Zhiming Cai


Country: China


  1. Wang Z, Zhou Q, Li A, Huang W, Cai Z, Chen W. Extracellular matrix protein 1 (ECM1) is associated with carcinogenesis potential of human bladder cancer. Onco Targets Ther. 2019;12:1423-1432 pubmed publisher
  2. Gao Q, Liu Y, Xie H, Zhong Y, Liao X, Zhan H, et al. Lentivirus-mediated shRNA targeting MUTYH inhibits malignant phenotypes of bladder cancer SW780 cells. Onco Targets Ther. 2018;11:6101-6109 pubmed publisher
    ..Our data suggest that MUTYH is a new participant in bladder urothelial carcinoma. MUTYH may play a role as a biomarker and therapeutic target in BC. ..
  3. Shao Z, Deng W, Li S, He J, Ren S, Huang W, et al. GlnR-Mediated Regulation of ectABCD Transcription Expands the Role of the GlnR Regulon to Osmotic Stress Management. J Bacteriol. 2015;197:3041-7 pubmed publisher
    ..Meanwhile, the work reveals the multiple roles of GlnR in bacterial physiology. ..
  4. Guo X, Tian Z, Wang X, Pan S, Huang W, Shen Y, et al. Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2α. Acta Biochim Biophys Sin (Shanghai). 2015;47:106-13 pubmed publisher
    ..These data demonstrate that KDM6B is a new hypoxia response gene regulated by HIF-2α. Our results also show that KDM6B is a potential co-activator of HIF-α, which is important for the activation of hypoxia response genes. ..
  5. Duan Y, Zhang Q, Liu Y, Mou L, Li G, Gui Y, et al. Dendritic cells in semen of infertile men: association with sperm quality and inflammatory status of the epididymis. Fertil Steril. 2014;101:70-77.e3 pubmed publisher
    ..The abundance and activation of seminal DCs of infertile men may be closely associated with poor epididymal function and sperm quality. ..
  6. Wu S, Huang P, Li C, Huang Y, Li X, Wang Y, et al. Telomerase reverse transcriptase gene promoter mutations help discern the origin of urogenital tumors: a genomic and molecular study. Eur Urol. 2014;65:274-7 pubmed publisher
    ..Hence, TERT promoter mutations may serve as important markers for the differential diagnosis and surveillance of urogenital tumors. ..
  7. Lin G, Wang X, Yi W, Zhang C, Xu G, Zhu X, et al. A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma. J Transl Med. 2015;13:166 pubmed publisher
    ..Our results suggest that this type of vaccine formulation has great potentiality in preventive vaccines against OCT4 expressing tumors. ..
  8. Feng W, Dai Y, Mou L, Cooper D, Shi D, Cai Z. The potential of the combination of CRISPR/Cas9 and pluripotent stem cells to provide human organs from chimaeric pigs. Int J Mol Sci. 2015;16:6545-56 pubmed publisher
    ..Genetic modification of chimaeric pigs could also provide useful models for developing therapies for various human diseases, especially in relation to drug development. ..
  9. Fu X, Liu Y, Zhuang C, Liu L, Cai Z, Huang W. Synthetic artificial microRNAs targeting UCA1-MALAT1 or c-Myc inhibit malignant phenotypes of bladder cancer cells T24 and 5637. Mol Biosyst. 2015;11:1285-9 pubmed publisher
    ..These devices can inhibit proliferation, induce apoptosis, and suppress migration of the two bladder cancer cell lines. The synthetic artificial microRNAs may represent a kind of novel genetic devices for treating human bladder cancer. ..

More Information


  1. Zhou M, Hara H, Dai Y, Mou L, Cooper D, Wu C, et al. Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation. Int J Mol Sci. 2016;17: pubmed publisher
    ..Finally, we discuss the implications and challenges of applying miRNA to monitor organ survival and immune rejection in allo- or xeno-transplantation. ..
  2. Lin J, Liu Y, Zhan Y, Zhuang C, Liu L, Fu X, et al. Synthetic Tet-inducible small hairpin RNAs targeting hTERT or Bcl-2 inhibit malignant phenotypes of bladder cancer T24 and 5637 cells. Tumour Biol. 2016;37:3115-21 pubmed publisher
    ..The Tet-inducible small hairpin RNAs may provide a novel strategy for the treatment of human bladder cancer in the future. ..
  3. Xie H, Zhan H, Gao Q, Li J, Zhou Q, Chen Z, et al. Synthetic artificial "long non-coding RNAs" targeting oncogenic microRNAs and transcriptional factors inhibit malignant phenotypes of bladder cancer cells. Cancer Lett. 2018;422:94-106 pubmed publisher
    ..Our devices, all in all, provided a novel strategy and methodology for cancer studies, and might show a great potential for cancer therapy if the challenges of in vivo DNA delivery are overcome. ..
  4. Zhou Q, Hao L, Huang W, Cai Z. The Golgi-Associated Plant Pathogenesis-Related Protein GAPR-1 Enhances Type I Interferon Signaling Pathway in Response to Toll-Like Receptor 4. Inflammation. 2016;39:706-17 pubmed publisher
    ..Understanding the mechanism of GAPR-1 in type I IFN signaling pathway would provide strategies for treatment of infectious diseases. ..
  5. Chen M, Zhuang C, Liu Y, Li J, Dai F, Xia M, et al. Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer. Cancer Lett. 2016;376:155-64 pubmed publisher
    ..Our findings provide new insights into the role of the lncRNA HIF1A-AS2 in the bladder cancer. ..
  6. Liu L, Liu Y, Zhuang C, Xu W, Fu X, Lv Z, et al. Inducing cell growth arrest and apoptosis by silencing long non-coding RNA PCAT-1 in human bladder cancer. Tumour Biol. 2015;36:7685-9 pubmed publisher
    ..Our data suggest that PCAT-1 plays oncogenic roles and can be used as a therapeutic target for treating human bladder cancer. ..
  7. Mou L, Zhang Q, Diao R, Cai Z, Gui Y. A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia. Reprod Biol Endocrinol. 2015;13:79 pubmed publisher
    ..A novel variant (Chr5.133706925 A > G) residing in the UBE2B gene promoter region confers a high risk for IA in a Chinese population. These results support a role for UBE2B in the pathogenesis of IA. ..
  8. Luo K, Wei Chen -, Lung W, Wei X, Cheng B, Cai Z, et al. EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9. J Nutr Biochem. 2017;41:56-64 pubmed publisher
    ..In conclusion, our study demonstrated that EGCG was effective in inhibition SW780 cell proliferation and migration, and presented first evidence that EGCG inhibited SW780 tumor growth by down-regulation of NF-κB and MMP-9. ..
  9. Wang X, Guo X, Yu W, Li C, Gui Y, Cai Z. Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis. BMC Cancer. 2014;14:196 pubmed publisher
    ..MAT2A is a transcriptional corepressor for HO-1 expression by supplying SAM for methyltransferases, which may be one of potential mechanism of MAT2A as tumor suppressor in kidney carcinogenesis. ..