D C Chang

Summary

Affiliation: Clear Water Bay
Country: China

Publications

  1. ncbi request reprint Multiple types of calcium signals are associated with cell division in zebrafish embryo
    D C Chang
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Microsc Res Tech 49:111-22. 2000
  2. ncbi request reprint Degradation of cyclin B is required for the onset of anaphase in Mammalian cells
    Donald C Chang
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 278:37865-73. 2003
  3. ncbi request reprint Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells
    K Q Luo
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Biochem Biophys Res Commun 283:1054-60. 2001
  4. ncbi request reprint Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells
    W Gao
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, China
    J Cell Sci 114:2855-62. 2001
  5. ncbi request reprint Cytosolic Ca(2+) signal is involved in regulating UV-induced apoptosis in hela cells
    Y Pu
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Biochem Biophys Res Commun 282:84-9. 2001
  6. ncbi request reprint Different thresholds of MPF inactivation are responsible for controlling different mitotic events in mammalian cell division
    Naihan Xu
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Cell Cycle 6:1639-45. 2007
  7. ncbi request reprint Ca2+ signal blockers can inhibit M/A transition in mammalian cells by interfering with the spindle checkpoint
    Naihan Xu
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China
    Biochem Biophys Res Commun 306:737-45. 2003
  8. doi request reprint Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest
    Lingli Zhou
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Life Sci 83:394-403. 2008
  9. ncbi request reprint Regulation of the localization and stability of Cdc6 in living yeast cells
    Kathy Q Luo
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Biochem Biophys Res Commun 306:851-9. 2003
  10. ncbi request reprint The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region
    Kathy Q Luo
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Biochem Biophys Res Commun 318:303-10. 2004

Collaborators

  • Kathy Q Luo
  • H Tian
  • Naihan Xu
  • Yan Chen
  • Shi Lung Lin
  • Jie Chen
  • Huiqi He
  • Yuanzhi Lao
  • Yongmei Pu
  • Yinliang Yin
  • Lingli Zhou
  • Liying Zhou
  • Jun Yuan
  • Quan Bin Han
  • Yi Kuen Lee
  • Y Lao
  • Hongjun Fu
  • Y Pu
  • Chao Jun Li
  • Gu Dai
  • Yifan Han
  • Wenming Li
  • Nelson T K Lee
  • Mingtao Li
  • L L Zhou
  • Rongbiao Pi
  • Yue Yue Yu
  • W Gao
  • Jun Ning Wei
  • W K Chan
  • Shi Lin Chen
  • Guo Xin Shi
  • Guang Zhu
  • Chun Feng Qiao
  • Nian Yun Yang
  • Jing Zheng Song
  • Vivian C Yu
  • Hong Xi Xu
  • Yue Shao
  • Kang Xiao
  • Houwei Luo
  • Cheng Chen
  • Yulin Liu
  • Hua Yu
  • Karl W K Tsim
  • Yuanping Pang
  • Peng Li
  • Wei Liu
  • L Y Zhou
  • Xue Mei Sun
  • Ling Nga Chan
  • Chuan Jun Wen
  • Dong Hong Zhao
  • Hugh H N Chan
  • Nikolaus J Sucher

Detail Information

Publications27

  1. ncbi request reprint Multiple types of calcium signals are associated with cell division in zebrafish embryo
    D C Chang
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Microsc Res Tech 49:111-22. 2000
    ..When this type of Ca(2+) transient was blocked by injecting BAPTA or heparin, cell cleavage regressed and the structure of the contractile band could no longer be maintained...
  2. ncbi request reprint Degradation of cyclin B is required for the onset of anaphase in Mammalian cells
    Donald C Chang
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 278:37865-73. 2003
    ..This result suggests that, in mammalian cells, the majority of cyclin B1 must be destroyed before the cell can enter anaphase...
  3. ncbi request reprint Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells
    K Q Luo
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Biochem Biophys Res Commun 283:1054-60. 2001
    ..This technique will be highly useful for correlating the caspase-3 activation with other apoptotic events and for rapid-screening of potential drugs that may target the apoptotic process...
  4. ncbi request reprint Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells
    W Gao
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, China
    J Cell Sci 114:2855-62. 2001
    ..In addition, we found evidence that cytochrome c was also released before mitochondrial swelling in apoptosis induced by other cell death-inducing treatments, including tumor necrosis factor (TNF) and actinomycin D...
  5. ncbi request reprint Cytosolic Ca(2+) signal is involved in regulating UV-induced apoptosis in hela cells
    Y Pu
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Biochem Biophys Res Commun 282:84-9. 2001
    ..The depletion of Ca(2+) in ER is believed to stimulate apoptosis and thus would counterbalance the protection effect of BAPTA/AM in suppressing the cytosolic Ca(2+) elevation...
  6. ncbi request reprint Different thresholds of MPF inactivation are responsible for controlling different mitotic events in mammalian cell division
    Naihan Xu
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Cell Cycle 6:1639-45. 2007
    ..92 +/- 1.7 microM. We suggest that the decreasing order of these thresholds plays an important role in triggering the initiation of successive mitotic events in cell division...
  7. ncbi request reprint Ca2+ signal blockers can inhibit M/A transition in mammalian cells by interfering with the spindle checkpoint
    Naihan Xu
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PR China
    Biochem Biophys Res Commun 306:737-45. 2003
    ..These results suggest that one pathway for the blockage of M/A transition by suppressing cytosolic Ca(2+) level is due to its interference with the mitotic spindle checkpoint...
  8. doi request reprint Tanshinone IIA, an isolated compound from Salvia miltiorrhiza Bunge, induces apoptosis in HeLa cells through mitotic arrest
    Lingli Zhou
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Life Sci 83:394-403. 2008
    ..Tanshinone IIA (Tan IIA) is a compound isolated from Salvia miltiorrhiza Bunge (Danshen). The aim of this study is to investigate the mechanisms of its anti-cancer effect...
  9. ncbi request reprint Regulation of the localization and stability of Cdc6 in living yeast cells
    Kathy Q Luo
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Biochem Biophys Res Commun 306:851-9. 2003
    ..These observations suggest that the stability of Cdc6 protein is regulated by two factors: nuclear localization and phosphorylation by CDK1...
  10. ncbi request reprint The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region
    Kathy Q Luo
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Biochem Biophys Res Commun 318:303-10. 2004
    ..Based on this finding, we suggest that the H-b index can be a useful guideline for future siRNA design...
  11. ncbi request reprint Measuring dynamics of caspase-8 activation in a single living HeLa cell during TNFalpha-induced apoptosis
    Kathy Q Luo
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Biochem Biophys Res Commun 304:217-22. 2003
    ..Results of these single-cell measurements suggested that caspase-3 was activated by caspase-8 through two parallel pathways during TNFalpha-induced apoptosis in HeLa cells...
  12. ncbi request reprint SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tail
    Yinliang Yin
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Cell Cycle 7:1423-32. 2008
    ..Taken together, these findings suggest that SET8 can be a negative regulator of DNA replication and the destruction of SET8 is required for the onset of S phase...
  13. pmc A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine
    H Tian
    Bioengineering Graduate Program, Department of Chemical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Br J Pharmacol 150:321-34. 2007
    ..We report the development of a very efficient cell-based high throughput screening (HTS) method, which utilizes a novel bio-sensor that selectively detects apoptosis based on the fluorescence resonance energy transfer (FRET) technique...
  14. ncbi request reprint Smac/DIABLO and cytochrome c are released from mitochondria through a similar mechanism during UV-induced apoptosis
    L L Zhou
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Apoptosis 10:289-99. 2005
    ....
  15. ncbi request reprint Study of the functional role of Bcl-2 family proteins in regulating Ca(2+) signals in apoptotic cells
    Y Lao
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P R China
    Biochem Soc Trans 35:1038-9. 2007
    ..On the basis of our findings, we suggest that Bax may interact with IP(3)Rs to facilitate the release of Ca(2+) from the ER during apoptosis...
  16. doi request reprint Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis
    Liying Zhou
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    J Cell Sci 121:2186-96. 2008
    ..25 microm wide and composed of more than 100 protein molecules. These findings suggest that the Bax-Bak structure responsible for releasing mitochondrial proteins during apoptosis is not channel-like...
  17. doi request reprint Mobilization of Ca2+ from endoplasmic reticulum to mitochondria plays a positive role in the early stage of UV- or TNFalpha-induced apoptosis
    Yuanzhi Lao
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Biochem Biophys Res Commun 373:42-7. 2008
    ..Taken together, these findings suggest that Ca(2+) mobilization from ER to mitochondria can play a significant role in the apoptotic signaling pathway...
  18. doi request reprint Nonlinear current response of micro electroporation and resealing dynamics for human cancer cells
    Huiqi He
    Bioengineering Graduate Program, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Bioelectrochemistry 72:161-8. 2008
    ..In addition, cell membrane recovery dynamics after electroporation was also studied and the resealing time constants were determined for different pulse treatments...
  19. ncbi request reprint Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons
    Hongjun Fu
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
    J Proteome Res 6:2435-46. 2007
    ....
  20. ncbi request reprint Using a micro electroporation chip to determine the optimal physical parameters in the uptake of biomolecules in HeLa cells
    Huiqi He
    Bioengineering Graduate Program, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
    Bioelectrochemistry 70:363-8. 2007
    ..Comparing to the traditional instrument, MEMS-based micro electroporation chip can greatly shorten the experimental time...
  21. ncbi request reprint Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways
    Rongbiao Pi
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Neurochem 91:1219-30. 2004
    ....
  22. ncbi request reprint A Ca2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cells
    Yongmei Pu
    Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Biochem Biophys Res Commun 299:762-9. 2002
    ..We found that cytochrome c was not yet released from mitochondria. These findings suggest the existence of certain apoptotic pathways, in which an early Ca(2+) signal is activated upstream of cytochrome c release...
  23. doi request reprint A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway
    Hong Lei Tian
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Cancer Lett 297:18-30. 2010
    ..In conclusion, ATA is a novel anticancer agent with potent in vitro and in vivo anticancer ability. ROS-mediated Bax activation should be the mechanism by which ATA induces apoptosis and inhibits tumor growth...
  24. ncbi request reprint The association of calmodulin with central spindle regulates the initiation of cytokinesis in HeLa cells
    Yue Yue Yu
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Sciences, Nanjing Normal University, Nanjing 210097, Jiangsu Province, China
    Int J Biochem Cell Biol 36:1562-72. 2004
    ....
  25. ncbi request reprint Calmodulin bound to stress fibers but not microtubules involves regulation of cell morphology and motility
    Jun Yuan
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Normal University, 1 Wen Yuan Road, Nanjing, China
    Int J Biochem Cell Biol 40:284-93. 2008
    ..The data we have got from living cells suggested that CaM affect cell morphology and motility through binding to stress fibers and regulate f-actin polymerization...
  26. ncbi request reprint Isolation and identification of gene-specific microRNAs
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 342:313-20. 2006
    ..According to this proof- of-principle method, we now have the knowledge to design pre-miRNA inserts that are more efficient and effective for the intronic miRNA-expressing system...
  27. doi request reprint Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis
    Quan Bin Han
    Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, PR China
    Phytochemistry 69:2187-92. 2008
    ..The results showed that xanthones with an unsaturated prenyl group had stronger cytotoxic activity against cancer cells, whereas those with hydroxylated prenyl groups had none...