Gong Hong Wei


Affiliation: Chinese Academy of Medical Sciences
Country: China


  1. request reprint
    Chen H, Wang F, Gao P, Pei J, Liu Y, Xu T, et al. Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm. Circ Res. 2016;119:1076-1088 pubmed
    ..These findings provide evidence that SIRT1 reduction links vascular senescence and inflammation to AAAs and that SIRT1 in vascular smooth muscle cells provides a therapeutic target for the prevention of AAA formation. ..
  2. Chen H, Guo S, Li Z, Lu Y, Jiang D, Zhang R, et al. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. J Neurosci. 2014;34:11897-912 pubmed publisher
    ..These findings indicate that, rather than activating a delayed innate immune response, IRF9 directly activates neuronal death signaling pathways through the downregulation of Sirt1 deacetylase in response to acute I/R stress. ..
  3. Tang X, Chen X, Chen H, Liu D. Mitochondrial Sirtuins in cardiometabolic diseases. Clin Sci (Lond). 2017;131:2063-2078 pubmed publisher
    ..The potential therapeutic strategies by targetting mitochondrial Sirtuins to improve mitochondrial function in CMDs are also addressed. ..
  4. Liu Y, Wang T, Zhang R, Fu W, Wang X, Wang F, et al. Calorie restriction protects against experimental abdominal aortic aneurysms in mice. J Exp Med. 2016;213:2473-2488 pubmed
    ..Together, our findings suggest that CR may be an effective intervention that protects against AAA formation. ..
  5. Xu P, Wang T, Liu X, Wang N, Sun L, Zhang Z, et al. Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency. Stem Cell Res Ther. 2019;10:9 pubmed publisher
    ..Taken together, we have identified a new regulatory role of Sirt6 in reprogramming and maintenance of pluripotency. ..
  6. Ding Y, Tang X, Chen H, Liu D. Epigenetic Regulation of Vascular Aging and Age-Related Vascular Diseases. Adv Exp Med Biol. 2018;1086:55-75 pubmed publisher
    ..Moreover, the possibility of targeting epigenetic regulation to delay vascular aging and treat age-related vascular diseases is also discussed. ..
  7. Wang X, Xu M, Zhao G, Liu G, Hao D, Lv X, et al. Exploring CTCF and cohesin related chromatin architecture at HOXA gene cluster in primary human fibroblasts. Sci China Life Sci. 2015;58:860-6 pubmed publisher
  8. Liu G, Zhao G, Chen X, Hao D, Zhao X, Lv X, et al. The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster. Nucleic Acids Res. 2016;44:2613-27 pubmed publisher
    ..This study suggests how PRC2 is recruited to the Hoxa locus in mESCs, and implies an elaborate mechanism for Hoxa gene regulation in mESCs. ..
  9. Zhang R, Chen H, Liu D. The Four Layers of Aging. Cell Syst. 2015;1:180-6 pubmed publisher
    ..Malfunctions within each layer-and connections between them-produce the aged phenotype and its associated susceptibility to disease. ..

More Information


  1. Wang F, Chen H, Yan Y, Liu Y, Zhang S, Liu D. Baicalein protects against the development of angiotensin II-induced abdominal aortic aneurysms by blocking JNK and p38 MAPK signaling. Sci China Life Sci. 2016;59:940-9 pubmed publisher
    ..In addition, it blocks AngII cascade by downregulating angiotensin type 1 receptor (AT1R) and inhibiting mitogen-activated protein kinases (MAPKs). Taken together, our findings show that BAI is an effective agent for AAA prevention. ..
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    Xu Z, Chen F, Zhang L, Lu J, Xu P, Liu G, et al. Non-integrating lentiviral vectors based on the minimal S/MAR sequence retain transgene expression in dividing cells. Sci China Life Sci. 2016;59:1024-1033 pubmed
    ..In conclusion, the minimal S/MAR sequence retained the non-integrating lentiviral vectors in dividing cells, which indicates that SNIL vectors have the potential for use as a gene transfer tool. ..
  3. Lu J, Chen F, Xu Z, Zhang L, Xu P, Liu D, et al. Membrane immunoglobulin expressed by retroviral vector gene transfer mimics partial function of the B-cell receptor in vivo. Sci China Life Sci. 2016;59:49-58 pubmed publisher
    ..Therefore, we provide a methodology for rapidly analyzing the downstream signals of B-cell receptors both in vitro and in vivo, which could expedite the identification of proteins involved in B-cell function. ..
  4. Yan Y, Pei J, Zhang Y, Zhang R, Wang F, Gao P, et al. The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation. Arterioscler Thromb Vasc Biol. 2017;37:291-300 pubmed publisher
    ..Our findings reveal, for the first time, a protective role of the PC in AAA formation and suggest PONs as promising targets for AAA prevention. ..
  5. Lin Q, Wang D, Zhang Z, Liu D. The Applications of Viral Vector-mediated Gene Therapy in China. Hum Gene Ther. 2017;: pubmed publisher
    ..Undoubtedly, Chinese researchers have contributed to this progress. In this review, we highlight the disease applications and strategies of viral vector-mediated gene therapy in preclinical studies and clinical trials in China. ..
  6. Zhang Z, Xu J, Liu Y, Wang T, Pei J, Cheng L, et al. Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation. J Genet Genomics. 2018;45:25-32 pubmed publisher
    ..Overexpression of SIRT1 had the opposite effects. Thus, macrophage specific knockout of SIRT1 influences macrophage polarization and accelerates Ang II-induced AAA formation. ..
  7. request reprint
    Pei J, Yan Y, Tang X, Zhang Y, Cui S, Zhang Z, et al. Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice. Sci China Life Sci. 2016;59:1115-1122 pubmed
    ..Taken together, our results identify a novel anti-hypertrophic role for the PON gene cluster, suggesting a possible strategy for the treatment of cardiac hypertrophy through elevating the levels of the PON gene family. ..
  8. Li Z, Xi Y, Zhu W, Zeng C, Zhang Z, Guo Z, et al. Positive regulation of hepatic miR-122 expression by HNF4?. J Hepatol. 2011;55:602-611 pubmed publisher
    ..Using overexpression and knockdown strategies, we show that HNF4? positively regulates miR122 expression in both Huh7 cells and the mouse liver. Our results suggest that HNF4? is a key regulator of miR-122 expression in the liver. ..
  9. Zhang Y, Qu Y, Lin Y, Wu X, Chen H, Wang X, et al. Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients. Nat Commun. 2017;8:464 pubmed publisher
    ..Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation. ..
  10. Cheng L, Zhang Z, Chen H, Liu D. Epigenetic regulation in cell senescence. J Mol Med (Berl). 2017;95:1257-1268 pubmed publisher