayRico K H Lo
Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 18:2143-53. 2006..Collectively, our results demonstrate for the first time that stimulation of Galpha(16) can lead to STAT1-dependent c-Fos transcriptional activation via PLCbeta, c-Src/JAK and ERK pathways... - Multiple Gi proteins participate in nerve growth factor-induced activation of c-Jun N-terminal kinases in PC12 cellsPrudence H Tso
Department of Biochemistry, the Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Neurochem Res 34:1101-12. 2009..Collectively, these studies indicate that NGF-dependent JNK activity may be mediated via G(i1-3) proteins, JAK3, Src, p38 MAPK and the MEK/ERK cascade... - The beta6/alpha5 regions of Galphai2 and GalphaoA increase the promiscuity of Galpha16 but are insufficient for pertussis toxin-catalyzed ADP-ribosylationCecilia S S Wong
Department of Biochemistry, Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Eur J Pharmacol 473:105-15. 2003..Although incorporation of a Galphai-like beta6/alpha5 region into the C-terminus of Galpha16 increases its promiscuity, this region is not sufficient to support recognition by pertussis toxin... - Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cellsEddy H T Wu
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 17:881-90. 2005..This is the first study that demonstrates the involvement of G(i/o) proteins in NGF-induced Akt signaling... - Gbetagamma signaling and Ca2+ mobilization co-operate synergistically in a Sos and Rac-dependent manner in the activation of JNK by Gq-coupled receptorsAnthony S L Chan
Department of Biochemistry, The Biotechnology Research Institute, and the Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 16:823-36. 2004..We propose that the co-operative effect between Gbetagamma-mediated signaling and the increased intracellular Ca(2+) level represents a robust mechanism for the stimulation of JNK by G(q)-coupled receptors... - Regulation of STAT3 by mu-opioid receptors in human neuroblastoma SH-SY5Y cellsJessie W F Yuen
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Neuroreport 15:1431-5. 2004..The present study provides a foundation to explore the importance of STAT3 signaling in the regulation of neuronal growth and differentiation by the mu-opioid receptor... - Replacement of the alpha5 helix of Galpha16 with Galphas-specific sequences enhances promiscuity of Galpha16 toward Gs-coupled receptorsAnjali Hazari
Department of Biochemistry, The Biotechnology Research Institute, and the Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 16:51-62. 2004..Similar results were observed for agonist-induced Ca(2+) mobilizations. These results show that incorporating the alpha5 helix of Galpha(s) into Galpha(16) can increase the promiscuity of 16s25 towards G(s)-coupled receptors... - Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinaseAndrew M F Liu
Department of Biochemistry, Molecular Neuroscience Center, Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Biol Chem 281:35812-25. 2006..However, unlike the mechanisms employed by Galpha(i) and Galpha(14/16), Galpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase for STAT3 activation... - Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNKRico K H Lo
Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 18:307-17. 2006..Taken together, these results demonstrate for the first time that hIP activation by cicaprost can lead to STAT1 and STAT3 phosphorylations via signaling pathways involving PTX-insensitive G proteins, ERK and JNK... - Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cellsEddy H T Wu
Department of Biochemistry, Molecular Neuroscience Center, Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 18:285-93. 2006..This is the first study that demonstrates the augmentation effect between M4 mAChR and NGF receptor, and the regulatory role of mAChR on tuberin... - Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell typesLisa Y Yung
Biotechnology Research Institute and Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Planta Med 78:115-21. 2012..Our data indicate that AG-IV and CAG may exert their cellular effects through the activation of the Src/MEK/ERK pathway... - Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediatesRico K H Lo
Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Mol Pharmacol 65:1427-39. 2004..These results demonstrate for the first time that Galpha14 activation can lead to STAT3 stimulation via a complex signaling network involving multiple intermediates... - Kappa-opioid receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cellsAngel Y F Kam
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
J Pharmacol Exp Ther 310:301-10. 2004..These studies demonstrate that the activation of JNK by kappa-opioid receptors is routed via Gbetagamma, Src, FAK, Sos, Rac, and Cdc42... - Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via G(i/o) proteinsLisa Y Yung
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 20:1538-44. 2008..Collectively, these studies indicate that NGF-dependent p38 MAPK activity may be mediated via G(i2) protein, Src, and the MEK/ERK cascade... - Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin-1alpha in human U87 astrocytoma cellsAngel Y F Kam
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 19:2106-17. 2007..We have thus identified a possible linkage among FPRL1, MAPKs, astrocytic activation and the inflammatory response... - The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with Galpha16Anthony S L Chan
Department of Biochemistry, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
J Neurochem 87:697-708. 2003..These results indicate that efficient coupling of the delta-opioid receptor to Galpha16 requires the participation of most of the intracellular regions, including the first intracellular loop... - Activation of STAT3 by specific Galpha subunits and multiple Gbetagamma dimersJessie W F Yuen
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Int J Biochem Cell Biol 42:1052-9. 2010..These results suggested that the activation of STAT family members by Galpha(16) or Galpha(14) was selective and that distinct combinations of Gbetagamma complexes can also regulate the STAT signaling pathway... - Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-kappa B kinase in human U87 astrocytoma cellsAngel Y F Kam
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Hong Kong, China
J Neurochem 103:1553-66. 2007..Taken together, these results demonstrate that FPRL-1 is capable of activating NFkappaB signaling through IKK phosphorylation and this may serve as a useful therapeutical target for FPRL-1-related diseases... - Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Galpha 14-coupled pathwaysYaji Tian
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
Eur J Immunol 34:785-95. 2004..CCR1 and Galpha14 or Galpha16 are co-expressed in several cell types and we hypothesize that selective activation of chemokine receptors provides a mechanism by which chemokines are able to fine-tune intracellular signaling pathways... - Galpha16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)Andrew M F Liu
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 22:1448-58. 2010..Collectively, our results suggest that Galpha16 regulates multiple signaling pathways by activating Ras through its association with TPR1, but TPR1 is not required for Galpha16 to stimulate phospholipase Cbeta... - Molecular determinants for the differential coupling of Galpha(16) to the melatonin MT1, MT2 and Xenopus Mel1c receptorsFrank P L Lai
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Neurochem 80:736-45. 2002..Our results suggest that Galpha(16) can discern structural differences amid the three melatonin receptors and provide evidence for functional distinction of Mel1c from MT1 and MT2 receptors... - Regulation of STAT3 activity by G16-coupled receptorsEddy H T Wu
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Biochem Biophys Res Commun 303:920-5. 2003..This is the first study that demonstrates the stimulatory effect of ORL(1) and fMLP receptors on STAT3 activity... - Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cellsEddy H T Wu
Department of Biochemistry, the Molecular Neuroscience Center, The Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Biochem Biophys Res Commun 334:838-44. 2005..This is the first study that demonstrates the regulatory role of opioid receptors on tuberin... - The aqueous extract of Radix Glycyrrhizae stimulates mitogen-activated protein kinases and nuclear factor-kappaB in Jurkat T-cells and THP-1 monocytic cellsAnthony S L Chan
Department of Biochemistry, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
Am J Chin Med 34:263-78. 2006.... - Opioid receptor-like (ORL1) receptor utilizes both G(oA) and G(oB) for signal transductionPrudence H Tso
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Protein Pept Lett 13:437-41. 2006..However, development of AC superactivation and loss of ERK1/2 responsiveness induced by chronic activation of the ORL1 receptors remained PTX-sensitive... - Identification of a stretch of six divergent amino acids on the alpha5 helix of Galpha16 as a major determinant of the promiscuity and efficiency of receptor couplingMaurice K C Ho
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People's Republic of China
Biochem J 380:361-9. 2004.... - Regulation of mTOR and p70 S6 kinase by the muscarinic M4 receptor in PC12 cellsGrace P W Chan
Department of Biochemistry, the Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Biol Int 33:230-8. 2009..Collectively, these findings suggest that PP2A and PTEN may be involved in fine tuning the regulation of Akt/tuberin/mTOR/p70S6K in PC12 cells by M(4) mAChR and TrkA, respectively... - Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1Dawna H T Kwan
Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Cell Biochem 113:3486-97. 2012..Our results suggest that TPR1 is required for Gα(14) to stimulate Ras-dependent signaling pathways, but not for the propagation of signals along Ras-independent pathways... - Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligandsYueqing Hu
Department of Biochemistry, The Biotechnology Research Institute, and the Molecular Neuroscience Centre, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Bioorg Med Chem Lett 20:2582-5. 2010..It was discovered that a benzyloxyl substituent incorporated at C6 position of the 3-methoxyphenyl ring dramatically enhanced the MT(2) binding affinity and at the same time decreased MT(1) binding affinity... - Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptorAngel Y F Kam
Department of Biochemistry, the Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
J Neurochem 84:503-13. 2003..Collectively, these results demonstrate functional regulation of JNK by the delta-opioid receptor, and this pathway requires Gbetagamma, Src kinases and the small GTPases Rac and Cdc42... - Reporter gene assaysAndy M F Liu
Department of Biochemistry, Molecular Neuroscience Center, Biotechnology Research Institute, Hong Kong University of Science and Technology, Hong Kong, China
Methods Mol Biol 486:109-23. 2009.... - Constitutive activation of the opioid receptor-like (ORL1) receptor by mutation of Asn133 to tryptophan in the third transmembrane regionKenneth W L Kam
Department of Biochemistry, Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clearwater Bay, Hong Kong, China
J Neurochem 83:1461-70. 2002..In conclusion, our results demonstrate that a mutation in the third transmembrane domain is able to increase the basal signalling activity of the human ORL1 receptor... - Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascadeEddy H T Wu
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
FEBS J 273:2388-98. 2006..Collectively, this study demonstrated the inhibitory effect of activated G alpha11, G alpha14, G alpha16, G alpha12 and G alpha13 on pro-survival Akt signaling... - RGS19 enhances cell proliferation through its C-terminal PDZ motifPrudence H Tso
Department of Biochemistry, The Biotechnology Research Institute, and the Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Cell Signal 22:1700-7. 2010..This study demonstrates that RGS19, in addition to acting as a GAP, is able to stimulate cell proliferation in a GIPC-dependent manner... - Involvement of G i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neuronsEddy H T Wu
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Mol Pharmacol 67:1195-205. 2005..Together, this study demonstrates the regulatory effect of NGF and G(i/o) signaling on tuberin... - RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signalingPrudence H Tso
Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Cancer Lett 309:199-208. 2011..Consistent with an elevated Akt activity, increased levels of phosphorylated Bad and c-Raf and a diminished expression of TSC2 were detected, thus demonstrating that RGS19 can deregulate cell proliferation via multiple pathways... - Activation of the human FPRL-1 receptor promotes Ca2+ mobilization in U87 astrocytoma cellsDawna H T Kwan
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Neurochem Res 33:125-33. 2008..Our data demonstrated that activation of Gi-coupled FPRL-1 can lead to Ca2+ influx possibly via SOCs in U87 and FPRL-1/CHO cells... - Gq-mediated activation of c-Jun N-terminal kinase by the gastrin-releasing peptide-preferring bombesin receptor is inhibited upon costimulation of the Gs-coupled dopamine D1 receptor in COS-7 cellsAnthony S L Chan
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Mol Pharmacol 68:1354-64. 2005.... - CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Gα(14/16) signaling and IL-6 releaseMaggie M K Lee
Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Immunol 189:5266-76. 2012.... - Interleukin-6 autocrine signaling mediates melatonin MT(1/2) receptor-induced STAT3 Tyr(705) phosphorylationWinnie W I Lau
Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Pineal Res 52:477-89. 2012..Our results demonstrate that melatonin receptor/Gα(16) coupling is capable of triggering the production of cytokines including IL-6, and this autocrine loop may account for the subsequent STAT3 phosphorylation at Tyr(705) ... - Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signalingAndrew Mf Liu
Division of Life Science and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
BMC Struct Biol 11:17. 2011..Using Gα16 as a model, we asked if its recently discovered adaptor protein tetratricopeptide repeat 1 (TPR1) binds to the same region as its canonical effector, phospholipase Cβ (PLCβ)... - Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteinsAnthony S L Chan
Department of Biochemistry the Biotechnology Research Institute, and the Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 14:249-57. 2002..This report demonstrates the stimulatory effect of melatonin receptors on JNK, and provides experimental evidence for a functional coupling between the G(i)-coupled melatonin receptor and Gs, in terms of adenylyl cyclase activation... - CCR1-mediated activation of Nuclear Factor-kappaB in THP-1 monocytic cells involves Pertussis Toxin-insensitive Galpha(14) and Galpha(16) signaling cascadesMaggie M K Lee
Department of Biochemistry, Molecular Neuroscience Center, Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
J Leukoc Biol 86:1319-29. 2009..The ability of CCR1 to signal through Galpha(14/16) thus provides a linkage for chemokines to regulate NF-kappaB-dependent responses... - Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase CLydia S W Poon
Department of Biochemistry, Biotechnology Research Institute, and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Cell Signal 21:737-44. 2009.... - Mu-opioid receptor-mediated phosphorylation of IkappaB kinase in human neuroblastoma SH-SY5Y cellsAndrew M F Liu
Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong University of Science and Technology, Kowloon, SAR, China
Neurosignals 14:136-42. 2005..These data suggest that the mu-opioid receptor is capable of simulating NFkappaB signaling via the phosphorylation of IKK and p65 in human neuroblastoma SH-SY5Y cells... - CKBM stimulates MAPKs but inhibits LPS-induced IFN-gamma in lymphocytesAnthony S L Chan
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Phytother Res 20:725-31. 2006.... - In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activatorJing Zhu
Biotechnology Research Institute, Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
Drug Metab Pharmacokinet 25:477-86. 2010..The present study indicates that CAG is efficiently absorbed through intestinal epithelium. However, extensive first-pass hepatic metabolism would limit the oral bioavailability of this compound... - A hematopoietic perspective on the promiscuity and specificity of Galpha16 signalingYan Su
Biotechnology Research Institute, Molecular Neuroscience Center, Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, SAR, China
Neurosignals 17:71-81. 2009..This review aims to provide an updated appreciation and rational discussion of Galpha(16) signaling with regard to its promiscuity and specificity... - Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiationYu Pong Ng
Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong, SAR, China
Neurosignals 17:111-20. 2009..Our observations provide novel insights on the signalling mechanisms underlying the regulation of neuronal differentiation by NGF and cAMP... - Galpha(16/z) chimeras efficiently link a wide range of G protein-coupled receptors to calcium mobilizationAndrew M F Liu
Department of Biochemisty, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
J Biomol Screen 8:39-49. 2003..Collectively, these studies help to validate the promiscuity of the Galpha(16/z) chimeras as well as their application in contemporary drug-screening assays that are based on ligand-induced Ca(2+) mobilization... - In search of novel and therapeutically significant melatoninergic ligandsSejal M Mody
Department of Biochemistry and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Recent Pat CNS Drug Discov 2:241-5. 2007..In this review an overview of recently developed novel melatoninergic ligands is provided including recently filed patents and compounds undergoing clinical evaluation... - 3-Methoxylphenylpropyl amides as novel receptor subtype-selective melatoninergic ligands: characterization of physicochemical and pharmacokinetic propertiesJing Zhu
Section of Biochemistry and Cell Biology, Division of Life Sciences, and the Biotechnology Research Institute, Clear Water Bay, Kowloon, Hong Kong
Xenobiotica 41:35-45. 2011..Metabolite profiling unveiled that C6-ether linkage and methoxy substituents were likely the major metabolic soft spots in their structures, which provided important information for further improvement of their structural stability... - G protein-linked effector and second messenger systems involved in melatonin signal transductionDavid C New
Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, Hong Kong, China
Neurosignals 12:59-70. 2003..This review will attempt to summarize recent research by many groups that has revealed numerous subtleties of the melatonin-coupled signaling pathways... - Expression of Gα(z) in C2C12 cells restrains myogenic differentiationHua Mei
Section of Biochemistry and Cell Biology, Division of Life Science, Biotechnology Research Institute, Molecular Neuroscience Center, The State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Cell Signal 23:389-97. 2011..These results support a novel role of Gα(z) in restraining myogenic differentiation through the disruption of Rho signaling... - Naturally occurring phenylethanoid glycosides: potential leads for new therapeuticsGuangmiao Fu
Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Curr Med Chem 15:2592-613. 2008..Particular attention will be given to the novel structures identified to date and the prominent therapeutic values associated with these molecules... - The ORL1 receptor: molecular pharmacology and signalling mechanismsDavid C New
Department of Biochemistry, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Neurosignals 11:197-212. 2002.... - The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Galpha(16) and inhibits the canonical phospholipase Cbeta pathwayWendy W S Yeung
Department of Biochemistry, the Molecular Neuroscience Center, and the Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Cell Signal 21:1317-25. 2009..Taken together, these results suggest that p63RhoGEF binds to activated Galpha(16) and inhibits its signaling pathways...