X Chang

Summary

Country: China

Publications

  1. pmc PADI2 Is Significantly Associated with Rheumatoid Arthritis
    Xiaotian Chang
    Medical Research Center of Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, P R China
    PLoS ONE 8:e81259. 2013
  2. pmc Expression of peptidylarginine deiminase type 4 in ovarian tumors
    Lin Wang
    Research Center for Medicinal Biotechnology, Shandong Academy of Medicinal Sciences Key Laboratory for Biotech Drugs Ministry of Health and Provincial Laboratory for Modern Medicine and Technology of Shandong, Jinan, Shandong 250062, PR China
    Int J Biol Sci 6:454-64. 2010
  3. pmc Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis
    Lin Wang
    Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jinan, Shandong, P R China
    PLoS ONE 8:e53301. 2013
  4. pmc Investigating citrullinated proteins in tumour cell lines
    Zhongmin Jiang
    Medical Research Center of Qianfoshan Hospital, Shandong University, Jingshi road 16766, Jinan, Shandong 250014, P, R, China
    World J Surg Oncol 11:260. 2013
  5. pmc Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction
    Yabing Zheng
    Medical Research Center of Shandong Provincial Qianfoshan Hospital, Shandong University, Jingshi road 16766, Jinan, Shandong 250014, PR China
    BMC Musculoskelet Disord 13:256. 2012
  6. ncbi request reprint Glycolysis and rheumatoid arthritis
    Xiaotian Chang
    Key Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Bio Drugs of Ministry of Health, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jinan, Shandong, China
    Int J Rheum Dis 14:217-22. 2011
  7. pmc Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis
    Xiaotian Chang
    National Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Modern Medicine and Technology of Shandong, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong, 250062, PR China
    Arthritis Res Ther 13:R124. 2011
  8. pmc Investigating the pathogenic role of PADI4 in oesophageal cancer
    Xiaotian Chang
    Research Center For Medicinal Biotechnology Center, Shandong Academy of Medicinal Sciences National Laboratory for Biotech Drugs Ministry of Health and Provincial Laboratory for Modern Medicine and Technology of Shandong, Jinan, P R China
    Int J Biol Sci 7:769-81. 2011
  9. pmc Increased expression of carbonic anhydrase I in the synovium of patients with ankylosing spondylitis
    Xiaotian Chang
    National Laboratory for Bio Drugs of Ministry of Health, Research Center for Medicinal Biotechnology of Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong, 250062, PR China
    BMC Musculoskelet Disord 11:279. 2010
  10. pmc PADI4 and tumourigenesis
    Xiaotian Chang
    Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Modern Medicine and Technology of Shandong, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong, 250062, PR China
    Cancer Cell Int 10:7. 2010

Collaborators

Detail Information

Publications19

  1. pmc PADI2 Is Significantly Associated with Rheumatoid Arthritis
    Xiaotian Chang
    Medical Research Center of Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, P R China
    PLoS ONE 8:e81259. 2013
    ..Increased expression of PADI2 was detected in RA synovial tissues compared with samples from patients with OA and AS. PADI2 is significantly associated with RA and may be involved in the pathogenesis of the disease. ..
  2. pmc Expression of peptidylarginine deiminase type 4 in ovarian tumors
    Lin Wang
    Research Center for Medicinal Biotechnology, Shandong Academy of Medicinal Sciences Key Laboratory for Biotech Drugs Ministry of Health and Provincial Laboratory for Modern Medicine and Technology of Shandong, Jinan, Shandong 250062, PR China
    Int J Biol Sci 6:454-64. 2010
    ..The results suggest an important role for PADI4 in the tumorigenesis of ovary cancers that are under the regulation of estrogen...
  3. pmc Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis
    Lin Wang
    Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jinan, Shandong, P R China
    PLoS ONE 8:e53301. 2013
    ..This study also suggests that hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in RA...
  4. pmc Investigating citrullinated proteins in tumour cell lines
    Zhongmin Jiang
    Medical Research Center of Qianfoshan Hospital, Shandong University, Jingshi road 16766, Jinan, Shandong 250014, P, R, China
    World J Surg Oncol 11:260. 2013
    ..However, as citrullinated proteins have not been systematically investigated in tumours, the present study aimed to identify novel citrullinated proteins in tumours by 2-D western blotting (2-D WB)...
  5. pmc Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction
    Yabing Zheng
    Medical Research Center of Shandong Provincial Qianfoshan Hospital, Shandong University, Jingshi road 16766, Jinan, Shandong 250014, PR China
    BMC Musculoskelet Disord 13:256. 2012
    ..This study investigated the effect of CA1 on joint inflammation and tissue destruction in transgenic mice that over-express CA1 (CA1-Tg)...
  6. ncbi request reprint Glycolysis and rheumatoid arthritis
    Xiaotian Chang
    Key Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Bio Drugs of Ministry of Health, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jinan, Shandong, China
    Int J Rheum Dis 14:217-22. 2011
    ..Lactate and pyruvate, substrates of RA synovium metabolism, stimulate abnormal cell proliferation, angiogenesis and pannus formation...
  7. pmc Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis
    Xiaotian Chang
    National Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Modern Medicine and Technology of Shandong, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong, 250062, PR China
    Arthritis Res Ther 13:R124. 2011
    ..Our previous study detected increased TXNDC5 expression in the synovial tissues of rheumatoid arthritis (RA) patients using proteomic methods. The current study investigated a pathogenic role for TXNDC5 in RA...
  8. pmc Investigating the pathogenic role of PADI4 in oesophageal cancer
    Xiaotian Chang
    Research Center For Medicinal Biotechnology Center, Shandong Academy of Medicinal Sciences National Laboratory for Biotech Drugs Ministry of Health and Provincial Laboratory for Modern Medicine and Technology of Shandong, Jinan, P R China
    Int J Biol Sci 7:769-81. 2011
    ..085, p=0.0256, OR=2.7). The results suggest that PADI4 expression is related to the tumorigenic process of EC and the DCA-induced apoptosis. The PADI4 gene may be a valid EC susceptibility gene...
  9. pmc Increased expression of carbonic anhydrase I in the synovium of patients with ankylosing spondylitis
    Xiaotian Chang
    National Laboratory for Bio Drugs of Ministry of Health, Research Center for Medicinal Biotechnology of Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong, 250062, PR China
    BMC Musculoskelet Disord 11:279. 2010
    ..The present study used a proteomic approach to identify novel AS-specific proteins by simultaneously comparing the expression profiles of synovial membranes from patients with AS, rheumatoid arthritis (RA) and osteoarthritis (OA)...
  10. pmc PADI4 and tumourigenesis
    Xiaotian Chang
    Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Modern Medicine and Technology of Shandong, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong, 250062, PR China
    Cancer Cell Int 10:7. 2010
    ..PADI4 is expressed in CD34+ stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. These findings suggest that PADI4 may play an important role in tumourigenesis...
  11. pmc Increased PADI4 expression in blood and tissues of patients with malignant tumors
    Xiaotian Chang
    Key Laboratory for Bio Drugs of Ministry of Health, Research Center for Medicinal Biotechnology, Shandong Academy of Medical Sciences, Jingshi Road 89, Jinan, Shandong, 250062, PR China
    BMC Cancer 9:40. 2009
    ..Peptidylarginine deiminase type 4 (PAD4/PADI4) post-translationally converts peptidylarginine to citrulline. Recent studies suggest that PADI4 represses expression of p53-regulated genes via citrullination of histones at gene promoters...
  12. ncbi request reprint Citrullination of fibronectin in rheumatoid arthritis synovial tissue
    X Chang
    The Laboratory for Rheumatic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, 1 7 22 Suehiro, Yokohama, Kanagawa, 230 0045, Japan
    Rheumatology (Oxford) 44:1374-82. 2005
    ..We investigated the citrullination of Fn and its potential contribution to the pathogenesis of RA...
  13. pmc Treat ankylosing spondylitis with methazolamide
    Xiaotian Chang
    National Laboratory for Bio Drugs of Ministry of Health, Provincial Laboratory for Modern Medicine and Technology of Shandong, Research Center for Medicinal Biotechnology of Shandong Academy of Medical Sciences, Jingshi Road 18877, Jinan, Shandong 250062, P R China
    Int J Med Sci 8:413-9. 2011
    ..This study aimed to evaluate the effectiveness and safety of methazolamide, an anti-carbonic anhydrase drug, for treating patients with AS...
  14. ncbi request reprint Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis
    X Chang
    Laboratory for Rheumatic Diseases, SNP Research Center, Institute of Physical and Chemical Research RIKEN, 1 7 22 Suehiro, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Rheumatology (Oxford) 44:40-50. 2005
    ..Here, we localized the expression of PADI4 and the citrullinated protein product in synovial RA tissue...
  15. ncbi request reprint The inhibition of antithrombin by peptidylarginine deiminase 4 may contribute to pathogenesis of rheumatoid arthritis
    X Chang
    the Laboratory of Rheumatic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, 1 7 22 Suchiro, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    Rheumatology (Oxford) 44:293-8. 2005
    ..Here, we investigate whether human PADI4 can inhibit antithrombin by catalysing antithrombin citrullination and how the enzyme is involved in RA pathogenesis...
  16. ncbi request reprint CUL1, a component of E3 ubiquitin ligase, alters lymphocyte signal transduction with possible effect on rheumatoid arthritis
    R Kawaida
    SNP Research Center, RIKEN, Yokohama, Kanagawa, Japan
    Genes Immun 6:194-202. 2005
    ..Our data suggest that the regulation of CUL1 expression in immunological tissues may affect the susceptibility of RA via altering lymphocyte signal transduction...
  17. pmc CD38 and E2F transcription factor 2 have uniquely increased expression in rheumatoid arthritis synovial tissues
    X Chang
    Medical Research Center of Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
    Clin Exp Immunol 176:222-31. 2014
    ..This study suggests that the uniquely increased expression of CD38 and E2F2 in RA synovial tissues contribute to the immunoactivation of the disease. ..
  18. ncbi request reprint Increased expression of alpha 1-anti-trypsin in the synovial tissues of patients with ankylosing spondylitis
    S Sun
    Department of Joint Surgery, Provincial Hospital affiliated to Shandong University, Jinan, Shandong, PR China
    Clin Exp Rheumatol 30:39-44. 2012
    ..Using a proteomics approach, we detected a significantly increased expression of alpha 1-anti-trypsin (ATA1) in synovial membranes of patients with AS...