J L Santos

Summary

Affiliation: University of Chile
Country: Chile

Publications

  1. ncbi request reprint [Genetic epidemiology of obesity: family studies]
    Jose Luis Santos
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    Rev Med Chil 133:349-61. 2005
  2. ncbi request reprint [Association between tumor necrosis factor-alpha promoter polymorphisms and type 2 diabetes and obesity in Chilean elderly women]
    José Luis Santos M
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    Rev Med Chil 134:1099-106. 2006
  3. ncbi request reprint [Genotype-by-nutrition interaction: interpretation of epidemiological studies]
    José Luis Santos M
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile
    Rev Med Chil 135:792-9. 2007
  4. ncbi request reprint Adiposity and bone mineral density of Chilean elderly women in relation to toll-like receptor 4 gene polymorphisms
    J L Santos
    Laboratory of Genetic and Nutrition Epidemiology, Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, Chile
    Ann Hum Biol 33:585-92. 2006
  5. ncbi request reprint Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile
    F Perez-Bravo
    Department of Public Nutrition Genetic Epidemiology Unit, Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, P O Box 138 11, Chile
    Acta Diabetol 43:93-8. 2006
  6. ncbi request reprint [Prevalence of obesity, hypertension and dyslipidemia in rural aboriginal groups in Chile]
    F Perez
    Unidad de Nutrición Pública, Instituto de Nutricion y Tecnologia de los Alimentos INTA, Universidad de Chile, Santiago
    Rev Med Chil 127:1169-75. 1999
  7. ncbi request reprint Plasma leptin and insulin levels in Aymara natives from Chile
    J L Santos
    Department of Epidemiology, Institute of Nutrition and Food Technology, University of Chile, Santiago
    Ann Hum Biol 27:271-9. 2000
  8. ncbi request reprint Prevalence of type 2 diabetes and obesity in rural Mapuche population from Chile
    F Perez-Bravo
    Molecular Biology Laboratory, INTA University of Chile, Santiago, Chile
    Nutrition 17:236-8. 2001
  9. ncbi request reprint Low prevalence of type 2 diabetes despite a high average body mass index in the Aymara natives from Chile
    J L Santos
    Laboratory of Epidemiology, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Nutrition 17:305-9. 2001
  10. ncbi request reprint [Obesity and leptin association in three Chilean aboriginal populations]
    F Perez
    Unidades de Biología Molecular y Epidemiología Nutricional, INTA, Universidad de Chile, Santiago, Chile
    Rev Med Chil 128:45-52. 2000

Collaborators

Detail Information

Publications37

  1. ncbi request reprint [Genetic epidemiology of obesity: family studies]
    Jose Luis Santos
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    Rev Med Chil 133:349-61. 2005
    ..Topics related to study design will acquire increasing importance in order to avoid methodological problems related to trait definition, sample sizes, population stratification by ethnicity and other confounding factors...
  2. ncbi request reprint [Association between tumor necrosis factor-alpha promoter polymorphisms and type 2 diabetes and obesity in Chilean elderly women]
    José Luis Santos M
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    Rev Med Chil 134:1099-106. 2006
    ..Tumor necrosis factor-alpha (TNF-alpha) has an increased expression in the adipose tissue of obese subjects and is involved in insulin resistance...
  3. ncbi request reprint [Genotype-by-nutrition interaction: interpretation of epidemiological studies]
    José Luis Santos M
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile
    Rev Med Chil 135:792-9. 2007
    ..These study designs and analytical methods are equally valid for the assessment of genotype-environment or genotype-genotype interaction...
  4. ncbi request reprint Adiposity and bone mineral density of Chilean elderly women in relation to toll-like receptor 4 gene polymorphisms
    J L Santos
    Laboratory of Genetic and Nutrition Epidemiology, Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, Chile
    Ann Hum Biol 33:585-92. 2006
    ..On the other hand, the adipose tissue of obese subjects shows an increased expression of the proinflammatory cytokine, tumour necrosis factor-alpha (TNF-alpha), which is released after lipopolysaccharide recognition by TLR4...
  5. ncbi request reprint Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile
    F Perez-Bravo
    Department of Public Nutrition Genetic Epidemiology Unit, Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, P O Box 138 11, Chile
    Acta Diabetol 43:93-8. 2006
    ..37, 95% CI 1.319-4.277, p=0.004) It is unlikely that Ala54Thr polymorphism of the FABP2 gene plays a relevant role in obesity and insulin resistance in Chilean ethnic groups...
  6. ncbi request reprint [Prevalence of obesity, hypertension and dyslipidemia in rural aboriginal groups in Chile]
    F Perez
    Unidad de Nutrición Pública, Instituto de Nutricion y Tecnologia de los Alimentos INTA, Universidad de Chile, Santiago
    Rev Med Chil 127:1169-75. 1999
    ..The investigation of a possible relationship between this low prevalence of diabetes and obesity, hypertension and serum lipid profiles in both groups is worthwhile...
  7. ncbi request reprint Plasma leptin and insulin levels in Aymara natives from Chile
    J L Santos
    Department of Epidemiology, Institute of Nutrition and Food Technology, University of Chile, Santiago
    Ann Hum Biol 27:271-9. 2000
    ..9) were detected at alpha 0.05 level. Thus, in the special ecosystem where the Aymara population live, a strong and independent association between sex, obesity and insulin levels with plasma leptin levels has been detected...
  8. ncbi request reprint Prevalence of type 2 diabetes and obesity in rural Mapuche population from Chile
    F Perez-Bravo
    Molecular Biology Laboratory, INTA University of Chile, Santiago, Chile
    Nutrition 17:236-8. 2001
    ..The prevalence estimated in this study is higher than that reported 15 y ago. This suggests an important role of lifestyle changes as a possible explanation for epidemiologic transition...
  9. ncbi request reprint Low prevalence of type 2 diabetes despite a high average body mass index in the Aymara natives from Chile
    J L Santos
    Laboratory of Epidemiology, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Nutrition 17:305-9. 2001
    ..5%), high physical activity levels and low plasma-insulin concentrations may have been responsible in part for the low prevalence of DM2 in the Aymara population...
  10. ncbi request reprint [Obesity and leptin association in three Chilean aboriginal populations]
    F Perez
    Unidades de Biología Molecular y Epidemiología Nutricional, INTA, Universidad de Chile, Santiago, Chile
    Rev Med Chil 128:45-52. 2000
    ..Although there is a clear relationship between body mass index and leptin levels, few authors have addressed the possible influence of ethnic factors on these levels...
  11. doi request reprint Melanocortin-3 receptor gene variants: association with childhood obesity and eating behavior in Chilean families
    A M Obregon
    Department of de Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Nutrition 26:760-5. 2010
    ..To evaluate the association between melanocortin-3 receptor common genetic polymorphisms with childhood obesity and eating behavior in Chilean families...
  12. ncbi request reprint [Lipoprotein lipase gene polymorphism in non-insulin-dependent diabetics: preliminary study]
    F Perez
    INTA, Universidad de Chile, Santiago
    Rev Med Chil 125:1329-34. 1997
    ..Lipoprotein lipase plays a crucial role in plasma lipoprotein metabolism. Several lipoprotein lipase gene polymorphisms have been found associated with lipid levels, premature atherosclerosis and cardiovascular disease...
  13. ncbi request reprint Applicability of the case-parent design in the etiological research of Type 1 diabetes in Chile and other genetically mixed populations
    J L Santos
    Department of Nutritional Epidemiology, Institute of Nutrition and Food Technology INTA, University of Chile, Santiago
    Diabetes Res Clin Pract 43:143-6. 1999
    ....
  14. ncbi request reprint Transmission of high-risk HLA-DQB1 alleles in Chilean type 1 diabetic patients and their parents: stratification by the presence of ICA or GAD65 autoantibodies
    F Perez-Bravo
    Molecular Biology Laboratory, INTA, University of Chile, Santiago, Spain
    Autoimmunity 33:285-91. 2001
    ....
  15. ncbi request reprint Incidence rate of type 1 diabetes in Santiago (Chile) by HLA-DQA1 and DQB1 genotypes
    N Diaz
    Genetics and Metabolic Diseases Program, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Eur J Epidemiol 18:787-92. 2003
    ..26-78.67). This study shows an application on how a transformation of the logistic equation based on Bayes' theorem can be used to estimate incidence rates from case-control studies and population-based incidence rates...
  16. ncbi request reprint [Auto-antibody profile and breast feeding in type 1 diabetic patients]
    F Perez-Bravo
    Unidad de Nutrición Pública, Laboratorio de Biologia Molecular, Instituto de Nutricion y Tecnologia de los Alimentos INTA, Universidad de Chile, Casilla 138 11 Santiago, Chile
    Rev Med Chil 129:611-9. 2001
    ..Breast feeding duration and the early exposure to milk substitutes are environmental factors associated to etiology of type 1 diabetes...
  17. ncbi request reprint Genetic differences in HLA-DQA1* and DQB1* allelic distributions between celiac and control children in Santiago, Chile
    F Perez-Bravo
    Molecular Biology Laboratory, Institute of Nutrition and Food Technology INTA, University of Chile, Santiago
    Hum Immunol 60:262-7. 1999
    ..This is concordant with the high frequency of DR4 alleles (in linkage disequilibrium with DQB1*0302) detected in Amerind groups in Chile, where DQB1*0302 is more frequent than DQB1*0201...
  18. doi request reprint Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior
    M Valladares
    Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Nutr Neurosci 13:71-8. 2010
    ..To screen for mutations in the coding region of the melanocortin-4 receptor (MC4R) gene and to assess the association between the rs17782313 variant near MC4R with childhood obesity and eating behavior...
  19. ncbi request reprint Increasing incidence of type 1 diabetes in population from Santiago of Chile: trends in a period of 18 years (1986-2003)
    E Carrasco
    Department of Diabetes, Hospital San Juan de Dios, Faculty of Medicine, University of Chile, Santiago, Chile, South America
    Diabetes Metab Res Rev 22:34-7. 2006
    ..STUDY OBJECTIVE AND SETTING: The aim of this study is to determine the incidence rate of type 1 diabetes in the metropolitan region of Santiago, Chile from 1 January 1986 to 31 December 2003...
  20. ncbi request reprint Anthropometric measurements in the elderly population of Santiago, Chile
    J L Santos
    Public Health Nutrition Area, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Nutrition 20:452-7. 2004
    ..We describe age and sex differences in weight, height, body mass index, knee height, waist circumference, midarm circumference, triceps skinfold thickness, arm muscle area, and calf circumference in Chilean elderly subjects...
  21. ncbi request reprint Prevalence of Type II diabetes mellitus and insulin resistance in parents of women with polycystic ovary syndrome
    T Sir-Petermann
    Laboratory of Endocrinology, Department of Medicine, School of Medicine, San Juan de Dios Hospital and Food Technology Institute, University of Chile, Santiago, Chile
    Diabetologia 45:959-64. 2002
    ..To investigate antecedents of metabolic disorders in family members of patients with PCOS, we evaluated glucose tolerance and insulin resistance in parents of patients with PCOS compared to parents of healthy women...
  22. ncbi request reprint Association between aminolevulinate dehydrase genotypes and blood lead levels in children from a lead-contaminated area in Antofagasta, Chile
    F Perez-Bravo
    Unidad de Nutrición Pública, Programa de Epidemiología Genética, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, PO Box 138 11, Santiago, Chile
    Arch Environ Contam Toxicol 47:276-80. 2004
    ....
  23. ncbi request reprint Linkage disequilibrium between MSX1 and non-syndromic cleft lip/palate in the Chilean population
    J Suazo
    Laboratory of Genetic Epidemiology, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    J Dent Res 83:782-5. 2004
    ..01). The authors' findings support the hypothesis of the contribution of MSX1 in the etiology of NSCLP in the Chilean population...
  24. ncbi request reprint FABP2 Ala54Thr polymorphism and diabetes in Chilean elders
    Cecilia Albala
    Public Health Nutrition Unit, Chronic Diseases and Genetic Epidemiology Research Laboratory, Institute of Nutrition and Food Technology INTA University of Chile, Casilla, Santiago, P O Box 138 1, El Libiano 5524, Chile
    Diabetes Res Clin Pract 77:245-50. 2007
    ..The aim of this study was to estimate the prevalence of FABP2 genotypes in 223 Chilean subjects (136 women and 87 men aged 65-79 years) and its association with type 2 diabetes in a 4 years follow-up...
  25. ncbi request reprint No evidence for an association between genetic polymorphisms of beta(2)- and beta(3)-adrenergic receptor genes with body mass index in Aymara natives from Chile
    Jose Luis Santos
    Programa de Epidemiología Genética, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    Nutrition 18:255-8. 2002
    ..We assessed the association between Gln27Glu and Trp64Arg genetic polymorphisms of the beta(2) (ADRB2) and beta(3) (ADRB3) adrenergic receptor genes with body mass index and other cardiovascular risk factors...
  26. ncbi request reprint Association between HLA-DQB1 alleles and type 1 diabetes in a case-parents study conducted in Santiago, Chile
    J L Santos
    Department of Epidemiology, Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, Chile
    Am J Epidemiol 153:794-8. 2001
    ..9, 11.6); DQB1(*)0301 was considered the baseline allele. When case-parents trios were used, alleles DQB1(*)0302 and DQB1(*)0201 were strongly associated with a higher risk of type 1 diabetes in the population of SANTIAGO:..
  27. doi request reprint Plasma levels of interleukin-6 and interleukin-18 after an acute physical exercise: relation with post-exercise energy intake in twins
    C Almada
    Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Physiol Biochem 69:85-95. 2013
    ..The present study in monozygotic twins shows increased IL-6 plasma levels after acute physical exercise with a significant reduction in energy intake, supporting a linkage between IL-6 and acute post-exercise eating behaviour...
  28. ncbi request reprint Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load
    Teresa Sir-Petermann
    Laboratory of Endocrinology, Department of Medicine, School of Medicine, San Juan de Dios Hospital, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Nutrition 20:905-10. 2004
    ..ovary syndrome (PCOS) who were carriers and non-carriers of the glycine-to-arginine substitution at codon 972 (Gly972Arg) variant of insulin receptor substrate-1 and to assess insulin response after oral high- and low-glycemic loads..
  29. doi request reprint Association between bone morphogenetic protein 4 gene polymorphisms with nonsyndromic cleft lip with or without cleft palate in a chilean population
    José Suazo
    1 Human Genetics Program, Institute of Biomedical Sciences, School of Medicine, Catholic University of Chile, Santiago, Chile
    DNA Cell Biol 29:59-64. 2010
    ..The findings of our study support a role for BMP4 in NSCLP in the admixed Chilean population...
  30. doi request reprint Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: case-parent design
    Barbara Angel
    Genetic Epidemiology Laboratory, Nutrition and Food Technology Institute INTA, University of Chile, Santiago, Chile
    Diabetes Res Clin Pract 85:e34-6. 2009
    ..A significant overall association with T1D (p=0.028) was observed, possibly due to an overtransmission of the G-T haplotype...
  31. ncbi request reprint [Anthropometry, body composition and functional limitations in the elderly]
    Patricia Arroyo
    Unidad de Salud Pública y Nutrición, Laboratorio de Epidemiología Nutricional y Genética, Instituto de Nutrición y Tecnología en Alimentos, Universidad de Chile, Chile
    Rev Med Chil 135:846-54. 2007
    ..Functional limitations limit the independence and jeopardize the quality of life of elderly subjects...
  32. ncbi request reprint [Use of case-parents trio for epidemiological studies of association between genetic polymorphisms and complex diseases]
    Jose Luis Santos
    Instituto de Nutricion y Tecnologia de los Alimentos INTA, Universidad de Chile, Programa de Epidemiología Genética, Macul 5540, Santiago, Chile
    Rev Med Chil 130:1307-15. 2002
    ..In this article, we review the analysis of case-parent trios using unrelated affected cases as an epidemiological study design for testing association between genetic polymorphisms and disease...
  33. ncbi request reprint Association between 10 microsatellite markers and nonsyndromic cleft lip palate in the Chilean population
    Rafael Blanco
    Human Genetics Program, Institute of Biomedical Sciences, School of Medicine, University of Chile, Santiago, Chile
    Cleft Palate Craniofac J 41:163-7. 2004
    ..The objective of this case-control study was to evaluate the possible association between nonsyndromic cleft lip/palate (NSCLP) and 10 genetic markers in four chromosomal regions in the admixed Spanish-Amerindian Chilean population...
  34. ncbi request reprint Tryptophan 64 --> arginine polymorphism of beta-3-adrenergic receptor in Chilean women with polycystic ovary syndrome
    Francisco Perez-Bravo
    Laboratory of Endocrinology, Department of Medicine, School of Medicine, San Juan de Dios Hospital, University of Chile, Santiago, Chile
    Clin Endocrinol (Oxf) 62:126-31. 2005
    ..In addition, we evaluated the relationship of the Trp64Arg variant with other metabolic components of this syndrome...
  35. ncbi request reprint [Multivariate study of the evolution of body dimensions in elderly Chilean women]
    Lydia Lera
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago de Chile, Chile
    Arch Latinoam Nutr 57:219-23. 2007
    ..The results obtained suggested a regular chronological evolution during the first 24 months of observation with a change in structure after 30 months of the study, thereby classifying subjects according to body composition...
  36. ncbi request reprint VDR polymorphisms influence the immune response in type 1 diabetic children from Santiago, Chile
    Diego Garcia
    Genetic Epidemiology Laboratory, Nutrition and Food Technology Institute, University of Chile, Santiago, Chile
    Diabetes Res Clin Pract 77:134-40. 2007
    ....
  37. doi request reprint Parent-of-origin effects for MSX1 in a Chilean population with nonsyndromic cleft lip/palate
    José Suazo
    Programa de Genética Humana, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Am J Med Genet A 152:2011-6. 2010
    ..The full mechanism of MSX1 in the development of NSCLP has not been fully understood...