X Chen

Summary

Affiliation: Central South University
Country: China

Publications

  1. ncbi request reprint Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway
    X Chen
    Department of Pharmacology, Hunan Medical University, Changsha, China
    Clin Exp Pharmacol Physiol 24:958-9. 1997
  2. ncbi request reprint Simvastatin inhibits cardiac hypertrophy and angiotensin-converting enzyme activity in rats with aortic stenosis
    J D Luo
    Department of Pharmacology, Guangzhou Medical College, China
    Clin Exp Pharmacol Physiol 26:903-8. 1999
  3. ncbi request reprint Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage
    J X Chen
    Department of Pharmacology, Hunan Medical University, Changsha, 410078, P R China
    Pharmacol Res 43:63-9. 2001
  4. ncbi request reprint K(Ca) channel-opening activity of Ginkgo Biloba extracts and ginsenosides in cultured endothelial cells
    Z Li
    Department of Pharmacology, Hunan Medical University, Changsha, China
    Clin Exp Pharmacol Physiol 28:441-5. 2001
  5. ncbi request reprint Pretreatment with ramiprilat induces cardioprotection against free radical injury in guinea-pig isolated heart: involvement of bradykinin, protein kinase C and prostaglandins
    Z Q Jin
    Department of Pharmacology, Hunan Medical University, Changsha, PR China
    Clin Exp Pharmacol Physiol 27:257-62. 2000
  6. ncbi request reprint Rapamycin inhibits human glioma cell proliferation through down-regulating mammalian target of rapamycin pathway and up-regulating microRNA-143
    C Li
    Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China
    Head Neck Oncol 4:66. 2012
  7. pmc Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes
    J D Luo
    Department of Pharmacology, Guangzhou Medical College, Guangzhou 510182, China Central Laboratory, The First Military Medical University, Guangzhou 510000, China
    Br J Pharmacol 132:159-64. 2001

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway
    X Chen
    Department of Pharmacology, Hunan Medical University, Changsha, China
    Clin Exp Pharmacol Physiol 24:958-9. 1997
    ..In addition, our data support the potential of these compounds as therapeutic strategies in cerebral ischaemia and other related vascular dysfunctions...
  2. ncbi request reprint Simvastatin inhibits cardiac hypertrophy and angiotensin-converting enzyme activity in rats with aortic stenosis
    J D Luo
    Department of Pharmacology, Guangzhou Medical College, China
    Clin Exp Pharmacol Physiol 26:903-8. 1999
    ..Thus, HMG-CoA reductase inhibitors may be beneficial for the clinical treatment of cardiac hypertrophy...
  3. ncbi request reprint Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage
    J X Chen
    Department of Pharmacology, Hunan Medical University, Changsha, 410078, P R China
    Pharmacol Res 43:63-9. 2001
    ..The mechanism of Ginkgo Biloba Extract-induced HO-1 gene expression and the increase in HO activity may be related to alteration of intracellular glutathione levels...
  4. ncbi request reprint K(Ca) channel-opening activity of Ginkgo Biloba extracts and ginsenosides in cultured endothelial cells
    Z Li
    Department of Pharmacology, Hunan Medical University, Changsha, China
    Clin Exp Pharmacol Physiol 28:441-5. 2001
    ..These compounds may regulate nitric oxide release by changing the cell membrane potential in vascular endothelial cells...
  5. ncbi request reprint Pretreatment with ramiprilat induces cardioprotection against free radical injury in guinea-pig isolated heart: involvement of bradykinin, protein kinase C and prostaglandins
    Z Q Jin
    Department of Pharmacology, Hunan Medical University, Changsha, PR China
    Clin Exp Pharmacol Physiol 27:257-62. 2000
    ..6. In conclusion, ramiprilat pretreatment induces cardioprotection against either DPPH or *O2- free radical injury. The protective effect depends on activation of B2 receptors and PKC. Prostaglandin synthesis is also involved...
  6. ncbi request reprint Rapamycin inhibits human glioma cell proliferation through down-regulating mammalian target of rapamycin pathway and up-regulating microRNA-143
    C Li
    Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China
    Head Neck Oncol 4:66. 2012
    ..These data suggest a promising, novel rapamycin- and miR-143-based therapy to treat malignant glioma...
  7. pmc Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes
    J D Luo
    Department of Pharmacology, Guangzhou Medical College, Guangzhou 510182, China Central Laboratory, The First Military Medical University, Guangzhou 510000, China
    Br J Pharmacol 132:159-64. 2001
    ..NA-induced increases of intracellular ROS and cardiomyocyte hypertrophy requires both alpha and beta adrenoceptors activation in neonatal rat cardiomyocytes. The increases of ROS induced by NA is required for hypertrophy...