Guanbin Song


Affiliation: Chongqing University
Country: China


  1. Liu L, Luo Q, Sun J, Song G. Cytoskeletal control of nuclear morphology and stiffness are required for OPN-induced bone marrow-derived mesenchymal stem cell migration. Biochem Cell Biol. 2019;: pubmed publisher
    ..We suggest that the cytoskeletal-nuclear interconnectivity through the SUN1 proteins plays an important role in the OPN-promoted BMSC migration. ..
  2. Sun J, Luo Q, Liu L, Song G. Low-level shear stress induces differentiation of liver cancer stem cells via the Wnt/β-catenin signalling pathway. Exp Cell Res. 2018;: pubmed publisher
  3. HALIM A, Luo Q, Ju Y, Song G. A Mini Review Focused on the Recent Applications of Graphene Oxide in Stem Cell Growth and Differentiation. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..We also discuss the possible molecular mechanisms of graphene oxide in controlling stem cell growth and differentiation. ..
  4. Wen Y, Gao X, Wang A, Yang Y, Liu S, Yu Z, et al. Substrate stiffness affects neural network activity in an extracellular matrix proteins dependent manner. Colloids Surf B Biointerfaces. 2018;170:729-735 pubmed publisher
  5. Chen Q, Zhou J, Zhang B, Chen Z, Luo Q, Song G. Cyclic Stretching Exacerbates Tendinitis by Enhancing NLRP3 Inflammasome Activity via F-Actin Depolymerization. Inflammation. 2018;41:1731-1743 pubmed publisher
    ..These results may provide theoretical support for a new treatment strategy for preventing excessive inflammation in the tendon. ..
  6. Mao X, Gavara N, Song G. Nuclear Mechanics and Stem Cell Differentiation. Stem Cell Rev. 2015;11:804-12 pubmed publisher
  7. Zhang B, Luo Q, Deng B, Morita Y, Ju Y, Song G. Construction of tendon replacement tissue based on collagen sponge and mesenchymal stem cells by coupled mechano-chemical induction and evaluation of its tendon repair abilities. Acta Biomater. 2018;74:247-259 pubmed publisher
    ..These results suggest that this approach could offer a practical benefit in tendon healing and future tendon tissue engineering. ..
  8. Sun J, Luo Q, Liu L, Song G. Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1/2 signalling pathway. Cancer Lett. 2018;427:1-8 pubmed publisher
    ..Overall, our study demonstrates that shear stress promotes LCSC migration through the activation of the FAK-ERK1/2 signalling pathways, which further results in a reduction of organized actin and softer cell bodies. ..
  9. Zhang B, Luo Q, Chen Z, Sun J, Xu B, Ju Y, et al. Cyclic mechanical stretching promotes migration but inhibits invasion of rat bone marrow stromal cells. Stem Cell Res. 2015;14:155-64 pubmed publisher

More Information


  1. Chen Z, Luo Q, Yuan L, Song G. Microgravity directs stem cell differentiation. Histol Histopathol. 2017;32:99-106 pubmed publisher
    ..In this review, we summarize the current understanding of the effects of microgravity on stem cell differentiation that control the fate of stem cells. ..
  2. Luo Q, Kuang D, Zhang B, Song G. Cell stiffness determined by atomic force microscopy and its correlation with cell motility. Biochim Biophys Acta. 2016;1860:1953-60 pubmed publisher
    ..This review provides an overview of the current understanding of the correlation between AFM-determined cell stiffness and motility, the determinants of this detecting method, as well as clues to optimize detecting parameters. ..
  3. Liu L, Luo Q, Sun J, Ju Y, Morita Y, Song G. Chromatin organization regulated by EZH2-mediated H3K27me3 is required for OPN-induced migration of bone marrow-derived mesenchymal stem cells. Int J Biochem Cell Biol. 2018;96:29-39 pubmed publisher
    ..Thus, our results identify a mechanism by which ERK1/2 signalling drives specific chromatin modifications in BMSCs, which alters chromatin organization and thereby enables OPN-mediated BMSC migration. ..
  4. Zhang B, Luo Q, Kuang D, Ju Y, Song G. Mechano-growth factor E peptide promotes healing of rat injured tendon. Biotechnol Lett. 2016;38:1817-25 pubmed publisher
    ..MGF-C25E plays an important role in promoting healing of injured rat tendon and could be used as a potential therapeutic factor for tendon repair. ..
  5. Sun J, Luo Q, Liu L, Zhang B, Shi Y, Ju Y, et al. Biomechanical profile of cancer stem-like cells derived from MHCC97H cell lines. J Biomech. 2016;49:45-52 pubmed publisher
    ..These results demonstrated a close relationship between the cell Young׳s modulus and metastatic potential of HHCs, which suggest that Young׳s modulus detected by AFM can be used to evaluate metastatic potential of cancer cells. ..
  6. Liu L, Luo Q, Sun J, Song G. Nucleus and nucleus-cytoskeleton connections in 3D cell migration. Exp Cell Res. 2016;348:56-65 pubmed publisher
    ..Thus, we suggest that alterations in the nuclear structure may facilitate cellular reorganizations that are necessary for efficient migration. ..
  7. Mao X, Chen Z, Luo Q, Zhang B, Song G. Simulated microgravity inhibits the migration of mesenchymal stem cells by remodeling actin cytoskeleton and increasing cell stiffness. Cytotechnology. 2016;68:2235-2243 pubmed
    ..Taken together, we propose that SMG inhibits migration of BMSCs through remodeling F-actin and increasing cell stiffness. ..
  8. Liu L, Luo Q, Sun J, Wang A, Shi Y, Ju Y, et al. Decreased nuclear stiffness via FAK-ERK1/2 signaling is necessary for osteopontin-promoted migration of bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2017;355:172-181 pubmed publisher
    ..This study provides strong evidence for the role of nuclear mechanics in BMSC migration as well as new insight into the molecular mechanisms of OPN-promoted BMSC migration. ..
  9. Sun J, Luo Q, Liu L, Yang X, Zhu S, Song G. Salinomycin attenuates liver cancer stem cell motility by enhancing cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signalling pathway. Toxicology. 2017;384:1-10 pubmed publisher
    ..Overall, these results showed that salinomycin inhibits the migration and invasion of LCSCs through the dephosphorylated FAK and ERK1/2 pathways, reflecting the changes in cell stiffness resulting from the increased actin cytoskeleton. ..
  10. Liu Q, Luo Q, HALIM A, Song G. Targeting lipid metabolism of cancer cells: A promising therapeutic strategy for cancer. Cancer Lett. 2017;401:39-45 pubmed publisher
    ..Understanding the regulation of lipid metabolism in cancer cells has important implications for exploring a new therapeutic strategy for management and treatment of cancer. ..
  11. Chen Q, Liang Q, Zhuang W, Zhou J, Zhang B, Xu P, et al. Tenocyte proliferation and migration promoted by rat bone marrow mesenchymal stem cell-derived conditioned medium. Biotechnol Lett. 2018;40:215-224 pubmed publisher
    ..MSC-CM-induced tenocyte migration was accompanied by cytoskeletal polymerization and increases in cellular and nuclear stiffness. ..
  12. Chen Z, Luo Q, Lin C, Song G. Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells through down regulating the transcriptional co-activator TAZ. Biochem Biophys Res Commun. 2015;468:21-6 pubmed publisher
    ..Taken together, we propose that microgravity inhibits osteogenic differentiation of BMSCs due to decreased TAZ expression and that LPA can efficiently reverse the reduced osteogenic differentiation via the Rock-TAZ pathway. ..