Zhi Qi Xiong
Affiliation: Chinese Academy of Sciences
Zhu Z, Liu J, Yang C, Li M, Wu R, Xiong Z. Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells. Cell Death Dis. 2019;10:118 pubmed publisher
..These results unveil new molecular mechanism for optimizing TRAIL-directed therapeutic efficacy against cancer. ..
Yao X, Cheng X, Wang C, Zhao M, Guo X, Su H, et al
. Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification. Neuron. 2018;98:1116-1123.e5 pubmed publisher
..Our findings provide strong evidence that loss-of-function mutations of MYORG cause brain calcification in humans and mice. ..
Zhu Z, Liu J, Li K, Zheng J, Xiong Z. KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells. Oncogene. 2018;37:2936-2952 pubmed publisher
..Taken together, our findings demonstrate that KPNB1 is required for proteostasis maintenance and its inhibition induces apoptosis in glioblastoma cells through UPR-mediated deregulation of Bcl-2 family members. ..
Li Y, Wang J, Zhou Y, Li D, Xiong Z. Rcan1 deficiency impairs neuronal migration and causes periventricular heterotopia. J Neurosci. 2015;35:610-20 pubmed publisher
..Together, these findings demonstrate that Rcan1 acts upstream from Flna in regulating radial migration and suggest that impairment of Rcan1-Flna pathway may underlie PH pathogenesis. ..