Research Topics
Genomes and Genes | Lin ChenSummaryCountry: China Publications
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Publications
Roles of FGF signaling in skeletal development and human genetic diseasesLin Chen
Trauma Center, Center of Medical Molecular Genetics, Daping Hospital, Third Military Medical University, Daping, Chongqing 400042, China
Front Biosci 10:1961-76. 2005..In this review, we discuss the results of recent studies on FGF receptors to illustrate mechanisms through which the abnormally activated FGF/FGFR signaling results in these diseases...
Fibroblast growth factor receptor 1 regulates the differentiation and activation of osteoclasts through Erk1/2 pathwayXiumin Lu
State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Biochem Biophys Res Commun 390:494-9. 2009..The phosphorylation of Erk1/2 mitogen-activated protein (MAP) kinase was also decreased. Our results suggest that FGFR1 is indispensable for complete differentiation and activation of osteoclasts in mice...- [Effect of p21 on the changes in renal tubular epithelial cells after ischemia/reperfusion injury of kidney]Kai long Li
Center of Medical Molecular Genetics, State Key Laboratory of Trauma, Burn and Combined Injury, Trauma Center of PLA, The Third Military Medical University, Chongqing 400042, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17:606-10. 2005..To investigate the contribution of p21 gene in renal tubular epithelial cells in p21 (+/+) and p21 (-/-) mice of young and old ages at different times after kidney ischemia/reperfusion injury (IRI)... 
Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesisNan Su
State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
Hum Mol Genet 19:1199-210. 2010..Our studies provide new insight into the mechanism underlying the development of ACH...- Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasiaYangli Xie
State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Hum Mol Genet 21:3941-55. 2012..The increased expression of PTHrP and down-regulated FGFR3 level may be responsible for the positive effects of PTH on bone phenotype of ACH and TDII mice... - Serum bone alkaline phosphatase in assessing illness severity of infected neonates in the neonatal intensive care unitYaozong Zhang
State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
Int J Biol Sci 8:30-8. 2012.... - Generation of Fgfr3 conditional knockout miceNan Su
State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Int J Biol Sci 6:327-32. 2010..This animal model will be useful to study distinct roles of FGFR3 in different tissues at different ages... - Dynamic morphological changes in the skulls of mice mimicking human Apert syndrome resulting from gain-of-function mutation of FGFR2 (P253R)XiaoLan Du
State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
J Anat 217:97-105. 2010..The changes in form characterized in this study will help to elucidate the mechanisms through which the Pro253Arg mutation in fibroblast growth factor receptor 2 affects craniofacial development and causes Apert syndrome... - [Study on Tie2 mRNA level in peripheral blood associated with the severity of sepsis]Jing Yang
State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:361-3. 2010..To investigate the possibility that the level of Tie2 mRNA in peripheral blood could reflect the severity of sepsis... - Cross-talk between FGF and other cytokine signalling pathways during endochondral bone developmentMin Jin
State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Peoples Republic of China
Cell Biol Int 36:691-6. 2012..In this review, we focus on the interplay between FGF signalling and other pathways, which is tightly regulated both spatially and temporally during endochondral skeletal development... - [Generation of bone morphogenetic protein 4 conditional RNA interference mice]Fu bing Li
Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Yi Chuan 30:341-6. 2008.... - Gain-of-function mutation of FGFR3 results in impaired fracture healing due to inhibition of chondrocyte differentiationNan Su
State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Biochem Biophys Res Commun 376:454-9. 2008..These results indicated that activating mutation of FGFR3 could lead to impaired bone repair due to inhibition of chondrocyte differentiation... - [The change in Toll-like receptor 4 gene expression in skeleton of endotoxemia mice]Zi yu Zhao
State Key Laboratory of Trauma, Burns, and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:13-6. 2009..To explore the changes in gene expression of bone in endotoxemia in mice... - [Clinical research of dialyzer reprocessing machine W-F168-B]Lichuan Yang
Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 26:1325-8. 2009..In conclusion, these two dialyzer reprocessing machines are similar in the effect of the dialyzer's performance and the subject's dialysis sufficiency. The reused dialyzers reprocessed by these two machines are safe for use... - Clinical characteristics of paroxysmal kinesigenic choreoathetosis: diagnosis, treatment and prognosisHuicong Kang
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Huazhong Univ Sci Technolog Med Sci 29:118-21. 2009..3% patients. It was concluded that PKC was a common disease of movement disorder. The therapy by AEDs was very effective. PKC should be differentiated from epilepsy and the relationship between PKC and epilepsy needs further research... - Characterizing the complexity of spontaneous electrical signals in cultured neuronal networks using approximate entropyLin Chen
BrittonChanceCenter forBiomedical Photonics, HuazhongUniversity of Science and Technology, Wuhan 430074, China
IEEE Trans Inf Technol Biomed 13:405-10. 2009..This suggests that the proposed method is a valid procedure for tracking the dynamic variation in neuronal signals and can distinguish the different firing patterns of neuronal networks in terms of their complexity... - [Ligation and resection of the inferior vena cava during surgical removal of the retroperitoneal tumors involving the inferior vena cava: feasibility and safety assessment]Bo Wei
Department of General Surgery, General Hospital of PLA, Beijing 100853, China
Nan Fang Yi Ke Da Xue Xue Bao 29:922-4, 928. 2009..To assess the feasibility and safety of excising or patching the inferior vena cava (IVC) without replacement in patients with primary retroperitoneal tumors (PRPT) involving the IVC... - [Relationship of neuroendocrine differentiation to biological behavior of prostate cancer]Xiu Ling Wu
First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325003, China
Zhonghua Yi Xue Za Zhi 89:472-5. 2009..To investigate the relationship between neuroendocrine differentiation (NED) in prostate cancer and hormone refractory prostate cancer... - [Effect of sustained increasing fibroblast growth factor signal on development of epiphyseal plate cultured in vitro]Liangjun Yin
Department of Orthopaedics, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 24:953-7. 2010..The biological effects of fibroblast growth factor (FGF) may be different under different intensities and durations. To investigate the impact of sustained increasing FGF signal upon the development of epiphyseal plate... - Optimization of process conditions with attention to the sludge reduction and stable immobilization in a novel Tubificidae-reactorYu Tian
State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology SKLUWRE, HIT, Harbin 150090, China
Bioresour Technol 101:6069-76. 2010..The optimum conditions were found to be DO of 1.0-1.6 mg/L and ISC of 3000-4000 mg/L respectively, while keeping FHIA at 12 times/d and SRT at 2d... - [Studies on chemical components of Cirsium segestum]Qing Zhou
Guangdong Pharmaceutical University, Guangzhou 510006, China
Zhong Yao Cai 30:45-7. 2007..They were 5,7-dihydroxyflavone, baicalin, oleanolic acid, cholesterol, methyl ursolate and rutin. The first to the fifth of which were got from Cirsium segestum for the first time... - Simultaneous determination of sorbic and benzoic acids in food dressing by headspace solid-phase microextraction and gas chromatographyChunzhou Dong
Department of Sanitary Technology, Hubei College of Traditional Chinese Medicine, Wuhan 430064, China
J Chromatogr A 1117:109-14. 2006..Recoveries for the two analytes in all the samples tested ranged from 83.44 to 113.2%. Practical applicability was demonstrated through the simultaneous determination of sorbic and benzoic acids in the three complex samples... - [Effects of Sini decoction on vascular stenosis after iliac artery balloon injury and oxidative stress in rabbits]Yong Liu
Department of Cardiology, Third Affiliated Hospital, Sun Yat sun University, Guangzhou 510630, China
Nan Fang Yi Ke Da Xue Xue Bao 26:1559-62. 2006..To investigate the effect of Sini decoction (SND) in preventing vascular restenosis and protecting against oxidative stress after rabbit iliac artery balloon injury... - Efficient multi-site-directed mutagenesis directly from genomic templateFengtao Luo
State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042 China
J Biosci 37:965-9. 2012..This method was effectively applied for multi-site-directed mutagenesis directly from mouse genomic DNA, as well as for combination, deletion or insertion of DNA fragments... - Role of FGFs/FGFRs in skeletal development and bone regenerationXiaoLan Du
State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
J Cell Physiol 227:3731-43. 2012..This review has also provided a perspective view on future work for exploring the roles and action mechanisms of FGF signaling in skeletal development, genetic skeletal diseases, and fracture healing... - Is there a relationship between bone and critical illness?Yaozong Zhang
State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Med Hypotheses 76:615-7. 2011..Published data and our own work have led us to hypothesize that the bone plays an important role in the pathogenesis and outcome of critical illness... - [Effect of p53 on the variation of renal tubular epithelial cells after kidney ischemia/reperfusion injury]Kai long Li
Center of Medical Molecular Genetics, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23:6-10. 2007.... - A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesisLiangjun Yin
State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China
Bone 42:631-43. 2008..And the Erk1/2 signaling pathway partially mediated the effects of P253R mutation of Fgfr2 on cranial sutures and long bones... - FGF signaling: its role in bone development and human skeleton diseasesNan Su
State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Front Biosci 13:2842-65. 2008..In this review, we are going to give a summary of the role of FGFs/FGFRs in skeleton development and diseases, and pay more attention to those recent progresses... - eNOS correlates with mitochondrial biogenesis in hearts of congenital heart disease with cyanosisJuan Xiao
Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, PR, China
Arq Bras Cardiol 99:780-8. 2012..The adaptive mechanisms that protect myocardium metabolism during hypoxia are coordinated in part by nitric oxide (NO)... - Cardioprotective effect of mangiferin on left ventricular remodeling in ratsDezhi Zheng
Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China
Pharmacology 90:78-87. 2012..Based on these results, we conclude that mangiferin has a therapeutic effect on post-MI left ventricular remodeling and improves cardiac function... - Tie2 mRNA in peripheral blood: a new marker to assess damage of endothelial cells in a rat model of sepsisJing Yang
State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Trauma Laboratory, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Chin J Traumatol 13:308-12. 2010..To evaluate the endothelial cell damage by detecting the circulating Tie2 mRNA level in a rat model of sepsis... - Animal model of ascending aortic stenosis in rabbits without endotracheal intubationZhe Zhao
Department of Cardiovascular Surgery, Second Affiliated Hospital, Third Military Medical University, Chongqing, China
J Card Surg 25:253-7. 2010..We developed an animal model of pressure overload hypertrophy caused by constriction of the ascending aorta in rabbits that does not require endotracheal intubation... - Anti-inflammatory effect of erythropoietin pretreatment on cardiomyocytes with hypoxia/reoxygenation injury and the possible mechanismChuan Qin
Department of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
Chin J Traumatol 11:352-8. 2008..To investigate the anti-inflammatory effect of erythropoietin (EPO) pretreatment on cardiomyocytes exposed to hypoxia/reoxygenation injury (H/R) and explore the possible mechanism... - Increased metallothionein in light damaged mouse retinasLin Chen
F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Exp Eye Res 79:287-93. 2004..Increased expression of the antioxidant MT in the light damaged mouse retina suggests that upregulation of MT is an important acute retinal response to photo-oxidative stress... - A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosisLin Chen
Genetics of Development and Disease Branch, NIDDK NIH, 10 9N105, 10 Center Drive, Bethesda, MD 20892, USA
Bone 33:169-78. 2003..Thus, our data reveal that dysregulated apoptosis plays an important role in the pathogenesis of AS related phenotypes... - The kinetics and mechanism of the formation of crystalline phase of dipalmitoylphosphatidylethanolamine dispersed in aqueous dimethyl sulfoxide solutionsLin Chen
Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China
Chem Phys Lipids 127:153-9. 2004..The inducement of lamellar crystal phase in DPPE by DMSO is discussed in terms of the dehydration effect of DMSO and competitive molecular interactions between DMSO, water, and the phospholipid... - Ultraviolet sealing and poly(dimethylacrylamide) modification for poly(dimethylsiloxane)/glass microchipsLin Chen
College of Chemistry and Chemical Engineering, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, P.R. China
Electrophoresis 25:914-21. 2004..A high efficiency of theoretical plates with at least 1365 (105 000 N/m) and a good reproducibility with relative standard deviations (RSD) below 4% in five successive separations were achieved... - [Expression of proliferating cell nuclear antigen/bcl-2 in gray gingival tissue]Lin Chen
Dept. of Prosthodontics, Stomatological Hospital of Zunyi Medical College, Zunyi 563003, China
Hua Xi Kou Qiang Yi Xue Za Zhi 22:180-2. 2004..05). CONCLUSION: There were a correlation between the expression of PCNA and inflammation of the gray gingival tissue; The expression of PCNA and bcl-2 protein does not indicate that gray gingival tissue had dysplasia change... - Light damage induced changes in mouse retinal gene expressionLin Chen
F.M. Kirby Center for Molecular Ophthalmology Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Exp Eye Res 79:239-47. 2004..The genes found upregulated by light damage may affect the survival of photoreceptors subjected to photo-oxidative stress... - Increased expression of ceruloplasmin in the retina following photic injuryLin Chen
F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA
Mol Vis 9:151-8. 2003..The purpose of this study was to determine whether retinal ceruloplasmin is upregulated following photo-oxidation, to localize ceruloplasmin protein, and to determine which ceruloplasmin isoform is present in the retina... - Molecular and biochemical characterization of the Skp2-Cks1 binding interfaceWei Wang
Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309, USA
J Biol Chem 279:51362-9. 2004..These results uncovered the specificity of the Skp2-Cks1 interaction and reveal a critical function for the structurally flexible carboxyl-terminal tail region of Skp2 in Cks1 recognition and substrate ubiquitination... - The partition of cholesterol between ordered and fluid bilayers of phosphatidylcholine: a synchrotron X-ray diffraction studyLin Chen
Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, PR China
Biochim Biophys Acta 1768:2873-81. 2007..09 to 0.15 it was found that the liquid-crystal and gel phases each contained about 10% of the cholesterol molecules and the liquid-ordered phase was comprised of 30% cholesterol molecules... - Neuroprotective effects of hydroxyethylpuerarin against focal cerebral ischemia-reperfusion in ratsZi Ying Wang
Institute of Pharmacology, School of Medicine, Shandong University, Jinan 250012, Shandong, P R China
Chin J Physiol 50:211-6. 2007..All these findings suggest that HEP might provide neuroprotection against focal cerebral ischemia/reperfusion injury probably through its antioxidant and anti-inflammatory property... - Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not BakRachel T Uren
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
J Cell Biol 177:277-87. 2007.... - Structural determinants for alpha-neurotoxin sensitivity in muscle nAChR and their implications for the gating mechanismCosma D Dellisanti
Molecular and Computational Biology, Department of Chemistry and Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 2910, USA
Channels (Austin) 1:234-7. 2007..These analyses not only help understand the structural determinants for neurotoxin sensitivity in muscle-type nAChR, but also shed light on its gating mechanism... - Dynamic analysis of ABA accumulation in relation to the rate of ABA catabolism in maize tissues under water deficitHuibo Ren
College of Agronomy and Biotechnology, State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing, China
J Exp Bot 58:211-9. 2007..The present study suggests that ABA catabolism is rapid enough to play an important role in the regulation of ABA accumulation... - [Effects of irbesartan on nitric oxide system in the heart of diabetic rats]Xiao Xian Qian
Department of Cardiology, Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
Nan Fang Yi Ke Da Xue Xue Bao 26:1359-62. 2006..To investigate the effects of irbesartan for heart protection and on heart nitric oxide (NO) system in diabetic rats... - Phase diagram of androsterol-dipalmitoylphosphatidylcholine mixtures dispersed in excess waterWenying Gao
Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
J Phys Chem B 112:8375-82. 2008..We conclude that androsterol is less effective in promoting the formation of an ordered phase, and furthermore, this ordered phase is less compact than the normal lamellar liquid-ordered phase... - [Impact of loss of sympathetic innervation on peripheral nerve regeneration: an experimental study with rats]Ke Sha
Department of Orthopedics, First Affiliated Hospital of Guasngxi Medical University, Nanning 530021, China
Zhonghua Yi Xue Za Zhi 86:1069-72. 2006..However, the wet weight 4 and 8 weeks later were significantly greater in the healthy side then in the affected side (both P < 0.05). CONCLUSION: Resection of sympathetic nerve is advantageous on nerve regeneration... - [Effects of tetramethylpyrazine on fibrosis of atrial tissue and atrial fibrillation in a canine model of congestive heart failure induced by ventricular tachypacing]Ya zhou Lin
Department of Cardiology, Fujian Provincial Research Institute for Cardiovascular Diseases, Fujian Provincial Hospital, Fuzhou, Fujian Province 350001, China
Zhong Xi Yi Jie He Xue Bao 4:35-8. 2006..To explore the effects of tetramethylpyrazine (TMP) on fibrosis of atrial tissue and atrial fibrillation in a canine model of congestive heart failure (CHF) induced by ventricular tachypacing... - Chemopreventive effect of five drugs on renal interstitial fibrosis induced by an aristolochic acid-containing Chinese herb in ratsShaoming Zhu
Department of Nephrology, Taihe Hospital and Affiliated Hospital of Yunyang Medical College, Shiyan City, Hubei Province, China
Am J Nephrol 25:23-9. 2005..This study focuses on the chemopreventive effect of five drugs on renal interstitial fibrosis induced by an aristolochic acid-containing Chinese herb Mu-Tong... - [Gly374Arg mutation in Fgfr3 causes achondroplasia in mice.]Jian-min Wang
Department of Clinical Biological Technology, State Key Laboratory of Trauma Medicine, Chongqing, 400042 P. R. China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:537-41. 2004..CONCLUSION: The model of Fgfr3-Gly374Arg mutation causing achondroplasia in mice has been established successfully... - The involvement of lipid rafts in epidermal growth factor-induced chemotaxis of breast cancer cellsYing Liu
Beijing National Laboratory for Molecular Sciences BNLMS and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
Mol Membr Biol 24:91-101. 2007..Taken together, our study indicated that integrity of lipid rafts was critical in EGF-induced chemotaxis of human breast cancer cells...