Research Topics
| Chunying ChenSummaryAffiliation: Chinese Academy of Sciences Country: China Publications
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Detail Information
Publications
The roles of serum selenium and selenoproteins on mercury toxicity in environmental and occupational exposureChunying Chen
Laboratory of Nuclear Analytical Techniques and Laboratory for Nanoscale Materials and Related Bio Environmental Sciences, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People s Republic of China
Environ Health Perspect 114:297-301. 2006..First, they may bind more Hg through their highly reactive selenol group, and second, their antioxidative properties help eliminate the reactive oxygen species induced by Hg in vivo...
Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing miceJiangxue Wang
Lab for Bio-Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, Beijing 100049, PR China
Biochem Pharmacol 71:872-81. 2006..The results suggest that [Gd@C82(OH)22]n nanoparticle treatment could regulate ROS production in vivo...
Organic selenium supplementation increases mercury excretion and decreases oxidative damage in long-term mercury-exposed residents from Wanshan, ChinaYu Feng Li
Multidiscipline Initiative Center and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
Environ Sci Technol 46:11313-8. 2012..This 3-month selenium supplementation trial indicated that organic selenium supplementation could increase mercury excretion and decrease urinary malondialdehyde and 8-hydroxy-2-deoxyguanosine levels in local residents...- Modulation of oxidative stress by functionalized fullerene materials in the lung tissues of female C57/BL mice with a metastatic Lewis lung carcinomaFang Jiao
CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety NCNST IHEP, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
J Nanosci Nanotechnol 10:8632-7. 2010.... - Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in miceYang Liu
Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China
J Nanosci Nanotechnol 9:6335-43. 2009..The present results are helpful to get better understanding of the risk assessment and evaluation for copper nanoparticles... - Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO(2) nanoparticlesJiangxue Wang
Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China
Toxicology 254:82-90. 2008..Although understanding the mechanisms requires further investigation, the present results suggest that we should pay attention to potential risk of occupational exposure for large-scaled production of TiO(2) nanoparticles... - Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavengerJun Jie Yin
Division of Nanomedicine and Nanobiology, National Center for Nanoscience and Technology of China, 11, First North Rd, Zhongguancun, Beijing, People s Republic of China, 100190
Mol Pharmacol 74:1132-40. 2008.... - Potent angiogenesis inhibition by the particulate form of fullerene derivativesHuan Meng
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
ACS Nano 4:2773-83. 2010..We propose that using nanoscale "particulate" itself as a new form of medicine (particulate medicine) may be superior to the traditional "molecular" form of medicine (molecular medicine) in cancer treatment... - Detection of mercury-, arsenic-, and selenium-containing proteins in fish liver from a mercury polluted area of Guizhou Province, ChinaLina Li
Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
J Toxicol Environ Health A 71:1266-9. 2008..The bands may be corresponding to the antagonistic effect of Se against the toxicity of Hg and As. In addition, Hg and As often coexist in the same band, suggesting that the two elements may be involved in the same metabolic processes... - Potential neurological lesion after nasal instillation of TiO(2) nanoparticles in the anatase and rutile crystal phasesJiangxue Wang
Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China
Toxicol Lett 183:72-80. 2008.... - Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2'-deoxyguanosine concentrations, and serum redox status in persons exposed to mercuryChunying Chen
Key Laboratory of Nuclear Analytical Techniques and Laboratory for Nanoscale Materials and Related Bio-Environmental Sciences, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, Peoples Republic of China
Clin Chem 51:759-67. 2005..Measurement of urinary 8-OHdG could be useful for evaluating in vivo oxidative DNA damage in mercury-exposed populations... - Mercury in human hair and blood samples from people living in Wanshan mercury mine area, Guizhou, China: an XAS studyYu Feng Li
Key Laboratory of Nuclear Analytical Techniques, Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
J Inorg Biochem 102:500-6. 2008..228+/-0.002 nm and 4.08 in serum, respectively. The techniques for speciation, structural and binding information described in this study will find the potential application in similar studies of other elements... - Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubesCuicui Ge
CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience and Technology of China, Chinese Academy of Sciences, Beijing, P R China
Nanotoxicology 6:526-42. 2012..The co-existence of metal residues in SWCNTs can aggravate the adverse effects... - Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particlesHuan Meng
Lab for Bio Environmental Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
Toxicol Lett 175:102-10. 2007..The nano-copper particles may not compromise the mice directly, however, they lead to the accumulation of excessive alkalescent substance and heavy metal ions (copper ions) culminating the metabolic alkalosis and copper ion overload... - [Preliminary study on cellular status of selenium and oxidative stress in human hepatocellular carcinoma and normal liver]Chunying Chen
Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039, China
Wei Sheng Yan Jiu 33:543-6. 2004..These findings suggested the antioxidative defense-related enzymes and antioxidant were largely regulated in hepatoma cells, whereas the cause is not clear and requires further studies... - Acute toxicological effects of copper nanoparticles in vivoZhen Chen
Lab for Bio-Environmental Health Sciences of Nanoscale Materials, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918, Beijing 100049, China
Toxicol Lett 163:109-20. 2006..Several factors such as huge specific surface area, ultrahigh reactivity, exceeding consumption of H(+), etc. that likely cause the grave nanotoxicity observed in vivo are discussed... - Binding of blood proteins to carbon nanotubes reduces cytotoxicityCuicui Ge
Chinese Academy of Sciences Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, China
Proc Natl Acad Sci U S A 108:16968-73. 2011..These findings have shed light toward the design of safe carbon nanotube nanomaterials by comprehensive preconsideration of their interactions with human serum proteins... - Hepatic distribution of iron, copper, zinc and cadmium-containing proteins in normal and iron overload miceYan Zhang
Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, People s Republic of China
Biometals 22:251-9. 2009..It means that excessive iron accumulation in vivo may affect the metabolism of other element such as Zn and Cd... - Scalp hair as a biomarker in environmental and occupational mercury exposed populations: suitable or not?Yu Feng Li
Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
Environ Res 107:39-44. 2008..However, hair still can be used as an indicator for methyl mercury exposure because, generally, there is almost no exogenous contamination of methyl mercury in hair... - Multihydroxylated [Gd@C82(OH)22]n nanoparticles: antineoplastic activity of high efficiency and low toxicityChunying Chen
Lab for Bio-Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
Nano Lett 5:2050-7. 2005..05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity... - Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterialsFeng Zhao
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China
Small 7:1322-37. 2011..The intracellular uptake pathways of the nanoparticles and the cellular responses, with potential signaling pathways activated by nanoparticle interactions, are also discussed... - Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responsesChunying Chen
Key Laboratory of Nuclear Analytical Techniques and Institute of High Energy Physics, Chinese Academy of Sciences, P O Box 918, Beijing 100039, PR China
Sci Total Environ 366:627-37. 2006..The present results were beneficial to understand the existing states of Hg in vivo and evaluate the interaction of toxic and essential elements... - Detection of metalloproteins in human liver cytosol by synchrotron radiation X-ray fluorescence combined with gel filtration chromatography and isoelectric focusing separationYuxi Gao
Institute of High Energy Physics and Laboratory of Nuclear Analytical Techniques, Chinese Academy of Sciences, PO Box 918, Beijing 100039, P R China
Analyst 127:1700-4. 2002..In addition, the Cu-containing bands with pI of 5.0 and below 4.8 were also detected. It is demonstrated that the procedure could be widely used in further investigations of the chemical species of trace elements in biological samples... - Fate and toxicity of metallic and metal-containing nanoparticles for biomedical applicationsYu Feng Li
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, China
Small 7:2965-80. 2011..Several issues regarding the nanotoxicity assessment and future directions on the study of the fate of these nanoparticles are also proposed... - [Toxicological study of quantum dots]Fangrui Yin
Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
Wei Sheng Yan Jiu 37:760-3. 2008.... - A panel study for cardiopulmonary effects produced by occupational exposure to inhalable titanium dioxideSen Zhen
From the Department of Occupational and Environmental Health Sciences, School of Public Health Mr Zhen, Ms Qian, and Dr Jia and Department of Environmental Sciences Dr Wei, Peking University, Beijing, Centers for Disease Control and Prevention, Mr Zhen, Changzhou City, Jiangsu Province Center for Disease Control and Prevention, Mr Zhang, Jinan City, Shandong Province and National Center for Nanoscience and Technology Dr Chen, Beijing, People s Republic of China
J Occup Environ Med 54:1389-94. 2012..To investigate titanium dioxide (TiO2) exposure level in the finished product workshop, and its short-term cardiopulmonary effects, based on exposure assessment... - Speciation and subcellular location of se-containing proteins in human liver studied by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and hydride generation-atomic fluorescence spectrometric detectionChunying Chen
Institute of High Energy Physics and Laboratory of Nuclear Analytical Techniques, Chinese Academy of Sciences, Beijing
Anal Bioanal Chem 372:426-30. 2002..The specific subcellular distributions of different Se-containing proteins suggest that they could play important biological roles in each organelle... - Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissuesYingbin Liu
Department of Surgery, Second Affiliated Hospital of Zhejiang University, Hangzhou, China
Hepatogastroenterology 54:2291-6. 2007..The aim of this study was to investigate the relationship between metalloproteins distributions and cancer development in human liver tissues... - Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administrationJiangxue Wang
Laboratory for Bio Environmental Effects of Nanomaterials and Nanosafety and Key Laboratory of Nuclear Analytical Techniques, National Center for NanoScience and Technology and Institute of High Energy Physics, Beijing 100080, PR China
Toxicol Lett 168:176-85. 2007..Biodistribution experiment showed that TiO(2) mainly retained in the liver, spleen, kidneys, and lung tissues, which indicated that TiO(2) particles could be transported to other tissues and organs after uptake by gastrointestinal tract... - Element content and element correlations in Chinese human liverPeiqun Zhang
Institute of High Energy Physics and Key Laboratory of Nuclear Analytical Techniques, Chinese Academy of Sciences, P.O. Box 918, 100039 Beijing, China
Anal Bioanal Chem 380:773-81. 2004..these correlations could be rationally explained by the similarity of the electronic structures of the elements and/or their physiological functions in the human body...