Lei Chen

Summary

Country: China

Publications

  1. ncbi A two-step similarity-based method for prediction of drug's target group
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, People s Republic of China
    Protein Pept Lett 20:364-70. 2013
  2. ncbi Analysis of metabolic pathway using hybrid properties
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, People s Republic of China
    Protein Pept Lett 19:99-107. 2012
  3. ncbi Prediction of protein-protein interaction sites by random forest algorithm with mRMR and IFS
    Bi Qing Li
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 7:e43927. 2012
  4. ncbi Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches
    Tao Huang
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biochimie 94:1017-25. 2012
  5. ncbi Classification and analysis of regulatory pathways using graph property, biochemical and physicochemical property, and functional property
    Tao Huang
    Institute of Systems Biology, Shanghai University, Shanghai, People s Republic of China
    PLoS ONE 6:e25297. 2011
  6. ncbi Predicting Anatomical Therapeutic Chemical (ATC) classification of drugs by integrating chemical-chemical interactions and similarities
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, China
    PLoS ONE 7:e35254. 2012
  7. ncbi Analysis of protein pathway networks using hybrid properties
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Molecules 15:8177-92. 2010
  8. ncbi Computational analysis of HIV-1 resistance based on gene expression profiles and the virus-host interaction network
    Tao Huang
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 6:e17291. 2011
  9. ncbi Predicting the network of substrate-enzyme-product triads by combining compound similarity and functional domain composition
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, PR China
    BMC Bioinformatics 11:293. 2010
  10. ncbi Predicting chemical toxicity effects based on chemical-chemical interactions
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, China
    PLoS ONE 8:e56517. 2013

Collaborators

Detail Information

Publications13

  1. ncbi A two-step similarity-based method for prediction of drug's target group
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, People s Republic of China
    Protein Pept Lett 20:364-70. 2013
    ..The results show that using graph representation to encode drug is a good choice in this area. We expect that this contribution will provide some help to understand drug-target interaction network...
  2. ncbi Analysis of metabolic pathway using hybrid properties
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, People s Republic of China
    Protein Pept Lett 19:99-107. 2012
    ..26%. It is anticipated that this novel approach and encouraging result may give meaningful illumination to investigate this important topic...
  3. ncbi Prediction of protein-protein interaction sites by random forest algorithm with mRMR and IFS
    Bi Qing Li
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 7:e43927. 2012
    ..It is anticipated that our prediction method will become a useful tool for identifying PPI sites, and that the feature analysis described in this paper will provide useful insights into the mechanisms of interaction...
  4. ncbi Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches
    Tao Huang
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Biochimie 94:1017-25. 2012
    ..Moreover, it has not escaped our notice that, after some modification, the current model can also be used to study many other phenotype prediction problems from the angle of systems biology...
  5. ncbi Classification and analysis of regulatory pathways using graph property, biochemical and physicochemical property, and functional property
    Tao Huang
    Institute of Systems Biology, Shanghai University, Shanghai, People s Republic of China
    PLoS ONE 6:e25297. 2011
    ..It is anticipated that our report may stimulate a series of follow-up investigations in this new and challenging area...
  6. ncbi Predicting Anatomical Therapeutic Chemical (ATC) classification of drugs by integrating chemical-chemical interactions and similarities
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, China
    PLoS ONE 7:e35254. 2012
    ....
  7. ncbi Analysis of protein pathway networks using hybrid properties
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    Molecules 15:8177-92. 2010
    ..88%. It is anticipated that, this novel approach and encouraging result, although preliminary yet, may stimulate extensive investigations into this important topic...
  8. ncbi Computational analysis of HIV-1 resistance based on gene expression profiles and the virus-host interaction network
    Tao Huang
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    PLoS ONE 6:e17291. 2011
    ..These proteins may be useful targets for AIDS prevention or therapy, as intervention in these pathways could disrupt communication with virus-targeted proteins and HIV-1 infection...
  9. ncbi Predicting the network of substrate-enzyme-product triads by combining compound similarity and functional domain composition
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, PR China
    BMC Bioinformatics 11:293. 2010
    ....
  10. ncbi Predicting chemical toxicity effects based on chemical-chemical interactions
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, Shanghai, China
    PLoS ONE 8:e56517. 2013
    ..50%, substantially higher than the rate of 25.43% achieved by random guesses. Encouraged by the promising results, we expect that our method will become a useful tool in screening out drugs with high toxicity...
  11. ncbi Using compound similarity and functional domain composition for prediction of drug-target interaction networks
    Lei Chen
    College of Information Engineering, Shanghai Maritime University, China
    Med Chem 6:388-95. 2010
    ..23%, 94.74%, 97.80%, and 97.51%, respectively, indicating that compound similarity and functional domain composition are very effective to predict drug-target interaction networks...
  12. ncbi A fast-FENICA method on resting state fMRI data
    Nizhuan Wang
    College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
    J Neurosci Methods 209:1-12. 2012
    ..This proposed effective group analysis method is expected to have wide applicability...
  13. ncbi Cancer incidence and mortality in patients with type 2 diabetes treated with human insulin: a cohort study in shanghai
    Yunjuan Gu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital Shanghai Diabetes Institute Shanghai Clinical Centre of Diabetes, Shanghai, China Department of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China
    PLoS ONE 8:e53411. 2013
    ..The aim was to investigate the association between human insulin and cancer incidence and mortality in Chinese patients with type 2 diabetes...