Xiao Xin Yan

Summary

Affiliation: Central South University
Country: China

Publications

  1. pmc Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    PLoS ONE 7:e37599. 2012
  2. pmc Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China
    PLoS ONE 7:e48782. 2012
  3. pmc BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China
    Exp Neurol 235:228-37. 2012
  4. pmc Chronic lead exposure reduces doublecortin-expressing immature neurons in young adult guinea pig cerebral cortex
    Jufang Huang
    Department of Anatomy and Neurobiology, Central South University School of Basic Medical Sciences, Changsha, Hunan, China
    BMC Neurosci 13:82. 2012
  5. pmc Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients
    Xiaoxin Jiang
    The First Affiliated Hospital, Nanhua University, Hengyang, China
    BMC Immunol 13:62. 2012
  6. pmc β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    Eur J Neurosci 32:1223-38. 2010
  7. doi request reprint Experimental epidural hematoma causes cerebral infarction and activates neocortical glial and neuronal genesis in adult guinea pigs
    Aihua Pan
    Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    J Neurosci Res 91:249-61. 2013
  8. pmc BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology
    Yan Cai
    Department of Human Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China
    Neurotox Res 21:160-74. 2012
  9. pmc Layer I as a putative neurogenic niche in young adult guinea pig cerebrum
    Kun Xiong
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    Mol Cell Neurosci 45:180-91. 2010
  10. pmc γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ
    Fei Liu
    Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China
    Eur J Neurosci 37:1714-25. 2013

Collaborators

Detail Information

Publications15

  1. pmc Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    PLoS ONE 7:e37599. 2012
    ..This novel neuronal alteration indicates that impairments in membrane protein metabolism, possibly due to neuronal calcium mishandling and/or enhancement of calcium sensitive proteolysis, occur during aging and in transgenic AD mice...
  2. pmc Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China
    PLoS ONE 7:e48782. 2012
    ....
  3. pmc BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China
    Exp Neurol 235:228-37. 2012
    ..These findings suggest that BACE1 is involved in aberrant limbic axonal sprouting in a model of temporal lobe epilepsy, warranting further investigation into the role of BACE1 in physiological vs. pathological neuronal plasticity...
  4. pmc Chronic lead exposure reduces doublecortin-expressing immature neurons in young adult guinea pig cerebral cortex
    Jufang Huang
    Department of Anatomy and Neurobiology, Central South University School of Basic Medical Sciences, Changsha, Hunan, China
    BMC Neurosci 13:82. 2012
    ..Using young adult guinea pigs as an experimental model, the present study explored if chronic Pb exposure affects cortical DCX + immature neurons and those around the subventricular and subgranular zones (SVZ, SGZ)...
  5. pmc Elevation of soluble major histocompatibility complex class I related chain A protein in malignant and infectious diseases in Chinese patients
    Xiaoxin Jiang
    The First Affiliated Hospital, Nanhua University, Hengyang, China
    BMC Immunol 13:62. 2012
    ..Cells infected by microbiological pathogens may release sMICA, whereas less is known whether and to what extent serum sMICA levels may change in infectious diseases...
  6. pmc β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    Eur J Neurosci 32:1223-38. 2010
    ..The data provide a mechanistic explanation for why senile plaques are present preferentially near the cerebral vasculature...
  7. doi request reprint Experimental epidural hematoma causes cerebral infarction and activates neocortical glial and neuronal genesis in adult guinea pigs
    Aihua Pan
    Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    J Neurosci Res 91:249-61. 2013
    ..These findings point to potential therapeutic targets for improving neuronal recovery in clinical management of EDH...
  8. pmc BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology
    Yan Cai
    Department of Human Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan 410013, China
    Neurotox Res 21:160-74. 2012
    ....
  9. pmc Layer I as a putative neurogenic niche in young adult guinea pig cerebrum
    Kun Xiong
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    Mol Cell Neurosci 45:180-91. 2010
    ....
  10. pmc γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ
    Fei Liu
    Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China
    Eur J Neurosci 37:1714-25. 2013
    ..The CP appears to be a previously unrecognised non-neuronal contributor to CSF Aβ, probably at reduced levels in AD...
  11. pmc Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response
    Ju fang Huang
    Department of Anatomy and Neurobiology, Central South University, Changsha, Hunan, China
    BMC Neurosci 14:16. 2013
    ..Evidence suggests that necroptosis may be a mode of neuronal death in the retina...
  12. pmc Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury
    Jian Ming Li
    Neuroscience Research Center, Changsha Medical University, Changsha, 410219, Hunan, China
    Neurotox Res 24:1-14. 2013
    ..Spinal neuritic plaque formation is enhanced after peripheral axotomy, suggesting a retrograde transneuronal modulation on pathogenesis...
  13. pmc Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan 410013, China
    Exp Neurol 216:342-56. 2009
    ..These data suggest that immature neurons persist into adulthood in many cortical areas in cats and primates, and that these cells appear to undergo development and differentiation to become functional subgroups of GABAergic interneurons...
  14. doi request reprint Can BACE1 inhibition mitigate early axonal pathology in neurological diseases?
    Xiao Xin Yan
    Department of Anatomy and Neurobiology, Central South University Xiangya School of Medicine, Changsha, Hunan, China
    J Alzheimers Dis 38:705-18. 2014
    ..Finally, we propose pharmacological inhibition of excessive BACE1 activity as an option to mitigate early axonal pathology occurring in AD and other neurological disorders. ..
  15. doi request reprint Somal and dendritic development of human CA3 pyramidal neurons from midgestation to middle childhood: a quantitative Golgi study
    Dahua Lu
    Department of Anatomy and Neurobiology, Central South University, Xiangya School of Medicine, Changsha, Hunan, China
    Anat Rec (Hoboken) 296:123-32. 2013
    ..Spine development and likely synaptogenesis on CA3 pyramidal cells progress during the third prenatal trimester and may continue throughout childhood...