Ju Cao

Summary

Country: China

Publications

  1. pmc Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    EMBO Mol Med 6:120-40. 2014
  2. doi request reprint Pneumococcal ClpP modulates the maturation and activation of human dendritic cells: implications for pneumococcal infections
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    J Leukoc Biol 93:737-49. 2013
  3. doi request reprint Bronchial epithelial cells release IL-6, CXCL1 and CXCL8 upon mast cell interaction
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Cytokine 56:823-31. 2011
  4. pmc Reduced expression of cenp-e in human hepatocellular carcinoma
    Zijie Liu
    The Key Laboratory of Laboratory Medical Diagnostics, ministry of education the faculty of laboratory medicine, Chongqing Medical University, Chongqing PR China
    J Exp Clin Cancer Res 28:156. 2009
  5. pmc Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)
    Nan Li
    Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Faculty of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, PR China
    BMC Microbiol 9:129. 2009
  6. ncbi request reprint Protection against pneumococcal infection elicited by immunization with multiple pneumococcal heat shock proteins
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Vaccine 31:3564-71. 2013
  7. doi request reprint Synergy of IL-27 and TNF-α in regulating CXCL10 expression in lung fibroblasts
    Shanshan Dong
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Am J Respir Cell Mol Biol 48:518-30. 2013
  8. doi request reprint Immunization with DnaJ (hsp40) could elicit protection against nasopharyngeal colonization and invasive infection caused by different strains of Streptococcus pneumoniae
    Yali Cui
    Key Laboratory of Diagnostic Medicine designated by the Ministry of Education, Chongqing Medical University, Department of Laboratory Medicine, Chongqing, PR China
    Vaccine 29:1736-44. 2011
  9. doi request reprint IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10
    Ju Cao
    Department of Laboratory Medicine, Molecular Oncology and Epigenetics Laboratory, The First Affiliated Hospital of Chongqing Medical University, No 1 Youyi Road, Yuzhong District, Chongqing, 400016, China
    Chest 141:121-30. 2012
  10. doi request reprint Pneumococcal proteins PspA and PspC induce CXCL8 production in human neutrophils: implications in pneumococcal infections
    Ju Cao
    Department of Laboratory Medicine, West China Hospital, Sichuan University, No 37, Guo Xue Xiang, Chengdu 610041, China
    Microbes Infect 12:1051-60. 2010

Collaborators

Detail Information

Publications26

  1. pmc Activation of IL-27 signalling promotes development of postinfluenza pneumococcal pneumonia
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    EMBO Mol Med 6:120-40. 2014
    ..Our study defines what we believe to be a novel role of IL-27 in impairing host innate immunity against pneumococcal infection. ..
  2. doi request reprint Pneumococcal ClpP modulates the maturation and activation of human dendritic cells: implications for pneumococcal infections
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    J Leukoc Biol 93:737-49. 2013
    ..This study describes a novel role of ClpP in the interaction of DCs with pneumococci that could provide new insight for the progression of pneumococcal diseases and has important implications for designing pneumococcal protein vaccines...
  3. doi request reprint Bronchial epithelial cells release IL-6, CXCL1 and CXCL8 upon mast cell interaction
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Cytokine 56:823-31. 2011
    ..These data indicate that the interaction of mast cells with bronchial epithelial cells may represent a crucial mechanism of regulating local inflammatory response in allergic asthma...
  4. pmc Reduced expression of cenp-e in human hepatocellular carcinoma
    Zijie Liu
    The Key Laboratory of Laboratory Medical Diagnostics, ministry of education the faculty of laboratory medicine, Chongqing Medical University, Chongqing PR China
    J Exp Clin Cancer Res 28:156. 2009
    ..We investigate the expression of CENP-E in human hepatocellular carcinoma,. and analyze the effect of low CENP-E expression on chromosome separation in normal liver cell line (LO2)...
  5. pmc Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)
    Nan Li
    Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Faculty of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, PR China
    BMC Microbiol 9:129. 2009
    ..pneumoniae, VicR/K is the unique one essential for bacterium growth, and block agents to which, if can be found, may be developed as effective antibiotics against S. pneumoniae infection...
  6. ncbi request reprint Protection against pneumococcal infection elicited by immunization with multiple pneumococcal heat shock proteins
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Vaccine 31:3564-71. 2013
    ..Thus, inclusion of multiple pneumococcal HSPs is important for the development of protein-based pneumococcal vaccines. ..
  7. doi request reprint Synergy of IL-27 and TNF-α in regulating CXCL10 expression in lung fibroblasts
    Shanshan Dong
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Am J Respir Cell Mol Biol 48:518-30. 2013
    ..Our findings suggest that IL-27 has the potential to amplify airway inflammation via the induction of CXCL10 from HLFs, in combination with TNF-α...
  8. doi request reprint Immunization with DnaJ (hsp40) could elicit protection against nasopharyngeal colonization and invasive infection caused by different strains of Streptococcus pneumoniae
    Yali Cui
    Key Laboratory of Diagnostic Medicine designated by the Ministry of Education, Chongqing Medical University, Department of Laboratory Medicine, Chongqing, PR China
    Vaccine 29:1736-44. 2011
    ..Our results therefore support the potential of DnaJ as a conserved pneumococcal protein vaccine...
  9. doi request reprint IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10
    Ju Cao
    Department of Laboratory Medicine, Molecular Oncology and Epigenetics Laboratory, The First Affiliated Hospital of Chongqing Medical University, No 1 Youyi Road, Yuzhong District, Chongqing, 400016, China
    Chest 141:121-30. 2012
    ..We, therefore, have studied its concentrations in the sputum and plasma of patients with COPD and patients with pulmonary TB (PTB), and further investigated the mechanism-of-action effects of IL-27 on bronchial epithelial cells in vitro...
  10. doi request reprint Pneumococcal proteins PspA and PspC induce CXCL8 production in human neutrophils: implications in pneumococcal infections
    Ju Cao
    Department of Laboratory Medicine, West China Hospital, Sichuan University, No 37, Guo Xue Xiang, Chengdu 610041, China
    Microbes Infect 12:1051-60. 2010
    ..Together, our results demonstrated that the induction of CXCL8 in human neutrophils activated by PspA and PspC was regulated by p38 MAPK and NF-κB pathways...
  11. pmc Immunization with a ZmpB-based protein vaccine could protect against pneumococcal diseases in mice
    Yi Gong
    Department of Laboratory Medicine, Chongqing Medical University, Chongqing, People s Republic of China
    Infect Immun 79:867-78. 2011
    ..Taken together, our results suggest that ZmpB is a good candidate pneumococcal vaccine antigen...
  12. doi request reprint Protection against pneumococcal infection elicited by immunization with glutamyl tRNA synthetase, polyamine transport protein D and sortase A
    Xun Min
    Department of Laboratory Medicine, Chongqing Medical University, Chongqing, China
    Vaccine 30:3624-33. 2012
    ....
  13. ncbi request reprint An efficient alternative marker for specific identification of Mycobacterium tuberculosis
    Jianing Zhao
    Department of Laboratory Medicine, College of Laboratory Medicine, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, People s Republic of China
    World J Microbiol Biotechnol 30:2189-97. 2014
    ..In conclusion, mtss90 may be an efficient alternative marker for species-specific identification of MTB and could be used for the diagnosis of tuberculosis combined with other genetic markers. ..
  14. doi request reprint Modulation of human bronchial epithelial cells by pneumococcal choline binding protein A
    Ju Cao
    Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China
    Hum Immunol 72:37-46. 2011
    ..pneumoniae. Our study therefore suggests that pneumococcal CbpA plays an immunopathophysiologic role by activating human bronchial epithelial cells in pneumococcal infections...
  15. doi request reprint Molecular mechanisms of the secretion of cytokines and chemokines from human monocytes activated by pneumococcal surface protein A (PspA): Roles of mitogen-activated protein kinases and NF-kappaB
    Ju Cao
    Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
    Microb Pathog 48:220-9. 2010
    ..Taken together, our findings provide insight for PspA-mediated activation of human monocytes via NF-kappaB and MAPKs signaling cascades in the pathogenesis of invasive pneumococcal infection...
  16. doi request reprint Increased production of circulating soluble co-stimulatory molecules CTLA-4, CD28 and CD80 in patients with rheumatoid arthritis
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    Int Immunopharmacol 14:585-92. 2012
    ..Therefore, the elevated production of circulating soluble T-cell co-stimulatory molecules should contribute to the pathogenesis of RA, and serum sCTLA-4 could potentially serve as a new marker of RA disease activity...
  17. doi request reprint Silencing of PCDH10 in hepatocellular carcinoma via de novo DNA methylation independent of HBV infection or HBX expression
    Song Fang
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, No 1 Youyi Road, Yuzhong District, 400016, Chongqing, People s Republic of China
    Clin Exp Med 13:127-34. 2013
    ....
  18. doi request reprint IL-27 is elevated in acute lung injury and mediates inflammation
    Fang Xu
    Department of Emergency and Intensive Care Unit, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    J Clin Immunol 33:1257-68. 2013
    ..Therefore, IL-27 is a critical cytokine in ALI/ARDS and inhibition of IL-27 may open a promising approach for ALI/ARDS patients. ..
  19. doi request reprint Nosocomial spread of carbapenem-resistant Acinetobacter baumannii (types ST75 and ST137) carrying blaOXA-23-like gene with an upstream ISAba1 in a Chinese hospital
    Wei Dai
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, No 1 Youyi Road, Yuzhong District, Chongqing 400016, PR China
    Infect Genet Evol 14:98-101. 2013
    ..In conclusion, ST75- and ST137-type CRAB isolates that produced the blaOXA-23-like gene with an upstream ISAba1 contributed to the nosocomial outbreaks studied in this work...
  20. doi request reprint Establishment of an experimental method for detecting circulating miRNAs in BDL mice
    Shuangshuang Yang
    Department of Laboratory Medicine, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, People s Republic of China
    Clin Exp Med 12:273-7. 2012
    ....
  21. pmc Analysis of factors influencing the generation of unqualified clinical samples and measures to prevent this generation
    Xiaofei Lai
    Department of Laboratory Medicine, First Affiliated Hospital of Chongqing Medical University, Chongqing, P R China
    Ann Lab Med 32:216-9. 2012
    ..We investigated the influence of pre-analytical factors on the results of clinical tests and thereby analyzed approaches to improve quality management in clinical laboratories...
  22. doi request reprint Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population
    Yu Xiang
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People s Republic of China
    Mol Biol Rep 39:7019-23. 2012
    ..Further characterization of miRNA SNPs may open new avenue for the study of cancer and therapeutic interventions...
  23. doi request reprint Aberrant production of soluble co-stimulatory molecules CTLA-4 and CD28 in patients with chronic hepatitis B
    Ju Cao
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, No 1 Youyi Road, Yuzhong District, Chongqing 400016, China
    Microb Pathog 51:262-7. 2011
    ..The aberrant production of soluble co-stimulatory molecules should reflect the dysregulation of T cell activation and is related to the pathogenesis and severity of chronic HBV infection...
  24. ncbi request reprint In vivo characterization of Streptococcus pneumoniae genes involved in the pathogenesis of meningitis by differential fluorescence induction
    Wen Chun Xu
    Department of Laboratory Medicine, Key Laboratory of Diagnostic Medicine Ministry of Education, Chongqing Medical University, Chongqing, China
    Saudi Med J 31:382-8. 2010
    ..To further understand the pathogenesis of pneumococcal meningitis, and provide some target candidates for the development of drugs...
  25. doi request reprint The effect of curcumin on sepsis-induced acute lung injury in a rat model through the inhibition of the TGF-β1/SMAD3 pathway
    Fang Xu
    Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China
    Int Immunopharmacol 16:1-6. 2013
    ..05). Therefore, curcumin played a protective role in sepsis-induced ALI, possibly through the inhibition of the expression of TGF-β1/SMAD3 pathway which may provide a new strategy for the treatment of sepsis-induced ALI...
  26. ncbi request reprint Silencing of the annexin II gene down-regulates the levels of S100A10, c-Myc, and plasmin and inhibits breast cancer cell proliferation and invasion
    Jian Zhang
    Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    Saudi Med J 31:374-81. 2010
    ..To explore the roles of annexin II in breast cancer progression, and to study the effect of annexin II on breast cancer cell proliferation and invasion...