Ze Guang Han

Summary

Affiliation: Chinese National Human Genome Center at Shanghai
Country: China

Publications

  1. doi request reprint Schistosoma genomics: new perspectives on schistosome biology and host-parasite interaction
    Ze Guang Han
    Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 201203, China
    Annu Rev Genomics Hum Genet 10:211-40. 2009
  2. doi request reprint DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma
    Xiao Xu
    National Human Genome Center of Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Mol Cancer Ther 11:629-38. 2012
  3. pmc Identification of candidate genes for human pituitary development by EST analysis
    Yueyun Ma
    Center for Clinical Laboratory Medicine of PLA, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    BMC Genomics 10:109. 2009
  4. doi request reprint Recent progress in genomic [corrected] research of liver cancer
    Zeguang Han
    Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China
    Sci China C Life Sci 52:24-30. 2009
  5. ncbi request reprint A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma
    Zhi Gang Xu
    Chinese National Human Genome Center at Shanghai, Shanghai, China
    Hepatology 38:735-44. 2003
  6. ncbi request reprint A novel recently evolved gene C19orf24 encodes a non-classical secreted protein
    Xin rong Wang
    School of Life Science and Technology, Shanghai Jiao Tong University, Shanghai, China
    Cell Mol Biol Lett 11:161-70. 2006
  7. ncbi request reprint hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma
    Yu bo Zhou
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Biochem Biophys Res Commun 355:679-86. 2007
  8. ncbi request reprint Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein
    Feng Liu
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, PR China
    Gene 315:71-8. 2003
  9. ncbi request reprint Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma
    Jian Huang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Carcinogenesis 28:1094-103. 2007
  10. pmc Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling
    Jian Huang
    National Human Genome Center, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 351 Guo Shou Jing Road, Shanghai, People s Republic of China
    J Clin Invest 120:223-41. 2010

Collaborators

Detail Information

Publications36

  1. doi request reprint Schistosoma genomics: new perspectives on schistosome biology and host-parasite interaction
    Ze Guang Han
    Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 201203, China
    Annu Rev Genomics Hum Genet 10:211-40. 2009
    ..Importantly, these functional genomics analyses lay a foundation on which to develop new antischistosome vaccines as well as drug targets and diagnostic markers for treatment and control of schistosomiasis...
  2. doi request reprint DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma
    Xiao Xu
    National Human Genome Center of Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Mol Cancer Ther 11:629-38. 2012
    ....
  3. pmc Identification of candidate genes for human pituitary development by EST analysis
    Yueyun Ma
    Center for Clinical Laboratory Medicine of PLA, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    BMC Genomics 10:109. 2009
    ....
  4. doi request reprint Recent progress in genomic [corrected] research of liver cancer
    Zeguang Han
    Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China
    Sci China C Life Sci 52:24-30. 2009
    ..Besides, identification of genetic susceptible against risk of liver malignancy is also an important aspect of research in this field...
  5. ncbi request reprint A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma
    Zhi Gang Xu
    Chinese National Human Genome Center at Shanghai, Shanghai, China
    Hepatology 38:735-44. 2003
    ..In conclusion, these data suggest that LZP is a liver-specific protein involved possibly in hepatocellular function and development, and the protein could be used as potential negative biomarker for HCC pathologic diagnosis...
  6. ncbi request reprint A novel recently evolved gene C19orf24 encodes a non-classical secreted protein
    Xin rong Wang
    School of Life Science and Technology, Shanghai Jiao Tong University, Shanghai, China
    Cell Mol Biol Lett 11:161-70. 2006
    ....
  7. ncbi request reprint hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma
    Yu bo Zhou
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Biochem Biophys Res Commun 355:679-86. 2007
    ..However, the tunicamicin treatment and pulse-chase experiments showed that hZG16 protein had a similar molecular function with rZG16 that take part in glycoproteins' secretion in a bus mode...
  8. ncbi request reprint Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein
    Feng Liu
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, PR China
    Gene 315:71-8. 2003
    ..6 kb band and extra 1.2 kb band in placenta. Subcellular localization and immunoblotting assays indicated that hTLP19 might be secreted out of cell through trans-Golgi network (TGN)...
  9. ncbi request reprint Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma
    Jian Huang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Carcinogenesis 28:1094-103. 2007
    ..These data suggest that DLK1 as an imprinted gene could be significantly up-regulated in HCC due to certain epigenetic events and contribute to the oncogenesis of this tumor...
  10. pmc Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling
    Jian Huang
    National Human Genome Center, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 351 Guo Shou Jing Road, Shanghai, People s Republic of China
    J Clin Invest 120:223-41. 2010
    ..Taken together, these data suggest that the plasma membrane protein SCARA5 can contribute to HCC tumorigenesis and metastasis via activation of the FAK signaling pathway...
  11. ncbi request reprint Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein
    Zhi Gang Xu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 220 Han Dan Road, Shanghai, 200433, China
    DNA Seq 15:81-7. 2004
    ..Mouse LZP mRNA is expressed specifically in hepatocytes. Our data also showed that mouse LZP localizes mostly on nuclear envelope, and at the same time, it can be secreted into blood in a truncated form...
  12. doi request reprint E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation
    Qing Deng
    National Human Genome Center, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201203, China
    Cancer Res 70:782-91. 2010
    ..Together, our findings suggest that E2F8 contributes to the oncogenic potential of HCC and may constitute a potential therapeutic target in this disease...
  13. doi request reprint Hepatic stellate cells modulate the differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cells
    Xing Deng
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
    J Cell Physiol 217:138-44. 2008
    ..Moreover, Kupffer cell activated HSCs rather than culture activated HSCs expressed hepatocyte growth factor mRNA. We draw the conclusion that fully activated HSCs could modulate MSCs differentiation into hepatocyte-like cells...
  14. pmc Discovering multiple transcripts of human hepatocytes using massively parallel signature sequencing (MPSS)
    Jian Huang
    Department of Chemistry of Fudan University and Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
    BMC Genomics 8:207. 2007
    ..To discover the molecular basis of hepatocyte function, we employed Massively Parallel Signature Sequencing (MPSS) to determine the transcriptomic profile of adult human hepatocytes obtained by laser capture microdissection (LCM)...
  15. doi request reprint hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro
    Bingbing Wan
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University and Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    FEBS Lett 582:3185-92. 2008
    ..Our data also revealed that hOLFML1 is N-glycosylated and its secretion is triggered by serum. Taken together, these findings suggest that hOLFML1 may play a significant role in the regulation of cell proliferation in vitro...
  16. doi request reprint RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells
    Yinghui Fu
    National Human Genome Centre of Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, 200025, Shanghai, China
    Mol Biol Rep 38:693-702. 2011
    ..The data indicated that adenovirus-mediated RNA interference can suppress tumourigenicity in vivo of HCC cells. Our data suggest that CITRON may be a potential target for therapeutic intervention in HCC...
  17. pmc Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination
    Ke Sheng Wang
    Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
    PLoS ONE 6:e23571. 2011
    ..These data suggest that IRTKS is a novel regulator of p53, modulating low level of MDM2-mediated p53 ubiquitination in unstressed cells...
  18. ncbi request reprint Transcriptome study in China
    Ze Guang Han
    Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Zhanjiang High Tech Park, Pudong, Shanghai 201203, China
    C R Biol 326:949-57. 2003
    ..In addition, EST sequencing for model organisms, including rat, zebrafish, Schistosoma japonicum and rice was performed, aiming at identifying genes associated with physiological and/or pathological characteristics...
  19. ncbi request reprint Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource
    Wei Hu
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Nat Genet 35:139-47. 2003
    ....
  20. pmc Genome-wide identification of Schistosoma japonicum microRNAs using a deep-sequencing approach
    Jian Huang
    Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
    PLoS ONE 4:e8206. 2009
    ..Genome-wide identification of miRNAs in a given organism is a critical step to facilitating our understanding of genome organization, genome biology, evolution, and posttranscriptional regulation...
  21. ncbi request reprint Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesis
    Hui Qiang
    Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, Shanghai, China
    Liver Int 26:1126-37. 2006
    ..To analyze the gene expression pattern in rat hepatic fibrogenesis and further assess the role of some key genes during the pathological process...
  22. ncbi request reprint [Molecular cloning and characterization of hMGRAP, a human secreted protein with multiple glutamine repeat]
    Hong Zhu
    East China University of Science and Technology Shanghai 200237, China
    Yi Chuan 27:7-13. 2005
    ..In summary, a novel human gene encoding a secreted protein hMGRAP has been screened and cloned, and its biological function may specifically relate to its repeated glutamic acid sequence...
  23. doi request reprint ARHI, as a novel suppressor of cell growth and downregulated in human hepatocellular carcinoma, could contribute to hepatocarcinogenesis
    Jian Huang
    Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Chinese National Human Genome Center at Shanghai, Shanghai, China
    Mol Carcinog 48:130-40. 2009
    ..Our current observations provide evidences that ARHI downregulated in HCCs could play a role in liver cancer via acting as a tumor suppressor gene, which mainly was triggered by the epigenetic events in HCC specimens...
  24. ncbi request reprint cDNA microarray reveals signaling pathways involved in hormones expression of human pituitary
    Yue Yun Ma
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Gen Comp Endocrinol 143:184-92. 2005
    ....
  25. pmc SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum
    Feng Liu
    Shanghai MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, PR China
    BMC Genomics 9:304. 2008
    ..japonicum, to enable more efficient access and utility of these data and to facilitate the study of schistosome biology, physiology and evolution...
  26. pmc Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation
    Xin Zhang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center, Shanghai 201203, China
    Proc Natl Acad Sci U S A 104:9517-22. 2007
    ..This inhibitory effect was reversed by blocking p38 and ERK MAPK. These data provide evidence for the role of ING4 in mediating the effect of low K intake on ROMK channel activity by stimulation of p38 and ERK MAPK...
  27. pmc Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma
    Jian Huang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
    BMC Cancer 7:126. 2007
    ..However, whether the down-regulation of SFRP1 can contribute to hepatocarcinogenesis still remains unclear...
  28. doi request reprint The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin function
    Zhi Qin Wang
    Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center, Shanghai, China
    J Immunol 183:6646-56. 2009
    ....
  29. pmc Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum
    Feng Liu
    double daggerShanghai Ministry of Science and Technology Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Mol Cell Proteomics 8:1236-51. 2009
    ..japonicum ES proteins, provides an insight into host-parasite interactions, and establishes a resource for the development of diagnostic agents and vaccines for the control of schistosomiasis...
  30. ncbi request reprint Correlation between genomic DNA copy number alterations and transcriptional expression in hepatitis B virus-associated hepatocellular carcinoma
    Jian Huang
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    FEBS Lett 580:3571-81. 2006
    ....
  31. pmc New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum
    Feng Liu
    Chinese National Human Genome Center, Shanghai, China
    PLoS Pathog 2:e29. 2006
    ....
  32. doi request reprint hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence
    Yu bo Zhou
    Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai, 201203, China
    Mol Cell Biochem 317:61-8. 2008
    ..Our data provided a basis for functional studies of BolA protein family...
  33. doi request reprint Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling
    Hua Xiong
    Department of Gastroenterology, Shanghai Jiao Tong University School of Medicine Ren Ji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
    J Cell Mol Med 13:3668-79. 2009
    ....
  34. doi request reprint Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene
    Chuan Yin
    Department of Gastroenterology, Changzheng Hospital, Shanghai, China
    Hepatology 48:1528-39. 2008
    ....
  35. doi request reprint Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules
    Hai Lian Shen
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center, Shanghai, China
    Mol Cell Biochem 321:73-83. 2009
    ..The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens...
  36. doi request reprint mTOR signaling pathway is a target for the treatment of colorectal cancer
    Yan Jie Zhang
    Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai, China
    Ann Surg Oncol 16:2617-28. 2009
    ..Herein, the purpose of this study was to analyze the distribution pattern of mTOR signaling components in CRC and adenoma and to determine whether targeted inhibition of mTOR could be a potential therapeutic strategy for CRC...