Kaiyong Cai

Summary

Affiliation: Chongqing University
Country: China

Publications

  1. ncbi Regulation of endothelial cells migration on poly(D, L-lactic acid) films immobilized with collagen gradients
    Kaiyong Cai
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China
    Colloids Surf B Biointerfaces 79:291-7. 2010
  2. doi Construction of microenvironment onto titanium substrates to regulate the osteoblastic differentiation of bone marrow stromal cells in vitro and osteogenesis in vivo
    Min Lai
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, People s Republic of China
    J Biomed Mater Res A 101:653-66. 2013
  3. doi Surface functionalization of titanium substrates with cecropin B to improve their cytocompatibility and reduce inflammation responses
    Dawei Xu
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China
    Colloids Surf B Biointerfaces 110:225-35. 2013
  4. doi Fabrication of selenium-deposited and chitosan-coated titania nanotubes with anticancer and antibacterial properties
    Xiuyong Chen
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, Joint College of Biomedical Engineering, Chongqing University, Chongqing 400044, PR China
    Colloids Surf B Biointerfaces 103:149-57. 2013
  5. doi Regulation of the differentiation of mesenchymal stem cells in vitro and osteogenesis in vivo by microenvironmental modification of titanium alloy surfaces
    Yan Hu
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
    Biomaterials 33:3515-28. 2012
  6. pmc Effects of titanium nanoparticles on adhesion, migration, proliferation, and differentiation of mesenchymal stem cells
    Yanhua Hou
    Key Laboratory of Biorheological Science and Technology and Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People s Republic of China
    Int J Nanomedicine 8:3619-30. 2013
  7. doi The use of hyaluronan to regulate protein adsorption and cell infiltration in nanofibrous scaffolds
    Linhao Li
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China
    Biomaterials 33:3428-45. 2012
  8. doi TiO2 nanotubes as drug nanoreservoirs for the regulation of mobility and differentiation of mesenchymal stem cells
    Yan Hu
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People s Republic of China
    Acta Biomater 8:439-48. 2012
  9. doi Electrospun poly (ɛ-caprolactone)/silk fibroin core-sheath nanofibers and their potential applications in tissue engineering and drug release
    Linhao Li
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
    Int J Biol Macromol 49:223-32. 2011
  10. doi Surface engineering of titanium with potassium hydroxide and its effects on the growth behavior of mesenchymal stem cells
    Kaiyong Cai
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
    Acta Biomater 6:2314-21. 2010

Collaborators

Detail Information

Publications38

  1. ncbi Regulation of endothelial cells migration on poly(D, L-lactic acid) films immobilized with collagen gradients
    Kaiyong Cai
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China
    Colloids Surf B Biointerfaces 79:291-7. 2010
    ..It is potentially important for understanding the controlled angiogenesis for implantation of tissue-engineered constructs...
  2. doi Construction of microenvironment onto titanium substrates to regulate the osteoblastic differentiation of bone marrow stromal cells in vitro and osteogenesis in vivo
    Min Lai
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, People s Republic of China
    J Biomed Mater Res A 101:653-66. 2013
    ..This work provides an approach to fabricate high-performance titanium-based implants with enhanced bone osseointegration...
  3. doi Surface functionalization of titanium substrates with cecropin B to improve their cytocompatibility and reduce inflammation responses
    Dawei Xu
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China
    Colloids Surf B Biointerfaces 110:225-35. 2013
    ..The approach presented here has great potential in the development of antibacterial titanium-based implants in clinical applications. ..
  4. doi Fabrication of selenium-deposited and chitosan-coated titania nanotubes with anticancer and antibacterial properties
    Xiuyong Chen
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, Joint College of Biomedical Engineering, Chongqing University, Chongqing 400044, PR China
    Colloids Surf B Biointerfaces 103:149-57. 2013
    ..The approach in this study provides an alternative to fabricate anticancer and antibacterial titanium-based implants for potential clinical application...
  5. doi Regulation of the differentiation of mesenchymal stem cells in vitro and osteogenesis in vivo by microenvironmental modification of titanium alloy surfaces
    Yan Hu
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
    Biomaterials 33:3515-28. 2012
    ..The study therefore presents an alternative to fabricate bio-functionalized Ti6Al4V-based implants for potential application in orthopedics field...
  6. pmc Effects of titanium nanoparticles on adhesion, migration, proliferation, and differentiation of mesenchymal stem cells
    Yanhua Hou
    Key Laboratory of Biorheological Science and Technology and Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People s Republic of China
    Int J Nanomedicine 8:3619-30. 2013
    ..Here we report the potential impact of titanium oxide (TiO2) nanoparticles on adhesion, migration, proliferation, and differentiation of mesenchymal stem cells (MSC) from the cellular level to the molecular level in the Wistar rat...
  7. doi The use of hyaluronan to regulate protein adsorption and cell infiltration in nanofibrous scaffolds
    Linhao Li
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China
    Biomaterials 33:3428-45. 2012
    ..These findings suggest that such an HA-based nanofibrous scaffold resists protein adsorption and enhances cell infiltration, may offer possibilities to overcome the limitations of electrospinning technology...
  8. doi TiO2 nanotubes as drug nanoreservoirs for the regulation of mobility and differentiation of mesenchymal stem cells
    Yan Hu
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People s Republic of China
    Acta Biomater 8:439-48. 2012
    ..More importantly, the system demonstrated that it was capable of promoting the osteoblastic differentiation of MSCs. This study may have potential impact on the development of bone implants for enhanced bone osseointegration...
  9. doi Electrospun poly (ɛ-caprolactone)/silk fibroin core-sheath nanofibers and their potential applications in tissue engineering and drug release
    Linhao Li
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China
    Int J Biol Macromol 49:223-32. 2011
    ..The produced nanofibrous scaffolds with sustained drug release have potential application in tissue engineering...
  10. doi Surface engineering of titanium with potassium hydroxide and its effects on the growth behavior of mesenchymal stem cells
    Kaiyong Cai
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
    Acta Biomater 6:2314-21. 2010
    ..More importantly, our results suggest that the modified titanium substrates have great potential for inducing MSCs to differentiate into osteoblasts. The approach presented here may be exploited to fabricate titanium-based implants...
  11. ncbi Influences of magnetized hydroxyapatite on the growth behaviors of osteoblasts and the mechanism from molecular dynamics simulation
    Weihu Yang
    Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China
    Mater Sci Eng C Mater Biol Appl 33:3753-9. 2013
    ..Nevertheless, the (211) crystal face of mHA still had a relatively higher electron density than that of HA, thus possessing better protein adsorption than that of HA, and in turn promoting the biological functions of osteoblasts. ..
  12. doi Surface engineering of titanium substrates with chitosan-atorvastatin conjugate for reduced inflammation responses and improved cytocompatibility
    Daichao Xie
    Key Laboratory of Biorheological Science and Technology of Ministry of Education, Joint College of Biomedical Engineering, Chongqing University, Chongqing 400044, China
    J Biomed Mater Res A 101:2005-14. 2013
    ..The study thus presents an alternative to fabricate bio-functionalized titanium-based implants for further clinical application...
  13. doi Surface mediated in situ differentiation of mesenchymal stem cells on gene-functionalized titanium films fabricated by layer-by-layer technique
    Yan Hu
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
    Biomaterials 30:3626-35. 2009
    ..The approach presented here has potential applications in the development of gene-stimulating biomaterials and implant technology...
  14. doi Regulation of the behaviors of mesenchymal stem cells by surface nanostructured titanium
    Min Lai
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
    Colloids Surf B Biointerfaces 97:211-20. 2012
    ..This approach for the fabrication of surface nanostructured titanium may be exploited in the development of high performance titanium-based implants...
  15. doi Improved endothelialization of NiTi alloy by VEGF functionalized nanocoating
    Weixing Shen
    Key Laboratory of Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
    Colloids Surf B Biointerfaces 94:347-53. 2012
    ..The approach presented here affords an alternative for surface modification of NiTi implants applied as heart and vascular implant devices...
  16. ncbi Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles
    Zhong Luo
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, P R China
    Adv Mater 24:431-5. 2012
    ..The endocytotic pathway and endosomal escape of the smart controlled drug release system is proposed. ..
  17. ncbi Effects of mesoporous SiO2 , Fe3 O4 , and TiO2 nanoparticles on the biological functions of endothelial cells in vitro
    Yanhua Hou
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, People s Republic of China
    J Biomed Mater Res A 102:1726-36. 2014
    ..We found that cytoskeleton and integrity of cells were destroyed by different NPs. Additionally, the production of reactive oxygen species damaged the mitochondria of cells, in turn leading to cells apoptosis and death...
  18. ncbi Microstructure, mechanical and bio-corrosion properties of Mn-doped Mg-Zn-Ca bulk metallic glass composites
    Jingfeng Wang
    National Engineering Research Center for Magnesium Alloys, College of Materials Science and Engineering, Chongqing University, Chongqing 400044, PR China
    Mater Sci Eng C Mater Biol Appl 33:3832-8. 2013
    ..Mg68.5Zn27Ca4Mn0.5 exhibits the highest bio-corrosion resistance, biocompatibility and has desirable mechanical properties, which could suggest to be used as biomedical materials in the future...
  19. ncbi Biocompatible magnetic liposomes for temperature triggered drug delivery
    Xingwei Ding
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, PR China
    Nanoscale 4:6289-92. 2012
    ..The TSMLs are stable below 39 °C and most drugs (5-(and-6)-carboxylfluorescein: 68% and doxorubicin: 90%) release within 1 h at 42 °C. Furthermore, TSMLs could deliver the anticancer drugs into cells to induce cell apoptosis...
  20. ncbi Hydrazone-bearing PMMA-functionalized magnetic nanocubes as pH-responsive drug carriers for remotely targeted cancer therapy in vitro and in vivo
    Xingwei Ding
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, P R China
    ACS Appl Mater Interfaces 6:7395-407. 2014
    ..All results suggest that hydrazide-tailoring PMMA-coated magnetic nanocube would be a promising pH-responsive drug carrier for remotely targeted cancer therapy in vitro and in vivo. ..
  21. doi Recyclable heparin and chitosan conjugated magnetic nanocomposites for selective removal of low-density lipoprotein from plasma
    Jinghua Li
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, People s Republic of China
    J Mater Sci Mater Med 25:1055-64. 2014
    ..The recyclable magnetic adsorbent had good blood compatibility due to the conjugation of heparin to the chitosan-coated magnetic nanocomposites. The fabricated magnetic adsorbent could be applied for LDL apheresis without side effects...
  22. doi Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity
    Zhong Luo
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR of China
    Adv Healthc Mater 1:321-5. 2012
    ..It demonstrates great potential for both cell-specific endocytosis and intracellular pH-responsive controlled release of drugs. A possible endocytosis pathway/mechanism of the smart controlled drug release system is proposed...
  23. ncbi [Application of layer-by-layer technique on surface engineering of gene-activated biomaterials]
    Yan Hu
    College of Bioengineering, Chongqing University, Chongqing 400044, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 25:738-41. 2008
    ..These are of great significance to biomaterial researches...
  24. doi Inkjet printing of laminin gradient to investigate endothelial cellular alignment
    Kaiyong Cai
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China
    Colloids Surf B Biointerfaces 72:230-5. 2009
    ..It is potentially important for understanding cell alignment/ingrowth behavior for angiogenesis and implant technology including tissue-engineered structures...
  25. doi Surface functionalization of TiO2 nanotubes with bone morphogenetic protein 2 and its synergistic effect on the differentiation of mesenchymal stem cells
    Min Lai
    Key Laboratory of Biorheological Science and Technology, Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China
    Biomacromolecules 12:1097-105. 2011
    ..The approach presented here has potential application for the development of titanium-based implants for enhanced bone osseointegration...
  26. doi Cell-specific gene transfection from a gene-functionalized poly(d,l-lactic acid) substrate fabricated by the layer-by-layer assembly technique
    Kaiyong Cai
    College of Bioengineering, Chongqing University, Chongqing, PR China
    Angew Chem Int Ed Engl 47:7479-81. 2008
  27. ncbi Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity
    Zhong Luo
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore
    Biomaterials 35:7951-62. 2014
    ..On the whole, this drug delivery system exhibits a great potential as an efficient carrier for targeted tumor therapy in vitro and in vivo. ..
  28. ncbi Redox-responsive nanocarrier based on heparin end-capped mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo
    Liangliang Dai
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, P R China
    Langmuir 30:7867-77. 2014
    ..The study affords a promising nanocarrier for redox-responsive cargo delivery with high curative efficiency for cancer therapy. ..
  29. doi Influence of the titania nanotubes dimensions on adsorption of collagen: an experimental and computational study
    Weihu Yang
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China
    Mater Sci Eng C Mater Biol Appl 34:410-6. 2014
    ..The calculated interaction energies indicated that the TiNTs with bigger dimensions had higher interaction energies, thus leading to the higher collagen adsorption. ..
  30. doi β-Cyclodextrin conjugated magnetic nanoparticles for diazepam removal from blood
    Kaiyong Cai
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, PR China
    Chem Commun (Camb) 47:7719-21. 2011
    ..The diazepam is arrested by the conjugated β-CD and then the adsorbed diazepam is efficiently removed by an external magnetic field. These particles have potential applications in hemoperfusion or separation of other toxins and drugs...
  31. ncbi [Preparation and cytocompatibility study of poly (epsilon-caprolactone)/silk sericin nanofibrous scaffolds]
    Haibin Li
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 28:305-9. 2011
    ..Furthermore, the capability of hydrophile increased with the SS addition, which improved FEK4 cells adhesion and proliferation on the scaffolds...
  32. doi Effects of micropatterned curvature on the motility and mechanical properties of airway smooth muscle cells
    Jimin Xu
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, and Bioengineering College, Chongqing University, 174 Shapingzhengjie Street, Chongqing 400044, China
    Biochem Biophys Res Commun 415:591-6. 2011
    ..These results may provide valuable insights to understanding the heterogeneity of airway constrictions in asthma as well as the developing and functioning of other tubular organs and tissue engineering...
  33. doi TGF-β1 promoted MMP-2 mediated wound healing of anterior cruciate ligament fibroblasts through NF-κB
    Yequan Wang
    Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, PR China
    Connect Tissue Res 52:218-25. 2011
    ..The migration process is mediated by MMP-2 and NF-κB pathway is involved in TGF-β1-mediated MMP-2 release...
  34. ncbi Surface functionalization of titanium substrates with chitosan-lauric acid conjugate to enhance osteoblasts functions and inhibit bacteria adhesion
    Lu Zhao
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China
    Colloids Surf B Biointerfaces 119:115-25. 2014
    ..Overall, this study developed a promising approach to fabricate functional Ti-based orthopedic implants, which could enhance the biological functions of osteoblasts and concurrently reduce bacteria adhesion. ..
  35. ncbi Surface modification of titanium substrates with silver nanoparticles embedded sulfhydrylated chitosan/gelatin polyelectrolyte multilayer films for antibacterial application
    Wen Li
    Key Laboratory of Biorheological Science and Technology Chongqing University, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, People s Republic of China
    J Mater Sci Mater Med 25:1435-48. 2014
    ..This study provides a simple, versatile and generalized methodology to design functional titanium implants with good cyto-compatibility and antibacterial activity for potential clinical applications...
  36. ncbi Biomedical nanomaterials for imaging-guided cancer therapy
    Yuran Huang
    College of Bioengineering, Chongqing University, 174 Shazheng Road, Shapingba, Chongqing, China
    Nanoscale 4:6135-49. 2012
    ..It is hoped that this review might provide new impetus to understand nanotechnology and nanomaterials employed for imaging-guided cancer therapy...
  37. ncbi Surface modification of titanium thin film with chitosan via electrostatic self-assembly technique and its influence on osteoblast growth behavior
    Kaiyong Cai
    College of Bioengineering, Chongqing University, Chongqing, P R China
    J Mater Sci Mater Med 19:499-506. 2008
    ..These results suggest that surface modification of titanium film was successfully achieved via deposition of PEI/(PSS/Chi)x layers, which is useful to enhance the biocompatibility of the titanium film...
  38. ncbi Histological study of surface modified three dimensional poly (D, L-lactic acid) scaffolds with chitosan in vivo
    Kaiyong Cai
    College of Bioengineering, Chong Qing University, Chong Qing, 400044, PR China
    J Mater Sci Mater Med 18:2017-24. 2007
    ..The histological results have shown a higher bone formation potential and better biocompatibility of chitosan-modified 3-D PDLLA scaffolds as compared with the control group scaffolds...