Research Topics
Genomes and Genes
| Ze Guang HanSummaryAffiliation: Chinese National Human Genome Center at Shanghai Country: China Publications
| Collaborators
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Detail Information
Publications
DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinomaXiao Xu
National Human Genome Center of Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Mol Cancer Ther 11:629-38. 2012....
Identification of candidate genes for human pituitary development by EST analysisYueyun Ma
Center for Clinical Laboratory Medicine of PLA, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
BMC Genomics 10:109. 2009....- Schistosoma genomics: new perspectives on schistosome biology and host-parasite interactionZe Guang Han
Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 201203, China
Annu Rev Genomics Hum Genet 10:211-40. 2009..Importantly, these functional genomics analyses lay a foundation on which to develop new antischistosome vaccines as well as drug targets and diagnostic markers for treatment and control of schistosomiasis... - Recent progress in genomic [corrected] research of liver cancerZeguang Han
Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China
Sci China C Life Sci 52:24-30. 2009..Besides, identification of genetic susceptible against risk of liver malignancy is also an important aspect of research in this field... 
A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinomaZhi Gang Xu
Chinese National Human Genome Center at Shanghai, Shanghai, China
Hepatology 38:735-44. 2003..In conclusion, these data suggest that LZP is a liver-specific protein involved possibly in hepatocellular function and development, and the protein could be used as potential negative biomarker for HCC pathologic diagnosis...- hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinomaYu bo Zhou
Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
Biochem Biophys Res Commun 355:679-86. 2007..However, the tunicamicin treatment and pulse-chase experiments showed that hZG16 protein had a similar molecular function with rZG16 that take part in glycoproteins' secretion in a bus mode... - A novel recently evolved gene C19orf24 encodes a non-classical secreted proteinXin rong Wang
School of Life Science and Technology, Shanghai Jiao Tong University, Shanghai, China
Cell Mol Biol Lett 11:161-70. 2006.... - Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory proteinFeng Liu
Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, PR China
Gene 315:71-8. 2003..6 kb band and extra 1.2 kb band in placenta. Subcellular localization and immunoblotting assays indicated that hTLP19 might be secreted out of cell through trans-Golgi network (TGN)... - Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinomaJian Huang
Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
Carcinogenesis 28:1094-103. 2007..These data suggest that DLK1 as an imprinted gene could be significantly up-regulated in HCC due to certain epigenetic events and contribute to the oncogenesis of this tumor... - Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signalingJian Huang
National Human Genome Center, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, 351 Guo Shou Jing Road, Shanghai, People s Republic of China
J Clin Invest 120:223-41. 2010..Taken together, these data suggest that the plasma membrane protein SCARA5 can contribute to HCC tumorigenesis and metastasis via activation of the FAK signaling pathway... - E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferationQing Deng
National Human Genome Center, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201203, China
Cancer Res 70:782-91. 2010..Together, our findings suggest that E2F8 contributes to the oncogenic potential of HCC and may constitute a potential therapeutic target in this disease... - Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory proteinZhi Gang Xu
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 220 Han Dan Road, Shanghai, 200433, China
DNA Seq 15:81-7. 2004..Mouse LZP mRNA is expressed specifically in hepatocytes. Our data also showed that mouse LZP localizes mostly on nuclear envelope, and at the same time, it can be secreted into blood in a truncated form... - Hepatic stellate cells modulate the differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cellsXing Deng
Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China
J Cell Physiol 217:138-44. 2008..Moreover, Kupffer cell activated HSCs rather than culture activated HSCs expressed hepatocyte growth factor mRNA. We draw the conclusion that fully activated HSCs could modulate MSCs differentiation into hepatocyte-like cells... - RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cellsYinghui Fu
National Human Genome Centre of Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, 200025, Shanghai, China
Mol Biol Rep 38:693-702. 2011..The data indicated that adenovirus-mediated RNA interference can suppress tumourigenicity in vivo of HCC cells. Our data suggest that CITRON may be a potential target for therapeutic intervention in HCC... - hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitroBingbing Wan
State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University and Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
FEBS Lett 582:3185-92. 2008..Our data also revealed that hOLFML1 is N-glycosylated and its secretion is triggered by serum. Taken together, these findings suggest that hOLFML1 may play a significant role in the regulation of cell proliferation in vitro... - Discovering multiple transcripts of human hepatocytes using massively parallel signature sequencing (MPSS)Jian Huang
Department of Chemistry of Fudan University and Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
BMC Genomics 8:207. 2007..To discover the molecular basis of hepatocyte function, we employed Massively Parallel Signature Sequencing (MPSS) to determine the transcriptomic profile of adult human hepatocytes obtained by laser capture microdissection (LCM)... - Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitinationKe Sheng Wang
Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
PLoS ONE 6:e23571. 2011..These data suggest that IRTKS is a novel regulator of p53, modulating low level of MDM2-mediated p53 ubiquitination in unstressed cells... - Genome-wide identification of Schistosoma japonicum microRNAs using a deep-sequencing approachJian Huang
Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
PLoS ONE 4:e8206. 2009..Genome-wide identification of miRNAs in a given organism is a critical step to facilitating our understanding of genome organization, genome biology, evolution, and posttranscriptional regulation... - [Molecular cloning and characterization of hMGRAP, a human secreted protein with multiple glutamine repeat]Hong Zhu
East China University of Science and Technology Shanghai 200237, China
Yi Chuan 27:7-13. 2005..In summary, a novel human gene encoding a secreted protein hMGRAP has been screened and cloned, and its biological function may specifically relate to its repeated glutamic acid sequence... - ARHI, as a novel suppressor of cell growth and downregulated in human hepatocellular carcinoma, could contribute to hepatocarcinogenesisJian Huang
Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Chinese National Human Genome Center at Shanghai, Shanghai, China
Mol Carcinog 48:130-40. 2009..Our current observations provide evidences that ARHI downregulated in HCCs could play a role in liver cancer via acting as a tumor suppressor gene, which mainly was triggered by the epigenetic events in HCC specimens... - Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulationXin Zhang
Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center, Shanghai 201203, China
Proc Natl Acad Sci U S A 104:9517-22. 2007..This inhibitory effect was reversed by blocking p38 and ERK MAPK. These data provide evidence for the role of ING4 in mediating the effect of low K intake on ROMK channel activity by stimulation of p38 and ERK MAPK... - Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinomaJian Huang
Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
BMC Cancer 7:126. 2007..However, whether the down-regulation of SFRP1 can contribute to hepatocarcinogenesis still remains unclear... - SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicumFeng Liu
Shanghai MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, PR China
BMC Genomics 9:304. 2008..japonicum, to enable more efficient access and utility of these data and to facilitate the study of schistosome biology, physiology and evolution... - The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin functionZhi Qin Wang
Shanghai MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center, Shanghai, China
J Immunol 183:6646-56. 2009.... - Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicumFeng Liu
double daggerShanghai Ministry of Science and Technology Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
Mol Cell Proteomics 8:1236-51. 2009..japonicum ES proteins, provides an insight into host-parasite interactions, and establishes a resource for the development of diagnostic agents and vaccines for the control of schistosomiasis... - Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha geneChuan Yin
Department of Gastroenterology, Changzheng Hospital, Shanghai, China
Hepatology 48:1528-39. 2008..Our study also implies that differentiation therapy may present as one of the best strategies for cancer treatment through the induction of cell differentiation by key transcription factors... - hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergenceYu bo Zhou
Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai, 201203, China
Mol Cell Biochem 317:61-8. 2008..Our data provided a basis for functional studies of BolA protein family... - Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signallingHua Xiong
Department of Gastroenterology, Shanghai Jiao Tong University School of Medicine Ren Ji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
J Cell Mol Med 13:3668-79. 2009.... - Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubulesHai Lian Shen
Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center, Shanghai, China
Mol Cell Biochem 321:73-83. 2009..The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens... - mTOR signaling pathway is a target for the treatment of colorectal cancerYan Jie Zhang
Shanghai Institute of Digestive Disease, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai, China
Ann Surg Oncol 16:2617-28. 2009..Herein, the purpose of this study was to analyze the distribution pattern of mTOR signaling components in CRC and adenoma and to determine whether targeted inhibition of mTOR could be a potential therapeutic strategy for CRC...