Lei Chen

Summary

Country: China

Publications

  1. doi request reprint A hybrid method for prediction and repositioning of drug Anatomical Therapeutic Chemical classes
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, People s Republic of China
    Mol Biosyst 10:868-77. 2014
  2. doi request reprint Prediction of drug target groups based on chemical-chemical similarities and chemical-chemical/protein connections
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, People s Republic of China Electronic address
    Biochim Biophys Acta 1844:207-13. 2014
  3. ncbi request reprint A two-step similarity-based method for prediction of drug's target group
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, People s Republic of China
    Protein Pept Lett 20:364-70. 2013
  4. ncbi request reprint Analysis of metabolic pathway using hybrid properties
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, People s Republic of China
    Protein Pept Lett 19:99-107. 2012
  5. pmc Prediction of effective drug combinations by chemical interaction, protein interaction and target enrichment of KEGG pathways
    Lei Chen
    Institute of Systems Biology, Shanghai University, Shanghai 200444, China College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Biomed Res Int 2013:723780. 2013
  6. pmc Predicting drugs side effects based on chemical-chemical interactions and protein-chemical interactions
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Biomed Res Int 2013:485034. 2013
  7. pmc Prediction of protein-protein interaction sites by random forest algorithm with mRMR and IFS
    Bi Qing Li
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 7:e43927. 2012
  8. pmc Predicting Anatomical Therapeutic Chemical (ATC) classification of drugs by integrating chemical-chemical interactions and similarities
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, China
    PLoS ONE 7:e35254. 2012
  9. doi request reprint Validating the performance of one-time decomposition for fMRI analysis using ICA with automatic target generation process
    Shengnan Yao
    Digital Image and Intelligent Computation Laboratory, College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Magn Reson Imaging 31:970-5. 2013
  10. doi request reprint Analysis of protein pathway networks using hybrid properties
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Molecules 15:8177-92. 2010

Collaborators

Detail Information

Publications20

  1. doi request reprint A hybrid method for prediction and repositioning of drug Anatomical Therapeutic Chemical classes
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, People s Republic of China
    Mol Biosyst 10:868-77. 2014
    ..It was conceivable that the proposed method could be used as an efficient tool to identify ATC-classes of novel drugs or to discover novel uses of known drugs. ..
  2. doi request reprint Prediction of drug target groups based on chemical-chemical similarities and chemical-chemical/protein connections
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, People s Republic of China Electronic address
    Biochim Biophys Acta 1844:207-13. 2014
    ..This article is part of a Special Issue entitled: Computational Proteomics, Systems Biology & Clinical Implications. Guest Editor: Yudong Cai. ..
  3. ncbi request reprint A two-step similarity-based method for prediction of drug's target group
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, People s Republic of China
    Protein Pept Lett 20:364-70. 2013
    ..The results show that using graph representation to encode drug is a good choice in this area. We expect that this contribution will provide some help to understand drug-target interaction network...
  4. ncbi request reprint Analysis of metabolic pathway using hybrid properties
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, People s Republic of China
    Protein Pept Lett 19:99-107. 2012
    ..26%. It is anticipated that this novel approach and encouraging result may give meaningful illumination to investigate this important topic...
  5. pmc Prediction of effective drug combinations by chemical interaction, protein interaction and target enrichment of KEGG pathways
    Lei Chen
    Institute of Systems Biology, Shanghai University, Shanghai 200444, China College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Biomed Res Int 2013:723780. 2013
    ..These important features may help to gain insights into the mechanisms of drug combinations, and the proposed prediction model could become a useful tool for screening possible drug combinations. ..
  6. pmc Predicting drugs side effects based on chemical-chemical interactions and protein-chemical interactions
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Biomed Res Int 2013:485034. 2013
    ....
  7. pmc Prediction of protein-protein interaction sites by random forest algorithm with mRMR and IFS
    Bi Qing Li
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 7:e43927. 2012
    ..It is anticipated that our prediction method will become a useful tool for identifying PPI sites, and that the feature analysis described in this paper will provide useful insights into the mechanisms of interaction...
  8. pmc Predicting Anatomical Therapeutic Chemical (ATC) classification of drugs by integrating chemical-chemical interactions and similarities
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, China
    PLoS ONE 7:e35254. 2012
    ....
  9. doi request reprint Validating the performance of one-time decomposition for fMRI analysis using ICA with automatic target generation process
    Shengnan Yao
    Digital Image and Intelligent Computation Laboratory, College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Magn Reson Imaging 31:970-5. 2013
    ..Furthermore, the ROC (Receiver Operating Characteristic) power analysis also denoted the better signal reconstruction performance of ATGP-ICA than that of RDICA...
  10. doi request reprint Analysis of protein pathway networks using hybrid properties
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Molecules 15:8177-92. 2010
    ..88%. It is anticipated that, this novel approach and encouraging result, although preliminary yet, may stimulate extensive investigations into this important topic...
  11. doi request reprint Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches
    Tao Huang
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biochimie 94:1017-25. 2012
    ..Moreover, it has not escaped our notice that, after some modification, the current model can also be used to study many other phenotype prediction problems from the angle of systems biology...
  12. pmc Classification and analysis of regulatory pathways using graph property, biochemical and physicochemical property, and functional property
    Tao Huang
    Institute of Systems Biology, Shanghai University, Shanghai, People s Republic of China
    PLoS ONE 6:e25297. 2011
    ..It is anticipated that our report may stimulate a series of follow-up investigations in this new and challenging area...
  13. doi request reprint SACICA: a sparse approximation coefficient-based ICA model for functional magnetic resonance imaging data analysis
    Nizhuan Wang
    Digital Image and Intelligent Computation Laboratory, Shanghai Maritime University, Shanghai 201306, China
    J Neurosci Methods 216:49-61. 2013
    ..In addition, the SACICA combined with Fast-FENICA proposed by Wang et al. (2012) was demonstrated to conduct the group analysis effectively on the resting-state data set...
  14. pmc Predicting chemical toxicity effects based on chemical-chemical interactions
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, China
    PLoS ONE 8:e56517. 2013
    ..50%, substantially higher than the rate of 25.43% achieved by random guesses. Encouraged by the promising results, we expect that our method will become a useful tool in screening out drugs with high toxicity...
  15. pmc Predicting the network of substrate-enzyme-product triads by combining compound similarity and functional domain composition
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, PR China
    BMC Bioinformatics 11:293. 2010
    ....
  16. ncbi request reprint Using compound similarity and functional domain composition for prediction of drug-target interaction networks
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, China
    Med Chem 6:388-95. 2010
    ..23%, 94.74%, 97.80%, and 97.51%, respectively, indicating that compound similarity and functional domain composition are very effective to predict drug-target interaction networks...
  17. pmc Computational analysis of HIV-1 resistance based on gene expression profiles and the virus-host interaction network
    Tao Huang
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 6:e17291. 2011
    ..These proteins may be useful targets for AIDS prevention or therapy, as intervention in these pathways could disrupt communication with virus-targeted proteins and HIV-1 infection...
  18. doi request reprint MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients
    Ruo Yu Wang
    International Co operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Shanghai, China The Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China
    Gastroenterology 145:1436-48.e1-12. 2013
    ..However, little is known about the role of MUC15 in pathogenesis of hepatocellular carcinoma (HCC)...
  19. doi request reprint A fast-FENICA method on resting state fMRI data
    Nizhuan Wang
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    J Neurosci Methods 209:1-12. 2012
    ..This proposed effective group analysis method is expected to have wide applicability...
  20. pmc Cancer incidence and mortality in patients with type 2 diabetes treated with human insulin: a cohort study in Shanghai
    Yunjuan Gu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 8:e53411. 2013
    ..The aim was to investigate the association between human insulin and cancer incidence and mortality in Chinese patients with type 2 diabetes...