Affiliation: Chinese Academy of Sciences
Li L, Li Y, Zhao D, Jin M, Ni H. Leptin-regulated autophagy plays a role in long-term neurobehavioral injury after neonatal seizures and the regulation of zinc/cPLA2 and CaMK II signaling in cerebral cortex. Epilepsy Res. 2018;146:103-111 pubmed publisher
..Autophagy-mediated Zn/cPLA2 and CaMK II signaling in the cerebral cortex may be involved in the neuroprotective effect of leptin. Our results provide new clues for anti-epileptogenetic treatment. ..
Ni H, Sun Q, Tian T, Feng X, Sun B. Prophylactic treatment with melatonin before recurrent neonatal seizures: Effects on long-term neurobehavioral changes and the underlying expression of metabolism-related genes in rat hippocampus and cerebral cortex. Pharmacol Biochem Behav. 2015;133:25-30 pubmed publisher
..Our findings provide support for ACAT-1/Cathepsin-E as well as CaMK II being potential targets for the treatment of neonatal seizure-induced brain damage by melatonin. ..
Ni H, Chen S, Li L, Jin M. Alterations in the Neurobehavioral Phenotype and ZnT3/CB-D28k Expression in the Cerebral Cortex Following Lithium-Pilocarpine-Induced Status Epilepticus: the Ameliorative Effect of Leptin. Biol Trace Elem Res. 2018;: pubmed publisher
..Moreover, consecutive leptin treatment is effect at counteracting these hyperexcitability-related changes, suggesting a potential clinical significance. ..
Ni H, Chen S, Li L, Jin M. Leptin treatment prevents long-term abnormalities in cognition, seizure threshold, hippocampal mossy fiber sprouting and ZnT3/CB-D28k expression in a rat developmental "twist" seizure model. Epilepsy Res. 2018;139:164-170 pubmed publisher
..These novel findings established that leptin has a neuroprotective role in the model of cholinergic neonatal SE and highlights ZnT3/CB-D28k associated-Zn (2+)/Ca (2+) signaling as a promising therapeutic target. ..
Ni H, Li C, Tao L, Cen J. Physical exercise improves learning by modulating hippocampal mossy fiber sprouting and related gene expression in a developmental rat model of penicillin-induced recurrent epilepticus. Toxicol Lett. 2009;191:26-32 pubmed publisher
..These results showed that physical exercise improved learning capacity by modulating hippocampal regenerative sprouting and related gene expression in a developmental rat model of penicillin-induced recurrent epilepticus. ..
Ni H, Feng X, Xiao Z, Tao L, Jin M. Dynamic pattern of gene expression of ZnT-4, caspase-3, LC3, and PRG-3 in rat cerebral cortex following flurothyl-induced recurrent neonatal seizures. Biol Trace Elem Res. 2011;143:1607-15 pubmed publisher
..The results suggest that the disturbed expression pattern of the four genes might play a role in the pathophysiology of recurrent neonatal seizure-induced acute and long-term brain damage. ..
Ni H, Jiang Y, Tao L, Jin M, Wu X. ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats. Toxicol Lett. 2009;184:145-50 pubmed publisher
..Our results suggest that the long-term adverse effects of recurrent neonatal seizures on cognition and mossy fiber sprouting may be associated with the down-regulated expression of ZnT-1 and CaMK II in hippocampus. ..
Ni H, Feng X, Gong Y, Tao L, Wu X. Acute phase expression pattern of ZnTs, LC3, and beclin-1 in rat Hippocampus and its regulation by 3-methyladenine following recurrent neonatal seizures. Biol Trace Elem Res. 2011;143:320-31 pubmed publisher
Ni H, Zhao D, Tian T. Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures. Epilepsy Res. 2016;120:13-8 pubmed publisher