Sheng Hua Chu

Summary

Country: China

Publications

  1. Yang B, Ma Y, Chu S. Silencing SATB1 overcomes temozolomide resistance by downregulating MGMT expression and upregulating SLC22A18 expression in human glioblastoma cells. Cancer Gene Ther. 2018;25:309-316 pubmed publisher
    ..Finally, in TMZ-resistant GBM, SATB1 knockdown enhanced TMZ efficacy. Consequently, SATB1 inhibition might be a promising strategy combined with TMZ chemotherapy to treat TMZ-resistant GBM. ..
  2. Chu S, Feng D, Ma Y, Zhang H, Zhu Z, Li Z, et al. Promoter methylation and downregulation of SLC22A18 are associated with the development and progression of human glioma. J Transl Med. 2011;9:156 pubmed publisher
    ..SLC22A18 downregulation via promoter methylation is associated with the development and progression of glioma, suggesting that SLC22A18 is an important tumor suppressor in glioma. ..
  3. Chu S, Ma Y, Feng D, Zhang H, Qiu J, Zhu Z. Effect of 5-Aza-2'-deoxycytidine on SLC22A18 in glioma U251 cells. Mol Med Rep. 2012;5:138-41 pubmed publisher
    ..The hypermethylation of SLC22A18 may be related to the transcriptional silencing of this gene. The growth inhibitory effects of 5-Aza-CdR treatment in vivo remain recognizable. ..
  4. Chu S, Ma Y, Feng D, Li Z, Jiang P. Correlation between SATB1 and Bcl-2 expression in human glioblastoma multiforme. Mol Med Rep. 2013;7:139-43 pubmed publisher
    ..Therefore, assessment of SATB1 and Bcl-2 co-expression may provide important information for the diagnosis, therapy and prognosis of GBM. ..
  5. Chu S, Ma Y, Feng D, Zhang H, Qiu J, Zhu Z, et al. Relationship between SATB1 expression and prognosis in astrocytoma. J Clin Neurosci. 2013;20:543-7 pubmed publisher
  6. Chu S, Feng D, Ma Y, Zhu Z, Zhang H, Qiu J. Stabilization of hepatocyte growth factor mRNA by hypoxia-inducible factor 1. Mol Biol Rep. 2009;36:1967-75 pubmed publisher
    ..These studies are the first to demonstrate that overexpression of HIF-1alpha increases HGF mRNA stability. Our results also suggest that stabilization of HGF mRNA by hypoxia is mediated, at least in part, by HIF-1. ..
  7. request reprint
    Chu S, Ma Y, Feng D, Zhang H, Qiu J, Zhu Z. c-Met antisense oligodeoxynucleotides increase sensitivity of human glioma cells to paclitaxel. Oncol Rep. 2010;24:189-94 pubmed
    ..01). Thus, c-Met antisense oligodeoxynucleotides increase the sensitivity of human glioma cells to paclitaxel. Combined use of the two agents could be a novel and attractive strategy in human glioma treatment. ..
  8. Chu S, Feng D, Ma Y, Zhang H, Zhu Z, Li Z, et al. Expression of HGF and VEGF in the cerebral tissue of adult rats with chronic hydrocephalus after subarachnoid hemorrhage. Mol Med Rep. 2011;4:785-91 pubmed publisher
    ..Our results indicate that HGF and VEGF participate in the pathological injury and repair of cerebral tissue in rats with chronic hydrocephalus after subarachnoid hemorrhage. ..
  9. Chu S, Ma Y, Feng D, Zhang H, Zhu Z, Li Z, et al. Correlation of low SLC22A18 expression with poor prognosis in patients with glioma. J Clin Neurosci. 2012;19:95-8 pubmed publisher
    ..This study suggests that SLC22A18 functions as a tumor suppressor in glioma and represents a candidate biomarker for long-term survival in this disease. ..

More Information

Publications11

  1. Chu S, Ma Y, Feng D, Zhang H, Zhu Z, Li Z, et al. Upregulation of SATB1 is associated with the development and progression of glioma. J Transl Med. 2012;10:149 pubmed publisher
    ..SATB1 may have an important role as a positive regulator of glioma development and progression, and that SATB1 might be a useful molecular marker for predicting the prognosis of glioma. ..
  2. Chu S, Ma Y, Feng D, Li Z, Jiang P. Predictive value of the SLC22A18 protein expression in glioblastoma patients receiving temozolomide therapy. J Transl Med. 2013;11:69 pubmed publisher
    ..These results show that lack of SLC22A18 protein expression is superior to promoter methylation as a predictive tumor biomarker in GBM patients receiving temozolomide therapy. ..