Affiliation: Chinese Academy of Sciences
Liu Z, Cai H, Zhu H, Toque H, Zhao N, Qiu C, et al
. Protein kinase RNA-like endoplasmic reticulum kinase (PERK)/calcineurin signaling is a novel pathway regulating intracellular calcium accumulation which might be involved in ventricular arrhythmias in diabetic cardiomyopathy. Cell Signal. 2014;26:2591-600 pubmed publisher
..We concluded that PERK/calcineurin-pathway was involved in intracellular calcium regulation in myocytes in diabetic heart, which might be the mechanism inducing arrhythmias in DCM. ..
Liu Z, Zhao N, Zhu H, Zhu S, Pan S, Xu J, et al
. Circulating interleukin-1Î² promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2. Cardiovasc Diabetol. 2015;14:125 pubmed publisher
..Elevated circulating IL-1Î² contributed to promote ER stress- induced myocytes apoptosis by affecting IRAK-2/CHOP pathway in DCM. ..
Liu Z, Zhang Y, Tang Z, Xu J, Ma M, Pan S, et al
. Matrine attenuates cardiac fibrosis by affecting ATF6 signaling pathway in diabetic cardiomyopathy. Eur J Pharmacol. 2017;804:21-30 pubmed publisher
..Matrine attenuated cardiac compliance and improved left ventricular functions by exerting therapeutic effects against cardiac fibrosis via affecting ATF6 signaling pathway. ..
Liu Z, Lv Y, Zhang Y, Liu F, Zhu L, Pan S, et al
. Matrine-Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species-Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling. J Am Heart Assoc. 2017;6: pubmed publisher
..Matrine-type alkaloids exert endothelial protective effects against advanced glycation end products induced reactive oxygen species-mediated apoptosis by targeting MKK3/6 and enhancing their phosphorylation. ..