Zeng Chunyu


Country: China


  1. Wang W, Li L, Xia X, Fu W, Liao Q, Lan C, et al. Dedifferentiation, Proliferation, and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury. Circulation. 2017;136:834-848 pubmed publisher
    ..Intercellular Ca2+ signal from neighboring functioning cardiomyocytes through gap junctions induces the redifferentiation process. This novel mechanism contributes to new cardiomyocyte formation in post-MI hearts in mammals. ..
  2. Yang X, Yue R, Zhang J, Zhang X, Liu Y, Chen C, et al. Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways. J Am Heart Assoc. 2018;7: pubmed publisher
    ..These results indicate that gastrin can reduce myocardial IRI by activation of the RISK and SAFE pathways. ..
  3. Lu X, Ye Z, Zheng S, Ren H, Zeng J, Wang X, et al. Long-Term Exposure of Fine Particulate Matter Causes Hypertension by Impaired Renal D1 Receptor-Mediated Sodium Excretion via Upregulation of G-Protein-Coupled Receptor Kinase Type 4 Expression in Sprague-Dawley Rats. J Am Heart Assoc. 2018;7: pubmed publisher
    ..5-induced hypertension. ..
  4. Fu J, Han Y, Wang J, Liu Y, Zheng S, Zhou L, et al. Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK-Akt-eNOS-NO Pathway in the Spontaneously Hypertensive Rat. J Am Heart Assoc. 2016;5: pubmed
    ..We conclude that acute administration of irisin lowers blood pressure of SHRs by amelioration of endothelial dysfunction of the mesenteric artery through the AMPK-Akt-eNOS-NO signaling pathway. ..
  5. Zhang Y, Ren H, Lu X, He D, Han Y, Wang H, et al. Inhibition of D4 Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells. J Am Heart Assoc. 2016;5: pubmed publisher
    ..Activation of D4 receptor inhibits insulin receptor expression in RPT cells from WKY rats. The aberrant inhibition of D4 receptor on insulin receptor expression and effect might be involved in the pathogenesis of essential hypertension. ..
  6. Chen K, Xu Z, Liu Y, Wang Z, Li Y, Xu X, et al. Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury. Sci Transl Med. 2017;9: pubmed publisher
    ..These results demonstrate that irisin is a myokine that facilitates RIPC-mediated lung protection. Targeting the action of irisin in mitochondria presents a potential therapeutic intervention for pulmonary IR injury. ..
  7. Gong Z, Han Y, Wu L, Xia T, Ren H, Yang D, et al. Translocator protein 18 kDa ligand alleviates neointimal hyperplasia in the diabetic rat artery injury model via activating PKG. Life Sci. 2019;221:72-82 pubmed publisher
    ..TSPO may be a potential therapeutic target to reduce arterial remodeling induced by angioplasty in diabetes. ..
  8. Wang X, Wang J, Luo H, Chen C, Pei F, Cai Y, et al. Prenatal lipopolysaccharide exposure causes mesenteric vascular dysfunction through the nitric oxide and cyclic guanosine monophosphate pathway in offspring. Free Radic Biol Med. 2015;86:322-30 pubmed publisher
    ..In conclusion, prenatal LPS exposure programs vascular dysfunction of mesenteric arteries through increased oxidative stress and impaired NO-cGMP signaling pathway. ..
  9. Yang S, Han Y, Zheng S, Kou X, Asico L, Huang H, et al. Enhanced Natriuresis and Diuresis in Wistar Rats Caused by the Costimulation of Renal Dopamine D3 and Angiotensin II Type 2 Receptors. Am J Hypertens. 2015;28:1267-76 pubmed publisher
    ..Our current study indicates that D3R, in combination with AT2R, enhances natriuresis and diuresis, via ERK1/2-MAPK pathway, that may be involved in the regulation of blood pressure. ..

More Information


  1. Wang X, Luo H, Chen C, Chen K, Wang J, Cai Y, et al. Prenatal lipopolysaccharide exposure results in dysfunction of the renal dopamine D1 receptor in offspring. Free Radic Biol Med. 2014;76:242-50 pubmed publisher
    ..Normalization of renal D1R function by amelioration of oxidative stress may be a therapeutic target of fetal programming of hypertension. ..
  2. Chen Y, Asico L, Zheng S, Villar V, He D, Zhou L, et al. Gastrin and D1 dopamine receptor interact to induce natriuresis and diuresis. Hypertension. 2013;62:927-33 pubmed publisher
    ..An aberrant interaction between the renal CCK?BR and D1-like receptors (eg, D1 receptor) may play a role in the pathogenesis of hypertension. ..
  3. Cai J, Wu G, Jose P, Zeng C. Functional transferred DNA within extracellular vesicles. Exp Cell Res. 2016;349:179-183 pubmed publisher
    ..In this review, the focus is on the characteristics, biological functions, and roles in diseases of DNA within EVs. ..
  4. Lan C, Chen X, Zhang Y, Wang W, Wang W, Liu Y, et al. Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function. BMC Cardiovasc Disord. 2018;18:43 pubmed publisher
    ..Our study suggests that curcumin exerts a stroke preventive effect by attenuating oxidative stress to improve vascular endothelial function, which might be associated with UCP2 signaling. ..
  5. Yang Y, Chen C, Fu C, Xu Z, Lan C, Zeng Y, et al. Angiotensin II type 2 receptor inhibits expression and function of insulin receptor in rat renal proximal tubule cells. J Am Soc Hypertens. 2018;12:135-145 pubmed publisher
    ..The lost inhibitory effect of AT2R on insulin receptor expression may contribute to the pathophysiology of hypertension. ..
  6. Xia T, Guan W, Fu J, Zou X, Han Y, Chen C, et al. Tirofiban induces vasorelaxation of the coronary artery via an endothelium-dependent NO-cGMP signaling by activating the PI3K/Akt/eNOS pathway. Biochem Biophys Res Commun. 2016;474:599-605 pubmed publisher
    ..These findings suggest that tirofiban induces vasorelaxation via an endothelium-dependent NO-cGMP signaling through the activation of the Akt/eNOS/sGC pathway. ..
  7. Zhang Y, Cheng C, He D, Shi W, Fu C, Wang X, et al. Transcriptional gene silencing of dopamine D3 receptor caused by let-7d mimics in immortalized renal proximal tubule cells of rats. Gene. 2016;580:89-95 pubmed publisher
    ..It is suggested that miRNAs may act as a transcriptional gene regulator via the recognition of the homologous target site within the gene promoter. ..
  8. Yue R, Fu W, Liao X, Lan C, Liao Q, Li L, et al. Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction. Stem Cell Res Ther. 2017;8:17 pubmed publisher
    ..MET improves the survival of transplanted CDCs in the myocardium, thereby enhancing their therapeutic effect against MI injury. The pro-survival function of MET on CDCs might be associated with an AMPK-eNOS-dependent mechanism. ..
  9. Wang N, Chen C, Yang D, Liao Q, Luo H, Wang X, et al. Mesenchymal stem cells-derived extracellular vesicles, via miR-210, improve infarcted cardiac function by promotion of angiogenesis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2085-2092 pubmed publisher
    ..This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure - edited by Jun Ren & Megan Yingmei Zhang. ..
  10. Yang J, Villar V, Jones J, Jose P, Zeng C. G protein-coupled receptor kinase 4: role in hypertension. Hypertension. 2015;65:1148-55 pubmed publisher
  11. Chen K, Fu C, Chen C, Liu L, Ren H, Han Y, et al. Role of GRK4 in the regulation of arterial AT1 receptor in hypertension. Hypertension. 2014;63:289-96 pubmed publisher
    ..This study provides a mechanism by which GRK4, via regulation of arterial AT(1)R expression and function, participates in the pathogenesis of conduit vessel abnormalities in hypertension. ..