Lin Chen

Summary

Country: China

Publications

  1. ncbi request reprint Roles of FGF signaling in skeletal development and human genetic diseases
    Lin Chen
    Trauma Center, Center of Medical Molecular Genetics, Daping Hospital, Third Military Medical University, Daping, Chongqing 400042, China
    Front Biosci 10:1961-76. 2005
  2. doi request reprint Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia
    Yangli Xie
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Hum Mol Genet 21:3941-55. 2012
  3. pmc Overexpression of H1 calponin in osteoblast lineage cells leads to a decrease in bone mass by disrupting osteoblast function and promoting osteoclast formation
    Nan Su
    Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    J Bone Miner Res 28:660-71. 2013
  4. doi request reprint Fibroblast growth factor receptor 1 regulates the differentiation and activation of osteoclasts through Erk1/2 pathway
    Xiumin Lu
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Biochem Biophys Res Commun 390:494-9. 2009
  5. ncbi request reprint [Effect of p21 on the changes in renal tubular epithelial cells after ischemia/reperfusion injury of kidney]
    Kai long Li
    Center of Medical Molecular Genetics, State Key Laboratory of Trauma, Burn and Combined Injury, Trauma Center of PLA, The Third Military Medical University, Chongqing 400042, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17:606-10. 2005
  6. pmc Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis
    Nan Su
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    Hum Mol Genet 19:1199-210. 2010
  7. pmc Serum bone alkaline phosphatase in assessing illness severity of infected neonates in the neonatal intensive care unit
    Yaozong Zhang
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    Int J Biol Sci 8:30-8. 2012
  8. pmc Generation of Fgfr3 conditional knockout mice
    Nan Su
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Int J Biol Sci 6:327-32. 2010
  9. pmc Dynamic morphological changes in the skulls of mice mimicking human Apert syndrome resulting from gain-of-function mutation of FGFR2 (P253R)
    XiaoLan Du
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    J Anat 217:97-105. 2010
  10. ncbi request reprint [Study on Tie2 mRNA level in peripheral blood associated with the severity of sepsis]
    Jing Yang
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:361-3. 2010

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Roles of FGF signaling in skeletal development and human genetic diseases
    Lin Chen
    Trauma Center, Center of Medical Molecular Genetics, Daping Hospital, Third Military Medical University, Daping, Chongqing 400042, China
    Front Biosci 10:1961-76. 2005
    ..In this review, we discuss the results of recent studies on FGF receptors to illustrate mechanisms through which the abnormally activated FGF/FGFR signaling results in these diseases...
  2. doi request reprint Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia
    Yangli Xie
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Hum Mol Genet 21:3941-55. 2012
    ..The increased expression of PTHrP and down-regulated FGFR3 level may be responsible for the positive effects of PTH on bone phenotype of ACH and TDII mice...
  3. pmc Overexpression of H1 calponin in osteoblast lineage cells leads to a decrease in bone mass by disrupting osteoblast function and promoting osteoclast formation
    Nan Su
    Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    J Bone Miner Res 28:660-71. 2013
    ..The ratio of RANKL to OPG was significantly increased in Col1a1-Cnn1 osteoblasts. These findings reveal a novel function of CNN1 in maintaining bone homeostasis by coupling bone formation to bone resorption...
  4. doi request reprint Fibroblast growth factor receptor 1 regulates the differentiation and activation of osteoclasts through Erk1/2 pathway
    Xiumin Lu
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Biochem Biophys Res Commun 390:494-9. 2009
    ..The phosphorylation of Erk1/2 mitogen-activated protein (MAP) kinase was also decreased. Our results suggest that FGFR1 is indispensable for complete differentiation and activation of osteoclasts in mice...
  5. ncbi request reprint [Effect of p21 on the changes in renal tubular epithelial cells after ischemia/reperfusion injury of kidney]
    Kai long Li
    Center of Medical Molecular Genetics, State Key Laboratory of Trauma, Burn and Combined Injury, Trauma Center of PLA, The Third Military Medical University, Chongqing 400042, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17:606-10. 2005
    ..To investigate the contribution of p21 gene in renal tubular epithelial cells in p21 (+/+) and p21 (-/-) mice of young and old ages at different times after kidney ischemia/reperfusion injury (IRI)...
  6. pmc Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis
    Nan Su
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    Hum Mol Genet 19:1199-210. 2010
    ..Our studies provide new insight into the mechanism underlying the development of ACH...
  7. pmc Serum bone alkaline phosphatase in assessing illness severity of infected neonates in the neonatal intensive care unit
    Yaozong Zhang
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    Int J Biol Sci 8:30-8. 2012
    ....
  8. pmc Generation of Fgfr3 conditional knockout mice
    Nan Su
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Int J Biol Sci 6:327-32. 2010
    ..This animal model will be useful to study distinct roles of FGFR3 in different tissues at different ages...
  9. pmc Dynamic morphological changes in the skulls of mice mimicking human Apert syndrome resulting from gain-of-function mutation of FGFR2 (P253R)
    XiaoLan Du
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    J Anat 217:97-105. 2010
    ..The changes in form characterized in this study will help to elucidate the mechanisms through which the Pro253Arg mutation in fibroblast growth factor receptor 2 affects craniofacial development and causes Apert syndrome...
  10. ncbi request reprint [Study on Tie2 mRNA level in peripheral blood associated with the severity of sepsis]
    Jing Yang
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:361-3. 2010
    ..To investigate the possibility that the level of Tie2 mRNA in peripheral blood could reflect the severity of sepsis...
  11. ncbi request reprint Efficient multi-site-directed mutagenesis directly from genomic template
    Fengtao Luo
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042 China
    J Biosci 37:965-9. 2012
    ..This method was effectively applied for multi-site-directed mutagenesis directly from mouse genomic DNA, as well as for combination, deletion or insertion of DNA fragments...
  12. ncbi request reprint eNOS correlates with mitochondrial biogenesis in hearts of congenital heart disease with cyanosis
    Juan Xiao
    Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, PR, China
    Arq Bras Cardiol 99:780-8. 2012
    ..The adaptive mechanisms that protect myocardium metabolism during hypoxia are coordinated in part by nitric oxide (NO)...
  13. doi request reprint Cross-talk between FGF and other cytokine signalling pathways during endochondral bone development
    Min Jin
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Peoples Republic of China
    Cell Biol Int 36:691-6. 2012
    ..In this review, we focus on the interplay between FGF signalling and other pathways, which is tightly regulated both spatially and temporally during endochondral skeletal development...
  14. ncbi request reprint [Generation of bone morphogenetic protein 4 conditional RNA interference mice]
    Fu bing Li
    Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Yi Chuan 30:341-6. 2008
    ....
  15. doi request reprint Gain-of-function mutation of FGFR3 results in impaired fracture healing due to inhibition of chondrocyte differentiation
    Nan Su
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Biochem Biophys Res Commun 376:454-9. 2008
    ..These results indicated that activating mutation of FGFR3 could lead to impaired bone repair due to inhibition of chondrocyte differentiation...
  16. ncbi request reprint [The change in Toll-like receptor 4 gene expression in skeleton of endotoxemia mice]
    Zi yu Zhao
    State Key Laboratory of Trauma, Burns, and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:13-6. 2009
    ..To explore the changes in gene expression of bone in endotoxemia in mice...
  17. ncbi request reprint [Relationship of neuroendocrine differentiation to biological behavior of prostate cancer]
    Xiu Ling Wu
    First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325003, China
    Zhonghua Yi Xue Za Zhi 89:472-5. 2009
    ..To investigate the relationship between neuroendocrine differentiation (NED) in prostate cancer and hormone refractory prostate cancer...
  18. doi request reprint Characterizing the complexity of spontaneous electrical signals in cultured neuronal networks using approximate entropy
    Lin Chen
    BrittonChanceCenter forBiomedical Photonics, HuazhongUniversity of Science and Technology, Wuhan 430074, China
    IEEE Trans Inf Technol Biomed 13:405-10. 2009
    ..This suggests that the proposed method is a valid procedure for tracking the dynamic variation in neuronal signals and can distinguish the different firing patterns of neuronal networks in terms of their complexity...
  19. doi request reprint Clinical characteristics of paroxysmal kinesigenic choreoathetosis: diagnosis, treatment and prognosis
    Huicong Kang
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 29:118-21. 2009
    ..3% patients. It was concluded that PKC was a common disease of movement disorder. The therapy by AEDs was very effective. PKC should be differentiated from epilepsy and the relationship between PKC and epilepsy needs further research...
  20. ncbi request reprint [Ligation and resection of the inferior vena cava during surgical removal of the retroperitoneal tumors involving the inferior vena cava: feasibility and safety assessment]
    Bo Wei
    Department of General Surgery, General Hospital of PLA, Beijing 100853, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:922-4, 928. 2009
    ..To assess the feasibility and safety of excising or patching the inferior vena cava (IVC) without replacement in patients with primary retroperitoneal tumors (PRPT) involving the IVC...
  21. ncbi request reprint [Clinical research of dialyzer reprocessing machine W-F168-B]
    Lichuan Yang
    Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 26:1325-8. 2009
    ..In conclusion, these two dialyzer reprocessing machines are similar in the effect of the dialyzer's performance and the subject's dialysis sufficiency. The reused dialyzers reprocessed by these two machines are safe for use...
  22. doi request reprint Optimization of process conditions with attention to the sludge reduction and stable immobilization in a novel Tubificidae-reactor
    Yu Tian
    State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology SKLUWRE, HIT, Harbin 150090, China
    Bioresour Technol 101:6069-76. 2010
    ..The optimum conditions were found to be DO of 1.0-1.6 mg/L and ISC of 3000-4000 mg/L respectively, while keeping FHIA at 12 times/d and SRT at 2d...
  23. ncbi request reprint [Effect of sustained increasing fibroblast growth factor signal on development of epiphyseal plate cultured in vitro]
    Liangjun Yin
    Department of Orthopaedics, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:953-7. 2010
    ..The biological effects of fibroblast growth factor (FGF) may be different under different intensities and durations. To investigate the impact of sustained increasing FGF signal upon the development of epiphyseal plate...
  24. ncbi request reprint [Studies on chemical components of Cirsium segestum]
    Qing Zhou
    Guangdong Pharmaceutical University, Guangzhou 510006, China
    Zhong Yao Cai 30:45-7. 2007
    ..They were 5,7-dihydroxyflavone, baicalin, oleanolic acid, cholesterol, methyl ursolate and rutin. The first to the fifth of which were got from Cirsium segestum for the first time...
  25. ncbi request reprint Simultaneous determination of sorbic and benzoic acids in food dressing by headspace solid-phase microextraction and gas chromatography
    Chunzhou Dong
    Department of Sanitary Technology, Hubei College of Traditional Chinese Medicine, Wuhan 430064, China
    J Chromatogr A 1117:109-14. 2006
    ..Recoveries for the two analytes in all the samples tested ranged from 83.44 to 113.2%. Practical applicability was demonstrated through the simultaneous determination of sorbic and benzoic acids in the three complex samples...
  26. ncbi request reprint [Effects of Sini decoction on vascular stenosis after iliac artery balloon injury and oxidative stress in rabbits]
    Yong Liu
    Department of Cardiology, Third Affiliated Hospital, Sun Yat sun University, Guangzhou 510630, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1559-62. 2006
    ..To investigate the effect of Sini decoction (SND) in preventing vascular restenosis and protecting against oxidative stress after rabbit iliac artery balloon injury...
  27. doi request reprint A rabbit model to study regression of ventricular hypertrophy
    Zhe Zhao
    Department of Cardiovascular Surgery, Second Affiliated Hospital, Third Military Medical University, Chongqing 400037, China
    Heart Lung Circ 22:373-82. 2013
    ..The purpose of this study is to develop and characterise a reproducible rabbit model of LVH regression following pressure-induced myocardial hypertrophy...
  28. doi request reprint Localized all-cell knock-out (LACKO) strategy is needed for studying adult stage diseases
    XiaoLan Du
    Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Third Military Medical University Daping Hospital, Chongqing 400042, People s Republic of China
    Transgenic Res 21:1159-62. 2012
    ..We describe the concept of this new strategy in detail in this article...
  29. doi request reprint Role of FGFs/FGFRs in skeletal development and bone regeneration
    XiaoLan Du
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    J Cell Physiol 227:3731-43. 2012
    ..This review has also provided a perspective view on future work for exploring the roles and action mechanisms of FGF signaling in skeletal development, genetic skeletal diseases, and fracture healing...
  30. doi request reprint Is there a relationship between bone and critical illness?
    Yaozong Zhang
    State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Med Hypotheses 76:615-7. 2011
    ..Published data and our own work have led us to hypothesize that the bone plays an important role in the pathogenesis and outcome of critical illness...
  31. ncbi request reprint FGF signaling: its role in bone development and human skeleton diseases
    Nan Su
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Front Biosci 13:2842-65. 2008
    ..In this review, we are going to give a summary of the role of FGFs/FGFRs in skeleton development and diseases, and pay more attention to those recent progresses...
  32. ncbi request reprint [Effect of p53 on the variation of renal tubular epithelial cells after kidney ischemia/reperfusion injury]
    Kai long Li
    Center of Medical Molecular Genetics, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23:6-10. 2007
    ....
  33. doi request reprint A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis
    Liangjun Yin
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China
    Bone 42:631-43. 2008
    ..And the Erk1/2 signaling pathway partially mediated the effects of P253R mutation of Fgfr2 on cranial sutures and long bones...
  34. doi request reprint Cardioprotective effect of mangiferin on left ventricular remodeling in rats
    Dezhi Zheng
    Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Pharmacology 90:78-87. 2012
    ..Based on these results, we conclude that mangiferin has a therapeutic effect on post-MI left ventricular remodeling and improves cardiac function...
  35. doi request reprint Animal model of ascending aortic stenosis in rabbits without endotracheal intubation
    Zhe Zhao
    Department of Cardiovascular Surgery, Second Affiliated Hospital, Third Military Medical University, Chongqing, China
    J Card Surg 25:253-7. 2010
    ..We developed an animal model of pressure overload hypertrophy caused by constriction of the ascending aorta in rabbits that does not require endotracheal intubation...
  36. ncbi request reprint Tie2 mRNA in peripheral blood: a new marker to assess damage of endothelial cells in a rat model of sepsis
    Jing Yang
    State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Trauma Laboratory, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Chin J Traumatol 13:308-12. 2010
    ..To evaluate the endothelial cell damage by detecting the circulating Tie2 mRNA level in a rat model of sepsis...
  37. ncbi request reprint Anti-inflammatory effect of erythropoietin pretreatment on cardiomyocytes with hypoxia/reoxygenation injury and the possible mechanism
    Chuan Qin
    Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    Chin J Traumatol 11:352-8. 2008
    ..To investigate the anti-inflammatory effect of erythropoietin (EPO) pretreatment on cardiomyocytes exposed to hypoxia/reoxygenation injury (H/R) and explore the possible mechanism...
  38. ncbi request reprint The partition of cholesterol between ordered and fluid bilayers of phosphatidylcholine: a synchrotron X-ray diffraction study
    Lin Chen
    Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, PR China
    Biochim Biophys Acta 1768:2873-81. 2007
    ..09 to 0.15 it was found that the liquid-crystal and gel phases each contained about 10% of the cholesterol molecules and the liquid-ordered phase was comprised of 30% cholesterol molecules...
  39. ncbi request reprint [Expression of proliferating cell nuclear antigen/bcl-2 in gray gingival tissue]
    Lin Chen
    Dept of Prosthodontics, Stomatological Hospital of Zunyi Medical College, Zunyi 563003, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 22:180-2. 2004
    ..To study the expression of PCNA/bcl-2 protein in gray and normal gingival tissue, and to investigate the biological effect of procelain-fused-to-metals (PFM)...
  40. ncbi request reprint Neuroprotective effects of hydroxyethylpuerarin against focal cerebral ischemia-reperfusion in rats
    Zi Ying Wang
    Institute of Pharmacology, School of Medicine, Shandong University, Jinan 250012, Shandong, P R China
    Chin J Physiol 50:211-6. 2007
    ..All these findings suggest that HEP might provide neuroprotection against focal cerebral ischemia/reperfusion injury probably through its antioxidant and anti-inflammatory property...
  41. ncbi request reprint Molecular and biochemical characterization of the Skp2-Cks1 binding interface
    Wei Wang
    Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309, USA
    J Biol Chem 279:51362-9. 2004
    ..These results uncovered the specificity of the Skp2-Cks1 interaction and reveal a critical function for the structurally flexible carboxyl-terminal tail region of Skp2 in Cks1 recognition and substrate ubiquitination...
  42. ncbi request reprint Increased expression of ceruloplasmin in the retina following photic injury
    Lin Chen
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA
    Mol Vis 9:151-8. 2003
    ..The purpose of this study was to determine whether retinal ceruloplasmin is upregulated following photo-oxidation, to localize ceruloplasmin protein, and to determine which ceruloplasmin isoform is present in the retina...
  43. ncbi request reprint Ultraviolet sealing and poly(dimethylacrylamide) modification for poly(dimethylsiloxane)/glass microchips
    Lin Chen
    College of Chemistry and Chemical Engineering, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, P R China
    Electrophoresis 25:914-21. 2004
    ..A high efficiency of theoretical plates with at least 1365 (105 000 N/m) and a good reproducibility with relative standard deviations (RSD) below 4% in five successive separations were achieved...
  44. ncbi request reprint The kinetics and mechanism of the formation of crystalline phase of dipalmitoylphosphatidylethanolamine dispersed in aqueous dimethyl sulfoxide solutions
    Lin Chen
    Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China
    Chem Phys Lipids 127:153-9. 2004
    ..The inducement of lamellar crystal phase in DPPE by DMSO is discussed in terms of the dehydration effect of DMSO and competitive molecular interactions between DMSO, water, and the phospholipid...
  45. ncbi request reprint A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis
    Lin Chen
    Genetics of Development and Disease Branch, NIDDK NIH, 10 9N105, 10 Center Drive, Bethesda, MD 20892, USA
    Bone 33:169-78. 2003
    ..Thus, our data reveal that dysregulated apoptosis plays an important role in the pathogenesis of AS related phenotypes...
  46. ncbi request reprint Light damage induced changes in mouse retinal gene expression
    Lin Chen
    F M Kirby Center for Molecular Ophthalmology Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Eye Res 79:239-47. 2004
    ..The genes found upregulated by light damage may affect the survival of photoreceptors subjected to photo-oxidative stress...
  47. ncbi request reprint Dynamic analysis of ABA accumulation in relation to the rate of ABA catabolism in maize tissues under water deficit
    Huibo Ren
    College of Agronomy and Biotechnology, State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing, China
    J Exp Bot 58:211-9. 2007
    ..The present study suggests that ABA catabolism is rapid enough to play an important role in the regulation of ABA accumulation...
  48. ncbi request reprint Structural determinants for alpha-neurotoxin sensitivity in muscle nAChR and their implications for the gating mechanism
    Cosma D Dellisanti
    Molecular and Computational Biology, Department of Chemistry and Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 2910, USA
    Channels (Austin) 1:234-7. 2007
    ..These analyses not only help understand the structural determinants for neurotoxin sensitivity in muscle-type nAChR, but also shed light on its gating mechanism...
  49. ncbi request reprint [Effects of irbesartan on nitric oxide system in the heart of diabetic rats]
    Xiao Xian Qian
    Department of Cardiology, Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1359-62. 2006
    ..To investigate the effects of irbesartan for heart protection and on heart nitric oxide (NO) system in diabetic rats...
  50. ncbi request reprint [Impact of loss of sympathetic innervation on peripheral nerve regeneration: an experimental study with rats]
    Ke Sha
    Department of Orthopedics, First Affiliated Hospital of Guasngxi Medical University, Nanning 530021, China
    Zhonghua Yi Xue Za Zhi 86:1069-72. 2006
    ..To investigate the impact of loss of sympathetic innervation on peripheral nerve regeneration...
  51. ncbi request reprint The involvement of lipid rafts in epidermal growth factor-induced chemotaxis of breast cancer cells
    Ying Liu
    Beijing National Laboratory for Molecular Sciences BNLMS and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
    Mol Membr Biol 24:91-101. 2007
    ..Taken together, our study indicated that integrity of lipid rafts was critical in EGF-induced chemotaxis of human breast cancer cells...
  52. ncbi request reprint [Effects of tetramethylpyrazine on fibrosis of atrial tissue and atrial fibrillation in a canine model of congestive heart failure induced by ventricular tachypacing]
    Ya zhou Lin
    Department of Cardiology, Fujian Provincial Research Institute for Cardiovascular Diseases, Fujian Provincial Hospital, Fuzhou, Fujian Province 350001, China
    Zhong Xi Yi Jie He Xue Bao 4:35-8. 2006
    ..To explore the effects of tetramethylpyrazine (TMP) on fibrosis of atrial tissue and atrial fibrillation in a canine model of congestive heart failure (CHF) induced by ventricular tachypacing...
  53. doi request reprint Phase diagram of androsterol-dipalmitoylphosphatidylcholine mixtures dispersed in excess water
    Wenying Gao
    Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
    J Phys Chem B 112:8375-82. 2008
    ..We conclude that androsterol is less effective in promoting the formation of an ordered phase, and furthermore, this ordered phase is less compact than the normal lamellar liquid-ordered phase...
  54. ncbi request reprint Chemopreventive effect of five drugs on renal interstitial fibrosis induced by an aristolochic acid-containing Chinese herb in rats
    Shaoming Zhu
    Department of Nephrology, Taihe Hospital and Affiliated Hospital of Yunyang Medical College, Shiyan City, Hubei Province, China
    Am J Nephrol 25:23-9. 2005
    ..This study focuses on the chemopreventive effect of five drugs on renal interstitial fibrosis induced by an aristolochic acid-containing Chinese herb Mu-Tong...
  55. ncbi request reprint [Gly374Arg mutation in Fgfr3 causes achondroplasia in mice]
    Jian Min Wang
    Department of Clinical Biological Technology, State Key Laboratory of Trauma Medicine, Chongqing, 400042 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:537-41. 2004
    ..To establish the mouse model of Gly374Arg mutation in fibroblast growth factor receptor 3(Fgfr3) and to analyze the phenotype of the mutant mice...
  56. ncbi request reprint Increased metallothionein in light damaged mouse retinas
    Lin Chen
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Eye Res 79:287-93. 2004
    ..Increased expression of the antioxidant MT in the light damaged mouse retina suggests that upregulation of MT is an important acute retinal response to photo-oxidative stress...
  57. pmc Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak
    Rachel T Uren
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    J Cell Biol 177:277-87. 2007
    ....