Nan Chen

Summary

Country: China

Publications

  1. pmc Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists attenuate the profibrotic response induced by TGF-beta1 in renal interstitial fibroblasts
    Weiming Wang
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Mediators Inflamm 2007:62641. 2007
  2. pmc Distinct metabolic profile of primary focal segmental glomerulosclerosis revealed by NMR-based metabolomics
    Xu Hao
    Nephrology Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 8:e78531. 2013
  3. ncbi request reprint [Chronic renal disease and dialysis in China]
    Nan Chen
    Département de néphrologie de l hôpital Ruijin
    Bull Acad Natl Med 196:977-81. 2012
  4. ncbi request reprint [The efficacy and safety of continuous erythropoietin receptor activator in dialytic patients with chronic renal anemia: an open, randomized, controlled, multi-center trial]
    Nan Chen
    Shanghai Jiaotong University School of Medicine, Shanghai, China
    Zhonghua Nei Ke Za Zhi 51:502-7. 2012
  5. doi request reprint Analysis of early kidney damage in hospitalized patients with chronic kidney disease: a multicenter study
    Nan Chen
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    Ren Fail 34:329-33. 2012
  6. doi request reprint Challenging chronic kidney disease: experience from chronic kidney disease prevention programs in Shanghai, Japan, Taiwan and Australia
    Nan Chen
    Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, China
    Nephrology (Carlton) 15:31-6. 2010
  7. ncbi request reprint Two brothers in one Chinese family with collagen type III glomerulopathy
    Nan Chen
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Am J Kidney Dis 50:1037-42. 2007
  8. pmc Community-based study on CKD subjects and the associated risk factors
    Nan Chen
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, People s Republic of China
    Nephrol Dial Transplant 24:2117-23. 2009
  9. ncbi request reprint Effects of DC-SIGN expression on renal tubulointerstitial fibrosis in nephritis
    Tong Zhou
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China
    Front Biosci (Landmark Ed) 14:3814-24. 2009
  10. ncbi request reprint Effects of DC-SIGN expression on renal tubulointerstitial fibrosis in nephritis
    Tong Zhou
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China
    Front Biosci (Landmark Ed) 14:2935-43. 2009

Collaborators

Detail Information

Publications84

  1. pmc Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists attenuate the profibrotic response induced by TGF-beta1 in renal interstitial fibroblasts
    Weiming Wang
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Mediators Inflamm 2007:62641. 2007
    ..In order to elucidate the antifibrotic mechanism of PPAR-gamma agonists, we investigated the effects of PPAR-gamma activation on TGF-beta1-induced renal interstitial fibroblasts...
  2. pmc Distinct metabolic profile of primary focal segmental glomerulosclerosis revealed by NMR-based metabolomics
    Xu Hao
    Nephrology Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 8:e78531. 2013
    ..Currently, there is no practical noninvasive technique to predict different pathological types of glomerulopathies. In this study, the role of urinary metabolomics in the diagnosis and pathogenesis of FSGS was investigated...
  3. ncbi request reprint [Chronic renal disease and dialysis in China]
    Nan Chen
    Département de néphrologie de l hôpital Ruijin
    Bull Acad Natl Med 196:977-81. 2012
    ..In year 2010, the national dialysis registry, included 310 000 patients; 11 000 of them were living in Shanghai mean age 56 years M/F sex ratio 1.82. A governement program is underway to prevent and to detect CKD in China...
  4. ncbi request reprint [The efficacy and safety of continuous erythropoietin receptor activator in dialytic patients with chronic renal anemia: an open, randomized, controlled, multi-center trial]
    Nan Chen
    Shanghai Jiaotong University School of Medicine, Shanghai, China
    Zhonghua Nei Ke Za Zhi 51:502-7. 2012
    ..E.R.A.) once every 4 weeks by subcutaneous administration on hemoglobin (Hb) maintenance in dialytic patients with chronic renal anemia who had been treated with stable dose of erythropoietin (EPO)...
  5. doi request reprint Analysis of early kidney damage in hospitalized patients with chronic kidney disease: a multicenter study
    Nan Chen
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    Ren Fail 34:329-33. 2012
    ..To identify the risk factors for early kidney damage in hospitalized Chinese patients with chronic kidney disease (CKD)...
  6. doi request reprint Challenging chronic kidney disease: experience from chronic kidney disease prevention programs in Shanghai, Japan, Taiwan and Australia
    Nan Chen
    Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, China
    Nephrology (Carlton) 15:31-6. 2010
    ..Furthermore, opportunistic screening with emphasis on early detection was effective in CKD prevention. The studies from those regions share experiences on early prevention and management of CKD...
  7. ncbi request reprint Two brothers in one Chinese family with collagen type III glomerulopathy
    Nan Chen
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Am J Kidney Dis 50:1037-42. 2007
  8. pmc Community-based study on CKD subjects and the associated risk factors
    Nan Chen
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, People s Republic of China
    Nephrol Dial Transplant 24:2117-23. 2009
    ..The study was performed to investigate the prevalence, awareness and the risk factors of chronic kidney disease (CKD) in the community population in Shanghai, China...
  9. ncbi request reprint Effects of DC-SIGN expression on renal tubulointerstitial fibrosis in nephritis
    Tong Zhou
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China
    Front Biosci (Landmark Ed) 14:3814-24. 2009
    ..These results suggest that DC-SIGN plays an important role in DC-mediated renal tubular interstitial lesions induced by immuno-inflammatory responses...
  10. ncbi request reprint Effects of DC-SIGN expression on renal tubulointerstitial fibrosis in nephritis
    Tong Zhou
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China
    Front Biosci (Landmark Ed) 14:2935-43. 2009
    ..These results suggest that DC-SIGN plays an important role in DC-mediated renal tubular interstitial lesions induced by immuno-inflammatory responses...
  11. doi request reprint Propylthiouracil-induced antineutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis versus primary ANCA-associated renal vasculitis: a comparative study
    Yong Xi Chen
    Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200025, PR China
    J Rheumatol 39:558-63. 2012
    ..We analyzed the characteristics of patients with PTU-induced AAV with renal involvement and investigated the differences of the 2 diseases...
  12. pmc SUMOylation of PPARγ by rosiglitazone prevents LPS-induced NCoR degradation mediating down regulation of chemokines expression in renal proximal tubular cells
    Ying Lu
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China
    PLoS ONE 8:e79815. 2013
    ..The results unveil a new mechanism triggered by RGL for prevention of tubular inflammatory injury. ..
  13. doi request reprint Evaluation of anemia and serum iPTH, calcium, and phosphorus in patients with primary glomerulonephritis
    Ya Li
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Contrib Nephrol 181:31-40. 2013
    ..73 m(2). Primary glomerular disease remains the major cause of CKD in China, and complications such as anemia and metabolic bone disease are frequently present in GN patients...
  14. ncbi request reprint Analyzing fatal cases of Chinese patients with primary antineutrophil cytoplasmic antibodies-associated renal vasculitis: a 10-year retrospective study
    Yong Xi Chen
    Department of Nephrology, Shanghai Ruijin Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, PR China
    Kidney Blood Press Res 31:343-9. 2008
    ..Few studies have been published focusing on AASV patients with poor prognosis...
  15. ncbi request reprint Application of RIFLE criteria in Chinese patients with ANCA-associated renal vasculitis
    Yong Xi Chen
    Department of Nephrology, Shanghai Jiaotong University, School of Medicine, Shanghai, People s Republic of China
    Clin Exp Rheumatol 29:951-7. 2011
    ..Acute kidney injury (AKI) is common in patients with AASV but the value of RIFLE criteria is still unclear in those patients...
  16. ncbi request reprint [The association of single nucleotide P-selectin gene polymorphism with IgA nephropathy]
    Zhao Hui Wang
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, China
    Zhonghua Nei Ke Za Zhi 45:559-64. 2006
    ..P-selectin plays an important role in the pathogenesis and development of IgA nephropathy. The purpose of this study is to find a possible relationship between P-selectin gene polymorphism and IgA nephropathy...
  17. doi request reprint Screening of ACTN4 and TRPC6 mutations in a Chinese cohort of patients with adult-onset familial focal segmental glomerulosclerosis
    Qianying Zhang
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Contrib Nephrol 181:91-100. 2013
    ..The aim of this study was to determine the prevalence of TRPC6 and ACTN4 mutations in Chinese adult-onset familial FSGS...
  18. doi request reprint 15-Deoxy-Δ(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-κB activation via peroxisome proliferator activated receptor-γ-independent mechanism in renal tubular epithelial cells
    Ying Lu
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China
    Nephron Exp Nephrol 123:1-10. 2013
    ..However, no information is known about the effects of 15d-PGJ2 on chemokine expression in human proximal renal tubular cells (HPTECs) under inflammation...
  19. doi request reprint Tacrolimus combined with corticosteroids in idiopathic membranous nephropathy: a randomized, prospective, controlled trial
    Jing Xu
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Contrib Nephrol 181:152-62. 2013
    ..All of the side effects were mild and controlled, and there were fewer side effects in the tacrolimus group compared with the CTX group, indicating a better treatment tolerance in the tacrolimus group...
  20. doi request reprint Changing spectrum of biopsy-proven primary glomerular diseases over the past 15 years: a single-center study in China
    Xiaoxia Pan
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Contrib Nephrol 181:22-30. 2013
    ..The spectrum of PGD is different in different age groups. The frequency of EnPGN has decreased significantly, while that of MN has increased significantly...
  21. doi request reprint Twenty-one novel mutations identified in the COL4A5 gene in Chinese patients with X-linked Alport's syndrome confirmed by skin biopsy
    Jun Ma
    Department of Nephrology, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Nephrol Dial Transplant 26:4003-10. 2011
    ..Different mutations in the COL4A5 gene have been reported widely, but only a few mutations were identified in Chinese patients...
  22. doi request reprint Mycophenolate mofetil or tacrolimus compared with intravenous cyclophosphamide in the induction treatment for active lupus nephritis
    Xiao Li
    Department of Nephrology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Nephrol Dial Transplant 27:1467-72. 2012
    ..The objective of this study is to assess the efficacy and safety of mycophenolate mofetil (MMF) and tacrolimus compared with intravenous cyclophosphamide (IVC) as induction therapies for active lupus nephritis (ALN)...
  23. doi request reprint Identification of five novel variants in the thiazide-sensitive NaCl co-transporter gene in Chinese patients with Gitelman syndrome
    Ling Qin
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China
    Nephrology (Carlton) 14:52-8. 2009
    ..GS is caused by inactivating variants in the SLC12A3 gene, which encodes the thiazide-sensitive NaCl co-transporter. So far, more than 100 variants have been described in the SLC12A3 gene in Gitelman syndrome...
  24. doi request reprint Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II
    Chong Zhang
    Department of Nephrology, School of Medicine, Shanghai Jiao Tong University, China
    Nephron Physiol 118:p53-61. 2011
    ..In this report, we screened 4 Chinese PHA2 pedigrees for WNK4 mutations, identified a novel mutation, and studied its effects on NCC protein trafficking in vitro...
  25. ncbi request reprint Clinicopathological characteristics and outcome of Chinese patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: a 9-year retrospective study
    Wen Zhang
    Department of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    Nephron Clin Pract 112:c177-83. 2009
    ..Few studies have been published focusing on Chinese patients with TTP-HUS. We performed a retrospective study on the clinical characteristics and outcome of Chinese patients with TTP-HUS...
  26. doi request reprint Tacrolimus versus cyclophosphamide in steroid-dependent or steroid-resistant focal segmental glomerulosclerosis: a randomized controlled trial
    Hong Ren
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Am J Nephrol 37:84-90. 2013
    ..The efficacy and safety of tacrolimus (TAC) and cyclophosphamide (CTX) were prospectively examined in steroid-dependent or steroid-resistant primary focal segmental glomerulosclerosis (FSGS)...
  27. doi request reprint Identification and functional analysis of a novel TRPC6 mutation associated with late onset familial focal segmental glomerulosclerosis in Chinese patients
    Bin Zhu
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
    Mutat Res 664:84-90. 2009
    ..However, the role of TRPC6 variation in Chinese patients with late onset familial FSGS remains unclear. Here, we screened 31 Chinese pedigrees with late onset familial FSGS for changes in TRPC6 by DNA sequence analysis...
  28. pmc Predicting progression of IgA nephropathy: new clinical progression risk score
    Jingyuan Xie
    Nephrology Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 7:e38904. 2012
    ..The new progression risk score calculated based on these four baseline variables offers a simple clinical tool for risk stratification...
  29. ncbi request reprint Analysis of cardiovascular disease in Chinese inpatients with chronic kidney disease
    Xiao Nong Chen
    Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, PR China
    Intern Med 50:1797-801. 2011
    ..To investigate the prevalence of cardiovascular disease (CVD) in a Chinese patient population with different stages of chronic kidney disease (CKD)...
  30. doi request reprint Analyzing Chinese patients with post-operative acute kidney injury
    Wen Zhang
    Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China
    Ren Fail 33:795-800. 2011
    ..To investigate clinical characteristics and risk factors of Chinese patients with post-operative acute kidney injury (PO-AKI)...
  31. ncbi request reprint Valsartan inhibited the accumulation of dendritic cells in rat fibrotic renal tissue
    Kaiyin Wu
    Department of Nephrology, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
    Cell Mol Immunol 3:213-20. 2006
    ..The local DCs accumulation was related to tubulointerstitial fibrosis and renal dysfunction following renal ablation. Blockade to angiotensin II might be a potent way to attenuate renal immuno-inflammatory injury...
  32. doi request reprint Treatment and prognosis of primary focal segmental glomerulosclerosis
    Hong Ren
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, PR China
    Contrib Nephrol 181:109-18. 2013
    ..Steroids may be more effective in those who have better preserved renal function and milder glomerular sclerosis...
  33. doi request reprint Abnormal glucose metabolism and insulin sensitivity in Chinese patients with Gitelman syndrome
    Hong Ren
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Am J Nephrol 37:152-7. 2013
    ..Both hypokalemia and hypomagnesemia were reported to cause impaired glucose tolerance and/or insulin resistance, but it is unclear whether impaired glucose tolerance and/or insulin resistance are common in GS patients...
  34. doi request reprint Novel SLC12A3 mutations in Chinese patients with Gitelman's syndrome
    Leping Shao
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Nephron Physiol 108:p29-36. 2008
    ..Inactivating mutations of the SLC12A3 gene are the most common cause of Gitelman's syndrome (GS), a disorder inherited as an autosomal recessive trait. In a minority of cases, GS-like phenotypes are caused by mutations in the CLCNKB gene...
  35. ncbi request reprint PsL-EGFmAb inhibits the stimulatory functions of human dendritic cells via DC-SIGN
    Tong Zhou
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai 200025, China
    Front Biosci 13:7269-76. 2008
    ..Our present studies indicate that PsL-EGFmAb may be a useful reagent for regulating DC-SIGN expression and DC function...
  36. ncbi request reprint Analysis of factors associated with renal function in Chinese adults with congenital solitary kidney
    Yingyu Wang
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Intern Med 49:2203-9. 2010
    ..The purpose of this study was to identify factors that are independently associated with renal function progression in patients with congenital solitary kidney...
  37. ncbi request reprint ACTN4 gene mutations and single nucleotide polymorphisms in idiopathic focal segmental glomerulosclerosis
    Shengchuan Dai
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Nephron Clin Pract 111:c87-94. 2009
    ..To investigate the association between mutations or single nucleotide polymorphisms (SNPs) of the gene ACTN4 in Chinese patients with idiopathic focal segmental glomerulosclerosis (FSGS)...
  38. doi request reprint Increased risk of treatment failure and end-stage renal disease in familial focal segmental glomerular sclerosis
    Xu Hao
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Contrib Nephrol 181:101-8. 2013
    ..Few studies have compared familial FSGS (FFSGS) and sporadic FSGS (SFSGS). The aim of this study was to assess the clinical and pathological features and the prognosis of FSGS in patients with and without a family history of the disease...
  39. doi request reprint Protective effects of exogenous interleukin 18-binding protein in a rat model of acute renal ischemia-reperfusion injury
    Jun Wang
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Shock 37:333-40. 2012
    ..Exogenous IL-18BP attenuated renal injury caused by I/R via inhibiting inflammation in the renal tissue and protecting tubular epithelium and PTC endothelium...
  40. doi request reprint Phosphoproteomic study of human tubular epithelial cell in response to transforming growth factor-beta-1-induced epithelial-to-mesenchymal transition
    Yong Xi Chen
    Department of Nephrology, Shanghai Ruijin Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, PR China
    Am J Nephrol 31:24-35. 2010
    ..We applied isobaric tags for relative and absolute quantification (iTRAQ) technology to profile the phosphoproteins in tubular epithelial cells in response to TGF-beta-induced EMT in order to further study molecular events...
  41. doi request reprint Functional analysis of promoter mutations in the ACTN4 and SYNPO genes in focal segmental glomerulosclerosis
    Shengchuan Dai
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Nephrol Dial Transplant 25:824-35. 2010
    ..To investigate the promoter mutations of ACTN4 and SYNPO genes in patients with idiopathic focal segmental glomerulosclerosis (FSGS), and to provide functional analysis of these mutations in the role of FSGS occurrence...
  42. doi request reprint Re-evaluation of the classification system for membranoproliferative glomerulonephritis
    Yimin Lu
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Contrib Nephrol 181:175-84. 2013
    ..MGUS-associated MPGN was less frequent in the Chinese cohort. Future studies should be designed to evaluate the association of the new classification system and clinical outcomes of MPGN...
  43. ncbi request reprint [Impact of therapeutic time on the prognosis in critically ill patients with acute renal failure who needed renal replacement therapy]
    Ming li Zhu
    Shanghai Acute Renal Failure Work Group, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23:421-5. 2011
    ..To investigate the impact of therapeutic time on the prognosis in critically ill patients with acute renal failure (ARF) who needed renal replacement therapy (RRT), and to analyze the risk factors of death...
  44. ncbi request reprint [Analysis of drug-induced acute renal failure in Shanghai]
    Miao lin Che
    Department of Nephrology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
    Zhonghua Yi Xue Za Zhi 89:744-9. 2009
    ..To investigate the incidence and prognosis of drug-induced acute renal failure (ARF) in Shanghai...
  45. doi request reprint Peritubular capillary loss is ameliorated by ramipril or valsartan treatment
    Bin Zhang
    Department of Nephrology, Guangdong Provincial People s Hospital, Nanfang Medical University, Guangzhou, China
    Microcirculation 15:337-48. 2008
    ..To identify the preservation of peritubular capillaries conferred by ramipril or valsartan treatment as an additional mechanism for their renoprotection...
  46. doi request reprint 1H NMR spectroscopy analysis of metabolites in the kidneys provides new insight into pathophysiological mechanisms: applications for treatment with Cordyceps sinensis
    Fang Zhong
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Nephrol Dial Transplant 27:556-65. 2012
    ..The number of patients with chronic kidney disease (CKD) is continuously growing worldwide. Treatment with traditional Chinese medicine might slow the progression of CKD...
  47. doi request reprint Autophagy-sensitized cytotoxicity of quantum dots in PC12 cells
    Xiaoming Li
    Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility SSRF Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China
    Adv Healthc Mater 3:354-9. 2014
    ..Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions. ..
  48. doi request reprint Efficacy and safety of traditional chinese medicine (Shenqi particle) for patients with idiopathic membranous nephropathy: a multicenter randomized controlled clinical trial
    YiPing Chen
    Department of Nephrology, Longhua Hospital Affiliated to the Shanghai University of Traditional Chinese Medicine, Shanghai, China Electronic address
    Am J Kidney Dis 62:1068-76. 2013
    ..To compare the safety and efficacy of the traditional Chinese medicine Shenqi particle and standard therapy with prednisone and cyclophosphamide (control) in adult patients with idiopathic membranous nephropathy (IMN)...
  49. doi request reprint Fibroblast growth factor 23 is a predictor of aortic artery calcification in maintenance hemodialysis patients
    Zijin Chen
    Nephrology Department, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    Ren Fail 35:660-6. 2013
    ..Our study aimed to investigate the factors associated with elevated plasma FGF23 (cFGF23) levels in maintenance hemodialysis (MHD) patients and to determine whether plasma FGF23 level is related to aortic artery calcification (AAC)...
  50. ncbi request reprint Renal involvement and followup of 130 patients with primary Sjögren's syndrome
    Hon Ren
    Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, PR China
    J Rheumatol 35:278-84. 2008
    ..To identify the clinical characteristics, pathological changes, and outcome of patients with primary Sjögren's syndrome (pSS)...
  51. ncbi request reprint DC-SIGN modulates DC maturation and function in rat renal tubulointerstitial lesions
    Minchao Cai
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China
    Front Biosci (Landmark Ed) 17:1795-803. 2012
    ..PsL-EGFmAb inhibited DC migration, maturation and function by targeting DC-SIGN, and may therefore be a potential treatment for NTN...
  52. doi request reprint [Correlation between traditional Chinese medicine syndromes in primary immunoglobulin A nephropathy and A267G in 5'-untranslated region within exonal of megsin gene]
    Yi Fei Zhong
    Department of Nephrology, Longhua Hospital, Shanghai University of Tradtional Chinese Medicine, Shanghai 200032, China
    Zhong Xi Yi Jie He Xue Bao 6:463-7. 2008
    ....
  53. doi request reprint Coiled versus straight peritoneal dialysis catheters: a randomized controlled trial and meta-analysis
    Jingyuan Xie
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China
    Am J Kidney Dis 58:946-55. 2011
    ..The relative benefits of these designs have not been studied adequately. The objective of this study is to compare the clinical outcomes of coiled- versus straight-end swan neck peritoneal dialysis catheters...
  54. doi request reprint Chronic kidney disease is prevalent in Chinese patients admitted with verified cerebrovascular lesions and predicts short-term prognosis
    Jing Xu
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Nephrol Dial Transplant 26:2590-4. 2011
    ..While the link between CKD and cardiovascular events is well established, the link with cerebrovascular lesions (CVL) has been less well described...
  55. ncbi request reprint Clinical analysis of ANCA-associated renal vasculitis patients with chronic dialysis
    Yong Xi Chen
    Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200025, PR China
    Clin Exp Rheumatol 32:S5-10. 2014
    ..Currently, little has been published focusing on AAV patients with dialysis. We analysed AAV patients with chronic dialysis to provide more detailed information...
  56. ncbi request reprint [Effects of peroxisome proliferators-activated receptor gamma agonists on transforming growth factor-beta1 and Smads signal pathway: experiment with rat renal fibroblasts]
    Wei Ming Wang
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, China
    Zhonghua Yi Xue Za Zhi 86:740-4. 2006
    ....
  57. ncbi request reprint Anti-P-selectin lectin-EGF domain monoclonal antibody inhibits the maturation of human immature dendritic cells
    Tong Zhou
    Department of Nephrology, Rui Jin Hospital, Shanghai Second Medical University SSMU, Shanghai 200025, China
    Exp Mol Pathol 80:171-6. 2006
    ..Thus, blockade of selectins using PsL-EGFmAb will prove to be a valuable tool for the study of the molecular mechanisms of DC maturation, as well as for the prevention and treatment of DC-mediated autoimmunity...
  58. doi request reprint Interleukin-10 deficiency aggravates kidney inflammation and fibrosis in the unilateral ureteral obstruction mouse model
    Yuanmeng Jin
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Lab Invest 93:801-11. 2013
    ..Enhancement of IL-10 expression could be a potential anti-fibrosis therapy for patients with chronic kidney diseases. ..
  59. doi request reprint Analysis of the gene expression profile of curcumin-treated kidney on endotoxin-induced renal inflammation
    Fang Zhong
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People s Republic of China
    Inflammation 36:80-93. 2013
    ..The kidney gene expression profile in the inflammatory state was clarified by using gene chip technology. Furthermore, we confirmed that curcumin treatment can change the gene expression profile...
  60. ncbi request reprint Effect of MDR1 gene polymorphism on progression of end-stage renal disease
    Wei xia Zhang
    Institute of Clinical Pharmacology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Acta Pharmacol Sin 28:579-83. 2007
    ....
  61. doi request reprint PPAR-gamma agonists inhibit TGF-beta1-induced chemokine expression in human tubular epithelial cells
    Wei Ming Wang
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
    Acta Pharmacol Sin 30:107-12. 2009
    ....
  62. doi request reprint Treatment of progressive IgA nephropathy: an update
    Weiming Wang
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Contrib Nephrol 181:75-83. 2013
    ..However, there are currently controversies on the definition and treatment of progressive IgAN...
  63. ncbi request reprint Propylthiouracil-associated antineutrophil cytoplasmic autoantibody-positive vasculitis: retrospective study of 19 cases
    Yong Xi Chen
    Department of Nephrology, Shanghai Ruijin Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, China
    J Rheumatol 34:2451-6. 2007
    ..To investigate the features, followup data, and outcomes of patients with propylthiouracil (PTU)-associated antineutrophil cytoplasmic autoantibody (ANCA)-positive vasculitis...
  64. ncbi request reprint [Association of single nucleotide polymorphism of megsin gene with IgA nephropathy]
    Zhao Hui Wang
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medical, Shanghai 200025, China
    Zhonghua Yi Xue Za Zhi 86:1337-41. 2006
    ..To investigate whether the single nucleotide polymorphisms (SNPs) in the gene of megsin, a novel serine protease inhibitor, account for the pathogenicity of IgA nephropathy (IgAN)...
  65. ncbi request reprint Mycophenolate mofetil in induction and maintenance therapy of severe lupus nephritis: a meta-analysis of randomized controlled trials
    Bin Zhu
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
    Nephrol Dial Transplant 22:1933-42. 2007
    ..This meta-analysis of randomized controlled trials (RCTs) assesses the benefits and harms of MMF in the induction and maintenance therapy of severe LN...
  66. doi request reprint Pathogenesis of rapidly progressive glomerulonephritis: what do we learn?
    Yong Xi Chen
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Contrib Nephrol 181:207-15. 2013
    ..However, the role of LAMP-2 in the disease pathogenesis remains uncertain. We hope this review can help us to further understand the pathogenesis of the disease...
  67. ncbi request reprint Proteasome inhibitor inhibits proliferation and induces apoptosis in renal interstitial fibroblasts
    Bingbing Zhu
    Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, 200025, P R China
    Pharmacol Rep 65:1357-65. 2013
    ..This study aimed to investigate the role of a proteasome inhibitor on proliferation, apoptosis and related proteins in renal interstitial fibroblasts (NRK-49F)...
  68. ncbi request reprint Effect of interleukin-10 on the phenotype and function of cultured human dendritic cells
    Tong Zhou
    Department of Nephrology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Chin Med J (Engl) 118:1299-302. 2005
  69. doi request reprint High-frequency variant p.T60M in NaCl cotransporter and blood pressure variability in Han Chinese
    Leping Shao
    Department of Nephrology, Affiliated Hospital of Qingdao University School of Medicine, Qingdao, PR China
    Am J Nephrol 35:515-9. 2012
    ..However, the association of heterozygous NCC mutation p.Thr60Met and BP has not yet been studied...
  70. doi request reprint Improvement of awareness, treatment and control of hypertension among chronic kidney disease patients in China from 1999 to 2005
    Yu Wang
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China
    Hypertens Res 32:444-9. 2009
    ..Improvement of awareness and general control of hypertension were demonstrated. Education of both physicians and patients regarding optimal BP control should be reinforced in the future...
  71. doi request reprint Polyvalent DNA-graphene nanosheets "click" conjugates
    Zihao Wang
    Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China
    Nanoscale 4:394-9. 2012
    ..Therefore, this DNA-graphene conjugates could be explored as the assembly unit for advanced DNA nano-architectures in the field of DNA nanotechnology...
  72. doi request reprint Peritoneal dialysis outflow failure from omental wrapping diagnosed by catheterography
    Jing Yuan Xie
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, Peoples Republic of China
    Am J Kidney Dis 56:1006-11. 2010
    ..The catheter was stripped from the omentum and repositioned in the Douglas peritoneal sac. Catheterography is a reliable, safe, noninvasive, and inexpensive alternative procedure to diagnose outflow failure caused by omental wrapping...
  73. doi request reprint Clinical experience with nadroparin in patients undergoing dialysis for renal impairment
    Wen Zhang
    Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, China
    Hemodial Int 15:379-94. 2011
    ..Nadroparin administered by a bolus dose, followed by a continuous infusion was also shown to be effective and safe in patients undergoing continuous renal replacement therapy for acute renal failure...
  74. ncbi request reprint Detection of COL4A5 gene mutations in Chinese patients with Alport's syndrome
    Xiaoxia Pan
    Department of Nephrology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, People s Republic of China
    Nephrol Dial Transplant 19:1123-8. 2004
    ....
  75. doi request reprint Post liver transplantation acute kidney injury in a rat model of syngeneic orthotopic liver transplantation
    Jun Wang
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Lab Invest 91:1158-69. 2011
    ..Our results demonstrate that protection of the liver graft and inhibition of the systemic inflammatory response are vital in reducing the risk of post-LT AKI...
  76. ncbi request reprint Angiotensin II-mediated activation of fibrotic pathways through ERK1/2 in rat peritoneal mesothelial cells
    Jing Yuan Xie
    Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    Ren Fail 32:871-9. 2010
    ....
  77. doi request reprint A new locus for hereditary hypotrichosis simplex maps to chromosome 13q12.12 approximately 12.3 in a Chinese family
    Chao Xu
    State Key Laboratory of Medical Genomics, Center of Molecular Medicine, Ruijin Hospital, An Affiliate of Shanghai JiaoTong University Medical School, Shanghai, China
    J Cutan Pathol 37:758-63. 2010
    ..Hereditary hypotrichosis simplex (MIM 146520, HHS) is a rare form of nonsyndromic alopecia. The locus for autosomal dominant HHS was mapped to 18p11.32-p11.23 and 6p21.3, respectively, suggestive of genetic heterogeneity...
  78. pmc Mineral and bone disorder in Chinese dialysis patients: a multicenter study
    Xianglei Kong
    Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment Peking University, Ministry of Education, Beijing, China
    BMC Nephrol 13:116. 2012
    ..Studies regarding the status of MBD treatment in developing countries, especially in Chinese dialysis patients are extremely limited...
  79. doi request reprint The pheV phenylalanine tRNA gene Klebsiella pneumoniae clinical isolates is an integration hotspot for possible niche-adaptation genomic islands
    Nan Chen
    Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Central Urumqi Road, Shanghai, 200040, People s Republic of China
    Curr Microbiol 60:210-6. 2010
    ..We propose that the pheV-associated islands described in this study may contribute to fine tuning and adaptation of K. pneumoniae strains toward preferred infection and/or colonization pathways...
  80. ncbi request reprint [Transfection of recombinant bone morphogenetic protein-7 expressing plasmid into cultured human renal tubular epithelial cells attenuates the extracellular matrix accumulation induced by transforming growth factor-beta]
    Ya Li
    Department of Nephrology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Yi Xue Za Zhi 86:544-8. 2006
    ..To investigate the effects of bone morphogenetic protein (BMP)-7 on the extracellular matrix (ECM) accumulation induced by transforming growth factor (TGF)-beta...
  81. ncbi request reprint [Clinical features of polymyositis and dermatomyositis in four patients with renal involvement as mainly presentation.]
    Ying Qian
    Department of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Zhonghua Nei Ke Za Zhi 48:930-2. 2009
    ..To investigate the clinical features of polymyositis (PM) and dermatomyositis (DM) with renal involvement as mainly presentation...
  82. doi request reprint Serum proteome alteration of severe sepsis in the treatment of continuous renal replacement therapy
    Yu Gong
    Department of Nephrology, Affiliated Renmin Hospital, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, China
    Nephrol Dial Transplant 24:3108-14. 2009
    ..The aim of this research was to study the serum proteome alterations of severe sepsis patients in the treatment of CRRT. Improved knowledge of proteome alteration could lead to the development of more efficient treatment strategies...
  83. ncbi request reprint [The analysis of the factors for postoperative blood pressure recovery of aldosterone producing adenoma patients]
    Ding yi Liu
    Department of Urology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Wai Ke Za Zhi 42:587-9. 2004
    ..To investigate the factors regarding the recovery of postoperative blood pressure of aldosterone producing adenoma (APA) patients...
  84. doi request reprint The cytotoxicity of cadmium-based quantum dots
    Nan Chen
    Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    Biomaterials 33:1238-44. 2012
    ....