Research Topics


Juan Antonio Valdés


Country: Chile


  1. Aedo J, Zuloaga R, Boltaña S, Molina A, Valdés J. Membrane-initiated cortisol action modulates early pyruvate dehydrogenase kinase 2 (pdk2) expression in fish skeletal muscle. Comp Biochem Physiol A Mol Integr Physiol. 2019;233:24-29 pubmed publisher
    ..This work suggests that non-classical cortisol pathways contribute to regulate the early metabolic response to stress in fish skeletal muscle. ..
  2. Valenzuela C, Escobar Aguirre S, Zuloaga R, Vera Tobar T, Mercado L, Björnsson B, et al. Stocking density induces differential expression of immune-related genes in skeletal muscle and head kidney of fine flounder (Paralichthys adspersus). Vet Immunol Immunopathol. 2019;210:23-27 pubmed publisher
    ..The data suggests that chronic stress modulates the expression of these immune-related genes in a tissue-specific manner. ..
  3. Valdés J, Flores S, Fuentes E, Osorio Fuentealba C, Jaimovich E, Molina A. IGF-1 induces IP3 -dependent calcium signal involved in the regulation of myostatin gene expression mediated by NFAT during myoblast differentiation. J Cell Physiol. 2013;228:1452-63 pubmed publisher
    ..This is the first study to demonstrate a role of calcium-dependent signaling pathways in the mRNA expression of myostatin. ..
  4. Valenzuela C, Escobar D, Pérez L, Zuloaga R, Estrada J, Mercado L, et al. Transcriptional dynamics of immune, growth and stress related genes in skeletal muscle of the fine flounder (Paralichthys adpersus) during different nutritional statuses. Dev Comp Immunol. 2015;53:145-57 pubmed publisher
  5. Aedo J, Reyes A, Avendaño Herrera R, Molina A, Valdés J. Bacterial lipopolysaccharide induces rainbow trout myotube atrophy via Akt/FoxO1/Atrogin-1 signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2015;47:932-7 pubmed publisher
  6. Retamales A, Zuloaga R, Valenzuela C, Gallardo Escárate C, Molina A, Valdés J. Insulin-like growth factor-1 suppresses the Myostatin signaling pathway during myogenic differentiation. Biochem Biophys Res Commun. 2015;464:596-602 pubmed publisher
    ..These results demonstrate that the IGF-1/PI3K/Akt pathway may inhibit MSTN signaling during myoblast differentiation, providing new insight to existing knowledge on the complex crosstalk between both growth factors. ..
  7. Aedo J, Maldonado J, Aballai V, Estrada J, Bastias Molina M, Meneses C, et al. mRNA-seq reveals skeletal muscle atrophy in response to handling stress in a marine teleost, the red cusk-eel (Genypterus chilensis). BMC Genomics. 2015;16:1024 pubmed publisher
    ..This study is an important step towards understanding the atrophy system in non-model teleost species and provides novel insights on the cellular and molecular mechanisms that control skeletal muscle growth in early vertebrates. ..
  8. Valenzuela C, Zuloaga R, Poblete Morales M, Vera Tobar T, Mercado L, Avendaño Herrera R, et al. Fish skeletal muscle tissue is an important focus of immune reactions during pathogen infection. Dev Comp Immunol. 2017;73:1-9 pubmed publisher
    ..Finally, transcriptions of il-1β, il-8, tnfα, nkef-a, and hepcidin were also upregulated. These results suggest that fish skeletal muscle is an immunologically active organ that could play an important role against pathogens. ..
  9. Aballai V, Aedo J, Maldonado J, Bastias Molina M, Silva H, Meneses C, et al. RNA-seq analysis of the head-kidney transcriptome response to handling-stress in the red cusk-eel (Genypterus chilensis). Comp Biochem Physiol Part D Genomics Proteomics. 2017;24:111-117 pubmed publisher
    ..chilensis. This study is an important step towards understanding the immune adaptive response to stress in non-model teleost species. ..

More Information


  1. Iturriaga M, Espinoza M, Poblete Morales M, Feijóo C, Reyes A, Molina A, et al. Cytotoxic activity of Flavobacterium psychrophilum in skeletal muscle cells of rainbow trout (Oncorhynchus mykiss). Vet Microbiol. 2017;210:101-106 pubmed publisher
    ..These findings suggest that F. psychrophilum induces rainbow trout muscle apoptosis through the modulation of the NF-?B signaling as a mechanism for nutrient acquisition and survival. ..