Bernard M Y Cheung

Summary

Country: China

Publications

  1. ncbi request reprint Diastolic blood pressure is related to urinary sodium excretion in hypertensive Chinese patients
    B M Cheung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    QJM 93:163-8. 2000
  2. pmc Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Br J Clin Pharmacol 57:640-51. 2004
  3. doi request reprint A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong
    Thromb Haemost 103:728-35. 2010
  4. doi request reprint Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong
    Eur J Endocrinol 163:251-7. 2010
  5. doi request reprint Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population
    Chloe Y Y Cheung
    Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    J Clin Endocrinol Metab 95:1395-403. 2010
  6. doi request reprint Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene
    Bernard M Y Cheung
    Department of Medicine, Research Centre of Heart, Brain, Hormone and Healthy Aging, School of Public Health, University of Hong Kong, Hong Kong, People s Republic of China
    Eur J Endocrinol 165:571-7. 2011
  7. ncbi request reprint Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2)
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Am J Hypertens 21:17-22. 2008
  8. pmc Association between raised blood pressure and dysglycemia in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 31:1889-91. 2008
  9. ncbi request reprint Bioavailable testosterone predicts a lower risk of Alzheimer's disease in older men
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong
    J Alzheimers Dis 21:1335-45. 2010
  10. doi request reprint Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men
    K L Ong
    Department of Medicine, Faculty of Medicine, University of Hong Kong, Hong Kong
    Am J Hypertens 21:539-45. 2008

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Diastolic blood pressure is related to urinary sodium excretion in hypertensive Chinese patients
    B M Cheung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
    QJM 93:163-8. 2000
    ..07+/-0.03 and 0. 09+/-0.04 mmHg/mmol Na, respectively. Urinary sodium excretion was related to diastolic blood pressure in our hypertensive patients, accounting for 17% of the variance of diastolic blood pressure...
  2. pmc Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Br J Clin Pharmacol 57:640-51. 2004
    ..The aim of the study was to estimate the effect of statins on major coronary events and strokes, all-cause mortality and noncardiovascular mortality, and in different subgroups...
  3. doi request reprint A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong
    Thromb Haemost 103:728-35. 2010
    ..This suggests a possible causal role of fibrinogen in hypertension development, especially in men...
  4. doi request reprint Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong
    Eur J Endocrinol 163:251-7. 2010
    ..We therefore investigated whether single-nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adiponectin level and whether they were associated with hypertension...
  5. doi request reprint Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population
    Chloe Y Y Cheung
    Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    J Clin Endocrinol Metab 95:1395-403. 2010
    ..Further functional and fine-mapping studies to elucidate the roles of these putative obesity-related genes and genetic variants are warranted...
  6. doi request reprint Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene
    Bernard M Y Cheung
    Department of Medicine, Research Centre of Heart, Brain, Hormone and Healthy Aging, School of Public Health, University of Hong Kong, Hong Kong, People s Republic of China
    Eur J Endocrinol 165:571-7. 2011
    ..We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers...
  7. ncbi request reprint Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2)
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Am J Hypertens 21:17-22. 2008
    ..The metabolic syndrome is a predictor of diabetes and coronary events. We hypothesized that it also predicts hypertension...
  8. pmc Association between raised blood pressure and dysglycemia in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 31:1889-91. 2008
    ..To investigate the association between raised blood pressure and dysglycemia...
  9. ncbi request reprint Bioavailable testosterone predicts a lower risk of Alzheimer's disease in older men
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong
    J Alzheimers Dis 21:1335-45. 2010
    ..04 and 5.04 respectively. In conclusion, the serum level of bioavailable testosterone in late life predicts a lower risk of future AD development in older men...
  10. doi request reprint Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men
    K L Ong
    Department of Medicine, Faculty of Medicine, University of Hong Kong, Hong Kong
    Am J Hypertens 21:539-45. 2008
    ..The gene is located at 2p25.1, a susceptibility locus for hypertension. We studied the association of tagging single-nucleotide polymorphisms (SNPs) in the lipin 1 (LPIN1) gene with hypertension and blood pressure...
  11. doi request reprint Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors
    Wing Sun Chow
    From the Department of Medicine W S C, A X, Y C W, A W K T, C H Y F, H F T, B M Y C, K S L L, Research Centre of Heart, Brain, Hormone, and Healthy Aging A X, A W K T, H F T, B M Y C, K S L L, and Department of Radiology S C W C, M T C, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Arterioscler Thromb Vasc Biol 33:2454-9. 2013
    ..In this study, we examined the relationship between serum FGF21 levels and carotid intima-media thickness (IMT) in a large cohort of Southern Chinese subjects...
  12. ncbi request reprint Treatment and control of diabetes mellitus in the United States National Health and Nutrition Examination Survey, 1999-2002
    Kwok Leung Ong
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Ageing, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Cardiometab Syndr 1:301-7. 2006
    ..2%), while patients using diet treatment alone (65.9%) had the best glycemic control. There is a need to improve glycemic control. Better patient education, intensive lifestyle changes, and newer therapies need to be explored...
  13. doi request reprint Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10-year prospective study
    Cheng Chen
    Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong
    Clin Endocrinol (Oxf) 76:506-13. 2012
    ..Here we investigated the relationship of plasma PEDF concentration with BP and incident hypertension in a 10-year prospective study...
  14. pmc The KCNJ11 E23K polymorphism and progression of glycaemia in Southern Chinese: a long-term prospective study
    Chloe Y Y Cheung
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS ONE 6:e28598. 2011
    ..The KCNJ11 E23K variant is associated with type 2 diabetes mellitus (T2DM) in cross-sectional studies, but conflicting findings have been reported from prospective studies...
  15. ncbi request reprint Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Clin Endocrinol (Oxf) 68:730-7. 2008
    ..To investigate which of the components of the metabolic syndrome best predict its development...
  16. ncbi request reprint Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study
    G Neil Thomas
    Department of Community Medicine, The University of Hong Kong, Hong Kong, China
    Clin Endocrinol (Oxf) 66:666-71. 2007
    ..The metabolic syndrome has been associated with increased mortality in some Caucasian populations, but data in Asian populations are not available. We present data describing the association of the metabolic syndrome with mortality...
  17. doi request reprint Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study
    Cheng Chen
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Clin Endocrinol Metab 95:5074-81. 2010
    ..Here we investigated whether circulating PEDF levels predicted the development of the metabolic syndrome (MetS) in a 10-yr prospective study...
  18. doi request reprint Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Clin Chem Lab Med 46:523-7. 2008
    ..In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population...
  19. doi request reprint Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes
    Yuen Fung Yiu
    Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    Atherosclerosis 227:140-6. 2013
    ..The aim was to investigate the effect of vitamin D supplementation on endothelial function in patients with type 2 diabetes mellitus (DM)...
  20. doi request reprint Relationship of plasma interleukin-6 and its genetic variants with hypertension in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    Am J Hypertens 24:1331-7. 2011
    ..We investigated the associations of plasma IL6 and its genetic variants with hypertension in both cross-sectional and prospective study designs...
  21. ncbi request reprint Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study
    Aimin Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Circulation 115:1537-43. 2007
    ..In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria...
  22. doi request reprint Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study
    Chloe Y Y Cheung
    Department of Medicine, LKS Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, SAR, China
    Eur J Endocrinol 164:381-8. 2011
    ..In this study, we investigate whether these SNPs could also predict the persistence of central obesity and MetS in subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS) cohort...
  23. ncbi request reprint Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study
    Wing Sun Chow
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, People s Republic of China
    Hypertension 49:1455-61. 2007
    ..76; 95% CIs: 1.06 to 7.16; P=0.037 versus highest tertile). Our data suggest that hypoadiponectinaemia may be involved in the pathogenesis of hypertension in humans...
  24. doi request reprint Role of genetic variants in the gene encoding lipocalin-2 in the development of elevated blood pressure
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong
    Clin Exp Hypertens 33:484-91. 2011
    ..7 ± 16.4 mmHg vs. 117.9 ± 17.3 mmHg, P = 0.043). Our findings suggest, for the first time, that genetic variants in LCN2 may affect BP. Further studies on the role of lipocalin-2 in BP regulation are warranted...
  25. doi request reprint Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong SAR, China
    Int J Cardiol 135:156-61. 2009
    ..Alkaline phosphatase (ALP) is elevated in peripheral arterial disease (PAD). We therefore examined the relationship of PAD with ALP and other liver enzymes in the United States National Health and Nutrition Examination Survey 1999-2004...
  26. doi request reprint Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong
    Clin Endocrinol (Oxf) 74:206-13. 2011
    ..We studied the associations of SNPs in APOA5 with the metabolic syndrome (MetS) in the Hong Kong and Guangzhou Chinese...
  27. doi request reprint Serum β-2 microglobulin predicts mortality in people with diabetes
    Ching Lung Cheung
    Division of Clinical Pharmacology and Therapeutics, The University of Hong Kong, Pokfulam, Hong Kong, China
    Eur J Endocrinol 169:1-7. 2013
    ..Glycation of B2M is cytotoxic and may contribute to the risk of mortality in diabetic patients. Our objective was to evaluate the relationship between B2M and mortality in diabetic patients...
  28. doi request reprint Gamma-glutamyl transferase level predicts the development of hypertension in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong
    Clin Chim Acta 412:1326-31. 2011
    ..We investigated if hypertension is associated with increased activities of these plasma markers...
  29. doi request reprint A genetic variant in the gene encoding adrenomedullin predicts the development of dysglycemia over 6.4 years in Chinese
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong
    Clin Chim Acta 412:353-7. 2011
    ..We investigated the association of common single nucleotide polymorphisms (SNPs) in the gene encoding adrenomedullin (ADM) with dysglycemia in the Hong Kong Chinese population...
  30. ncbi request reprint Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort
    Annette W K Tso
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 30:2667-72. 2007
    ..Here we investigated whether serum A-FABP levels could predict the development of diabetes in a 10-year prospective study...
  31. pmc Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese
    Louisa Y F Wong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Dis Markers 24:167-73. 2008
    ..002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance...
  32. ncbi request reprint Prevalence, awareness, treatment, and control of hypertension: United States National Health and Nutrition Examination Survey 2001-2002
    Bernard M Y Cheung
    Department of Medicine and the Research Centre of Heart, Brain, Hormone and Healthy Aging, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Clin Hypertens (Greenwich) 8:93-8. 2006
    ..In 2001-2002, significantly more people with hypertension and diabetes reached a blood pressure target of <130/85 mm Hg. Overall, the control rates were low, especially among middle-aged Mexican-American men (8%)...
  33. ncbi request reprint Adrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide
    Yuk Yin Li
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China
    Neuropeptides 39:73-80. 2005
    ..The present results suggest that the biosynthesis and secretion of AM may be increased in cardiovascular tissues of rats injected with LPS, and that AM may play multiple roles in inflammation...
  34. doi request reprint Impact of combination therapy with amlodipine and atorvastatin on plasma adiponectin levels in hypertensive patients with coronary artery disease: combination therapy and adiponectin
    Mingfang Li
    Division of Cardiology, The University of Hong Kong, Hong Kong, China
    Postgrad Med 123:66-71. 2011
    ..The aim of this study was to investigate the impact of this combination therapy on plasma adiponectin levels...
  35. ncbi request reprint Differential induction of adrenomedullin, interleukins and tumour necrosis factor-alpha by lipopolysaccharide in rat tissues in vivo
    Yuk Yin Li
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    Clin Exp Pharmacol Physiol 32:1110-8. 2005
    ..The present results suggest that the biosynthesis and secretion of AM may be differentially regulated in various tissues of rats injected with LPS and that AM may interact with cytokines during inflammation...
  36. doi request reprint Late-life body mass index and waist circumference in amnestic mild cognitive impairment and Alzheimer's disease
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR
    J Alzheimers Dis 17:223-32. 2009
    ..002 and 0.018 respectively). In conclusion, late-life BMI and WC progressively decrease in older adults with normal cognition, aMCI, and AD. Low late-life BMI and WC represent potentially useful pre-clinical markers of aMCI and AD...
  37. doi request reprint The relationship between glucose metabolism, metabolic syndrome, and bone-specific alkaline phosphatase: a structural equation modeling approach
    Ching Lung Cheung
    Division of Clinical Pharmacology and Therapeutics, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    J Clin Endocrinol Metab 98:3856-63. 2013
    ..The relationship of serum alkaline phosphatase (total and bone-specific) with diabetes and metabolic syndrome (MetS), 2 major risk factors of vascular calcification, is largely unknown...
  38. pmc High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects
    Cheng Chen
    Department of Medicine, University of Hong Kong, Hong Kong
    Diabetes Care 34:2113-5. 2011
    ..4-year, population-based, prospective study...
  39. doi request reprint Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes
    Yuen Fung Yiu
    Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Clin Endocrinol Metab 96:E830-5. 2011
    ..The relationship of Vit-D deficiency with circulating endothelial progenitor cells and endothelial dysfunction in type 2 DM patients nonetheless remains unclear...
  40. ncbi request reprint Development of diabetes in Chinese with the metabolic syndrome: a 6-year prospective study
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 30:1430-6. 2007
    ..We investigated the association of the metabolic syndrome with new-onset diabetes in the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort...
  41. doi request reprint Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong, People s Republic of China
    Am J Hypertens 22:500-5. 2009
    ..In the present study, we investigated the relationship between F11R and hypertension by examining the levels of a circulating soluble form of F11R (sF11R) in hypertensive patients...
  42. ncbi request reprint The role of urotensin II in the metabolic syndrome
    Kwok Leung Ong
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Peptides 29:859-67. 2008
    ..These findings suggest a close relationship between urotensin II and at least some components of the metabolic syndrome, including hypertension, insulin resistance, hyperglycemia, and inflammation...
  43. doi request reprint Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong
    Hypertension 51:1142-8. 2008
    ..Although there is room for improvement in blood pressure control, our study has highlighted the importance of addressing concomitant cardiovascular risk factors in women with hypertension...
  44. pmc Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction
    Yu Cho Woo
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS ONE 7:e36868. 2012
    ..We evaluated the use of serum adiponectin, an anti-inflammatory adipokine, and several proinflammatory adipokines, as biomarkers of diabetes risk and whether they add to traditional risk factors in diabetes prediction...
  45. ncbi request reprint Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004
    Kwok Leung Ong
    Department of Medicine and the Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong
    Hypertension 49:69-75. 2007
    ..01). The improvement in blood pressure control is encouraging, although the prevalence of hypertension has not declined...
  46. doi request reprint The metabolic syndrome is associated with subclinical atherosclerosis independent of insulin resistance: the Guangzhou Biobank Cohort Study-CVD
    Lin Xu
    Department of Community Medicine, School of Public Health, University of Hong Kong, Hong Kong, China
    Clin Endocrinol (Oxf) 73:181-8. 2010
    ..We examined whether the association of the metabolic syndrome (MetS) and subclinical atherosclerosis is independent of insulin resistance in a Chinese community sample with no history of type 2 diabetes...
  47. ncbi request reprint Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
    Kwok Leung Ong
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Peptides 27:1659-67. 2006
    ..For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance...
  48. ncbi request reprint Prevalence of the metabolic syndrome in the United States National Health and Nutrition Examination Survey 1999-2002 according to different defining criteria
    Bernard M Y Cheung
    Department of Medicine and the Research Centre of Heart, Brain, Hormone and Healthy Ageing, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Clin Hypertens (Greenwich) 8:562-70. 2006
    ..Whether waist circumference is a prerequisite does not affect the diagnosis of the metabolic syndrome in the United States. The IDF definition identifies additional individuals at risk for cardiovascular disease...
  49. doi request reprint Reduced serum beta-trace protein is associated with metabolic syndrome
    Ching Lung Cheung
    Division of Clinical Pharmacology and Therapeutics, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Atherosclerosis 227:404-7. 2013
    ..trace protein (BTP), also known as lipocalin-type prostaglandin D2 synthase, has shown to regulate glucose and lipid metabolism in vivo. We sought to study the relationship of serum BTP with diabetes and metabolic syndrome (MetS)...
  50. pmc Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene
    Hoi Kin Wong
    Department of Medicine, University of Hong Kong, Hong Kong
    PLoS ONE 8:e70335. 2013
    ..There is some evidence that ADM may regulate adiponectin gene expression, but whether adiponectin can regulate ADM expression is unclear, and was therefore investigated...
  51. pmc Is human cytomegalovirus infection associated with hypertension? The United States National Health and Nutrition Examination Survey 1999-2002
    Chao Li
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    PLoS ONE 7:e39760. 2012
    ..We aimed to study the association between HCMV infection and hypertension in the United States National Health and Nutrition Examination Survey (NHANES)...
  52. pmc Diabetes and hypertension: is there a common metabolic pathway?
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Pokfulam, Hong Kong
    Curr Atheroscler Rep 14:160-6. 2012
    ..Physical activity plays an important protective role in the two diseases. Knowing the common causes and disease mechanisms allows a more effective and proactive approach in their prevention and treatment...
  53. ncbi request reprint A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer's disease in Chinese
    Leung Wing Chu
    Department of Medicine, The University of Hong Kong, Hong Kong
    Am J Med Genet B Neuropsychiatr Genet 144:1007-13. 2007
    ..Further functional analysis of this polymorphism should be a high priority...
  54. pmc Using glycosylated hemoglobin to define the metabolic syndrome in United States adults
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 33:1856-8. 2010
    ..To compare the use of GHb and fasting plasma glucose (FPG) to define the metabolic syndrome (MetS)...
  55. doi request reprint Haemoglobin A1c is superior to fasting glucose in predicting the incidence of diabetes over 8 years among Chinese
    Lawrence S C Law
    Department of Medicine, The University of Hong Kong, Hong Kong
    Diabetes Res Clin Pract 91:e53-6. 2011
    ....
  56. doi request reprint Utilization of lipid lowering medications among adults in the United States 1999-2006
    Mingfang Li
    Department of Medicine, The University of Hong Kong, Hong Kong
    Atherosclerosis 208:456-60. 2010
    ..We examined the use of lipid lowering medications and control of dyslipidemia among US adults in 1999-2006...
  57. ncbi request reprint Advantages of blood pressure optimization
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Adv Ther 22:285-96. 2005
    ..Optimization of BP is feasible, safe, and well tolerated; however, a larger study of longer duration may be needed to demonstrate improvements in LVM and endothelial function with conventional versus optimal therapy...
  58. ncbi request reprint Overview of dietary influences on atherosclerotic vascular disease: epidemiology and prevention
    G Neil Thomas
    Department of Community Medicine, University of Hong Kong, Hong Kong
    Cardiovasc Hematol Disord Drug Targets 7:87-97. 2007
    ..We also highlight the complexity and limitations of interpreting current diet-based epidemiological studies in isolation...
  59. ncbi request reprint Bioavailable testosterone is associated with a reduced risk of amnestic mild cognitive impairment in older men
    Leung Wing Chu
    Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, Faculty of Medicine, The University of Hong Kong, Hong Kong SAR
    Clin Endocrinol (Oxf) 68:589-98. 2008
    ..We investigated the risk of amnestic mild cognitive impairment (aMCI) in relation to serum bioavailable (BT) and total testosterone (TT) levels in older men...
  60. ncbi request reprint Identification of factors differentially associated with isolated impaired fasting glucose and isolated post-load impaired glucose tolerance: the Hong Kong Cardiovascular Risk Factor Study
    G Neil Thomas
    Department of Community Medicine, and School of Public Health, The University of Hong Kong, Hong Kong
    Eur J Endocrinol 155:623-32. 2006
    ....
  61. doi request reprint A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels
    Hoi Kin Wong
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Clin Endocrinol (Oxf) 79:504-9. 2013
    ..Therefore, we investigated whether plasma ADM levels are related to SNPs in the gene encoding IL-6 (IL6)...
  62. doi request reprint Management of obesity in the National Health and Nutrition Examination Survey (NHANES), 2007-2008
    Nithushi R Samaranayake
    Department of Medicine, University of Hong Kong, China
    Ann Epidemiol 22:349-53. 2012
    ..The prevalence of obesity has been increasing in the United States. We set out to investigate the use of pharmacologic and non-pharmacologic therapy for the treatment of obesity in recent years...
  63. doi request reprint Drug treatment for obesity in the post-sibutramine era
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Drug Saf 34:641-50. 2011
    ..There is now a clear need to find anti-obesity drugs that are effective and safe in the long term...
  64. ncbi request reprint The metabolic syndrome and vascular disease in Asia
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Cardiovasc Hematol Disord Drug Targets 7:79-85. 2007
    ..To minimise further development of the obesity pandemic and subsequent vascular disease, innovative population-based preventative lifestyle and therapeutic strategies interventions need to be introduced...
  65. ncbi request reprint The hypertension-diabetes continuum
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    J Cardiovasc Pharmacol 55:333-9. 2010
    ..However, obesity is on the increase in developed and developing countries. It is now time to focus on obesity and the metabolic syndrome, which require more a public health than a pharmacologic approach...
  66. pmc Queen Mary Utilization of Antihypertensive Drugs Study: use of antihypertensive drug classes in the hypertension clinic 1996-2004
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Br J Clin Pharmacol 60:90-7. 2005
    ..Utilization of antihypertensive drugs in the hypertension outpatient clinic is surveyed periodically in the Queen Mary Utilization of Antihypertensive Drugs Study (QUADS)...
  67. doi request reprint The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia
    Mingfang Li
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Diabetes Metab Res Rev 27:185-94. 2011
    ..Experimental studies suggest a potential link between hypoadiponectinaemia and the depletion of the EPC level. This study investigated the relationships between adiponectin level and EPC in patients with type 2 DM...
  68. ncbi request reprint Plasma concentration of urotensin II is raised in hypertension
    Bernard M Y Cheung
    University Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    J Hypertens 22:1341-4. 2004
    ..Urotensin II is the most potent vasoconstrictor known. Its role in hypertension has not been investigated. Here, we studied the plasma levels in hypertensive and normotensive human subjects...
  69. pmc Rhythm vs. rate control of atrial fibrillation meta-analysed by number needed to treat
    Cyrus R Kumana
    Department of Medicine, The University of Hong Kong, Hong Kong, SAR
    Br J Clin Pharmacol 60:347-54. 2005
    ..However, recent trials appear to challenge these assumptions...
  70. pmc Pharmacotherapy for obesity
    Mingfang Li
    Department of Medicine, The University of Hong Kong, Hong Kong
    Br J Clin Pharmacol 68:804-10. 2009
    ..Studies evaluating the long-term safety and efficacy of anti-obesity agents are needed...
  71. ncbi request reprint Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population
    Rong Rong
    Department of Medicine, Li Ka Shing Medical Faculty, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Endocrinol (Oxf) 65:198-205. 2006
    ..We studied the frequency of MC4R mutations in an obese southern Chinese population and the functional consequences of the novel variants identified...
  72. ncbi request reprint Therapeutic potential of angiotensin receptor blockers in hypertension
    Bernard M Y Cheung
    University of Hong Kong, Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    Expert Opin Investig Drugs 15:625-35. 2006
    ..For patients in whom angiotensin-converting enzyme inhibitors are indicated but not tolerated, an ARB should be considered. Periodic monitoring of renal function and electrolytes is required in patients treated with an ARB...
  73. pmc The metabolic syndrome in China
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Br J Clin Pharmacol 62:260-3. 2006
  74. doi request reprint Statins for people with diabetes
    Bernard M Y Cheung
    Department of Clinical Pharmacology, Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK
    Lancet 371:94-5. 2008
  75. pmc Effectiveness of lipid lowering drugs in general practice: study had two major flaws
    Bernard M Y Cheung
    BMJ 327:51; author reply 51. 2003