Wen Hua Chen

Summary

Country: China

Publications

  1. Li Z, Chen Y, Yuan D, Chen W. Synthesis of a dimeric 3α-hydroxy-7α,12α-diamino-5β-cholan-24-oate conjugate and its derivatives, and the effect of lipophilicity on their anion transport efficacy. Org Biomol Chem. 2017;15:2831-2840 pubmed publisher
    ..The present finding highlights the importance of high anionophoric activity in clarifying the effect of lipophilicity on ion-transport effectiveness. ..
  2. Chen M, Zheng Y, Cai X, Zhang H, Wang F, Tan C, et al. Inhibition of autophagic flux by cyclometalated iridium(iii) complexes through anion transportation. Chem Sci. 2019;10:3315-3323 pubmed publisher
    ..Our work provides a novel anticancer mechanism of metal complexes, which gives insights into the innovative structure-based design of new metallo-anticancer agents. ..
  3. Yu X, Hong X, Chen W. Fluorinated bisbenzimidazoles: a new class of drug-like anion transporters with chloride-mediated, cell apoptosis-inducing activity. Org Biomol Chem. 2019;17:1558-1571 pubmed publisher
    ..Mechanistic investigations suggest that these compounds are able to trigger cell apoptosis probably by disrupting the homeostasis of chloride anions. ..
  4. Hong X, Yu X, Zhang K, Chen W. Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides. Org Biomol Chem. 2018;16:8025-8029 pubmed publisher
    ..In contrast, an analogue without a morpholinyl group exhibits much lower ability to localize in lysosomes and is much less active in regulating the lysosomal pH. ..
  5. Yu X, Peng C, Sun X, Chen W. Synthesis, anionophoric activity and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters. Eur J Med Chem. 2018;152:115-125 pubmed publisher
    ..Mechanistic studies suggest that the transport of chloride anions across the cellular membranes plays a critical role in the cytotoxic effect and these compounds induce cell death probably via an apoptotic process. ..
  6. Yang J, Lin Y, Dong C, Zhou C, Chen J, Wang B, et al. Synthesis, hydrolytic DNA-cleaving activities and cytotoxicities of EDTA analogue-tethered pyrrole-polyamide dimer-based Ce(IV) complexes. Eur J Med Chem. 2014;87:168-74 pubmed publisher
    ..In addition, both complexes were found to display moderate inhibitory activity toward A549 and HepG-2 cells. ..
  7. Yan G, Li X, Ge B, Shi X, Chen Y, Yang X, et al. Synthesis and anticancer activities of 3-arylflavone-8-acetic acid derivatives. Eur J Med Chem. 2015;90:251-7 pubmed publisher
    ..In addition, compounds 9p-r were found to be able to induce tumor necrosis factor α (TNF-α) production in HPBMCs. ..
  8. Deng L, Li Z, Lu Y, Chen J, Zhou C, Wang B, et al. Synthesis and transmembrane anion/cation symport activity of a rigid bis(choloyl) conjugate functionalized with guanidino groups. Bioorg Med Chem Lett. 2015;25:745-8 pubmed publisher
    ..A Hill analysis reveals that two molecules of this compound are assembled into the transport-active species. ..
  9. Mo D, Dong S, Sun H, Chen J, Pang J, Xi B, et al. Synthesis and potent inhibitory activities of carboxybenzyl-substituted 8-(3-(R)-aminopiperidin-1-yl)-7-(2-chloro/cyanobenzyl)-3-methyl-3,7-dihydro-purine-2,6-diones as dipeptidyl peptidase IV (DPP-IV) inhibitors. Bioorg Med Chem Lett. 2015;25:1872-5 pubmed publisher
    ..Among them, compound 13 (IC50=36 nM) exhibited comparable activity with a positive control, Sitagliptin (IC50=16 nM). In addition, the structure-activity relationship of these compounds is also briefly discussed. ..

More Information

Publications15

  1. Li Z, Deng L, Chen J, Zhou C, Chen W. Does lipophilicity affect the effectiveness of a transmembrane anion transporter? Insight from squaramido-functionalized bis(choloyl) conjugates. Org Biomol Chem. 2015;13:11761-9 pubmed publisher
    ..However, lipophilicity exhibits little effect on the effectiveness of this set of compounds in terms of either k2/Kdiss or EC50 values. ..
  2. Zhou C, Yang J, Dong C, Wang Y, Sun B, Chen J, et al. Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine. Org Biomol Chem. 2016;14:191-7 pubmed publisher
    ..In addition, it shows no effect on the topology or thermal stability of the G-quadruplexes. ..
  3. Li Z, Deng L, Chen Y, Wu T, Chen W. Efficient transmembrane anion transport mediated by a bis(imidazolyl)-functionalized bis(choloyl) conjugate. Bioorg Med Chem Lett. 2016;26:3665-8 pubmed publisher
    ..In addition, this compound was found to exhibit much higher anionophoric activity than the analogue without imidazolyl groups, revealing the significant role of the imidazolyl groups in the anion transport process. ..
  4. Li Z, Liao T, Dong C, Yang J, Chen X, Liu L, et al. Specifically targeting mixed-type dimeric G-quadruplexes using berberine dimers. Org Biomol Chem. 2017;15:10221-10229 pubmed publisher
    ..These results may provide useful guidance for the rational design of selective multimeric G-quadruplex binders and potential anticancer agents. ..
  5. Peng C, Zhang M, Sun X, Cai X, Chen Y, Chen W. Highly efficient anion transport mediated by 1,3-bis(benzimidazol-2-yl)benzene derivatives bearing electron-withdrawing substituents. Org Biomol Chem. 2016;14:8232-6 pubmed publisher
    ..The benzimidazolyl-NH fragments, the relative position and the number of the benzimidazolyl groups on the central phenyl scaffold play an essential role in the transport. ..
  6. Cai X, Li Z, Chen W. Tripodal squaramide conjugates as highly effective transmembrane anion transporters. Bioorg Med Chem Lett. 2017;27:1999-2002 pubmed publisher