Chengju Wang


Affiliation: China Agricultural University
Country: China


  1. Zhou Y, Chen X, Teng M, Zhang J, Wang C. Toxicity effects of captan on different life stages of zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2019;69:80-85 pubmed publisher
    ..Among these, the most significant were tail bending and spine curvature. ..
  2. Zhang J, Qian L, Teng M, Mu X, Qi S, Chen X, et al. The lipid metabolism alteration of three spirocyclic tetramic acids on zebrafish (Danio rerio) embryos. Environ Pollut. 2019;248:715-725 pubmed publisher
    ..05 mg/L of spiromesifen and 2.00 mg/L would cause malformation on zebrafish embryos. This study will provide new insight that fatty acid metabolism may be a suitable biomarker for the spirocyclic tetramic acids in fish species. ..
  3. Qian L, Zhang J, Chen X, Qi S, Wu P, Wang C, et al. Toxic effects of boscalid in adult zebrafish (Danio rerio) on carbohydrate and lipid metabolism. Environ Pollut. 2019;247:775-782 pubmed publisher
    ..01 mg/L. In conclusion, our study identified that carbohydrate and lipid metabolism are the possible biological pathways that mediate boscalid-induced developmental effects. ..
  4. Qian L, Qi S, Cao F, Zhang J, Li C, Song M, et al. Effects of penthiopyrad on the development and behaviour of zebrafish in early-life stages. Chemosphere. 2019;214:184-194 pubmed publisher
    ..2 mg/L. In addition, the disorder of melanin synthesis and distribution was caused by penthiopyrad in larvae in accordance with changes in body colour and related gene expression at 8 dpe. ..
  5. Teng M, Zhu W, Wang D, Yan J, Qi S, Song M, et al. Acute exposure of zebrafish embryo (Danio rerio) to flutolanil reveals its developmental mechanism of toxicity via disrupting the thyroid system and metabolism. Environ Pollut. 2018;242:1157-1165 pubmed publisher
    ..Our study also indicated that flutolanil exposure led to alterations of endogenous metabolites, which induced the thyroid endocrine disruption in zebrafish. Ultimately, embryonic developmental toxicity was caused by flutolanil. ..
  6. Wang K, Mu X, Qi S, Chai T, Pang S, Yang Y, et al. Toxicity of a neonicotinoid insecticide, guadipyr, in earthworm (Eisenia fetida). Ecotoxicol Environ Saf. 2015;114:17-22 pubmed publisher
    ..AChE activity decreased at day 3 at 50 and 100mg/kg and then increased to control level. Our data indicate that guadipyr did not induce DNA damage in earthworms at concentration of <100mg/kg. ..
  7. Wang K, Pang S, Mu X, Qi S, Li D, Cui F, et al. Biological response of earthworm, Eisenia fetida, to five neonicotinoid insecticides. Chemosphere. 2015;132:120-6 pubmed publisher
    ..fetida, and they also damage the epidermal and midgut cells of earthworm. ..
  8. Qian L, Qi S, Cao F, Zhang J, Zhao F, Li C, et al. Toxic effects of boscalid on the growth, photosynthesis, antioxidant system and metabolism of Chlorella vulgaris. Environ Pollut. 2018;242:171-181 pubmed publisher
    ..vulgaris mainly through disturbing the photosynthesis, oxidative damage and energy metabolism. The present study provided a better understanding of the negative effects and mechanisms of bosaclid in microalgae. ..
  9. Qian L, Cui F, Yang Y, Liu Y, Qi S, Wang C. Mechanisms of developmental toxicity in zebrafish embryos (Danio rerio) induced by boscalid. Sci Total Environ. 2018;634:478-487 pubmed publisher
    ..Overall, changes in cell apoptosis, lipid metabolism and melanin synthesis and deposition might be responsible for developmental toxicity of boscalid to zebrafish embryos. ..

More Information


  1. Wang K, Qi S, Mu X, Chai T, Yang Y, Wang D, et al. Evaluation of the Toxicity, AChE Activity and DNA Damage Caused by Imidacloprid on Earthworms, Eisenia fetida. Bull Environ Contam Toxicol. 2015;95:475-80 pubmed publisher
    ..05 and 0.92 mg/kg respectively, the lowest observed effect concentration of imidacloprid about hatchability, growth, AChE activity and DNA damage was 0.02, 0.5, 0.1 and 0.5 mg/kg, respectively. ..
  2. Yang Y, Qi S, Chen J, Liu Y, Teng M, Wang C. Toxic Effects of Bromothalonil and Flutolanil on Multiple Developmental Stages in Zebrafish. Bull Environ Contam Toxicol. 2016;97:91-7 pubmed publisher
    ..This study provides a foundation for future investigation into the mechanism of bromothalonil and flutolanil toxicity in zebrafish. ..
  3. Wu J, Shen C, Zhang H, Lu W, Zhang Y, Wang C. Effective removal of nemacide fosthiazate from an aqueous solution using zero-valent iron. J Environ Manage. 2015;161:11-20 pubmed publisher
    ..The characterizations of ZVI before/after the reaction were employed to gain insight into the reaction mechanism. Finally, the main degradation products were investigated by means of an Agilent 1100 LC/MSD Ion Trap. ..
  4. Mu X, Chai T, Wang K, Zhu L, Huang Y, Shen G, et al. The developmental effect of difenoconazole on zebrafish embryos: A mechanism research. Environ Pollut. 2016;212:18-26 pubmed publisher
    ..Genes related to hatching, retinoic acid metabolism and lipid homeostasis were up-regulated by difenoconazole. ..
  5. Zhu L, Qi S, Cao F, Mu X, Yang Y, Wang C. Quizalofop-P-ethyl exposure increases estrogen axis activity in male and slightly decreases estrogen axis activity in female zebrafish (Danio rerio). Aquat Toxicol. 2017;183:76-84 pubmed publisher
  6. Li D, Gao Q, Xu L, Pang S, Liu Z, Wang C, et al. Characterization of glutathione S-transferases in the detoxification of metolachlor in two maize cultivars of differing herbicide tolerance. Pestic Biochem Physiol. 2017;143:265-271 pubmed publisher
    ..Collectively, higher-level expression of GST genes, leading to higher GST activity and faster herbicide detoxification, appears to be responsible for the difference in tolerance to metolachlor in two maize cultivars. ..
  7. Teng M, Qi S, Zhu W, Wang Y, Wang D, Dong K, et al. Effects of the bioconcentration and parental transfer of environmentally relevant concentrations of difenoconazole on endocrine disruption in zebrafish (Danio rerio). Environ Pollut. 2018;233:208-217 pubmed publisher
  8. Mu X, Wang K, Chai T, Zhu L, Yang Y, Zhang J, et al. Sex specific response in cholesterol level in zebrafish (Danio rerio) after long-term exposure of difenoconazole. Environ Pollut. 2015;197:278-86 pubmed publisher
    ..In comparison with males, female zebrafish showed different transcription modification of tested genes, and the cholesterol content maintain normal level during the whole exposure. ..
  9. Mu X, Chai T, Wang K, Zhang J, Zhu L, Li X, et al. Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages. Aquat Toxicol. 2015;160:57-68 pubmed publisher
    ..At 8 dpe, the modification in the transcription of the tested genes in the embryos and adult fish was similar, except for the genes related to the synthesis of sterols. ..
  10. Zhu L, Mu X, Wang K, Chai T, Yang Y, Qiu L, et al. Cyhalofop-butyl has the potential to induce developmental toxicity, oxidative stress and apoptosis in early life stage of zebrafish (Danio rerio). Environ Pollut. 2015;203:40-49 pubmed publisher
    ..Therefore, we speculated that oxidative stress-induced apoptosis should be responsible for abnormal development during embryogenesis after cyhalofop-butyl exposure. ..
  11. Teng M, Qi S, Zhu W, Wang Y, Wang D, Yang Y, et al. Sex-specific effects of difenoconazole on the growth hormone endocrine axis in adult zebrafish (Danio rerio). Ecotoxicol Environ Saf. 2017;144:402-408 pubmed publisher
    ..It was found that difenoconazole interfered with the growth endocrine system and sex-specifically altered the expression of GH/IGF axis related genes in adult zebrafish after a short-term exposure. ..
  12. Yang Y, Liu W, Li D, Qian L, Fu B, Wang C. Altered glycometabolism in zebrafish exposed to thifluzamide. Chemosphere. 2017;183:89-96 pubmed publisher
    ..Overall, thifluzamide caused dysfunctional glycometabolism and led to events that might contribute to various thifluzamide-induced abnormalities in zebrafish. ..
  13. Yang Y, Qi S, Wang D, Wang K, Zhu L, Chai T, et al. Toxic effects of thifluzamide on zebrafish (Danio rerio). J Hazard Mater. 2016;307:127-36 pubmed publisher
    ..These might be responsible for the adverse expansion of the apoptosis- and immune-related genes, which would facilitate the action of these factors in programmed cell death and might play a key role during the toxic events. ..
  14. Teng M, Zhu W, Wang D, Qi S, Wang Y, Yan J, et al. Metabolomics and transcriptomics reveal the toxicity of difenoconazole to the early life stages of zebrafish (Danio rerio). Aquat Toxicol. 2017;194:112-120 pubmed publisher
  15. Cui F, Chai T, Qian L, Wang C. Effects of three diamides (chlorantraniliprole, cyantraniliprole and flubendiamide) on life history, embryonic development and oxidative stress biomarkers of Daphnia magna. Chemosphere. 2017;169:107-116 pubmed publisher
    ..2, 14.1 and 30.8 ?g/L for chlorantraniliprole, cyantraniliprole and flubendiamide respectively. Our findings indicate that even low levels of diamides can pose ecological risks to aquatic ecosystems. ..
  16. Chai T, Cui F, Mu X, Yang Y, Qi S, Zhu L, et al. Stereoselective induction by 2,2',3,4',6-pentachlorobiphenyl in adult zebrafish (Danio rerio): Implication of chirality in oxidative stress and bioaccumulation. Environ Pollut. 2016;215:66-76 pubmed publisher
    ..Our findings might be helpful for elucidating the environmental risk of the two enantiomers of PCB91 that induce toxicity in aquatic organisms. ..