Juan F Santibanez

Summary

Affiliation: University of Chile
Country: Chile

Publications

  1. ncbi Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis
    Juan F Santibanez
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, INTA, Universidad de Chile, Casilla 138, Santiago 11, Chile
    FEBS Lett 579:6459-64. 2005
  2. ncbi JNK mediates TGF-beta1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
    Juan F Santibanez
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, INTA, Universidad de Chile, Casilla 138, Santiago 11, Chile
    FEBS Lett 580:5385-91. 2006
  3. doi ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion
    Nicolas Tobar
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, INTA, Universidad de Chile, Santiago, Chile
    Mol Cell Biochem 340:195-202. 2010
  4. doi SKIP is required for TGF-β1-induced epithelial mesenchymal transition and migration in transformed keratinocytes
    Victor Villar
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    FEBS Lett 584:4586-92. 2010
  5. ncbi Cyclic AMP inhibits TGFbeta1-induced cell-scattering and invasiveness in murine-transformed keratinocytes
    Juan F Santibanez
    Laboratorio de Biología Celular INTA, Universidad de Chile, Santiago, Chile
    Int J Cancer 107:715-20. 2003
  6. doi Rac1 modulates TGF-beta1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes
    Juan F Santibanez
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos INTA, Universidad de Chile, Santiago, Chile
    FEBS Lett 584:2305-10. 2010
  7. doi Spred2 inhibits TGF-beta1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition
    Victor Villar
    Cellular Biology Laboratory, Nutrition and Food Technology Institute, INTA, Universidad de Chile, Chile
    Int J Cancer 127:77-85. 2010
  8. pmc Skip Regulates TGF- β 1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells
    Victor Villar
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, 7810000 Santiago, Chile Department of Biology, University of the Balearic Islands, Ctra Valldemossa, km 7 5, 07122 Palma de Mallorca, Spain
    Prostate Cancer 2013:398253. 2013
  9. doi RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism
    Nicolas Tobar
    Laboratorio de Biologia Celular, INTA, Universidad de Chile, Casilla 138, Santiago 11, Chile
    Cancer Lett 267:125-32. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis
    Juan F Santibanez
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, INTA, Universidad de Chile, Casilla 138, Santiago 11, Chile
    FEBS Lett 579:6459-64. 2005
    ..These data suggests that the oncogenic Ha-Ras is important for Anisomycin-induced JNK activation and apoptosis in transformed keratinocytes...
  2. ncbi JNK mediates TGF-beta1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
    Juan F Santibanez
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, INTA, Universidad de Chile, Casilla 138, Santiago 11, Chile
    FEBS Lett 580:5385-91. 2006
    ..These results allow us to suggest a role of JNK in the TGF-beta1 induction of EMT in relation with the stimulation of malignant properties of mouse transformed keratinocytes...
  3. doi ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion
    Nicolas Tobar
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, INTA, Universidad de Chile, Santiago, Chile
    Mol Cell Biochem 340:195-202. 2010
    ..Thus, ROS-NFkappaB acts as the crucial signal in TGF-beta1-induced uPA and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1...
  4. doi SKIP is required for TGF-β1-induced epithelial mesenchymal transition and migration in transformed keratinocytes
    Victor Villar
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    FEBS Lett 584:4586-92. 2010
    ..Thus, these results suggest that SKIP is required for EMT and invasiveness induced by TGF-β1 in transformed cells...
  5. ncbi Cyclic AMP inhibits TGFbeta1-induced cell-scattering and invasiveness in murine-transformed keratinocytes
    Juan F Santibanez
    Laboratorio de Biología Celular INTA, Universidad de Chile, Santiago, Chile
    Int J Cancer 107:715-20. 2003
    ..The latter responses seem to depend on the activity of protein kinase A, as demonstrated by the activation of the Ras-ERK pathway by specific protein kinase A inhibitors...
  6. doi Rac1 modulates TGF-beta1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes
    Juan F Santibanez
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos INTA, Universidad de Chile, Santiago, Chile
    FEBS Lett 584:2305-10. 2010
    ..We propose that regulation of TGF-beta1-mediated plasticity of transformed keratinocytes requires the cooperation between the Rac1 and MAPK signalling pathways...
  7. doi Spred2 inhibits TGF-beta1-induced urokinase type plasminogen activator expression, cell motility and epithelial mesenchymal transition
    Victor Villar
    Cellular Biology Laboratory, Nutrition and Food Technology Institute, INTA, Universidad de Chile, Chile
    Int J Cancer 127:77-85. 2010
    ..Finally, SP cells could not respond to the TGF-beta1 stimulus on cell migration. Taken together, the data in the present study suggests that Spred2 is a regulator of TGF-beta1-induced malignance in transformed keratinocytes...
  8. pmc Skip Regulates TGF- β 1-Induced Extracellular Matrix Degrading Proteases Expression in Human PC-3 Prostate Cancer Cells
    Victor Villar
    Laboratorio de Biologia Celular, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, 7810000 Santiago, Chile Department of Biology, University of the Balearic Islands, Ctra Valldemossa, km 7 5, 07122 Palma de Mallorca, Spain
    Prostate Cancer 2013:398253. 2013
    ..Thus, SKIP is implicated in the regulation of extracellular matrix degradation and can therefore be suggested as a novel therapeutic target in prostate cancer treatment...
  9. doi RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism
    Nicolas Tobar
    Laboratorio de Biologia Celular, INTA, Universidad de Chile, Casilla 138, Santiago 11, Chile
    Cancer Lett 267:125-32. 2008
    ..We suggest that Rac1 plays a role in cellular migration not only limited to its known function in reorganization of the actin cytoskeleton, but also as part of the intracellular machinery that controls the redox balance...