Research Topics
| Min LiSummaryAffiliation: Central South University Country: China Publications
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Detail Information
Publications
Towards the identification of protein complexes and functional modules by integrating PPI network and gene expression dataMin Li
School of Information Science and Engineering, Central South University, Changsha, China
BMC Bioinformatics 13:109. 2012..However, most of them considered the PPI networks as static graphs and overlooked the dynamics inherent within these networks. Moreover, few of them can distinguish between protein complexes and functional modules...
A new essential protein discovery method based on the integration of protein-protein interaction and gene expression dataMin Li
School of Information Science and Engineering, Central South University, Changsha, Hunan, P R China
BMC Syst Biol 6:15. 2012..However, the network topology-based centrality measures are very sensitive to the robustness of network. Therefore, a new robust essential protein discovery method would be of great value...
Modifying the DPClus algorithm for identifying protein complexes based on new topological structuresMin Li
School of Information Science and Engineering, Central South University, Changsha, Hunan 410083, PR China
BMC Bioinformatics 9:398. 2008..As the size of protein-protein interaction set increases, a general trend is to represent the interactions as a network and to develop effective algorithms to detect significant complexes in such networks...
A local average connectivity-based method for identifying essential proteins from the network levelMin Li
School of Information Science and Engineering, Central South University, Changsha 410083, PR China
Comput Biol Chem 35:143-50. 2011..The comparison results based on the validations of sensitivity, specificity, F-measure, positive predictive value, negative predictive value, and accuracy consistently show that LAC outweighs these seven previous methods...
Identifying the overlapping complexes in protein interaction networksMin Li
School of Information Science and Engineering, Central South University, Changsha 410083, China
Int J Data Min Bioinform 4:91-108. 2010..The algorithm IPC-MCE is applied to the protein interaction network of Saccharomyces cerevisiae. Many well-known protein complexes are detected...
Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β(1-42)-injected rats and may be connected to synaptic changes in the hippocampusLin Zhou
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P R China
Can J Physiol Pharmacol 90:1446-55. 2012..These alterations were reversed by the administration of TSG, suggesting that TSG exerts anti-AD properties by protecting synaptic structure and function. TSG-induced upregulation of Src and NR2B may be responsible for this process...
A fast hierarchical clustering algorithm for functional modules discovery in protein interaction networksJianxin Wang
Department of Computer Science, School of Information Science and Engineering, Central South University, Changsha 410083, China
IEEE/ACM Trans Comput Biol Bioinform 8:607-20. 2011..Compared to other previous competing algorithms, our algorithm HC-PIN is faster and more accurate...
A comparison of the functional modules identified from time course and static PPI network dataXiwei Tang
School of Information Science and Engineering, Central South University, Changsha, 410083, China
BMC Bioinformatics 12:339. 2011..The shift from static to dynamic network analysis is essential for further understanding of molecular systems...
Identifying protein complexes from interactome based on essential proteins and local fitness methodJianxin Wang
School of Information Science and Engineering, Central South University, Changsha, 410005, China
IEEE Trans Nanobioscience 11:324-35. 2012..The program and related files available on https://github.com/gangchen/epof...
Identification of essential proteins based on edge clustering coefficientJianxin Wang
School of Information Science and Engineering, Central South University, Computer Building, Changsha 410083, China
IEEE/ACM Trans Comput Biol Bioinform 9:1070-80. 2012..Moreover, the essential proteins discovered by NC show significant cluster effect...
Identifying protein complexes from interaction networks based on clique percolation and distance restrictionJianxin Wang
School of Information Science and Engineering, Central South University, Changsha 410083, China
BMC Genomics 11:S10. 2010..Each protein might be subordinate multiple protein complexes in the real protein-protein interaction networks. Identifying overlapping protein complexes from protein-protein interaction networks is a considerable research topic...
Recent advances in clustering methods for protein interaction networksJianxin Wang
School of Information Science and Engineering, Central South University, Changsha 410083, China
BMC Genomics 11:S10. 2010..The predictions of protein functions and interactions based on modules will be covered. Finally, the performance of different clustering methods will be compared and the directions for future research will be discussed...
Integration of breast cancer gene signatures based on graph centralityJianxin Wang
School of Information Science and Engineering, Central South University, Changsha, 410083, China
BMC Syst Biol 5:S10. 2011..However due to small overlap between different signatures, it is challenging to integrate existing disjoint signatures to provide a unified insight on the association between gene expression and clinical outcome...
Identification of hierarchical and overlapping functional modules in PPI networksJianxin Wang
School of Information Science and Engineering, Central SouthUniversity, Changsha, 410083, China
IEEE Trans Nanobioscience 11:386-93. 2012..The experimental results show that OH-PIN outperforms the existing algorithms in terms of the functional enrichment and matching with known protein complexes...
An effective method for refining predicted protein complexes based on protein activity and the mechanism of protein complex formationJianxin Wang
School of Information Science and Engineering, Central South University, Changsha 410083, China
BMC Syst Biol 7:28. 2013....
hF-measure: A new measurement for evaluating clusters in protein-protein interaction networksMin Li
School of Information Science and Engineering, Central South University, Changsha, China
Proteomics 13:291-300. 2013..Especially, hF-measure(Tb) can capture the topology changes in clusters, which can also be used to the analysis of dynamic network...
Construction and application of dynamic protein interaction network based on time course gene expression dataJianxin Wang
School of Information Science and Engineering, Central South University, Changsha, China
Proteomics 13:301-12. 2013....
Tetrahydroxystilbene glucoside improves learning and (or) memory ability of aged rats and may be connected to the APP pathwayYing Hou
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People s Republic of China
Can J Physiol Pharmacol 89:801-9. 2011..TSG might exert this effect through the APP pathway, although further studies on the topic are required...
Predicting β-turns in protein using kernel logistic regressionMurtada Khalafallah Elbashir
School of Information Science and Engineering, Central South University, Changsha 410083, China
Biomed Res Int 2013:870372. 2013..In addition, KLR yields probabilistic outcome and has a well-defined extension to multiclass case...
