Ping Chen

Summary

Country: China

Publications

  1. doi request reprint Decreased MIZ1 Expression in Severe Experimental Acute Pancreatitis: A Rat Study
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, 201801, China
    Dig Dis Sci 61:758-66. 2016
  2. ncbi request reprint Combined chemotherapy of hydroxycampothecin with oxaliplatin as an adjuvant treatment for human colorectal cancer
    Yang Yao
    Department of Medical Oncology, Sixth People s Hospital, Shanghai Jiaotong University, China
    Tohoku J Exp Med 215:267-78. 2008
  3. doi request reprint Fractalkine upregulates inflammation through CX3CR1 and the Jak-Stat pathway in severe acute pancreatitis rat model
    Li Ya Huang
    Department of Gastroenterology, Affiliated Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
    Inflammation 35:1023-30. 2012
  4. doi request reprint siRNA-based targeting of fractalkine overexpression suppresses inflammation development in a severe acute pancreatitis rat model
    Liya Huang
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P R China
    Int J Mol Med 30:514-20. 2012
  5. pmc Protective effects of necrostatin-1 against concanavalin A-induced acute hepatic injury in mice
    Yingqun Zhou
    Department of Gastroenterology, The Tenth People s Hospital of Tongji University, Shanghai 200072, China
    Mediators Inflamm 2013:706156. 2013
  6. doi request reprint Protein inhibitor of activated STAT-1 is downregulated in gastric cancer tissue and involved in cell metastasis
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    Oncol Rep 28:2149-55. 2012
  7. doi request reprint The antagonist of the JAK-1/STAT-1 signaling pathway improves the severity of cerulein-stimulated pancreatic injury via inhibition of NF-κB activity
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    Int J Mol Med 27:731-8. 2011
  8. doi request reprint Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: partial mediation by the transcription factor NFAT1
    Weiqi Dai
    Department of Gastroenterology, Shanghai Tenth People s Hospital, Tongji University, School of Medicine, Shanghai, China
    Mol Carcinog 54:301-11. 2015
  9. doi request reprint High expression of RELM-α correlates with poor prognosis and promotes angiogenesis in gastric cancer
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P R China
    Oncol Rep 34:77-86. 2015
  10. doi request reprint Upregulation of PIAS1 protects against sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Cytokine 54:305-14. 2011

Collaborators

  • Hui Zhao
  • Feng Lin
  • Yang Yao
  • Jian Li
  • Lei He
  • Ling Xu
  • Yan Zhang
  • Ming Zhao
  • Lifu Wang
  • Xingpeng Wang
  • Pei Hong Wu
  • Xiaojian Zhou
  • Yun Fei Xia
  • Xiao Li
  • Jing Zhang
  • Li Yang
  • H Mastalerz
  • Meng Guo
  • Gang Li
  • Weiqi Dai
  • Yingqun Zhou
  • Xuanfu Xu
  • Li Ya Huang
  • Jie Lu
  • Chuanyong Guo
  • Fan Wang
  • Xianqun Fan
  • Yao Zong Yuan
  • Chunyi Shao
  • Miao Shen
  • Chunlei Lin
  • Chuanyin Li
  • Chang Chuan Pan
  • Ping Gu
  • Yu Fen Zhou
  • Liya Huang
  • Honglin Chen
  • Chun Hua Dai
  • ShangJie Wu
  • Aiping Tong
  • Hong Peng
  • Min Teng
  • Silke Schepelmann
  • Hong Luo
  • Bulbul Pandit
  • Hong Xia Li
  • Shun Lu
  • Mao Yu Li
  • Mengyu Zhu
  • Shumei Wu
  • Chengfen Wang
  • Dong Wu
  • Yao Fu
  • Junzhao Chen
  • Qinke Yao
  • Xiaolin Huang
  • Yong Dong Jin
  • ShengFang Ge
  • Limei Zhang
  • Xin Che
  • Jin Lu
  • Chenfen Wang
  • Zhiliang Wang
  • Chuangao Xie
  • Yuming Tang
  • Junwen Ma
  • Shengli He
  • Shu mei Wei
  • Wei Guang Li
  • Huizhong Gan
  • Shuxian Zhang
  • Jiahui Yu
  • Jin Huang
  • Jing Xia
  • Li Chao Yu
  • Li Ping Ge
  • Shun Bing Shi
  • Shuiping Zhao
  • Yan Gan
  • Xiqian Xing
  • Lijuan Chen
  • Canhua Huang
  • Quek Choon Lau
  • Qingsong Lin
  • Xia Zhao
  • Qing Hua Wu
  • Yun Li
  • Yan Chen
  • Lihong Wu
  • Yu Quan Wei

Detail Information

Publications38

  1. doi request reprint Decreased MIZ1 Expression in Severe Experimental Acute Pancreatitis: A Rat Study
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, 201801, China
    Dig Dis Sci 61:758-66. 2016
    ....
  2. ncbi request reprint Combined chemotherapy of hydroxycampothecin with oxaliplatin as an adjuvant treatment for human colorectal cancer
    Yang Yao
    Department of Medical Oncology, Sixth People s Hospital, Shanghai Jiaotong University, China
    Tohoku J Exp Med 215:267-78. 2008
    ..Taken together, the present study indicates that the combined chemotherapy of HCPT with L-OHP could become a new adjuvant treatment for CRC...
  3. doi request reprint Fractalkine upregulates inflammation through CX3CR1 and the Jak-Stat pathway in severe acute pancreatitis rat model
    Li Ya Huang
    Department of Gastroenterology, Affiliated Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
    Inflammation 35:1023-30. 2012
    ..These results showed FKN and CX3CR1 were involved inflammatory response in cerulein-stimulated AR42J cells. FKN upregulates inflammation through CX3CR1 and the Jak/Stat pathway in SAP rat models...
  4. doi request reprint siRNA-based targeting of fractalkine overexpression suppresses inflammation development in a severe acute pancreatitis rat model
    Liya Huang
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P R China
    Int J Mol Med 30:514-20. 2012
    ..More importantly, this study indicated that FKN, which is overexpressed in the SAP rat model, may serve as a novel and effective therapeutic target for SAP...
  5. pmc Protective effects of necrostatin-1 against concanavalin A-induced acute hepatic injury in mice
    Yingqun Zhou
    Department of Gastroenterology, The Tenth People s Hospital of Tongji University, Shanghai 200072, China
    Mediators Inflamm 2013:706156. 2013
    ..Necrostatin-1 (Nec-1) inhibits receptor-interacting protein 1 (RIP1) kinase and programmed necrosis. This study was designed to examine the protective effects and mechanisms of Nec-1 in concanavalin A- (ConA-) induced hepatitis in mice...
  6. doi request reprint Protein inhibitor of activated STAT-1 is downregulated in gastric cancer tissue and involved in cell metastasis
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    Oncol Rep 28:2149-55. 2012
    ..These data suggest that PIAS1 may function as a tumor suppressor to regulate gastric cancer cell metastasis by targeting the MAPK signaling pathway...
  7. doi request reprint The antagonist of the JAK-1/STAT-1 signaling pathway improves the severity of cerulein-stimulated pancreatic injury via inhibition of NF-κB activity
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    Int J Mol Med 27:731-8. 2011
    ..This study indicates that the JAK-1/STAT-1 signaling pathway activity is an early event in pancreatic inflammatory injury. Therefore, early treatment with its inhibitors might be beneficial for attenuation of pancreatic injury in SAP...
  8. doi request reprint Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: partial mediation by the transcription factor NFAT1
    Weiqi Dai
    Department of Gastroenterology, Shanghai Tenth People s Hospital, Tongji University, School of Medicine, Shanghai, China
    Mol Carcinog 54:301-11. 2015
    ..The fact that EMT can be reversed by genistein may shed light on the possible mechanisms for its role in liver cancer therapy...
  9. doi request reprint High expression of RELM-α correlates with poor prognosis and promotes angiogenesis in gastric cancer
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P R China
    Oncol Rep 34:77-86. 2015
    ....
  10. doi request reprint Upregulation of PIAS1 protects against sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Cytokine 54:305-14. 2011
    ..01). These findings suggest that PIAS1 could augment anti-inflammatory activity by inhibiting STAT1, thus attenuating the severity of SAP associated with ALI...
  11. ncbi request reprint SiRNA-mediated PIAS1 silencing promotes inflammatory response and leads to injury of cerulein-stimulated pancreatic acinar cells via regulation of the P38MAPK signaling pathway
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    Int J Mol Med 26:619-26. 2010
    ..It provides evidence that PIAS1 is a potential therapeutic target for AP...
  12. doi request reprint Anti-apoptotic effect of activated protein C on lipopolysaccharide-stimulated human umbilical vein endothelial cells is associated with the inhibition of the caspase-3 pathway
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P R China
    Mol Med Report 3:991-7. 2010
    ..Furthermore, APC may be useful in the treatment of infectious disease...
  13. ncbi request reprint [Effect of atorvastatin on inflammatory infiltration in the lung of rabbits with hypercholesterolemia]
    ShangJie Wu
    Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 34:608-15. 2009
    ..To determine the effect of atorvastatin on the hypercholesterolemia induced lesion in the lung...
  14. doi request reprint Fractalkine as a marker for assessment of severe acute pancreatitis
    Li Ya Huang
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China
    J Dig Dis 13:225-31. 2012
    ..The aim of this study was to study the role of fractalkine (FKN) in the development of severe acute pancreatitis (SAP) in animal model...
  15. ncbi request reprint Therapeutic effect of pirarubicin-based chemotherapy for osteosarcoma patients with lung metastasis
    Hui Zhao
    Department of Internal Oncology, Sixth People s Hospital, Shanghai Jiao Tong University, China
    J Chemother 22:119-24. 2010
    ..For osteosarcoma patients with secondary lung metastasis, THP-based chemotherapy regimens are safe and effective as a salvage chemotherapy option...
  16. pmc Treatment with retinoic acid and lens epithelial cell-conditioned medium in vitro directed the differentiation of pluripotent stem cells towards corneal endothelial cell-like cells
    Ping Chen
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P R China Department of Ophthalmology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P R China
    Exp Ther Med 9:351-360. 2015
    ....
  17. doi request reprint Enzyme-induced vitreolysis can alleviate the progression of diabetic retinopathy through the HIF-1α pathway
    Chuanyin Li
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Invest Ophthalmol Vis Sci 54:4964-70. 2013
    ..We studied the mechanism by which complete posterior vitreous detachment by enzyme-induced vitreolysis alleviates the progression of diabetic retinopathy...
  18. pmc Targeted transplantation of human umbilical cord blood endothelial progenitor cells with immunomagnetic nanoparticles to repair corneal endothelium defect
    Chunyi Shao
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Stem Cells Dev 24:756-67. 2015
    ....
  19. ncbi request reprint [Evaluation of the prognostic significance of refinement and stratification of distant metastasis status in 1016 cases of nasopharyngeal carcinoma]
    Chang Chuan Pan
    Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Chengdu 610041, China
    Zhonghua Zhong Liu Za Zhi 35:595-9. 2013
    ..To investigate the prognostic factors for nasopharyngeal carcinoma (NPC) with different metastatic status, and to improve the NPC management by multi-level refinement and stratification of M1 stage distant metastases...
  20. pmc Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells
    Xuanfu Xu
    Department of Gastroenterology, the Tenth People s Hospital of Shanghai, Tongji University, Shanghai, China
    PLoS ONE 7:e43119. 2012
    ..Because SHH promotes tumor development predominantly through Gli1, we sought to understand its mechanism by identifying Gli1 targets in pancreatic cancer cells...
  21. ncbi request reprint Activated protein C, an anticoagulant polypeptide, ameliorates severe acute pancreatitis via regulation of mitogen-activated protein kinases
    Ping Chen
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    J Gastroenterol 42:887-96. 2007
    ....
  22. doi request reprint Survivin and Smac gene expressions but not livin are predictors of prognosis in non-small cell lung cancer patients treated with adjuvant chemotherapy following surgery
    Chun Hua Dai
    Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Jiangsu, China
    Jpn J Clin Oncol 40:327-35. 2010
    ..However, result in previous studies of the association of these gene expressions with prognosis of patients with non-small cell lung cancer remains contradictory...
  23. pmc Electrospun chitosan-graft-poly (ɛ-caprolactone)/poly (ɛ-caprolactone) nanofibrous scaffolds for retinal tissue engineering
    Honglin Chen
    Department of Ophthalmology, Shanghai Ninth People s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Int J Nanomedicine 6:453-61. 2011
    ..Taken together, these results suggest that CS-PCL/PCL(20/80) scaffolds have potential application in retinal tissue engineering...
  24. pmc Heterogeneity in predisposition of hepatic cells to be induced into pancreatic endocrine cells by PDX-1
    Shun Lu
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100083, China
    World J Gastroenterol 11:2277-82. 2005
    ..In this study, potential plasticity of liver cells into pancreatic endocrine cells induced by PDX-1 was evaluated...
  25. ncbi request reprint Involvement of PKC, p38 MAPK and AP-2 in IL-1beta-induced expression of cyclooxygenase-2 in human pulmonary epithelial cells
    Ping Chen
    Department of Respiratory Medicine, The Second Affilitated Hospital, Central South University, Xiangya Medical School, Changsha, Hunan, China
    Respirology 11:18-23. 2006
    ..The aim of this study was to identify the signal molecules involved in IL-1beta-induced expression of cyclooxygenase (COX)-2 in human pulmonary epithelial (A549) cells...
  26. ncbi request reprint [Effects of electromagnetic fields of different frequencies on proliferation and DNA damage of gallbladder cancer cells]
    Ping Chen
    College of Life Science and Technology, Tongji University, Shanghai 200092, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:328-30. 2006
    ..To study the effects of low-power electromagnetic fields of different frequencies on proliferation and DNA damage of gallbladder cancer cells...
  27. pmc Inhibitors of cytochrome P450 4A suppress angiogenic responses
    Ping Chen
    Eye Care Services, Henry Ford Health System, One Ford Place, 4 D, Detroit, MI 48202 3450, USA
    Am J Pathol 166:615-24. 2005
    ..These results suggest that a product of CYP4A product, possibly 20-HETE, plays a critical role in the regulation of angiogenesis and may provide a useful target for reduction of pathological angiogenesis...
  28. ncbi request reprint Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416
    Bulbul Pandit
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Bioorg Med Chem 14:6492-501. 2006
    ..Results are compared to those of compound 1, our lead compound previously reported...
  29. doi request reprint Proteomic analysis of cellular protein alterations using a hepatitis B virus-producing cellular model
    Aiping Tong
    The State Key Laboratory of Biotherapy, West China Hospital, College of Life Science, Sichuan University, Chengdu, People s Republic of China
    Proteomics 8:2012-23. 2008
    ..15 and HepG2 cells. The proteins identified in this study would be useful in revealing the mechanisms underlying HBV-host cell interactions and the development of HCC. This study can also provide some useful clues for antiviral research...
  30. ncbi request reprint [Effect of lenti-mCCL20 on the growth of mouse tumor]
    Hong Xia Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:712-6. 2006
    ..We aim at inducing a potent antitumor immune response via CCL20 expressing in situ tumor...
  31. ncbi request reprint New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases
    Harold Mastalerz
    Department of Oncology Chemistry, 5 Research Parkway, Wallingford, CT 06492 1951, USA
    Bioorg Med Chem Lett 17:2036-42. 2007
    ..The lead compound exhibited promising oral efficacy in both EGFR and HER2 driven human tumor xenograft models. It is hypothesized that its C-5 morpholine side chain binds in the ribose phosphate portion of the ATP binding pocket...
  32. ncbi request reprint Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2
    Silke Schepelmann
    The Institute of Cancer Research, Cancer Research UK Centres for Cancer Therapeutics, London, United Kingdom
    Cancer Res 67:4949-55. 2007
    ....
  33. ncbi request reprint 5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases
    Harold Mastalerz
    Department of Oncology Chemistry, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492 1951, USA
    Bioorg Med Chem Lett 17:4947-54. 2007
    ..It is hypothesized that this solubilizing group extends into the ribose-phosphate portion of the ATP binding pocket and enhances the binding affinity of the inhibitor...
  34. ncbi request reprint [Dicer efficiently converts large dsRNAs into siRNAs suitable for COX-2 gene]
    Hong Luo
    Department of Respiratory Diseases Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:437-42. 2007
    ..To report the use of Dicer to cleave double-stranded RNA (dsRNAs) into small interference RNAs (D-siRNAs) that can target multiple sites within an mRNA, and to acquire an new method to cure inflammation of the airway and tumor...
  35. ncbi request reprint Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors
    Min Teng
    Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla, Inc, 10770 Science Center Drive, San Diego, California 92121 1194, USA
    J Med Chem 50:5253-6. 2007
    ..Compound 10c, showing no single agent effect, potentiated the antiproliferative effect of Gemcitabine in both prostate and breast cancer cell lines...
  36. ncbi request reprint Synergistic antitumor effect of CXCL10 with hyperthermia
    Ping Chen
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, 1 Keyuan Road 4, Gaopeng Street, High Technological Development Zone, Chengdu, Sichuan 610041, People s Republic of China
    J Cancer Res Clin Oncol 134:679-87. 2008
    ..In the present study, we try to investigate whether the combination therapy of hyperthermia, a physical antiangiogenic modality, with CXCL10 would completely eradicate the established solid tumors...
  37. doi request reprint Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells
    Hong Peng
    Department of Respiratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China
    Peptides 29:419-24. 2008
    ..These findings indicate that ET-1 plays important roles in regulating COX-2 expression and production of IL-8 in A549 cells. ET-1 mediated production of IL-8 is likely through a COX-2-dependent mechanism...
  38. ncbi request reprint [Establishment of protein profile of human small cell lung cancer cell line NCI-H446]
    Mao Yu Li
    Medical Experimental Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P R China
    Ai Zheng 23:1116-21. 2004
    ..This study was to establish a well-resolved, reproducible 2-DE map of proteome in SCLC cell line NCI-H446, and analyze its protein profiles...