Ben Zhan Zhu

Summary

Affiliation: Chinese Academy of Sciences
Country: China

Publications

  1. pmc Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G protein-coupled receptor 30 and estrogen receptor-α
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing, People s Republic of China
    Environ Health Perspect 119:1775-80. 2011
  2. pmc Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 109:16046-51. 2012
  3. doi request reprint Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Eco toxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China
    Chem Res Toxicol 24:30-4. 2011
  4. pmc Metal-independent decomposition of hydroperoxides by halogenated quinones: detection and identification of a quinone ketoxy radical
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China mail
    Proc Natl Acad Sci U S A 106:11466-71. 2009
  5. doi request reprint Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P R China
    Chem Res Toxicol 22:969-77. 2009
  6. pmc Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 104:17575-8. 2007
  7. pmc Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 104:3698-702. 2007
  8. pmc Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Proc Natl Acad Sci U S A 107:20686-90. 2010
  9. doi request reprint Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens
    Hao Qin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Free Radic Biol Med 63:459-66. 2013
  10. doi request reprint Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism
    Jie Shao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Free Radic Biol Med 60:177-82. 2013

Collaborators

Detail Information

Publications26

  1. pmc Low concentrations of bisphenol A induce mouse spermatogonial cell proliferation by G protein-coupled receptor 30 and estrogen receptor-α
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing, People s Republic of China
    Environ Health Perspect 119:1775-80. 2011
    ..The estrogenicity of BPA is generally mediated by nuclear estrogen receptors (ERs). However, low concentrations of BPA stimulate seminoma cell proliferation by an uncertain mechanism that does not involve activation of ERs...
  2. pmc Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 109:16046-51. 2012
    ....
  3. doi request reprint Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Eco toxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China
    Chem Res Toxicol 24:30-4. 2011
    ..We conclude that ergothioneine is a potent, natural sulfur-containing antioxidant that prevents copper-dependent oxidative damage to biological macromolecules by forming a redox-inactive ergothioneine-copper complex...
  4. pmc Metal-independent decomposition of hydroperoxides by halogenated quinones: detection and identification of a quinone ketoxy radical
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China mail
    Proc Natl Acad Sci U S A 106:11466-71. 2009
    ....
  5. doi request reprint Potential mechanism for pentachlorophenol-induced carcinogenicity: a novel mechanism for metal-independent production of hydroxyl radicals
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, P R China
    Chem Res Toxicol 22:969-77. 2009
    ....
  6. pmc Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 104:17575-8. 2007
    ..This represents a mechanism of HO* production that does not require redox-active transition metal ions...
  7. pmc Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 104:3698-702. 2007
    ..This represents a mechanism of organic alkoxyl radical formation not requiring the involvement of redox-active transition metal ions...
  8. pmc Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Proc Natl Acad Sci U S A 107:20686-90. 2010
    ....
  9. doi request reprint Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens
    Hao Qin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Free Radic Biol Med 63:459-66. 2013
    ....
  10. doi request reprint Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism
    Jie Shao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Free Radic Biol Med 60:177-82. 2013
    ..This is the first report that halogenated quinoid carcinogens and H2O2 can induce potent methyl oxidation of 5mdC via a metal-independent mechanism, which may partly explain their potential carcinogenicity...
  11. doi request reprint The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct
    Chun Hua Huang
    State Key Lab of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, CAS, Beijing 100085, China
    Chem Commun (Camb) 49:6436-8. 2013
    ....
  12. doi request reprint Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing 100085, PR China
    Toxicol Appl Pharmacol 267:88-94. 2013
    ..The present study provides a novel insight into the potential role of GPR30 in the initiation and progression of male germ cell cancer induced by environmentally relevant BPA...
  13. doi request reprint Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, 18 Shuangqing Road, Beijing 100085, PR China
    Toxicol Appl Pharmacol 259:133-42. 2012
    ....
  14. pmc Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism
    Ruichuan Yin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Centre for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Sci Rep 3:1269. 2013
    ....
  15. doi request reprint Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, Beijing 100085, PR China
    Toxicol Appl Pharmacol 266:335-44. 2013
    ....
  16. ncbi request reprint Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism
    Bailin Zhao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China, Disease Genomics and Individualized Medicine Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China, The Novo Nordisk Foundation Center for Protein Research, Ubiquitin Signalling Group, Faculty of Health Sciences, Blegdamsvej 3b, 2200, Copenhagen, Denmark and Group of DNA Metabolism, The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Nucleic Acids Res 42:1593-605. 2014
    ..Moreover, both Tet1/Tet2 knockout and dimethyloxalylglycine-induced Tet inhibition diminished the 5 hmC increase. These results suggest an iron-regulated Tet-dependent DNA demethylation mechanism mediated by redox-active biomolecules...
  17. doi request reprint Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes
    Zhi Guo Sheng
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Science, Chinese Academy of Sciences, 18 Shuangqing Road, Beijing 100085, PR China
    Toxicol Appl Pharmacol 267:74-87. 2013
    ..The present study provides a novel insight regarding the potential role of Nox-driven ROS in QNs-induced arthropathy...
  18. doi request reprint Detection and mechanistic investigation of halogenated benzoquinone induced DNA damage by photoelectrochemical DNA sensor
    Suping Jia
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Road, P O Box 2871, Beijing 100085, China
    Anal Bioanal Chem 397:2395-400. 2010
    ..The combined photoelectrochemistry, gel electrophoresis, and fluorescence data revealed distinctive differences between TFBQ and TCBQ in terms of DNA adduct formation and hydroxyl radical generation...
  19. doi request reprint Characterization of TCHQ-induced genotoxicity and mutagenesis using the pSP189 shuttle vector in mammalian cells
    Jing Wang
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, PR China
    Mutat Res 729:16-23. 2012
    ..These mutation hotspots accounted for 63% of all single base substitutions. We conclude that TCHQ induces sequence-specific DNA mutations at high frequencies. Therefore, the safety of using this product would be carefully examined...
  20. doi request reprint An electrochemical biosensor for the detection of tyrosine oxidation induced by Fenton reaction
    Na Qu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, 18 Shuangqing Road, Beijing 100085, China
    Biosens Bioelectron 26:2292-6. 2011
    ..Moreover, the lowest concentration of Fenton reagents that could be detected was 10 μM Fe(2+) or H(2)O(2), similar to the level in vivo. We suggest that the biosensor can be used to detect protein damage induced by Fenton reaction...
  21. ncbi request reprint Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex
    Ben Zhan Zhu
    Linus Pauling Institute, Oregon State University, Corvallis 97331, USA
    Free Radic Biol Med 32:1333-8. 2002
    ....
  22. ncbi request reprint Protection by tropolones against H2O2-induced DNA damage and apoptosis in cultured Jurkat cells
    Paschalis Thomas Doulias
    Laboratory of Biological Chemistry, University of Ioannina Medical School, 451 10, Ioannina, Greece
    Free Radic Res 39:125-35. 2005
    ....
  23. ncbi request reprint Metal-independent production of hydroxyl radicals by halogenated quinones and hydrogen peroxide: an ESR spin trapping study
    Ben Zhan Zhu
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 32:465-73. 2002
    ..Metal-independent production of *OH from H(2)O(2) was also observed with several other halogenated quinones...
  24. ncbi request reprint Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes
    Jung H Suh
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
    Redox Rep 9:57-61. 2004
    ..Our results suggest that DHLA chelates and inactivates redox-active transition metal ions in small-molecular, biological complexes without affecting iron- or copper-dependent enzyme activities...
  25. ncbi request reprint Ascorbate does not act as a pro-oxidant towards lipids and proteins in human plasma exposed to redox-active transition metal ions and hydrogen peroxide
    Jung Suh
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 34:1306-14. 2003
    ..Our data show that even in the presence of redox-active iron or copper and H(2)O(2), ascorbate acts as an antioxidant that prevents lipid peroxidation and does not promote protein oxidation in human plasma in vitro...
  26. ncbi request reprint Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage
    Ben Zhan Zhu
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    FEBS Lett 532:80-4. 2002
    ..These data demonstrate that PDTC is a potent antioxidant against HOCl-induced protein oxidative damage, suggesting that PDTC might be useful in the prevention and treatment of inflammatory conditions...