Ben Zhan Zhu

Summary

Affiliation: Chinese Academy of Sciences
Country: China

Publications

  1. ncbi Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 109:16046-51. 2012
  2. ncbi Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Eco toxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China
    Chem Res Toxicol 24:30-4. 2011
  3. ncbi Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Proc Natl Acad Sci U S A 107:20686-90. 2010
  4. ncbi Metal-independent decomposition of hydroperoxides by halogenated quinones: detection and identification of a quinone ketoxy radical
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China mail
    Proc Natl Acad Sci U S A 106:11466-71. 2009
  5. ncbi Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P R China
    Chem Res Toxicol 22:969-77. 2009
  6. ncbi Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 104:17575-8. 2007
  7. ncbi Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 104:3698-702. 2007
  8. ncbi Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing 100085, PR China
    Toxicol Appl Pharmacol 267:88-94. 2013
  9. ncbi Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing 100085, PR China
    Toxicol Appl Pharmacol 266:335-44. 2013
  10. ncbi Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, 18 Shuangqing Road, Beijing 100085, PR China
    Toxicol Appl Pharmacol 267:74-87. 2013

Collaborators

Detail Information

Publications21

  1. ncbi Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 109:16046-51. 2012
    ....
  2. ncbi Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Eco toxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China
    Chem Res Toxicol 24:30-4. 2011
    ..We conclude that ergothioneine is a potent, natural sulfur-containing antioxidant that prevents copper-dependent oxidative damage to biological macromolecules by forming a redox-inactive ergothioneine-copper complex...
  3. ncbi Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Proc Natl Acad Sci U S A 107:20686-90. 2010
    ....
  4. ncbi Metal-independent decomposition of hydroperoxides by halogenated quinones: detection and identification of a quinone ketoxy radical
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China mail
    Proc Natl Acad Sci U S A 106:11466-71. 2009
    ....
  5. ncbi Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P R China
    Chem Res Toxicol 22:969-77. 2009
    ....
  6. ncbi Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 104:17575-8. 2007
    ..This represents a mechanism of HO* production that does not require redox-active transition metal ions...
  7. ncbi Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 104:3698-702. 2007
    ..This represents a mechanism of organic alkoxyl radical formation not requiring the involvement of redox-active transition metal ions...
  8. ncbi Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing 100085, PR China
    Toxicol Appl Pharmacol 267:88-94. 2013
    ..The present study provides a novel insight into the potential role of GPR30 in the initiation and progression of male germ cell cancer induced by environmentally relevant BPA...
  9. ncbi Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing 100085, PR China
    Toxicol Appl Pharmacol 266:335-44. 2013
    ....
  10. ncbi Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, 18 Shuangqing Road, Beijing 100085, PR China
    Toxicol Appl Pharmacol 267:74-87. 2013
    ..The present study provides a novel insight regarding the potential role of Nox-driven ROS in QNs-induced arthropathy...
  11. ncbi Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, 18 Shuangqing Road, Beijing 100085, PR China
    Toxicol Appl Pharmacol 259:133-42. 2012
    ....
  12. ncbi Detection and mechanistic investigation of halogenated benzoquinone induced DNA damage by photoelectrochemical DNA sensor
    Suping Jia
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Road, P O Box 2871, Beijing 100085, China
    Anal Bioanal Chem 397:2395-400. 2010
    ..The combined photoelectrochemistry, gel electrophoresis, and fluorescence data revealed distinctive differences between TFBQ and TCBQ in terms of DNA adduct formation and hydroxyl radical generation...
  13. ncbi Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism
    Jie Shao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Free Radic Biol Med 60:177-82. 2013
    ..This is the first report that halogenated quinoid carcinogens and H2O2 can induce potent methyl oxidation of 5mdC via a metal-independent mechanism, which may partly explain their potential carcinogenicity...
  14. ncbi Characterization of TCHQ-induced genotoxicity and mutagenesis using the pSP189 shuttle vector in mammalian cells
    Jing Wang
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, PR China
    Mutat Res 729:16-23. 2012
    ..These mutation hotspots accounted for 63% of all single base substitutions. We conclude that TCHQ induces sequence-specific DNA mutations at high frequencies. Therefore, the safety of using this product would be carefully examined...
  15. ncbi An electrochemical biosensor for the detection of tyrosine oxidation induced by Fenton reaction
    Na Qu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, 18 Shuangqing Road, Beijing 100085, China
    Biosens Bioelectron 26:2292-6. 2011
    ..Moreover, the lowest concentration of Fenton reagents that could be detected was 10 μM Fe(2+) or H(2)O(2), similar to the level in vivo. We suggest that the biosensor can be used to detect protein damage induced by Fenton reaction...
  16. ncbi Protection by tropolones against H2O2-induced DNA damage and apoptosis in cultured Jurkat cells
    Paschalis-Thomas Doulias
    Laboratory of Biological Chemistry, University of Ioannina Medical School, 451 10, Ioannina, Greece
    Free Radic Res 39:125-35. 2005
    ....
  17. ncbi Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex
    Ben-Zhan Zhu
    Linus Pauling Institute, Oregon State University, Corvallis 97331, USA
    Free Radic Biol Med 32:1333-8. 2002
    ....
  18. ncbi Metal-independent production of hydroxyl radicals by halogenated quinones and hydrogen peroxide: an ESR spin trapping study
    Ben-Zhan Zhu
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 32:465-73. 2002
    ..Metal-independent production of *OH from H(2)O(2) was also observed with several other halogenated quinones...
  19. ncbi Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes
    Jung H Suh
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
    Redox Rep 9:57-61. 2004
    ..Our results suggest that DHLA chelates and inactivates redox-active transition metal ions in small-molecular, biological complexes without affecting iron- or copper-dependent enzyme activities...
  20. ncbi Ascorbate does not act as a pro-oxidant towards lipids and proteins in human plasma exposed to redox-active transition metal ions and hydrogen peroxide
    Jung Suh
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331-6512, USA
    Free Radic Biol Med 34:1306-14. 2003
    ..Our data show that even in the presence of redox-active iron or copper and H(2)O(2), ascorbate acts as an antioxidant that prevents lipid peroxidation and does not promote protein oxidation in human plasma in vitro...
  21. ncbi Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage
    Ben-Zhan Zhu
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331-6512, USA
    FEBS Lett 532:80-4. 2002
    ..These data demonstrate that PDTC is a potent antioxidant against HOCl-induced protein oxidative damage, suggesting that PDTC might be useful in the prevention and treatment of inflammatory conditions...