Gang Chen


Country: China


  1. request reprint
    Zhang X, Dang Y, Li P, Rong M, Hou X, Luo D, et al. Expression of tumor necrosis factor receptor-associated factor 6 in lung cancer tissues. Asian Pac J Cancer Prev. 2014;15:10591-6 pubmed
    ..TRAF6 might be an oncogene and the expression of TRAF6 protein is related to the progression of lung cancer. Thus, TRAF6 might become a target for diagnosis and gene therapy for lung cancer patients. ..
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    Jiang Y, Zhong T, Dang Y, Zou L, Yang L, Yang X, et al. Overexpression and clinicopathological contribution of DcR3 in bladder urothelial carcinoma tissues. Asian Pac J Cancer Prev. 2014;15:9137-42 pubmed
    ..The detection of DcR3 protein in the formalin- fixed and paraffin-embedded samples could assist to predict in prognosis of BUC patients. ..
  3. Pan L, Huang S, He R, Rong M, Dang Y, Chen G. Decreased expression and clinical significance of miR-148a in hepatocellular carcinoma tissues. Eur J Med Res. 2014;19:68 pubmed publisher
    ..Underexpression of miR-148a might be associated with HCC tumorigenesis and deterioration of HCC. miR-148a might act as a suppressor miRNA of HCC and it therefore has a potential role in prognosis of HCC patients. ..
  4. Huang L, Ren F, Tang R, Feng Z, Chen G. Prognostic Value of Expression of Cyclin E in Gastrointestinal Cancer: A Systematic Review and Meta-Analysis. Technol Cancer Res Treat. 2016;15:12-9 pubmed publisher
    ..028). In summary, overexpression of cyclin E is associated with poor prognosis in gastrointestinal cancer and expression of cyclin E determined by IHC might be a prognostic marker for gastrointestinal cancer in clinical practice. ..
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    Chen W, He D, Tang R, Ren F, Chen G. Ki-67 is a valuable prognostic factor in gliomas: evidence from a systematic review and meta-analysis. Asian Pac J Cancer Prev. 2015;16:411-20 pubmed
    ..In conclusion, the current meta-analysis revealed that Ki-67 expression might be a predicative factor for poor prognosis of glioma patients, emphasizing its importance as a predictor. ..
  6. Yushan R, Wenjie C, Suning H, Yiwu D, Tengfei Z, Madushi W, et al. Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study. World J Surg Oncol. 2015;13:223 pubmed publisher
    ..831, P<0.001). The CDK5 expression was also positively correlated with Ki-67 LI (r=0.347, P<0.001). The current result suggests that CDK5 may play an essential role in the tumorigenesis and aggressiveness of gliomas. ..
  7. Tang R, Zhong T, Dang Y, Zhang X, Li P, Chen G. Association between downexpression of MiR-203 and poor prognosis in non-small cell lung cancer patients. Clin Transl Oncol. 2016;18:360-8 pubmed publisher
    ..MiR-203 mimic could suppress the cell growth of five lung cancer cell lines tested to different degrees in vitro. MiR-203 could become a prognostic predictor in NSCLC and may be a new target for the molecular therapy of NSCLC patients. ..
  8. Wei K, Ye Z, Li Z, Dang Y, Chen X, Huang N, et al. An immunohistochemical study of cyclin-dependent kinase 5 (CDK5) expression in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC): a possible prognostic biomarker. World J Surg Oncol. 2016;14:34 pubmed publisher
    ..415, P=0.049) and lymphatic metastasis (r=0.469, P=0.024) in SCLCs. The results of this present study suggest that the CDK5 expression is associated with several clinicopathological factors linked with poorer prognosis. ..
  9. Pan D, Zhu M, Lin X, Lin X, He R, Ling Y, et al. Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China. Eur J Med Res. 2016;21:28 pubmed publisher
    ..CDK5 was positively interrelated to TNM stage (P = 0.017) in adenosquamous carcinoma. CDK5 may play a vital role in the development of cervical cancer, which may be a marker for the diagnosis, therapy and prognosis of cervical cancer. ..

More Information


  1. request reprint
    Dang Y, Zeng J, He R, Rong M, Luo D, Chen G. Effects of miR-152 on cell growth inhibition, motility suppression and apoptosis induction in hepatocellular carcinoma cells. Asian Pac J Cancer Prev. 2014;15:4969-76 pubmed
    ..miR-152 may act as a tumor suppressor miRNA by also targeting TNFRSF6B and is therefore a potential candidate biomarker for HCC diagnosis, prognosis and molecular therapy. ..
  2. Lan D, Zhang X, He R, Tang R, Li P, He Q, et al. MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance. Eur J Med Res. 2015;20:50 pubmed publisher
    ..154, P = 0.087), and EGFR protein expression (r = -0.612, P < 0.001). MiR-133a serves as a tumor-suppressive miRNA in human NSCLC, and its downregulation suggests deterioration in NSCLC patients. ..
  3. Zhang Y, Chen W, Gan T, Zhang X, Xie Z, Ye Z, et al. Clinical Significance and Effect of lncRNA HOXA11-AS in NSCLC: A Study Based on Bioinformatics, In Vitro and in Vivo Verification. Sci Rep. 2017;7:5567 pubmed publisher
    ..These results indicate that HOXA11-AS plays pivotal roles in NSCLC and it can become a novel therapeutic direction for treating NSCLC. ..
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    Pan L, Zhong T, Tang R, Li P, Dang Y, Huang S, et al. Upregulation and clinicopathological significance of long non-coding NEAT1 RNA in NSCLC tissues. Asian Pac J Cancer Prev. 2015;16:2851-5 pubmed
    ..617, p=0.001) and clinical TNM stage (r=-4.134, p<0.001). This study indicates that NEAT1 might be associated with oncogenesis and progression in NSCLC, and suggests application in molecular targeted therapy. ..
  5. Ren F, Yang H, He R, Lu J, Lin X, Liang H, et al. Analysis of microarrays of miR-34a and its identification of prospective target gene signature in hepatocellular carcinoma. BMC Cancer. 2018;18:12 pubmed publisher
    ..And the experiments in vivo and vitro will be conducted by our group to identify the specific mechanism of miR-34a in the progress and deterioration of HCC. ..
  6. He R, Li X, Liang L, Xie Y, Luo D, Ma J, et al. The suppressive role of miR-542-5p in NSCLC: the evidence from clinical data and in vivo validation using a chick chorioallantoic membrane model. BMC Cancer. 2017;17:655 pubmed publisher
    ..This evidence suggests that miR-542-5p is a potential tumor-suppressed miRNA in NSCLC, which has the potential to act as a diagnostic and therapeutic target of NSCLC. ..
  7. Rong M, Chen G, Dang Y. Increased miR-221 expression in hepatocellular carcinoma tissues and its role in enhancing cell growth and inhibiting apoptosis in vitro. BMC Cancer. 2013;13:21 pubmed publisher
    ..Moreover, miR-221 inhibitor could be useful to suppress proliferation and induce apoptosis in HCC cells. Thus miR-221 might be a critical targeted therapy strategy for HCC. ..