Shao J, Chen J, Li T, Zhao X. Spectroscopic and molecular docking studies of the in vitro interaction between puerarin and cytochrome P450. Molecules. 2014;19:4760-9 pubmed publisher
..UV-Vis and circular dichroism spectroscopies confirmed the micro-environmental and conformational changes of CYP1A2 and CYP2D6. The findings provide reliable evidence for clarifying the structures and functions of CYPs. ..
Ma C, Yan X, Yin G, Wang Y, Hu S, Xia W, et al
. Non-targeted metabolomic analysis on multidrug resistance hepatocellular carcinoma cell and reversal effect of annonaceous acetogenins. J Pharm Biomed Anal. 2019;164:489-495 pubmed publisher
..Annonaceous acetogenins impact these metabolism pathways. Metabolic pathway analysis coupled with stoichiometry analysis can be an effective tool to understand MDR mechanism and to potentially find new MDR reversal agents. ..
Ma C, Li Y, Wu H, Ji J, Sun Q, Song Y, et al
. Metabolomics analysis of the potential anticancer mechanism of annonaceous acetogenins on a multidrug resistant mammary adenocarcinoma cell. Anal Biochem. 2018;553:1-6 pubmed publisher
Miao Y, Shi Y, Li F, Shan C, Chen Y, Chen J, et al
. Metabolomics study on the toxicity of Annona squamosa by ultraperformance liquid-chromatography high-definition mass spectrometry coupled with pattern recognition approach and metabolic pathways analysis. J Ethnopharmacol. 2016;184:187-95 pubmed publisher
Li F, Li X, Miao Y, Shan C, Yuan F, Ma C, et al
. UHPLC-MS-based metabolomics analysis on mice bearing neoplasm (H22) for hispidulin. J Pharm Biomed Anal. 2016;125:310-8 pubmed publisher
..Most of the potential biomarkers related to the function of TCA (tricarboxylic acid cycle). The rise of potential biomarkers in the drug groups promoted the up-regulation of TCA cycle compared with the model group. ..
Cui M, Chen S, Wang H, Li Z, Chen H, Chen Y, et al
. Metabolic profiling investigation of Fritillaria thunbergii Miq. by gas chromatography-mass spectrometry. J Food Drug Anal. 2018;26:337-347 pubmed publisher
..Furthermore, carbodiimide, tryptophan, glucose-6-phosphate, xylose, 2-piperidinecarboxylic acid, monoamidomalonic acid, phenylalanine, and histidine were found to play an important role in the plant metabolism net of F. thunbergii. ..