Zhenzhou Jiang


Affiliation: China Pharmaceutical University
Country: China


  1. Zhang H, Jiang Z, Zhang L. Dual effect of T helper cell 17 (Th17) and regulatory T cell (Treg) in liver pathological process: From occurrence to end stage of disease. Int Immunopharmacol. 2019;69:50-59 pubmed publisher
    ..Still, more studies should be carried out to enrich the understandings of liver disease and Th17/Treg immune balance in the future. ..
  2. Yuan Z, Zhang H, Hasnat M, Ding J, Chen X, Liang P, et al. A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation. Toxicology. 2019;414:45-56 pubmed publisher
    ..Additionally, apoptosis and necroptosis played a vital role in the development of liver damage induced by TP-LPS co-treatment. ..
  3. Hasnat M, Yuan Z, Naveed M, Khan A, Raza F, Xu D, et al. Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity. Cell Biol Toxicol. 2018;: pubmed publisher
    ..For the alleviation of triptolide-induced hepatotoxicity, mitochondrial fission and mitochondrial autophagy signaling pathway can be targeted as a new therapeutic strategy. Graphical abstract ᅟ. ..
  4. Wang X, Zhang S, Xu Y, Zhang L, Jiang Z. The role of neutrophils in triptolide-induced liver injury. Chin J Nat Med. 2018;16:653-664 pubmed publisher
    ..In conclusion, the inflammatory response including neutrophil infiltration may play a role in TP-induced hepatotoxicity, but may not be severe enough to cause additional liver injury. ..
  5. Yang T, Khan G, Wu Z, Wang X, Zhang L, Jiang Z. Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases. Drug Discov Today. 2019;24:112-128 pubmed publisher
    ..We believe that the molecular mechanisms of cholestasis and the identification of key regulatory mechanisms of the enterohepatic circulation of BA could be pharmacologically targeted to cholestatic liver diseases. ..
  6. Wang Y, Xu Y, Jiang Z, Guerram M, Wang B, Zhu X, et al. Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in SGC-7901 cells and inhibits tumor growth in vivo. Molecules. 2015;20:1661-75 pubmed publisher
    ..Taken together, our findings provide a framework for further exploration of DPT as a novel chemotherapeutic for human gastric cancer. ..
  7. Wang X, Xue R, Zhang S, Zheng Y, Zhang L, Jiang Z. Activation of natural killer T cells contributes to triptolide-induced liver injury in mice. Acta Pharmacol Sin. 2018;39:1847-1854 pubmed publisher
    ..More importantly, the regulation of NKT cells may promote effective measures that control drug-induced liver injury. ..
  8. Yu Q, Jiang Z, Zhang L. Bile acid regulation: A novel therapeutic strategy in non-alcoholic fatty liver disease. Pharmacol Ther. 2018;190:81-90 pubmed publisher
    ..Here, we summarize the relationship of dysregulated BA metabolism and NAFLD, discuss the effects and mechanisms of dysregulated BAs-induced lipid metabolism disorder. Challenges in developing novel treatments are also discussed. ..
  9. Guerram M, Jiang Z, Sun L, Zhu X, Zhang L. Antineoplastic effects of deoxypodophyllotoxin, a potent cytotoxic agent of plant origin, on glioblastoma U-87 MG and SF126 cells. Pharmacol Rep. 2015;67:245-52 pubmed publisher
    ..Taken together, our data demonstrated that DPT possesses a potent in vitro cytotoxic activity and exerts its effect via G2/M arrest and apoptosis. ..

More Information


  1. Yousef B, Hassan H, Guerram M, Hamdi A, Wang B, Zhang L, et al. Pristimerin inhibits proliferation, migration and invasion, and induces apoptosis in HCT-116 colorectal cancer cells. Biomed Pharmacother. 2016;79:112-9 pubmed publisher
    ..Collectively, pristimerin exerted both in vitro and in vivo cytotoxic and anti-metastatic effects on HCT-116 cells, suggesting that pristimerin has potential as a new anticancer drug for treatment of colon cancer. ..
  2. Tian C, Ding P, Yuan Z, Li H, Zhao Y, Sun L, et al. A novel dual EGFR/HER2 inhibitor KU004 induces cell cycle arrest and apoptosis in HER2-overexpressing cancer cells. Apoptosis. 2015;20:1599-612 pubmed publisher
    ..Tumor volume was significantly smaller in KU004-treated group than that in lapatinib-treated group at comparable dose levels. Taken together, these findings demonstrate KU004 can be expected to be a promising anti-HER2 candidate. ..
  3. Li X, Liu R, Yu L, Yuan Z, Sun R, Yang H, et al. Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes. Toxicology. 2016;370:106-115 pubmed publisher
  4. Zhang Y, Guo H, Hassan H, Ding P, Su Y, Song Y, et al. Pyrazinamide induced hepatic injury in rats through inhibiting the PPAR? pathway. J Appl Toxicol. 2016;36:1579-1590 pubmed publisher
    ..Copyright © 2016 John Wiley & Sons, Ltd. ..
  5. Khaled M, Belaaloui G, Jiang Z, Zhu X, Zhang L. Antitumor effect of Deoxypodophyllotoxin on human breast cancer xenograft transplanted in BALB/c nude mice model. J Infect Chemother. 2016;22:692-6 pubmed publisher
    ..These findings suggest that this drug is a promising chemotherapy candidate against human breast carcinoma. ..
  6. Guerram M, Zhang L, Jiang Z. G-protein coupled receptors as therapeutic targets for neurodegenerative and cerebrovascular diseases. Neurochem Int. 2016;101:1-14 pubmed publisher
    ..This review will highlight the potential use of neurotransmitter GPCRs as emerging therapeutic targets for neurodegenerative and cerebrovascular diseases. ..
  7. Yousef B, Hassan H, Zhang L, Jiang Z. Pristimerin exhibits in vitro and in vivo anticancer activities through inhibition of nuclear factor-?B signaling pathway in colorectal cancer cells. Phytomedicine. 2018;40:140-147 pubmed publisher
    ..Pristimerin antitumor activities were mainly mediated through inhibition of NF-?B signaling pathway in colon tumor cells. These findings further explain that pristimerin has the therapeutic potential for targeting colon cancer. ..
  8. Guo H, Hassan H, Zhang Y, Dong S, Ding P, Wang T, et al. Pyrazinamide Induced Rat Cholestatic Liver Injury through Inhibition of FXR Regulatory Effect on Bile Acid Synthesis and Transport. Toxicol Sci. 2016;152:417-28 pubmed publisher
    ..Taken together, these results suggested that PZA-induced cholestatic liver injury was related to FXR inhibition, leading to the dysfunction in bile acid synthesis and transport. ..
  9. Yang T, Mei H, Xu D, Zhou W, Zhu X, Sun L, et al. Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis. Food Chem Toxicol. 2017;110:1-12 pubmed publisher
    ..S1PR1 may be a potential target for the prevention of drug-induced cholestatic liver injury. ..
  10. Liu R, Li X, Qiang X, Luo L, Hylemon P, Jiang Z, et al. Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line. J Biol Chem. 2015;290:30988-1002 pubmed publisher
    ..In conclusion, S1PR2 plays a critical role in TCA-induced COX-2 expression and CCA growth and may represent a novel therapeutic target for CCA. ..
  11. Li X, Liu R, Luo L, Yu L, Chen X, Sun L, et al. Role of AMP-activated protein kinase ?1 in 17?-ethinylestradiol-induced cholestasis in rats. Arch Toxicol. 2017;91:481-494 pubmed publisher
    ..AMPK?1 may represent an important therapeutic target for estrogen-induced cholestasis. ..
  12. Li X, Liu R, Zhang L, Jiang Z. The emerging role of AMP-activated protein kinase in cholestatic liver diseases. Pharmacol Res. 2017;125:105-113 pubmed publisher
    ..These findings provide novel insight regarding the potential use of AMPK as a therapeutic target for the treatment of cholestatic liver injury. ..
  13. Yang T, Shu T, Liu G, Mei H, Zhu X, Huang X, et al. Quantitative profiling of 19 bile acids in rat plasma, liver, bile and different intestinal section contents to investigate bile acid homeostasis and the application of temporal variation of endogenous bile acids. J Steroid Biochem Mol Biol. 2017;172:69-78 pubmed publisher
  14. Tian C, Yuan Z, Xu D, Ding P, Wang T, Zhang L, et al. Inhibition of glycolysis by a novel EGFR/HER2 inhibitor KU004 suppresses the growth of HER2+ cancer. Exp Cell Res. 2017;357:211-221 pubmed publisher
    ..Collectively, these data suggest that multifaceted targeting the aberrant glucose metabolism along with the upstream HER2 may be an effective approach for clinical treatment against HER2+ cancer. ..
  15. Guo H, Hassan H, Ding P, Wang S, Chen X, Wang T, et al. Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2?-ATF4-CHOP pathway. Toxicology. 2017;378:65-75 pubmed publisher
    ..These results have potential implications for the pathogenesis of PZA-induced hepatotoxicity in which ER stress especially PERK-eIF2?-ATF4-CHOP pathway participates in hepatocellular injury. ..
  16. Yu L, Liu X, Li X, Yuan Z, Yang H, Zhang L, et al. Protective effects of SRT1720 via the HNF1?/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicol Lett. 2016;264:1-11 pubmed publisher
  17. Li X, Yuan Z, Liu R, Hassan H, Yang H, Sun R, et al. UDCA and CDCA alleviate 17?-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats. Toxicol Appl Pharmacol. 2016;311:12-25 pubmed publisher
    ..Collectively, these results suggest that CDCA and UDCA protect against estrogen-induced cholestatic injury via PKA signaling pathway and up-regulation of EE-suppressed FXR, which suggests a potential therapeutic target for ICP. ..
  18. Zhang Y, Liu K, Hassan H, Guo H, Ding P, Han L, et al. Liver Fatty Acid Binding Protein Deficiency Provokes Oxidative Stress, Inflammation, and Apoptosis-Mediated Hepatotoxicity Induced by Pyrazinamide in Zebrafish Larvae. Antimicrob Agents Chemother. 2016;60:7347-7356 pubmed