Chunying Chen

Summary

Affiliation: Chinese Academy of Sciences
Country: China

Publications

  1. pmc The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure
    Chunying Chen
    Laboratory of Nuclear Analytical Techniques and Laboratory for Nanoscale Materials and Related Bio Environmental Sciences, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People s Republic of China
    Environ Health Perspect 114:297-301. 2006
  2. ncbi request reprint Modulation of oxidative stress by functionalized fullerene materials in the lung tissues of female C57/BL mice with a metastatic Lewis lung carcinoma
    Fang Jiao
    CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety NCNST IHEP, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    J Nanosci Nanotechnol 10:8632-7. 2010
  3. ncbi request reprint Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice
    Jiangxue Wang
    Lab for Bio Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, P O Box 918, Beijing 100049, PR China
    Biochem Pharmacol 71:872-81. 2006
  4. doi request reprint Organic selenium supplementation increases mercury excretion and decreases oxidative damage in long-term mercury-exposed residents from Wanshan, China
    Yu Feng Li
    Multidiscipline Initiative Center and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Environ Sci Technol 46:11313-8. 2012
  5. ncbi request reprint Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in mice
    Yang Liu
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China
    J Nanosci Nanotechnol 9:6335-43. 2009
  6. doi request reprint Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO(2) nanoparticles
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China
    Toxicology 254:82-90. 2008
  7. doi request reprint Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger
    Jun Jie Yin
    Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, 11, First North Rd, Zhongguancun, Beijing, People s Republic of China, 100190
    Mol Pharmacol 74:1132-40. 2008
  8. doi request reprint Detection of mercury-, arsenic-, and selenium-containing proteins in fish liver from a mercury polluted area of Guizhou Province, China
    Lina Li
    Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
    J Toxicol Environ Health A 71:1266-9. 2008
  9. ncbi request reprint Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles
    Huan Meng
    Lab for Bio Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Toxicol Lett 175:102-10. 2007
  10. doi request reprint Potent angiogenesis inhibition by the particulate form of fullerene derivatives
    Huan Meng
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    ACS Nano 4:2773-83. 2010

Collaborators

Detail Information

Publications32

  1. pmc The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposure
    Chunying Chen
    Laboratory of Nuclear Analytical Techniques and Laboratory for Nanoscale Materials and Related Bio Environmental Sciences, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People s Republic of China
    Environ Health Perspect 114:297-301. 2006
    ..First, they may bind more Hg through their highly reactive selenol group, and second, their antioxidative properties help eliminate the reactive oxygen species induced by Hg in vivo...
  2. ncbi request reprint Modulation of oxidative stress by functionalized fullerene materials in the lung tissues of female C57/BL mice with a metastatic Lewis lung carcinoma
    Fang Jiao
    CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety NCNST IHEP, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    J Nanosci Nanotechnol 10:8632-7. 2010
    ....
  3. ncbi request reprint Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice
    Jiangxue Wang
    Lab for Bio Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, P O Box 918, Beijing 100049, PR China
    Biochem Pharmacol 71:872-81. 2006
    ..The results suggest that [Gd@C82(OH)22]n nanoparticle treatment could regulate ROS production in vivo...
  4. doi request reprint Organic selenium supplementation increases mercury excretion and decreases oxidative damage in long-term mercury-exposed residents from Wanshan, China
    Yu Feng Li
    Multidiscipline Initiative Center and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Environ Sci Technol 46:11313-8. 2012
    ..This 3-month selenium supplementation trial indicated that organic selenium supplementation could increase mercury excretion and decrease urinary malondialdehyde and 8-hydroxy-2-deoxyguanosine levels in local residents...
  5. ncbi request reprint Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in mice
    Yang Liu
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China
    J Nanosci Nanotechnol 9:6335-43. 2009
    ..The present results are helpful to get better understanding of the risk assessment and evaluation for copper nanoparticles...
  6. doi request reprint Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO(2) nanoparticles
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China
    Toxicology 254:82-90. 2008
    ..Although understanding the mechanisms requires further investigation, the present results suggest that we should pay attention to potential risk of occupational exposure for large-scaled production of TiO(2) nanoparticles...
  7. doi request reprint Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger
    Jun Jie Yin
    Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, 11, First North Rd, Zhongguancun, Beijing, People s Republic of China, 100190
    Mol Pharmacol 74:1132-40. 2008
    ....
  8. doi request reprint Detection of mercury-, arsenic-, and selenium-containing proteins in fish liver from a mercury polluted area of Guizhou Province, China
    Lina Li
    Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
    J Toxicol Environ Health A 71:1266-9. 2008
    ..The bands may be corresponding to the antagonistic effect of Se against the toxicity of Hg and As. In addition, Hg and As often coexist in the same band, suggesting that the two elements may be involved in the same metabolic processes...
  9. ncbi request reprint Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles
    Huan Meng
    Lab for Bio Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Toxicol Lett 175:102-10. 2007
    ..The nano-copper particles may not compromise the mice directly, however, they lead to the accumulation of excessive alkalescent substance and heavy metal ions (copper ions) culminating the metabolic alkalosis and copper ion overload...
  10. doi request reprint Potent angiogenesis inhibition by the particulate form of fullerene derivatives
    Huan Meng
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    ACS Nano 4:2773-83. 2010
    ..We propose that using nanoscale "particulate" itself as a new form of medicine (particulate medicine) may be superior to the traditional "molecular" form of medicine (molecular medicine) in cancer treatment...
  11. doi request reprint Potential neurological lesion after nasal instillation of TiO(2) nanoparticles in the anatase and rutile crystal phases
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China
    Toxicol Lett 183:72-80. 2008
    ....
  12. ncbi request reprint Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2'-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury
    Chunying Chen
    Key Laboratory of Nuclear Analytical Techniques and Laboratory for Nanoscale Materials and Related Bio Environmental Sciences, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, Peoples Republic of China
    Clin Chem 51:759-67. 2005
    ....
  13. doi request reprint Selenium inhibits the phytotoxicity of mercury in garlic (Allium sativum)
    Jiating Zhao
    CAS Key Laboratory of Nuclear Analytical Techniques, Key Lab for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Environ Res 125:75-81. 2013
    ..Se exposure elicited decrease of Hg-S bonding in the form of Hg(GSH)2, together with Se-mediated alteration of Hg absorption, transportation and accumulation, may account for attenuated Hg phytotoxicity by Se in garlic. ..
  14. doi request reprint Mercury in human hair and blood samples from people living in Wanshan mercury mine area, Guizhou, China: an XAS study
    Yu Feng Li
    Key Laboratory of Nuclear Analytical Techniques, Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    J Inorg Biochem 102:500-6. 2008
    ..228+/-0.002 nm and 4.08 in serum, respectively. The techniques for speciation, structural and binding information described in this study will find the potential application in similar studies of other elements...
  15. doi request reprint Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes
    Cuicui Ge
    CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, P R China
    Nanotoxicology 6:526-42. 2012
    ..The co-existence of metal residues in SWCNTs can aggravate the adverse effects...
  16. ncbi request reprint [Preliminary study on cellular status of selenium and oxidative stress in human hepatocellular carcinoma and normal liver]
    Chunying Chen
    Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039, China
    Wei Sheng Yan Jiu 33:543-6. 2004
    ..These findings suggested the antioxidative defense-related enzymes and antioxidant were largely regulated in hepatoma cells, whereas the cause is not clear and requires further studies...
  17. ncbi request reprint Scalp hair as a biomarker in environmental and occupational mercury exposed populations: suitable or not?
    Yu Feng Li
    Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Environ Res 107:39-44. 2008
    ..However, hair still can be used as an indicator for methyl mercury exposure because, generally, there is almost no exogenous contamination of methyl mercury in hair...
  18. pmc Binding of blood proteins to carbon nanotubes reduces cytotoxicity
    Cuicui Ge
    Chinese Academy of Sciences Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, China
    Proc Natl Acad Sci U S A 108:16968-73. 2011
    ..These findings have shed light toward the design of safe carbon nanotube nanomaterials by comprehensive preconsideration of their interactions with human serum proteins...
  19. ncbi request reprint Acute toxicological effects of copper nanoparticles in vivo
    Zhen Chen
    Lab for Bio Environmental Health Sciences of Nanoscale Materials, Institute of High Energy Physics, Chinese Academy of Sciences, P O Box 918, Beijing 100049, China
    Toxicol Lett 163:109-20. 2006
    ..Several factors such as huge specific surface area, ultrahigh reactivity, exceeding consumption of H(+), etc. that likely cause the grave nanotoxicity observed in vivo are discussed...
  20. doi request reprint Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload mice
    Yan Zhang
    Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, People s Republic of China
    Biometals 22:251-9. 2009
    ..It means that excessive iron accumulation in vivo may affect the metabolism of other element such as Zn and Cd...
  21. ncbi request reprint Multihydroxylated [Gd@C82(OH)22]n nanoparticles: antineoplastic activity of high efficiency and low toxicity
    Chunying Chen
    Lab for Bio Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Nano Lett 5:2050-7. 2005
    ..05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity...
  22. doi request reprint Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials
    Feng Zhao
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
    Small 7:1322-37. 2011
    ..The intracellular uptake pathways of the nanoparticles and the cellular responses, with potential signaling pathways activated by nanoparticle interactions, are also discussed...
  23. ncbi request reprint Detection of metalloproteins in human liver cytosol by synchrotron radiation X-ray fluorescence combined with gel filtration chromatography and isoelectric focusing separation
    Yuxi Gao
    Institute of High Energy Physics and Laboratory of Nuclear Analytical Techniques, Chinese Academy of Sciences, PO Box 918, Beijing 100039, P R China
    Analyst 127:1700-4. 2002
    ..In addition, the Cu-containing bands with pI of 5.0 and below 4.8 were also detected. It is demonstrated that the procedure could be widely used in further investigations of the chemical species of trace elements in biological samples...
  24. ncbi request reprint Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responses
    Chunying Chen
    Key Laboratory of Nuclear Analytical Techniques and Institute of High Energy Physics, Chinese Academy of Sciences, P O Box 918, Beijing 100039, PR China
    Sci Total Environ 366:627-37. 2006
    ..The present results were beneficial to understand the existing states of Hg in vivo and evaluate the interaction of toxic and essential elements...
  25. ncbi request reprint [Distribution of arsenic species and its DNA damage in subchronic arsenite-exposed mice]
    Hanjun Li
    Multi Discipline Initiative Center, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Wei Sheng Yan Jiu 42:764-9, 776. 2013
    ..To study the arsenic distribution, speciation, its effects on the balance of other elements and the DNA damage by subchronic arsenite exposure in mice...
  26. doi request reprint A panel study for cardiopulmonary effects produced by occupational exposure to inhalable titanium dioxide
    Sen Zhen
    Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, People s Republic of China
    J Occup Environ Med 54:1389-94. 2012
    ..To investigate titanium dioxide (TiO(2)) exposure level in the finished product workshop, and its short-term cardiopulmonary effects, based on exposure assessment...
  27. doi request reprint Fate and toxicity of metallic and metal-containing nanoparticles for biomedical applications
    Yu Feng Li
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, China
    Small 7:2965-80. 2011
    ..Several issues regarding the nanotoxicity assessment and future directions on the study of the fate of these nanoparticles are also proposed...
  28. ncbi request reprint [Toxicological study of quantum dots]
    Fangrui Yin
    Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
    Wei Sheng Yan Jiu 37:760-3. 2008
    ....
  29. ncbi request reprint Speciation and subcellular location of se-containing proteins in human liver studied by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and hydride generation-atomic fluorescence spectrometric detection
    Chunying Chen
    Institute of High Energy Physics and Laboratory of Nuclear Analytical Techniques, Chinese Academy of Sciences, Beijing
    Anal Bioanal Chem 372:426-30. 2002
    ..The specific subcellular distributions of different Se-containing proteins suggest that they could play important biological roles in each organelle...
  30. ncbi request reprint Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues
    Yingbin Liu
    Department of Surgery, Second Affiliated Hospital of Zhejiang University, Hangzhou, China
    Hepatogastroenterology 54:2291-6. 2007
    ..The aim of this study was to investigate the relationship between metalloproteins distributions and cancer development in human liver tissues...
  31. ncbi request reprint Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    Jiangxue Wang
    Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
    Toxicol Lett 168:176-85. 2007
    ..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract...
  32. ncbi request reprint Element content and element correlations in Chinese human liver
    Peiqun Zhang
    Institute of High Energy Physics and Key Laboratory of Nuclear Analytical Techniques, Chinese Academy of Sciences, P O Box 918, 100039 Beijing, China
    Anal Bioanal Chem 380:773-81. 2004
    ..these correlations could be rationally explained by the similarity of the electronic structures of the elements and/or their physiological functions in the human body...