Wei-Xi Tian

Summary

Affiliation: Chinese Academy of Sciences
Country: China

Publications

  1. ncbi request reprint Inhibition of fatty acid synthase by polyphenols
    Wei Xi Tian
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing 100049, P R China
    Curr Med Chem 13:967-77. 2006
  2. ncbi request reprint Antimicrobial effect by extracts of rhizome of Alpinia officinarum Hance may relate to its inhibition of beta-ketoacyl-ACP reductase
    Hui Huang
    College of Life Sciences, Graduate University of Chinese Academy of Sciences, Beijing, P R China
    J Enzyme Inhib Med Chem 23:362-8. 2008
  3. doi request reprint A substitutive substrate for measurements of beta-ketoacyl reductases in two fatty acid synthase systems
    Ying hui Sun
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China
    J Biochem Biophys Methods 70:850-6. 2008
  4. doi request reprint Low concentration of condensed tannins from catechu significantly inhibits fatty acid synthase and growth of MCF-7 cells
    Shu yan Zhang
    College of Life Science, Graduate University of Chinese Academy of Sciences, P O Box 4588, Beijing 100049, PR China
    Biochem Biophys Res Commun 371:654-8. 2008
  5. ncbi request reprint Potent inhibition of fatty acid synthase by parasitic loranthus [Taxillus chinensis (dc.) danser] and its constituent avicularin
    Yan Wang
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing 100049, China
    J Enzyme Inhib Med Chem 21:87-93. 2006
  6. ncbi request reprint Inactivation mechanism of the beta-ketoacyl-[acyl carrier protein] reductase of bacterial type-II fatty acid synthase by epigallocatechin gallate
    Bing Hui Li
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing 100049, P R China
    Biochem Cell Biol 84:755-62. 2006
  7. ncbi request reprint Inhibitory activity of chlorogenic acid on enzymes involved in the fatty acid synthesis in animals and bacteria
    Bing Hui Li
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing, PR China
    IUBMB Life 58:39-46. 2006
  8. ncbi request reprint Evaluation of the inhibitory activities of aceraceous plants on fatty acid synthase
    Wen hua Zhao
    Department of Chemical Biology, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
    J Enzyme Inhib Med Chem 22:501-10. 2007
  9. ncbi request reprint The extract of leaves of Acer truncatum Bunge: A natural inhibitor of fatty acid synthase with antitumor activity
    Wen hua Zhao
    Department of Chemical Biology, Capital University of Medical Sciences, Beijing 100069, China
    J Enzyme Inhib Med Chem 21:589-96. 2006
  10. ncbi request reprint The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase
    Xuan Wang
    Department of Biology, Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China
    Biochem Pharmacol 66:2039-47. 2003

Collaborators

  • Hui Huang
  • Yan Wang
  • Rui Zhang
  • Bing Hui Li
  • Wen hua Zhao
  • Xuan Wang
  • Ying hui Sun
  • Xiao Dong Wu
  • Ya Tao Du
  • Shu yan Zhang
  • Ying xia Zhang
  • Fan Wang
  • Chao Gu Zheng
  • Qing Cheng
  • Xi Yun Yan
  • ChunChun Gao
  • Xiao feng Ma
  • - Zhe-Wang
  • Jin Feng Zhang
  • Hai Meng Zhou
  • Ke Sheng Song
  • Qing Xiang Guo
  • Yu Liu

Detail Information

Publications14

  1. ncbi request reprint Inhibition of fatty acid synthase by polyphenols
    Wei Xi Tian
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing 100049, P R China
    Curr Med Chem 13:967-77. 2006
    ..Their IC(50) values range from 5 microM to 40 microM. From these results, a common model for polyphenol inhibitor of FAS is conceived...
  2. ncbi request reprint Antimicrobial effect by extracts of rhizome of Alpinia officinarum Hance may relate to its inhibition of beta-ketoacyl-ACP reductase
    Hui Huang
    College of Life Sciences, Graduate University of Chinese Academy of Sciences, Beijing, P R China
    J Enzyme Inhib Med Chem 23:362-8. 2008
    ..The irreversible inhibition presented two phases. It is probable that the galangal extract inhibit FabG, thereby displaying antibacterial ability...
  3. doi request reprint A substitutive substrate for measurements of beta-ketoacyl reductases in two fatty acid synthase systems
    Ying hui Sun
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China
    J Biochem Biophys Methods 70:850-6. 2008
    ..The corresponding Km and kcat values of FAS were 126 mM and 4.63 s(-1) for EAA; 8.7 microM and 4.09 s(-1) for NADPH. Additionally, the inhibitory kinetics of FabG and FAS, by a known inhibitor EGCG, was also studied...
  4. doi request reprint Low concentration of condensed tannins from catechu significantly inhibits fatty acid synthase and growth of MCF-7 cells
    Shu yan Zhang
    College of Life Science, Graduate University of Chinese Academy of Sciences, P O Box 4588, Beijing 100049, PR China
    Biochem Biophys Res Commun 371:654-8. 2008
    ..The inhibition of both FAS activity and MCF-7 growth was exhibited by low concentrations of condensed tannins without FAS being precipitated. These results suggest tannins would be a valuable resource of bioactive substances...
  5. ncbi request reprint Potent inhibition of fatty acid synthase by parasitic loranthus [Taxillus chinensis (dc.) danser] and its constituent avicularin
    Yan Wang
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing 100049, China
    J Enzyme Inhib Med Chem 21:87-93. 2006
    ..In addition, we have found that avicularin existing in this herb can potently inhibit FAS. This glycosylated flavonoid and quercetin play an effective role in inhibiting FAS by parasitic loranthus...
  6. ncbi request reprint Inactivation mechanism of the beta-ketoacyl-[acyl carrier protein] reductase of bacterial type-II fatty acid synthase by epigallocatechin gallate
    Bing Hui Li
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing 100049, P R China
    Biochem Cell Biol 84:755-62. 2006
    ..Based on the results, we propose a mechanism for the interaction of EGCG with FabG:EGCG first binds reversibly to each subunit of FabG, followed by covalent modification and then aggregation of the 4 EGCG-modified subunits...
  7. ncbi request reprint Inhibitory activity of chlorogenic acid on enzymes involved in the fatty acid synthesis in animals and bacteria
    Bing Hui Li
    Department of Biology, Graduate University of Chinese Academy of Sciences, Beijing, PR China
    IUBMB Life 58:39-46. 2006
    ....
  8. ncbi request reprint Evaluation of the inhibitory activities of aceraceous plants on fatty acid synthase
    Wen hua Zhao
    Department of Chemical Biology, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
    J Enzyme Inhib Med Chem 22:501-10. 2007
    ..6), which may be related to the inhibition of lipogenesis in these cells...
  9. ncbi request reprint The extract of leaves of Acer truncatum Bunge: A natural inhibitor of fatty acid synthase with antitumor activity
    Wen hua Zhao
    Department of Chemical Biology, Capital University of Medical Sciences, Beijing 100069, China
    J Enzyme Inhib Med Chem 21:589-96. 2006
    ..2). It was infered that the inhibitory activity is likely attributable to the co-operative effect of the components...
  10. ncbi request reprint The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase
    Xuan Wang
    Department of Biology, Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China
    Biochem Pharmacol 66:2039-47. 2003
    ..Here we identify the galloyl moiety of green tea catechins as critical in the inactivation of the ketoacyl reductase activity of FAS for the first time...
  11. ncbi request reprint Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance
    Bing Hui Li
    Department of Biology, Graduate School of Chinese Academy of Sciences, PO Box 3908, Beijing 100039, People s Republic of China
    J Enzyme Inhib Med Chem 18:349-56. 2003
    ..Analysis of the kinetic results led to the conclusion that the inhibitory mechanism of GE is totally different from that of some other previously reported inhibitors of FAS, such as cerulenin, EGCG (epigallocatechin gallate) and C75...
  12. ncbi request reprint Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration
    Ya Tao Du
    Department of Biology, Graduate School of Chinese Academy of Sciences, Beijing, People s Republic China
    J Enzyme Inhib Med Chem 20:349-56. 2005
    ..In addition, Keemun black tea extract significantly reduced food intake, body weight and blood triglyceride of diet-induced obesity SD rats via oral administration...
  13. ncbi request reprint Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase
    Wei Xi Tian
    Department of Biology, The Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China
    Life Sci 74:2389-99. 2004
    ..These results indicate that many of weight reducing herbs used in TCM do so by inhibiting FAS. They also hold promise for the development of new nontoxic and low cost weight reducing substances from these herbs...
  14. ncbi request reprint Inhibitive effect of zinc ion on fatty acid synthase from chicken liver
    Fan Wang
    Department of Biological Sciences and Biotechnology, University of Tsinghua, Beijing 100084, PR China
    Int J Biochem Cell Biol 35:391-400. 2003
    ..This suggests that the phosphopantetheine SH group is the critical group in the cross-link and inhibition of FAS in the presence of Zn(2+)...