Genomes and Genes


Shiping Ma


Affiliation: China Pharmaceutical University
Country: China


  1. Yin Z, Yu H, Chen S, Ma C, Ma X, Xu L, et al. Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway. Behav Brain Res. 2015;292:288-99 pubmed publisher
  2. Deng X, Chen J, Li H, Ma Z, Ma S, Fu Q. Cardioprotective effects of timosaponin B II from Anemarrhenae asphodeloides Bge on isoproterenol-induced myocardial infarction in rats. Chem Biol Interact. 2015;240:22-8 pubmed publisher
    ..Taken together, our finding demonstrated that TB might have a potential benefit in preventing ischemic heart diseases like myocardial infarction. ..
  3. Deng X, Xue J, Li H, Ma Z, Fu Q, Qu R, et al. Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model. Physiol Behav. 2015;152:264-71 pubmed publisher
    ..Taken together, our findings suggested that GE exerted a potential antidepressant-like effect in CUMS mice model of depression, which may provide an insight into the potential of GE in therapeutic implications for depression. ..
  4. Li R, Wang X, Qin T, Qu R, Ma S. Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. Behav Brain Res. 2016;296:318-325 pubmed publisher
    ..In conclusion, our results demonstrate that apigenin exhibits antidepressant-like effects in CUMS rats, possibly by inhibiting IL-1β production and NLRP3 inflammasome expression via the up-regulation of PPARγ expression. ..
  5. Chen S, Yin Z, Jiang C, Ma Z, Fu Q, Qu R, et al. Asiaticoside attenuates memory impairment induced by transient cerebral ischemia-reperfusion in mice through anti-inflammatory mechanism. Pharmacol Biochem Behav. 2014;122:7-15 pubmed publisher
  6. Wang S, Liu J, Ji W, Chen W, Fu Q, Feng L, et al. Qifu-Yin attenuates AGEs-induced Alzheimer-like pathophysiological changes through the RAGE/NF-κB pathway. Chin J Nat Med. 2014;12:920-8 pubmed publisher
    ..In conclusion, QFY could attenuate AGEs-induced, Alzheimer-like pathophysiological changes. These neuroprotective effects might be related to the RAGE/NF-κB pathway and its anti-inflammatory activity. ..
  7. Qin T, Fang F, Song M, Li R, Ma Z, Ma S. Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced rats by attenuating neuronal apoptosis via regulating ROCK/Akt pathway. Behav Brain Res. 2017;317:147-156 pubmed publisher
    ..In conclusion, umbelliferone showed neuroprotective effects on CUMS-induced model of depression, which was associated with the inhibition of neuronal apoptosis modulated by ROCK/Akt pathway. ..
  8. FangFang -, Li H, Qin T, Li M, Ma S. Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway. Metab Brain Dis. 2017;32:385-393 pubmed publisher
    ..In conclusion, thymol exhibited beneficial effects on HFD-induced cognitive deficits through improving hippocampal insulin resistance, and activating Nrf2/HO-1 signaling. ..
  9. Li M, Li H, Fang F, Deng X, Ma S. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2017;639:114-119 pubmed publisher

Detail Information


  1. Chen J, Zhao D, Zhu M, Zhang M, Hou X, Ding W, et al. Paeoniflorin ameliorates AGEs-induced mesangial cell injury through inhibiting RAGE/mTOR/autophagy pathway. Biomed Pharmacother. 2017;89:1362-1369 pubmed publisher
    ..Furthermore, we found PF inhibited autophagy at least partly through inhibiting RAGE and upregulating the level of p-mTOR to against AGEs-induced mesangial cell dysfunction. Thus, PF could be a potential agent for the treatment of DN. ..
  2. Sun X, Li S, Xu L, Wang H, Ma Z, Fu Q, et al. Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats. Physiol Behav. 2017;174:162-169 pubmed publisher
  3. Li S, Sun X, Xu L, Sun R, Ma Z, Deng X, et al. Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK. Eur J Pharmacol. 2017;815:118-126 pubmed publisher
    ..Baicalin also suppressed cell apoptosis and enhanced mitophagy. These results suggested that baicalin protected against hyperglycemia aggravated I/R injury by regulating mitochondrial functions in a manner dependent on AMPK. ..
  4. Li H, Zhao Y, Zeng M, Fang F, Li M, Qin T, et al. Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis. Psychopharmacology (Berl). 2017;234:3385-3394 pubmed publisher
    ..Together, Our results suggest that SSD opposed UCMS-induced depressive behaviors in rats, which was mediated, partially, by the enhancement of HPA axis function and consolidation of hippocampal neurogenesis. ..
  5. Wang H, Sun X, Zhang N, Ji Z, Ma Z, Fu Q, et al. Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway. Physiol Behav. 2017;182:93-100 pubmed publisher
    ..We suppose that PTP1B inhibition may represent a promising approach to correct abnormal signaling linked to diabetes-induced cognitive impairment...
  6. Li H, Lin S, Qin T, Li H, Ma Z, Ma S. Senegenin exerts anti-depression effect in mice induced by chronic un-predictable mild stress via inhibition of NF-?B regulating NLRP3 signal pathway. Int Immunopharmacol. 2017;53:24-32 pubmed publisher
    ..These results demonstrate that SEN plays an important role in treatment CUMS-induced depression in mice, possibly via suppression of pathway activation associated with NLRP3 inflammasome...
  7. Lixing X, Zhouye J, Liting G, Ruyi Z, Rong Q, Shiping M. Saikosaponin-d-mediated downregulation of neurogenesis results in cognitive dysfunction by inhibiting Akt/Foxg-1 pathway in mice. Toxicol Lett. 2018;284:79-85 pubmed publisher
    ..These results indicated that SSd had a toxic effect on cognitive function in mice, which was associated with inhibiting the hippocampal neurogenesis via Akt/Foxg1 pathway. ..